-
1
-
-
81255188905
-
The lymphatic vasculature in disease
-
Alitalo K, (2011) The lymphatic vasculature in disease. Nat Med 17: 1371-1380.
-
(2011)
Nat Med
, vol.17
, pp. 1371-1380
-
-
Alitalo, K.1
-
2
-
-
0034041161
-
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
-
Karkkainen MJ, Ferrell RE, Lawrence EC, Kimak MA, Levinson KL, et al. (2000) Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema. Nat Genet 25: 153-159.
-
(2000)
Nat Genet
, vol.25
, pp. 153-159
-
-
Karkkainen, M.J.1
Ferrell, R.E.2
Lawrence, E.C.3
Kimak, M.A.4
Levinson, K.L.5
-
3
-
-
0035940403
-
A model for gene therapy of human hereditary lymphedema
-
Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, et al. (2001) A model for gene therapy of human hereditary lymphedema. Proc Natl Acad Sci U S A 98: 12677-12682.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12677-12682
-
-
Karkkainen, M.J.1
Saaristo, A.2
Jussila, L.3
Karila, K.A.4
Lawrence, E.C.5
-
4
-
-
47949083776
-
Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos
-
Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, et al. (2008) Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol 28: 4843-4850.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4843-4850
-
-
Haiko, P.1
Makinen, T.2
Keskitalo, S.3
Taipale, J.4
Karkkainen, M.J.5
-
5
-
-
78649899926
-
VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis
-
Zhang L, Zhou F, Han W, Shen B, Luo J, et al. (2010) VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res 20: 1319-1331.
-
(2010)
Cell Res
, vol.20
, pp. 1319-1331
-
-
Zhang, L.1
Zhou, F.2
Han, W.3
Shen, B.4
Luo, J.5
-
6
-
-
0032582502
-
Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
-
Dumont DJ, Jussila L, Taipale J, Lymboussaki A, Mustonen T, et al. (1998) Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 282: 946-949.
-
(1998)
Science
, vol.282
, pp. 946-949
-
-
Dumont, D.J.1
Jussila, L.2
Taipale, J.3
Lymboussaki, A.4
Mustonen, T.5
-
7
-
-
9144236286
-
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
-
Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, et al. (2004) Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 5: 74-80.
-
(2004)
Nat Immunol
, vol.5
, pp. 74-80
-
-
Karkkainen, M.J.1
Haiko, P.2
Sainio, K.3
Partanen, J.4
Taipale, J.5
-
8
-
-
0037024472
-
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
-
He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, et al. (2002) Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 94: 819-825.
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 819-825
-
-
He, Y.1
Kozaki, K.2
Karpanen, T.3
Koshikawa, K.4
Yla-Herttuala, S.5
-
9
-
-
12444343144
-
Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody
-
Pytowski B, Goldman J, Persaud K, Wu Y, Witte L, et al. (2005) Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. J Natl Cancer Inst 97: 14-21.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 14-21
-
-
Pytowski, B.1
Goldman, J.2
Persaud, K.3
Wu, Y.4
Witte, L.5
-
10
-
-
20144369085
-
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
-
Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, et al. (2005) Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest 115: 247-257.
-
(2005)
J Clin Invest
, vol.115
, pp. 247-257
-
-
Baluk, P.1
Tammela, T.2
Ator, E.3
Lyubynska, N.4
Achen, M.G.5
-
11
-
-
75649083174
-
Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1
-
Flister MJ, Wilber A, Hall KL, Iwata C, Miyazono K, et al. (2010) Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. Blood 115: 418-429.
-
(2010)
Blood
, vol.115
, pp. 418-429
-
-
Flister, M.J.1
Wilber, A.2
Hall, K.L.3
Iwata, C.4
Miyazono, K.5
-
12
-
-
79955957828
-
An important role of lymphatic vessel activation in limiting acute inflammation
-
Huggenberger R, Siddiqui SS, Brander D, Ullmann S, Zimmermann K, et al. (2011) An important role of lymphatic vessel activation in limiting acute inflammation. Blood 117: 4667-4678.
