메뉴 건너뛰기




Volumn 7, Issue 12, 2012, Pages

Ras/MAPK Signaling Modulates VEGFR-3 Expression through Ets-Mediated p300 Recruitment and Histone Acetylation on the Vegfr3 Gene in Lymphatic Endothelial Cells

Author keywords

[No Author keywords available]

Indexed keywords

E1A ASSOCIATED P300 PROTEIN; HISTONE H3; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; TRANSCRIPTION FACTOR ETS; VASCULOTROPIN RECEPTOR 3;

EID: 84871274937     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051639     Document Type: Article
Times cited : (18)

References (42)
  • 1
    • 81255188905 scopus 로고    scopus 로고
    • The lymphatic vasculature in disease
    • Alitalo K, (2011) The lymphatic vasculature in disease. Nat Med 17: 1371-1380.
    • (2011) Nat Med , vol.17 , pp. 1371-1380
    • Alitalo, K.1
  • 4
    • 47949083776 scopus 로고    scopus 로고
    • Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos
    • Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, et al. (2008) Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol 28: 4843-4850.
    • (2008) Mol Cell Biol , vol.28 , pp. 4843-4850
    • Haiko, P.1    Makinen, T.2    Keskitalo, S.3    Taipale, J.4    Karkkainen, M.J.5
  • 5
    • 78649899926 scopus 로고    scopus 로고
    • VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis
    • Zhang L, Zhou F, Han W, Shen B, Luo J, et al. (2010) VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res 20: 1319-1331.
    • (2010) Cell Res , vol.20 , pp. 1319-1331
    • Zhang, L.1    Zhou, F.2    Han, W.3    Shen, B.4    Luo, J.5
  • 6
    • 0032582502 scopus 로고    scopus 로고
    • Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
    • Dumont DJ, Jussila L, Taipale J, Lymboussaki A, Mustonen T, et al. (1998) Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 282: 946-949.
    • (1998) Science , vol.282 , pp. 946-949
    • Dumont, D.J.1    Jussila, L.2    Taipale, J.3    Lymboussaki, A.4    Mustonen, T.5
  • 7
    • 9144236286 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    • Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, et al. (2004) Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 5: 74-80.
    • (2004) Nat Immunol , vol.5 , pp. 74-80
    • Karkkainen, M.J.1    Haiko, P.2    Sainio, K.3    Partanen, J.4    Taipale, J.5
  • 8
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, et al. (2002) Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 94: 819-825.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 819-825
    • He, Y.1    Kozaki, K.2    Karpanen, T.3    Koshikawa, K.4    Yla-Herttuala, S.5
  • 9
    • 12444343144 scopus 로고    scopus 로고
    • Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody
    • Pytowski B, Goldman J, Persaud K, Wu Y, Witte L, et al. (2005) Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. J Natl Cancer Inst 97: 14-21.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 14-21
    • Pytowski, B.1    Goldman, J.2    Persaud, K.3    Wu, Y.4    Witte, L.5
  • 10
    • 20144369085 scopus 로고    scopus 로고
    • Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    • Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, et al. (2005) Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest 115: 247-257.
    • (2005) J Clin Invest , vol.115 , pp. 247-257
    • Baluk, P.1    Tammela, T.2    Ator, E.3    Lyubynska, N.4    Achen, M.G.5
  • 11
    • 75649083174 scopus 로고    scopus 로고
    • Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1
    • Flister MJ, Wilber A, Hall KL, Iwata C, Miyazono K, et al. (2010) Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. Blood 115: 418-429.
    • (2010) Blood , vol.115 , pp. 418-429
    • Flister, M.J.1    Wilber, A.2    Hall, K.L.3    Iwata, C.4    Miyazono, K.5
  • 12
    • 79955957828 scopus 로고    scopus 로고
    • An important role of lymphatic vessel activation in limiting acute inflammation
    • Huggenberger R, Siddiqui SS, Brander D, Ullmann S, Zimmermann K, et al. (2011) An important role of lymphatic vessel activation in limiting acute inflammation. Blood 117: 4667-4678.
