Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Prorok, Paulina ^a,b   Saint Pierre, Christine ^c   Gasparutto, Didier ^c   Fedorova, Olga S ^d   Ishchenko, Alexander A ^b   Leh, Hervé ^e   Buckle, Malcolm ^e   Tudek, Barbara ^b,f   Saparbaev, Murat ^b  

^a INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^b Gustave Roussy Comprehensive Cancer Institute   (France)

^c CEA GRENOBLE   (France)

^d INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^e Ecole Normale Superieure de Cachan   (France)

^f UNIVERSITY OF WARSAW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIHYDRO 5,6 DIHYDROXYTHYMINE; 8 HYDROXYGUANINE; DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE 1; DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; GLYCOL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DNA ADDUCT; DNA REPAIR; ENZYME SPECIFICITY; GEL MOBILITY SHIFT ASSAY; HELA CELL; HUMAN; HUMAN CELL; IC 50; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEOTIDE INCISION REPAIR; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; SURFACE PLASMON RESONANCE;

ADENINE; BIOCATALYSIS; CELL EXTRACTS; CELL-FREE SYSTEM; CYTOSINE; DNA ADDUCTS; DNA GLYCOSYLASES; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HELA CELLS; HUMANS; KINETICS; MUTAGENS; OLIGONUCLEOTIDES; OXIDATION-REDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; THYMINE; TIME FACTORS;

MAMMALIA;

EID: 84871293998     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051776     Document Type: Article

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