-
(2011)
Blood
, vol.117
, pp. 4667-4678
-
-
Huggenberger, R.1
Siddiqui, S.S.2
Brander, D.3
Ullmann, S.4
Zimmermann, K.5
-
13
-
-
79961149491
-
Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1
-
Yoshimatsu Y, Yamazaki T, Mihira H, Itoh T, Suehiro J, et al. (2011) Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. J Cell Sci 124: 2753-2762.
-
(2011)
J Cell Sci
, vol.124
, pp. 2753-2762
-
-
Yoshimatsu, Y.1
Yamazaki, T.2
Mihira, H.3
Itoh, T.4
Suehiro, J.5
-
14
-
-
84857645999
-
Mirtron MicroRNA-1236 Inhibits VEGFR-3 Signaling During Inflammatory Lymphangiogenesis
-
Jones D, Li Y, He Y, Xu Z, Chen H, et al. (2012) Mirtron MicroRNA-1236 Inhibits VEGFR-3 Signaling During Inflammatory Lymphangiogenesis. Arterioscler Thromb Vasc Biol 32: 633-642.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 633-642
-
-
Jones, D.1
Li, Y.2
He, Y.3
Xu, Z.4
Chen, H.5
-
15
-
-
0035212584
-
Co-expression of VEGF-C and its receptors, VEGFR-2 and VEGFR-3, in endothelial cells of lymphangioma. Implication in autocrine or paracrine regulation of lymphangioma
-
Huang HY, Ho CC, Huang PH, Hsu SM, (2001) Co-expression of VEGF-C and its receptors, VEGFR-2 and VEGFR-3, in endothelial cells of lymphangioma. Implication in autocrine or paracrine regulation of lymphangioma. Laboratory Investigation 81: 1729-1734.
-
(2001)
Laboratory Investigation
, vol.81
, pp. 1729-1734
-
-
Huang, H.Y.1
Ho, C.C.2
Huang, P.H.3
Hsu, S.M.4
-
16
-
-
3042780203
-
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
-
Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, et al. (2004) Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet 36: 683-685.
-
(2004)
Nat Genet
, vol.36
, pp. 683-685
-
-
Hong, Y.K.1
Foreman, K.2
Shin, J.W.3
Hirakawa, S.4
Curry, C.L.5
-
17
-
-
3042738138
-
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
-
Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, et al. (2004) Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet 36: 687-693.
-
(2004)
Nat Genet
, vol.36
, pp. 687-693
-
-
Wang, H.W.1
Trotter, M.W.2
Lagos, D.3
Bourboulia, D.4
Henderson, S.5
-
18
-
-
17744384709
-
VEGFR3 gene structure, regulatory region, and sequence polymorphisms
-
Iljin K, Karkkainen MJ, Lawrence EC, Kimak MA, Uutela M, et al. (2001) VEGFR3 gene structure, regulatory region, and sequence polymorphisms. FASEB J 15: 1028-1036.
-
(2001)
FASEB J
, vol.15
, pp. 1028-1036
-
-
Iljin, K.1
Karkkainen, M.J.2
Lawrence, E.C.3
Kimak, M.A.4
Uutela, M.5
-
19
-
-
36048978608
-
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
-
Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, et al. (2007) Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest 117: 3369-3382.
-
(2007)
J Clin Invest
, vol.117
, pp. 3369-3382
-
-
Shawber, C.J.1
Funahashi, Y.2
Francisco, E.3
Vorontchikhina, M.4
Kitamura, Y.5
-
20
-
-
0036840138
-
Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate
-
Hong YK, Harvey N, Noh YH, Schacht V, Hirakawa S, et al. (2002) Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn 225: 351-357.
-
(2002)
Dev Dyn
, vol.225
, pp. 351-357
-
-
Hong, Y.K.1
Harvey, N.2
Noh, Y.H.3
Schacht, V.4
Hirakawa, S.5
-
21
-
-
18544386859
-
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
-
Petrova TV, Makinen T, Makela TP, Saarela J, Virtanen I, et al. (2002) Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J 21: 4593-4599.
