Association of vitamin D receptor BsmI gene polymorphism with risk of osteoporosis: A meta-analysis of 41 studies

Molecular Biology Reports

Volumn 40, Issue 1, 2013, Pages 497-506

  Qin, Gang ^a   Dong, Zhiyong ^b   Zeng, Ping ^a   Liu, Mingwei ^a   Liao, Xiaobo ^a  

^a GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

^b PUTIAN UNIVERSITY   (China)

Author keywords

BsmI; Gene olymorphism; Meta analysis; Osteoporosis; Vitamin D receptor (VDR)

Indexed keywords

ARTICLE; ASIAN; CAUCASIAN; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HIGH RISK POPULATION; HUMAN; MOLECULAR PATHOLOGY; OSTEOPOROSIS; POPULATION RESEARCH; RACE DIFFERENCE; RECEPTOR GENE; SYSTEMATIC REVIEW; VITAMIN D RECEPTOR BSMI GENE;

ALLELES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; ODDS RATIO; OSTEOPOROSIS; POLYMORPHISM, GENETIC; POPULATION GROUPS; PUBLICATION BIAS; RECEPTORS, CALCITRIOL; RISK;

EID: 84871273366     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-2086-x     Document Type: Article

References (64)

1. Zwart M, Azagra R, Encabo G, Aguye A, Roca G, Guell S, Puchol N, Gene E, Lopez-Exposito F, Sola S, Ortiz S, Sancho P, Abado L, Iglesias M, Toran P, Diez-Perez A, Pujol-Salud J (2011) Measuring health-related quality of life in men with osteoporosis or osteoporotic fracture. BMC Public Health 11:775
2. Liu SZ, Tian LF, Xu P, Zhuang GH, Zheng F, Tian J, Ning QL, Zhu BF, Lu SM, Yan H (2011) Analysis of correlation between blood biochemical indicators and bone mineral density of post-menopausal women. Mol Biol Rep 38:939-948
3. Mendes AI, Mascarenhas MR, Matos S, Sousa I, Ferreira J, Barbosa AP, Bicho M, Jordan P (2011) A WNK4 gene variant relates to osteoporosis and not to hypertension in the Portuguese population. Mol Genet Metab 102:465-469
4. Kou I, Takahashi A, Urano T, Fukui N, Ito H, Ozaki K, Tanaka T, Hosoi T (2011) Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese. PLoS ONE 6:e19641
5. Guo Y, Yang TL, Liu YZ, Shen H, Lei SF, Yu N, Chen J, Xu T, Cheng Y, Tian Q, Yu P, Deng HW (2011) Mitochondria-wide association study of common variants in osteoporosis. Ann Hum Genet 75:569-574
6. Huang X, Cao Z, Zhang Z, Yang Y, Wang J, Fang D (2011) No association between vitamin D receptor gene polymorphisms and nasopharyngeal carcinoma in a Chinese Han population. Biosci Trends 5:99-103
7. Lee CS, Chen J, Wang Y, Williams JK, Ranly DM, Schwartz Z, Boyan BD (2011) Coordinated tether formation in anatomically distinct mice growth centers is dependent on a functional vitamin D receptor and is tightly linked to three-dimensional tissue morphology. Bone 49:419-427
8. Deng H, Liu F, Pan Y, Jin X, Wang H, Cao J (2011) BsmI, TaqI, ApaI, and FokI polymorphisms in the vitamin D receptor gene and periodontitis: a meta-analysis of 15 studies including 1338 cases and 1302 controls. J Clin Periodontol 38:199-207
9. Ozel L, Ata P, Ozel MS, Toros AB, Kara M, Unal E, Canbakan M, Erdogrul G, Aktas GE, Titiz MI (2011) Risk factors for osteoporosis after renal transplantation and effect of vitamin D receptor Bsm I polymorphism. Transplant Proc 43:858-862
10. Qin YH, Zhou TB, Su LN, Lei FY, Zhao YJ, Huang WF (2010) The efficacy of different dose intravenous immunoglobulin in treating acute idiopathic thrombocytopenic purpura: a meta-analysis of 13 randomized controlled trials. Blood Coagul Fibrinolysis 21:713-721
11. Zhou TB, Qin YH, Su LN, Lei FY, Huang WF, Zhao YJ (2011) ACE I/D gene polymorphism can't predict the steroid responsiveness in Asian children with idiopathic nephrotic syndrome: a meta-analysis. PLoS ONE 6:e19599
12. Zhou TB, Qin YH, Ou C, Su LN, Lei FY, Huang WF, Zhao YJ, Pang YS (2011) A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and steroid-sensitive nephrotic syndrome in children. J Renin Angiotensin Aldosterone Syst 13:175-183
