Cervical cancer with polymorphism in MTHFR C677T gene: A systematic review and meta-analysis

Molecular Biology Reports

Volumn 40, Issue 1, 2013, Pages 255-262

  Xu, Xiao Juan ^a   Zou, Li Wei ^a   Wang, De Bin ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Cervical cancer; Meta analysis; MTHFR C677T; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ALLELE; CANCER RISK; CANCER SUSCEPTIBILITY; CHINESE; DNA POLYMORPHISM; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MTHFR GENE; REVIEW; SYSTEMATIC REVIEW; UTERINE CERVIX CANCER;

ALLELES; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PUBLICATION BIAS; UTERINE CERVICAL NEOPLASMS;

EID: 84871316230     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-2056-3     Document Type: Review

References (30)

1. Seoud M, Tjalma WA, Ronsse V (2011) Cervical adenocarcinoma: moving towards better prevention. Vaccine 29(49):9148-9158
2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimatesof worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893-2917
3. Mutchinick OM, López MA, Luna L, Waxman J, Babinsky VE (1999) High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects. Mol Genet Metab 68(4):461-467
4. Uehara SK, Rosa G (2008) Association of homocysteinemia with high concentrations of serum insulin and uric acid in Brazilian subjects with metabolic syndrome genotyped for C677T polymorphism in the methylenetetrahydrofolate reductase gene. Nutr Res 28(11):760-766
5. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP et al (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10(1):111-113
6. Kim YI (1999) Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects. Nutr Rev 57(10):314-321
7. Lambropoulos AF, Agorastos T, Foka ZJ, Chrisafi S, Constantinidis TC, Bontis J, Kotsis A (2003) Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia. Cancer Lett 191(2):187-191
8. Ho CH, Kuo BI, Kong CW, Chau WK, Hsu HC, Gau JP, Yu YB (2005) Influence of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, B vitamins and other factors on plasma homocysteine and risk of thromboembolic disease in Chinese. J Chin Med Assoc 68(12):560-565
9. Sull JW, Jee SH, Yi S, Lee JE, Park JS, Kim S, Ohrr H (2004) The effect of methylenetetrahydrofolate reductase polymorphism C677T on cervical cancer in Korean women. Gynecol Oncol 95(3):557-563
10. Zoodsma M, Nolte IM, Schipper M, Oosterom E, van der Steege G, de Vries EG, te Meerman GJ, van der Zee AG (2005) Methylenetetrahydrofolate reductase (MTHFR) and susceptibility for (pre)neoplastic cervical disease. Hum Genet 116(4):247-254
11. Kang S, Kim JW, Kang GH, Park NH, Song YS, Kang SB, Lee HP (2005) Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer. Gynecol Oncol 96(1):173-180
12. Xiaochen M, Jintao W, Qin Z, Lin D, Yuying C, Zhimin W, Juanjuan D (2006) Relationship between Methylenetetrahydrofolate reductase polymorphism and cervical cancer susceptibility. Chin J Public Health I2(22):1427-1428
13. Shekari M, Sobti RC, Kordi Tamandani DM, Suri V (2008) Impact of methylenetetrahydrofolate reductase (MTHFR) codon (677) and methionine synthase (MS) codon (2756) on risk of cervical carcinogenesis in North Indian population. Arch Gynecol Obstet 278(6):517-524
14. Mostowska A, Myka M, Lianeri M, Roszak A, Jagodziński PP (2011) Folate and choline metabolism gene variants and development of uterine cervical carcinoma. Clin Biochem 44(8-9):596-600
15. Tong SY, Kim MK, Lee JK, Lee JM, Choi SW, Friso S, Song ES, Lee KB, Lee JP (2011) Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. Cancer Causes Control 22(1):63-72
16. Prasad VV, Wilkhoo H (2011) Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers. Onkologie 34(8-9):422-426
17. von Keyserling H, Bergmann T, Schuetz M, Schiller U, Stanke J, Hoffmann C, Schneider A, Lehrach H, Dahl A, Kaufmann AM (2011) Analysis of 4 single-nucleotide polymorphisms in relation to cervical dysplasia and cancer development using a high-throughput ligation-detection reaction procedure. Int J Gynecol Cancer 21(9):1664-1671
18. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539-1558
19. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557-560
20. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Controlled Clin Trials 7(3):177-188
21. Sterne JA, Egger M, Smith GD (2001) Systematic reviews in health care: investigating and dealing with publication and other biases in meta-analysis. BMJ 323:101-105
22. Zheng YZ, Tong J, Do XP, Pu XQ, Zhou BT (2000) Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population. Br J Haematol 109(4):870-874
23. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93(1):7-9
24. van der Put NM, Steegers-Theunissen RP, Frosst P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Rozen R, Blom HJ (1995) Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346(8982):1070-1071
25. Brugada R, Marian AJ (1997) A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction. Atherosclerosis 128(1):107-112
26. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57(6):1098-1102
27. Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford SA, Yasui Y, Potter JD (1999) Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev 8(8):659-668
28. Levine AJ, Siegmund KD, Ervin CM, Diep A, Lee ER, Frankl HD, Haile RW (2000) The methylenetetrahydrofolate reductase 677C->T polymorphism and distal colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev 9(7):657-663
29. Slattery ML, Potter JD, Samowitz W, Schaffer D, Leppert M (1999) Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 8(6):513-518
30. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, Morgan G (1999) Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci U S A 96(22):12810-12815