    • (2011) Blood , vol.117 , pp. 4667-4678
    • Huggenberger, R.1    Siddiqui, S.S.2    Brander, D.3    Ullmann, S.4    Zimmermann, K.5
  • 13
    • 79961149491 scopus 로고    scopus 로고
    • Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1
    • Yoshimatsu Y, Yamazaki T, Mihira H, Itoh T, Suehiro J, et al. (2011) Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. J Cell Sci 124: 2753-2762.
    • (2011) J Cell Sci , vol.124 , pp. 2753-2762
    • Yoshimatsu, Y.1    Yamazaki, T.2    Mihira, H.3    Itoh, T.4    Suehiro, J.5
  • 14
    • 84857645999 scopus 로고    scopus 로고
    • Mirtron MicroRNA-1236 Inhibits VEGFR-3 Signaling During Inflammatory Lymphangiogenesis
    • Jones D, Li Y, He Y, Xu Z, Chen H, et al. (2012) Mirtron MicroRNA-1236 Inhibits VEGFR-3 Signaling During Inflammatory Lymphangiogenesis. Arterioscler Thromb Vasc Biol 32: 633-642.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 633-642
    • Jones, D.1    Li, Y.2    He, Y.3    Xu, Z.4    Chen, H.5
  • 15
    • 0035212584 scopus 로고    scopus 로고
    • Co-expression of VEGF-C and its receptors, VEGFR-2 and VEGFR-3, in endothelial cells of lymphangioma. Implication in autocrine or paracrine regulation of lymphangioma
    • Huang HY, Ho CC, Huang PH, Hsu SM, (2001) Co-expression of VEGF-C and its receptors, VEGFR-2 and VEGFR-3, in endothelial cells of lymphangioma. Implication in autocrine or paracrine regulation of lymphangioma. Laboratory Investigation 81: 1729-1734.
    • (2001) Laboratory Investigation , vol.81 , pp. 1729-1734
    • Huang, H.Y.1    Ho, C.C.2    Huang, P.H.3    Hsu, S.M.4
  • 16
    • 3042780203 scopus 로고    scopus 로고
    • Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    • Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, et al. (2004) Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet 36: 683-685.
    • (2004) Nat Genet , vol.36 , pp. 683-685
    • Hong, Y.K.1    Foreman, K.2    Shin, J.W.3    Hirakawa, S.4    Curry, C.L.5
  • 17
    • 3042738138 scopus 로고    scopus 로고
    • Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    • Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, et al. (2004) Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet 36: 687-693.
    • (2004) Nat Genet , vol.36 , pp. 687-693
    • Wang, H.W.1    Trotter, M.W.2    Lagos, D.3    Bourboulia, D.4    Henderson, S.5
  • 18
    • 17744384709 scopus 로고    scopus 로고
    • VEGFR3 gene structure, regulatory region, and sequence polymorphisms
    • Iljin K, Karkkainen MJ, Lawrence EC, Kimak MA, Uutela M, et al. (2001) VEGFR3 gene structure, regulatory region, and sequence polymorphisms. FASEB J 15: 1028-1036.
    • (2001) FASEB J , vol.15 , pp. 1028-1036
    • Iljin, K.1    Karkkainen, M.J.2    Lawrence, E.C.3    Kimak, M.A.4    Uutela, M.5
  • 19
    • 36048978608 scopus 로고    scopus 로고
    • Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
    • Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, et al. (2007) Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest 117: 3369-3382.
    • (2007) J Clin Invest , vol.117 , pp. 3369-3382
    • Shawber, C.J.1    Funahashi, Y.2    Francisco, E.3    Vorontchikhina, M.4    Kitamura, Y.5
  • 20
    • 0036840138 scopus 로고    scopus 로고
    • Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate
    • Hong YK, Harvey N, Noh YH, Schacht V, Hirakawa S, et al. (2002) Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn 225: 351-357.
    • (2002) Dev Dyn , vol.225 , pp. 351-357
    • Hong, Y.K.1    Harvey, N.2    Noh, Y.H.3    Schacht, V.4    Hirakawa, S.5
  • 21
    • 18544386859 scopus 로고    scopus 로고
    • Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
    • Petrova TV, Makinen T, Makela TP, Saarela J, Virtanen I, et al. (2002) Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J 21: 4593-4599.
    • (2002) EMBO J , vol.21 , pp. 4593-4599
    • Petrova, T.V.1    Makinen, T.2    Makela, T.P.3    Saarela, J.4    Virtanen, I.5
