Structural mapping of post-translational modifications in human interleukin-24. Role of N-linked glycosylation and disulfide bonds in secretion and activity

Journal of Biological Chemistry

Volumn 284, Issue 44, 2009, Pages 30526-30533

  Fuson, Kerry L ^a   Zheng, Mingzhong ^b   Craxton, Molly ^c   Pataer, Abujiang ^d   Ramesh, Rajagopal ^d   Chada, Sunil ^e   Sutton, R Bryan ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b Introgen Therapeutics Inc   (United States)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e INTREXON CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-ANGIOGENIC ACTIVITY; BIOLOGICAL ACTIVITIES; CLINICAL APPLICATION; CYSTEINE RESIDUES; CYTOKINE ACTIVITY; CYTOKINES; DISULFIDE BONDS; GLYCOSYLATED; HOST CELLS; HUMAN INTERLEUKIN; IMMUNE STIMULATION; N-LINKED GLYCOSYLATION; POST-TRANSLATIONAL MODIFICATIONS; PRIMARY SEQUENCES; PROTEIN SOLUBILITY; SCALE-UP; SEQUENCE SIMILARITY; STRUCTURAL BASIS; STRUCTURAL MAPPING; STRUCTURE-FUNCTION RELATIONSHIP; T CELLS; TUMOR CELLS;

GLYCOSYLATION; SOLUBILITY; STRATEGIC PLANNING; SULFUR COMPOUNDS; SURFACE PROPERTIES; TERNARY SYSTEMS;

ESTERIFICATION;

CYTOKINE; INTERLEUKIN 24;

ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DISULFIDE BOND; ENZYME ACTIVITY; GENE MAPPING; GENE SEQUENCE; GENETIC CONSERVATION; GLYCOSYLATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; PROTEIN SECRETION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; SOLUBILITY; STRUCTURE ANALYSIS; UBIQUITINATION;

CYSTEINE; CYTOKINES; DISULFIDES; GLYCOSYLATION; HUMANS; INTERLEUKINS; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71049147216     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.036061     Document Type: Article

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