Identification of the benzyloxyphenyl pharmacophore: A structural unit that promotes sodium channel slow inactivation

ACS Chemical Neuroscience

Volumn 3, Issue 12, 2012, Pages 1037-1049

  King, Amber M ^a   Yang, Xiao Fang ^c   Wang, Yuying ^c   Dustrude, Erik T ^c   Barbosa, Cindy ^c   Due, Michael R ^c   Piekarz, Andrew D ^c   Wilson, Sarah M ^c   White, Fletcher A ^c   Salomé, Christophe ^a   Cummins, Theodore R ^c   Khanna, Rajesh ^c   Kohn, Harold ^a,b  

^a University of North Carolina   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

anticonvulsant activity; Benzyloxyphenyl pharmacophore; epilepsy; hyperexcitable neurons; slow inactivation; voltage gated sodium channels

Indexed keywords

BENZENE DERIVATIVE; CATECHOLAMINE DERIVATIVE; SODIUM CHANNEL; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.3; SODIUM CHANNEL NAV1.7; VOLTAGE GATED SODIUM CHANNEL;

ACETYLATION; ANTICONVULSANT ACTIVITY; ARTICLE; CELL SIZE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DOSE RESPONSE; ELECTROPHYSIOLOGY; MALE; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE CELL EXCITABILITY; NONHUMAN; PATCH CLAMP; PHARMACOPHORE; PRIORITY JOURNAL; RAT; SEIZURE; STEADY STATE; SYNTHESIS; WHOLE CELL;

ACETAMIDES; ANIMALS; ANTICONVULSANTS; FEMALE; HEK293 CELLS; HUMANS; MALE; MEMBRANE POTENTIALS; MICE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS;

EID: 84871318530     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn300129d     Document Type: Article

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