  • 22
    • 34247198981 scopus 로고    scopus 로고
    • Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades
    • Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, et al. (2007) Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell 18: 1421-1429.
    • (2007) Mol Biol Cell , vol.18 , pp. 1421-1429
    • Mishima, K.1    Watabe, T.2    Saito, A.3    Yoshimatsu, Y.4    Imaizumi, N.5
  • 23
    • 70350379641 scopus 로고    scopus 로고
    • Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells
    • Pan MR, Chang TM, Chang HC, Su JL, Wang HW, et al. (2009) Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells. J Cell Sci 122: 3358-3364.
    • (2009) J Cell Sci , vol.122 , pp. 3358-3364
    • Pan, M.R.1    Chang, T.M.2    Chang, H.C.3    Su, J.L.4    Wang, H.W.5
  • 24
    • 61849097153 scopus 로고    scopus 로고
    • Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate
    • Lee S, Kang J, Yoo J, Ganesan SK, Cook SC, et al. (2009) Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate. Blood 113: 1856-1859.
    • (2009) Blood , vol.113 , pp. 1856-1859
    • Lee, S.1    Kang, J.2    Yoo, J.3    Ganesan, S.K.4    Cook, S.C.5
  • 25
    • 77951833399 scopus 로고    scopus 로고
    • Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
    • Chen L, Mupo A, Huynh T, Cioffi S, Woods M, et al. (2010) Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol 189: 417-424.
    • (2010) J Cell Biol , vol.189 , pp. 417-424
    • Chen, L.1    Mupo, A.2    Huynh, T.3    Cioffi, S.4    Woods, M.5
  • 26
    • 77950346287 scopus 로고    scopus 로고
    • H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice
    • Ichise T, Yoshida N, Ichise H, (2010) H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice. Development 137: 1003-1013.
    • (2010) Development , vol.137 , pp. 1003-1013
    • Ichise, T.1    Yoshida, N.2    Ichise, H.3
  • 27
    • 79959466181 scopus 로고    scopus 로고
    • Genomic and biochemical insights into the specificity of ETS transcription factors
    • Hollenhorst PC, McIntosh LP, Graves BJ, (2011) Genomic and biochemical insights into the specificity of ETS transcription factors. Annu Rev Biochem 80: 437-471.
    • (2011) Annu Rev Biochem , vol.80 , pp. 437-471
    • Hollenhorst, P.C.1    McIntosh, L.P.2    Graves, B.J.3
  • 28
    • 0027984806 scopus 로고
    • The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway
    • Brunner D, Ducker K, Oellers N, Hafen E, Scholz H, et al. (1994) The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370: 386-389.
    • (1994) Nature , vol.370 , pp. 386-389
    • Brunner, D.1    Ducker, K.2    Oellers, N.3    Hafen, E.4    Scholz, H.5
  • 29
    • 0028239896 scopus 로고
    • The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway
    • O'Neill EM, Rebay I, Tjian R, Rubin GM, (1994) The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78: 137-147.
    • (1994) Cell , vol.78 , pp. 137-147
    • O'Neill, E.M.1    Rebay, I.2    Tjian, R.3    Rubin, G.M.4
  • 30
    • 0030048767 scopus 로고    scopus 로고
    • Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2
    • Yang BS, Hauser CA, Henkel G, Colman MS, Van Beveren C, et al. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol Cell Biol 16: 538-547.
    • (1996) Mol Cell Biol , vol.16 , pp. 538-547
    • Yang, B.S.1    Hauser, C.A.2    Henkel, G.3    Colman, M.S.4    Van Beveren, C.5
  • 31
    • 0031002072 scopus 로고    scopus 로고
    • Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2
    • Wasylyk C, Bradford AP, Gutierrez-Hartmann A, Wasylyk B, (1997) Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2. Oncogene 14: 899-913.
    • (1997) Oncogene , vol.14 , pp. 899-913
    • Wasylyk, C.1    Bradford, A.P.2    Gutierrez-Hartmann, A.3    Wasylyk, B.4
  • 32
    • 59649110012 scopus 로고    scopus 로고
    • Transcriptional control of endothelial cell development
    • De Val S, Black BL, (2009) Transcriptional control of endothelial cell development. Dev Cell 16: 180-195.
    • (2009) Dev Cell , vol.16 , pp. 180-195