-
(2002)
EMBO J
, vol.21
, pp. 4593-4599
-
-
Petrova, T.V.1
Makinen, T.2
Makela, T.P.3
Saarela, J.4
Virtanen, I.5
-
22
-
-
34247198981
-
Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades
-
Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, et al. (2007) Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell 18: 1421-1429.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 1421-1429
-
-
Mishima, K.1
Watabe, T.2
Saito, A.3
Yoshimatsu, Y.4
Imaizumi, N.5
-
23
-
-
70350379641
-
Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells
-
Pan MR, Chang TM, Chang HC, Su JL, Wang HW, et al. (2009) Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells. J Cell Sci 122: 3358-3364.
-
(2009)
J Cell Sci
, vol.122
, pp. 3358-3364
-
-
Pan, M.R.1
Chang, T.M.2
Chang, H.C.3
Su, J.L.4
Wang, H.W.5
-
24
-
-
61849097153
-
Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate
-
Lee S, Kang J, Yoo J, Ganesan SK, Cook SC, et al. (2009) Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate. Blood 113: 1856-1859.
-
(2009)
Blood
, vol.113
, pp. 1856-1859
-
-
Lee, S.1
Kang, J.2
Yoo, J.3
Ganesan, S.K.4
Cook, S.C.5
-
25
-
-
77951833399
-
Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
-
Chen L, Mupo A, Huynh T, Cioffi S, Woods M, et al. (2010) Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol 189: 417-424.
-
(2010)
J Cell Biol
, vol.189
, pp. 417-424
-
-
Chen, L.1
Mupo, A.2
Huynh, T.3
Cioffi, S.4
Woods, M.5
-
26
-
-
77950346287
-
H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice
-
Ichise T, Yoshida N, Ichise H, (2010) H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice. Development 137: 1003-1013.
-
(2010)
Development
, vol.137
, pp. 1003-1013
-
-
Ichise, T.1
Yoshida, N.2
Ichise, H.3
-
27
-
-
79959466181
-
Genomic and biochemical insights into the specificity of ETS transcription factors
-
Hollenhorst PC, McIntosh LP, Graves BJ, (2011) Genomic and biochemical insights into the specificity of ETS transcription factors. Annu Rev Biochem 80: 437-471.
-
(2011)
Annu Rev Biochem
, vol.80
, pp. 437-471
-
-
Hollenhorst, P.C.1
McIntosh, L.P.2
Graves, B.J.3
-
28
-
-
0027984806
-
The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway
-
Brunner D, Ducker K, Oellers N, Hafen E, Scholz H, et al. (1994) The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370: 386-389.
-
(1994)
Nature
, vol.370
, pp. 386-389
-
-
Brunner, D.1
Ducker, K.2
Oellers, N.3
Hafen, E.4
Scholz, H.5
-
29
-
-
0028239896
-
The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway
-
O'Neill EM, Rebay I, Tjian R, Rubin GM, (1994) The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78: 137-147.
-
(1994)
Cell
, vol.78
, pp. 137-147
-
-
O'Neill, E.M.1
Rebay, I.2
Tjian, R.3
Rubin, G.M.4
-
30
-
-
0030048767
-
Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2
-
Yang BS, Hauser CA, Henkel G, Colman MS, Van Beveren C, et al. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol Cell Biol 16: 538-547.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 538-547
-
-
Yang, B.S.1
Hauser, C.A.2
Henkel, G.3
Colman, M.S.4
Van Beveren, C.5
-
31
-
-
0031002072
-
Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2
-
Wasylyk C, Bradford AP, Gutierrez-Hartmann A, Wasylyk B, (1997) Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2. Oncogene 14: 899-913.
-
(1997)
Oncogene
, vol.14
, pp. 899-913
-
-
Wasylyk, C.1
Bradford, A.P.2
Gutierrez-Hartmann, A.3
Wasylyk, B.4
-
32
-
-
59649110012
-
Transcriptional control of endothelial cell development
-
De Val S, Black BL, (2009) Transcriptional control of endothelial cell development. Dev Cell 16: 180-195.
