Correlation of metallothionein expression with apoptosis in nasapharyngeal carcinoma

British Journal of Cancer

Volumn 82, Issue 6, 2000, Pages 1198-1203

  Jayasurya, A ^a   Bay, B H ^a   Yap, W M ^b   Tan, N G ^c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b TAN TOCK SENG HOSPITAL   (Singapore)

^c SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

Apoptosis; Metallothionein immunohistochemistry; Nasopharyngeal cancer; Nuclear localization; Ultrastructure

Indexed keywords

METALLOTHIONEIN;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL NUCLEUS; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOGOLD STAINING; IMMUNOHISTOCHEMISTRY; LABELING INDEX; MALE; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; RADIOSENSITIVITY; TISSUE SECTION;

EID: 0034053540     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.1999.1063     Document Type: Article

References (30)

1. Aoki Y and Suzuki KT (1991) Detection of metallothionein by Western blotting. Methods Enzymol 205: 108-114
2. Bahnson RR, Banner BF, Ernstoff MS, Lazo JS and Cherian MG (1991) Immunohistochemical localisation of metallothionien in transitional cell carcinoma of the bladder. J Urol 146: 1518-1520
3. Bailet JW, Mark RF, Abemayor E, Lee SP, Tran LM, Julliard G and Ward PH (1992) Nasopharyngeal carcinoma: treatment results with primary radiation therapy. Laryngoscope 102: 965-972
4. Bay BH, Chan YG, Fong CM and Leong HK (1997) Differential cellular zinc levels in metastatic and primary nasopharyngeal carcinoma. Int J Oncol 11: 745-748
5. Bay BH, Chan YG, Tuck YK and Leong HK (1998) Electron microscopic observations and X-ray microanalysis of a multinucleated giant cell. J Electron Microsc 47: 359-361
6. Briehl MM and Baker AF (1996) Modulation of the antioxidant defence as a factor in apoptosis. Cell Death Differ 3: 63-70
7. Buttke TM and Sandstrom PA (1994) Oxidative stress as a mediator of apoptosis. Immunol Today 15: 7-10
8. Cai L, Wang GJ, Xu ZL, Deng DX, Chakrabarti S and Cherian MG (1998) Metallothionein and apoptosis in primary human hepatocellular carcinoma from Northern China. Anticancer Res 18: 4667-4672
9. Cherian MG, Howell SB, Imura N, Klaassen CD, Koropatnick J, Lazo JS and Waalkes MP (1994) Role of metallothionein in carcinogenesis. Toxicol Applied Pharmacol 126: 1-5
10. Germain I, Tetu B, Brisson J, Mondor M and Cherian MG (1996) Markers of chemoresistance in ovarian carcinomas: an immunohistochemical study of 86 cases. Int J Gynecol Pathol 15: 54-62
11. Jin R, Bay BH, Tan PH and Tan BKH (1999) Metallothionein expression and zinc levels in invasive ductal carcinoma of the breast. Oncol Rep 6: 871-875
12. Kagi JHR and Schaffer A (1988) Biochemistry of metallothionein. Biochemistry 27: 8509-8514
13. Kelley SL, Basu A, Teicher BA, Hacker P, Hamer DH and Lazo JS (1988) Overexpression of metallothionein confers resistance to anticancer drugs. Science 241: 1813-1815
14. Kontozoglou TE, Banerjee D and Cherian MG (1989) Immunohistochemical localisation of metallothionein in human testicular embryonal adenocarcinoma. Virchows Arch 45: 545-549
15. Kouvidou CH, Stefanaki K, Dai Y, Tzardi M, Koutsoubi K, Darivianaki K, Karidi E, Rontogianni D, Zois E, Kakolyris S, Georgoulias V, Delides G and Kanavaros P (1997) P21/waf1 protein expression in nasopharyngeal carcinoma. Comparitive study with PCNA, P53 and MDM-2 protein expression. Anticancer Res 17: 2615-2620
16. Kuo SM, Kondo Y, DeFilippo JM, Ernstoff MS, Bahnson RR and Lazo JS (1994) Subcellular localization of metallothionein IIA in human bladder tumor cells using a novel epitope-specific antiserum. Toxicol Applied Pharmacol 125: 104-110
17. Lazo JS and Pitt BR (1995) Metallothionein and cell death by anticancer drugs. Annu Rev Pharmacol Toxicol 35: 635-653
18. Lo KW, Mok CH, Huang DP, Liu YX, Choi PH-K, Lee JCK and Tsao SW (1992) P53 mutation in human nasopharyngeal carcinomas. Anticancer Res 12: 1957-1964
19. McCormick CC and Lin LY (1991) Quantification and identification of metallothioneins by gel electrophoresis and silver staining. Meth Enzymol 205: 71-78
20. Meyn RE, Stephens LC and Milas L (1996) Programmed cell death and radioresistance. Cancer Metastasis Rev 15: 119-131
21. Oh Y and Mao L (1997) Biomarkers in head and neck carcinomas. Curr Opin Oncol 9: 247-256
22. Roychowdhury DF, Tseng A Jr, Fu KK, Weinberg V and Weidner N (1996) New prognostic factors in nasopharyngeal carcinoma. Cancer 77: 1419-1426
23. Schmid KW, Ellis IO, Gee JM, Darke BM, Lees WE, Kay J, Cryer A, Stark JM, Ofner D, Dunser M, Margreiter R, Daxenbichter G, Nicholson RI, Bier B, Bocker W and Jasani B (1993) Presence and possible significance of immunocytochemically demonstrable metallothionein overexpression in primary invasive ductal carcinoma of the breast. Virchows Arch 422: 153-159
24. Shanmugaratnam K, Chan SH, de-The G, Goh EH, Khor TH, Simons MJ and Tye CY (1979) Histopathology of nasopharyngeal carcinoma. Cancer 44: 1029-1044
25. Stirling JW and Graff PS (1995) Antigen unmasking for immunoelectron microscopy: labelling is improved by treating with sodium ethoxide or sodium metaperiodate, then heating on retrieval medium. J Histochem Cytochem 43: 115-123
26. Sundelin K, Jadner M, Norberg-Spaak L, Davidsson A and Hellquist HB (1997) Metallothionein and Fas (CD95) are expressed in squamous carcinoma of the tongue. Eur J Cancer 33: 1861-1864
27. Tan Y, Sinniah R, Bay B-H and Singh G (1999) Metallothionein expression and nuclear size in benign, borderline and malignant serous ovarian tumors. J Pathol 189: 60-65
28. Woo ES, Kondo Y, Watkins SC, Hoyt DG and Lazo JS (1996) Nucleophilic distribution of metallothionein in human tumor cells. Exp Cell Res 224: 365-371
29. Zhang X-H and Takenaka I (1998) Incidence of apoptosis and metallothionein expression in renal cell carcinoma. Br J Urol 81: 9-13
30. Zelger B, Hittmair A, Schir M, Ofner C, Ofner D, Fritsch PO, Bocker W, Jasani B and Schmid KW (1993) Immunohistochemically demonstrated metallothionein expression in malignant melanoma. Histopathology 23: 257-264