Influence of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, B vitamins and other factors on plasma homocysteine and risk of thromboembolic disease in Chinese

Journal of the Chinese Medical Association

Volumn 68, Issue 12, 2005, Pages 560-565

  Ho, Chao Hung ^a,b   Kuo, Benjamin Ing Tiau ^a,b   Kong, Chi Woon ^a,b   Chau, Wing Keung ^a,b   Hsu, Hui Chi ^a,b   Gau, Jyh Pyng ^a,b   Yu, Yuan Bin ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Folic acid level; Methylenetetrahydrofolate reductase polymorphism; Plasma homocysteine level; Thromboembolic disease; Vitamin B6 and B12 levels

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CHOLESTEROL; CYANOCOBALAMIN; FOLIC ACID; GLUCOSE; HOMOCYSTEINE; PYRIDOXINE; TRIACYLGLYCEROL; VITAMIN B GROUP;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLOOD CELL COUNT; CHINESE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DEEP VEIN THROMBOSIS; DIABETES MELLITUS; DIET RESTRICTION; DNA POLYMORPHISM; FOLIC ACID BLOOD LEVEL; GENDER; GENE MUTATION; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; PROTEIN BLOOD LEVEL; RISK FACTOR; THROMBOEMBOLISM; VITAMIN BLOOD LEVEL;

EID: 29544438764     PISSN: 17264901     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1726-4901(09)70094-2     Document Type: Article

References (23)

1. Chan CW, Hoaglund FT. Pulmonary thromboembolism and venous thrombosis in the Chinese. Clin Orthop Relat Res 1980;150:253-60.
2. Cheng KK, Lai ST, Yu TJ, Duo SM. Postoperative deep vein thrombosis in the Taiwanese Chinese population. Am J Surg 1987;153:302-5.
3. Woo KS, Tse LK, Tse CY, Metreweli C, Vallance-Owen J. The prevalence and pattern of pulmonary thromboembolism in the Chinese in Hong Kong. Int J Cardiol 1988;20:373-80.
4. Ho CH. Prevalence of activated protein C resistance in the Chinese population. Thromb Res 1997;88:409-12.
5. Ho CH, Chau WK, Hsu HC, Gau JP, Chih CM. Prevalence of factor V Leiden in the Chinese population. J Chin Med Assoc 1999;62:875-8.
6. Ho CH. Prevalence of prothrombin 20210 A allele and methylenetetrahydrofolate reductase C677T genetic mutations in the Chinese population. Ann Hematol 2000;79:239-42.
7. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
8. Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993;90:1004-8.
9. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-7.
10. Hajjar KA. Factor V Leiden - an unselfish gene? N Engl J Med 1994;331:1585-7.
11. Dahlback B. Resistance to activate protein C, the Arg506 to Gln mutation in the factor V gene, and venous thrombosis. Functional tests and DNA-based assays, pros and cons. Thromb Haemost 1995;73:739-42.
12. Dahlback B. Molecular genetics of venous thromboembolism. Ann Med 1995;27:187-92.
13. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995;346:1133-4.
14. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996;88:3698-703.
15. Chan LC, Bourke C, Lam CK, Liu HW, Brookes S, Jenkins V, Pasi J. Lack of activated protein C resistance in healthy Hong Kong Chinese blood donors - correlation with absence of Arg506-Gln mutation of factor V gene. Thromb Haemost 1996;75:522-3.
16. Selhub J, D'Angelo A. Hyperhomocysteinemia and thrombosis: acquired conditions. Thromb Haemost 1997;78:527-31.
17. Selhub J, Miller JW. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosyl-methionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 1992;55:131-8.
18. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996;93:7-9.
19. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57.
20. Guttormsen AB, Schneede J, Fiskerstrand T, Ueland PM, Refsum HM. Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects. J Nutr 1994;124:1934-41.
21. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993;270: 2693-8.
22. Daly L, Robinson K, Tan KS, Graham IM. Hyperhomocysteinaemia: a metabolic risk factor for coronary heart disease determined by both genetic and environmental influences? Q J Med 1993;86:685-9.
23. Ho CH. The influence of age, sex, vitamin B12, folate levels and methylenetetrahydrofolate reductase C677T genetic mutations on plasma homocysteine in the Chinese population. Haematologica 2000;85:1051-4.