13. Zhou TB, Ou C, Qin YH, Su LN, Lei FY, Huang WF, Zhao YJ, Pang YS, Yang KP (2011) Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis. J Renin Angiotensin Aldosterone Syst 12:601-610
14. Zhou TB, Qin YH, Su LN, Lei FY, Huang WF, Zhao YJ, Pang YS (2011) Insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme gene in steroid-resistant nephrotic syndrome for children: a genetic association study and meta-analysis. Ren Fail 33:741-748
15. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088-1101
16. Berg JP, Falch JA, Haug E (1996) Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in a high-endemic area of osteoporosis. Eur J Endocrinol 135:96-100
17. Vandevyver C, Wylin T, Cassiman JJ, Raus J, Geusens P (1997) Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. J Bone Miner Res 12:241-247
18. Poggi M, Aterini S, Nicastro L, Chiarugi V, Ruggiero M, Pacini S, Gulisano M (1999) Lack of association between body weight, bone mineral density and vitamin D receptor gene polymorphism in normal and osteoporotic women. Dis Markers 15:221-227
19. Langdahl BL, Gravholt CH, Brixen K, Eriksen EF (2000) Polymorphisms in the vitamin D receptor gene and bone mass, bone turnover and osteoporotic fractures. Eur J Clin Invest 30:608-617
20. Riggs BL, Nguyen TV, Melton LR, Morrison NA, O'Fallon WM, Kelly PJ, Egan KS, Sambrook PN, Muhs JM, Eisman JA (1995) The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res 10:991-996
21. Gomez C, Naves ML, Barrios Y, Diaz JB, Fernandez JL, Salido E, Torres A, Cannata JB (1999) Vitamin D receptor gene polymorphisms, bone mass, bone loss and prevalence of vertebral fracture: differences in postmenopausal women and men. Osteoporos Int 10:175-182
22. Feskanich D, Hunter DJ, Willett WC, Hankinson SE, Hollis BW, Hough HL, Kelsey KT, Colditz GA (1998) Vitamin D receptor genotype and the risk of bone fractures in women. Epidemiology 9:535-539
23. Gennari L, Becherini L, Masi L, Gonnelli S, Cepollaro C, Martini S, Mansani R, Brandi ML (1997) Vitamin D receptor genotypes and intestinal calcium absorption in postmenopausal women. Calcif Tissue Int 61:460-463
24. Melhus H, Kindmark A, Amer S, Wilen B, Lindh E, Ljunghall S (1994) Vitamin D receptor genotypes in osteoporosis. Lancet 344:949-950
25. Houston LA, Grant SF, Reid DM, Ralston SH (1996) Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population. Bone 18:249-252
26. Douroudis K, Tarassi K, Ioannidis G, Giannakopoulos F, Moutsatsou P, Thalassinos N, Papasteriades C (2003) Association of vitamin D receptor gene polymorphisms with bone mineral density in postmenopausal women of Hellenic origin. Maturitas 45:191-197
27. Musumeci M, Vadala G, Tringali G, Insirello E, Roccazzello AM, Simpore J, Musumeci S (2009) Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas. J Bone Miner Metab 27:424-434
28. Alvarez-Hernandez D, Naves M, Diaz-Lopez JB, Gomez C, Santamaria I, Cannata-Andia JB (2003) Influence of polymorphisms in VDR and COLIA1 genes on the risk of osteoporotic fractures in aged men. Kidney Int Suppl 85:S14-S18
29. Horst-Sikorska W, Wawrzyniak A, Celczynska-Bajew L, Marcinkowska M, Dabrowski S, Kalak R, Slomski R (2005) Polymorphism of VDR gene-the most effective molecular marker of osteoporotic bone fractures risk within postmenopausal women from Wielkopolska region of Poland. Endokrynol Pol 56:233-239
30. Aerssens J, Dequeker J, Peeters J, Breemans S, Broos P, Boonen S (2000) Polymorphisms of the VDR, ER and COLIA1 genes and osteoporotic hip fracture in elderly postmenopausal women. Osteoporos Int 11:583-591
31. Chatzipapas C, Boikos S, Drosos GI, Kazakos K, Tripsianis G, Serbis A, Stergiopoulos S, Tilkeridis C, Verettas DA, Stratakis CA (2009) Polymorphisms of the vitamin D receptor gene and stress fractures. Horm Metab Res 41:460-635