    • De Val, S.1    Black, B.L.2
  • 33
    • 82755182573 scopus 로고    scopus 로고
    • Regulation of endothelial cell development by ETS transcription factors
    • Meadows SM, Myers CT, Krieg PA, (2011) Regulation of endothelial cell development by ETS transcription factors. Semin Cell Dev Biol 22: 976-984.
    • (2011) Semin Cell Dev Biol , vol.22 , pp. 976-984
    • Meadows, S.M.1    Myers, C.T.2    Krieg, P.A.3
  • 34
    • 57149148250 scopus 로고    scopus 로고
    • Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors
    • De Val S, Chi NC, Meadows SM, Minovitsky S, Anderson JP, et al. (2008) Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell 135: 1053-1064.
    • (2008) Cell , vol.135 , pp. 1053-1064
    • De Val, S.1    Chi, N.C.2    Meadows, S.M.3    Minovitsky, S.4    Anderson, J.P.5
  • 35
    • 77449109789 scopus 로고    scopus 로고
    • Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
    • Bedford DC, Kasper LH, Fukuyama T, Brindle PK, (2010) Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics 5: 9-15.
    • (2010) Epigenetics , vol.5 , pp. 9-15
    • Bedford, D.C.1    Kasper, L.H.2    Fukuyama, T.3    Brindle, P.K.4
  • 36
    • 10044283146 scopus 로고    scopus 로고
    • Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
    • Foulds CE, Nelson ML, Blaszczak AG, Graves BJ, (2004) Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. Mol Cell Biol 24: 10954-10964.
    • (2004) Mol Cell Biol , vol.24 , pp. 10954-10964
    • Foulds, C.E.1    Nelson, M.L.2    Blaszczak, A.G.3    Graves, B.J.4
  • 37
    • 77953395033 scopus 로고    scopus 로고
    • Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP
    • Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, et al. (2010) Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc Natl Acad Sci U S A 107: 10026-10031.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 10026-10031
    • Nelson, M.L.1    Kang, H.S.2    Lee, G.M.3    Blaszczak, A.G.4    Lau, D.K.5
  • 38
    • 70349260738 scopus 로고    scopus 로고
    • Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis
    • Wei G, Srinivasan R, Cantemir-Stone CZ, Sharma SM, Santhanam R, et al. (2009) Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood 114: 1123-1130.
    • (2009) Blood , vol.114 , pp. 1123-1130
    • Wei, G.1    Srinivasan, R.2    Cantemir-Stone, C.Z.3    Sharma, S.M.4    Santhanam, R.5
  • 39
    • 84856540111 scopus 로고    scopus 로고
    • RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice
    • Lapinski PE, Kwon S, Lubeck BA, Wilkinson JE, Srinivasan RS, et al. (2012) RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clin Invest 122: 733-747.
    • (2012) J Clin Invest , vol.122 , pp. 733-747
    • Lapinski, P.E.1    Kwon, S.2    Lubeck, B.A.3    Wilkinson, J.E.4    Srinivasan, R.S.5
  • 40
    • 48349129069 scopus 로고    scopus 로고
    • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    • Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, et al. (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454: 656-660.
    • (2008) Nature , vol.454 , pp. 656-660
    • Tammela, T.1    Zarkada, G.2    Wallgard, E.3    Murtomaki, A.4    Suchting, S.5
  • 41
    • 0141753974 scopus 로고    scopus 로고
    • Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation
    • Shikama N, Lutz W, Kretzschmar R, Sauter N, Roth JF, et al. (2003) Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J 22: 5175-5185.
    • (2003) EMBO J , vol.22 , pp. 5175-5185
    • Shikama, N.1    Lutz, W.2    Kretzschmar, R.3    Sauter, N.4    Roth, J.F.5
  • 42
    • 42449090686 scopus 로고    scopus 로고
    • Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse
    • Yamaguchi T, Ichise T, Iwata O, Hori A, Adachi T, et al. (2008) Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse. FEBS J 275: 1988-1998.
    • (2008) FEBS J , vol.275 , pp. 1988-1998
    • Yamaguchi, T.1    Ichise, T.2    Iwata, O.3    Hori, A.4    Adachi, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.