-
(2009)
Dev Cell
, vol.16
, pp. 180-195
-
-
De Val, S.1
Black, B.L.2
-
33
-
-
82755182573
-
Regulation of endothelial cell development by ETS transcription factors
-
Meadows SM, Myers CT, Krieg PA, (2011) Regulation of endothelial cell development by ETS transcription factors. Semin Cell Dev Biol 22: 976-984.
-
(2011)
Semin Cell Dev Biol
, vol.22
, pp. 976-984
-
-
Meadows, S.M.1
Myers, C.T.2
Krieg, P.A.3
-
34
-
-
57149148250
-
Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors
-
De Val S, Chi NC, Meadows SM, Minovitsky S, Anderson JP, et al. (2008) Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell 135: 1053-1064.
-
(2008)
Cell
, vol.135
, pp. 1053-1064
-
-
De Val, S.1
Chi, N.C.2
Meadows, S.M.3
Minovitsky, S.4
Anderson, J.P.5
-
35
-
-
77449109789
-
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
-
Bedford DC, Kasper LH, Fukuyama T, Brindle PK, (2010) Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics 5: 9-15.
-
(2010)
Epigenetics
, vol.5
, pp. 9-15
-
-
Bedford, D.C.1
Kasper, L.H.2
Fukuyama, T.3
Brindle, P.K.4
-
36
-
-
10044283146
-
Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
-
Foulds CE, Nelson ML, Blaszczak AG, Graves BJ, (2004) Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. Mol Cell Biol 24: 10954-10964.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10954-10964
-
-
Foulds, C.E.1
Nelson, M.L.2
Blaszczak, A.G.3
Graves, B.J.4
-
37
-
-
77953395033
-
Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP
-
Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, et al. (2010) Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc Natl Acad Sci U S A 107: 10026-10031.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 10026-10031
-
-
Nelson, M.L.1
Kang, H.S.2
Lee, G.M.3
Blaszczak, A.G.4
Lau, D.K.5
-
38
-
-
70349260738
-
Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis
-
Wei G, Srinivasan R, Cantemir-Stone CZ, Sharma SM, Santhanam R, et al. (2009) Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood 114: 1123-1130.
-
(2009)
Blood
, vol.114
, pp. 1123-1130
-
-
Wei, G.1
Srinivasan, R.2
Cantemir-Stone, C.Z.3
Sharma, S.M.4
Santhanam, R.5
-
39
-
-
84856540111
-
RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice
-
Lapinski PE, Kwon S, Lubeck BA, Wilkinson JE, Srinivasan RS, et al. (2012) RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clin Invest 122: 733-747.
-
(2012)
J Clin Invest
, vol.122
, pp. 733-747
-
-
Lapinski, P.E.1
Kwon, S.2
Lubeck, B.A.3
Wilkinson, J.E.4
Srinivasan, R.S.5
-
40
-
-
48349129069
-
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
-
Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, et al. (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454: 656-660.
-
(2008)
Nature
, vol.454
, pp. 656-660
-
-
Tammela, T.1
Zarkada, G.2
Wallgard, E.3
Murtomaki, A.4
Suchting, S.5
-
41
-
-
0141753974
-
Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation
-
Shikama N, Lutz W, Kretzschmar R, Sauter N, Roth JF, et al. (2003) Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J 22: 5175-5185.
-
(2003)
EMBO J
, vol.22
, pp. 5175-5185
-
-
Shikama, N.1
Lutz, W.2
Kretzschmar, R.3
Sauter, N.4
Roth, J.F.5
-
42
-
-
42449090686
-
Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse
-
Yamaguchi T, Ichise T, Iwata O, Hori A, Adachi T, et al. (2008) Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse. FEBS J 275: 1988-1998.
-
(2008)
FEBS J
, vol.275
, pp. 1988-1998
-
-
Yamaguchi, T.1
Ichise, T.2
Iwata, O.3
Hori, A.4
Adachi, T.5
|