32. Valimaki S, Tahtela R, Kainulainen K, Laitinen K, Loyttyniemi E, Sulkava R, Valimaki M, Kontula K (2001) Relation of collagen type I alpha 1 (COLIA 1) and vitamin D receptor genotypes to bone mass, turnover, and fractures in early postmenopausal women and to hip fractures in elderly people. Eur J Intern Med 12:48-56
33. Garnero P, Munoz F, Borel O, Sornay-Rendu E, Delmas PD (2005) Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density. J Clin Endocrinol Metab 90:4829-4835
34. Zajickova K, Zofkova I, Bahbouh R, Krepelova A (2002) Vitamin D receptor gene polymorphisms, bone mineral density and bone turnover: FokI genotype is related to postmenopausal bone mass. Physiol Res 51:501-509
35. Wengreen H, Cutler DR, Munger R, Willing M (2006) Vitamin D receptor genotype and risk of osteoporotic hip fracture in elderly women of Utah: an effect modified by parity. Osteoporos Int 17:1146-1153
36. Wang XL, Zhu XY, Nei YK (2007) Analysis of relationship between vitamin D receptor gene polymorphism and osteoporotic fracture. Chin J Osteoporos 10:692-695
37. Ly A, Leng XJ, Chen RY, Li H, Tao GS, Zhang HH, Liu JW (2002) Association of vitamin D receptor gene polymorphisms with bone mineral density in Uighurs in China. J Health Care Med Chin PLA 1:41-42
38. Durusu TM, Bora TG, Uluturk TD, Dayangac ED, Tanriover A, Kilicarslan A, Oz SG, Erdem YH, Sozen T, Sain GG (2010) Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women. Clin Rheumatol 29:1285-1293
39. Dincel E, Sepici-Dincel A, Sepici V, Ozsoy H, Sepici B (2008) Hip fracture risk and different gene polymorphisms in the Turkish population. Clinics (Sao Paulo) 63:645-650
40. Lim SK, Park YS, Park JM, Song YD, Lee EJ, Kim KR, Lee HC, Huh KB (1995) Lack of association between vitamin D receptor genotypes and osteoporosis in Koreans. J Clin Endocrinol Metab 80:3677-3681
41. Zhang HH, Tao GS, Wu Q, Liu JW (1998) Preliminary studies on the relationship between vitamin D receptor genepolymorphism and osteoporosis in Chinese women. Chin J Epidemiol 1:12-14
42. Zhang QX, Wang WJ, Kuang JQ, Shen HL, Huang HX (2000) Relationship between the polymorphism of vitamin D receptor gene and bone mineral density in pre- and postmenopausal women. Acad J SUMS 5:376-379
43. Zhu MJ, XD Y, Wang F, Chen YH (2005) Relationship between vitam in D receptor genotypes and bone mineral density, bone metabolism in Guangxi Chuang and Han national postmenopausal women. Chin J Gerontol 25:278-280
44. Leng XW, Chen RY, LY A, Li H, Jiang YH, Tao GS, Zhang HH, Liu JW (2002) Relationship between vitamin D receptor gene alleles and bone mineral density in women from Urumqi. Chin J Endocrinol Metab 2:123
45. Zhang H, Su PJ, Chen F (2011) Relationship between vitamin D receptor gene polymorphism and bone mineral density and traditional Chinese medicine differentiation type in postmenopausal women in Zhongshan area of Guangdong. Chin J Tradit Med Traumatol Orthop 2:19-21
46. Liu J, Miao YD, He PY, Guo SQ, Zhang YQ, Chen LX (2005) Study on the relationship between vitamin D receptor gene polymorphisms and bone mineral density in old men. Chin J Osteoporos 2:159-163
47. Liang W, Xiu LL, Liang YQ (2002) The association between vitamin D receptor gene polymorphism and osteoporosis. Acad J SUMS 1:47-49
48. Pollak RD, Blumenfeld A, Bejarano-Achache I, Idelson M, Celinke HD (2001) The BsmI vitamin D receptor gene polymorphism in Israeli populations and in perimenopausal and osteoporotic Ashkenazi women. Am J Nephrol 21:185-188
49. Chen X, Li YH, Zhang LP, Qiu TF, Peng H, Deng ZL, Wang YJ (2003) The relationship between vitamin D receptor gene and bone mineral density in osteoporosis in Chongqing area. Chongqing Med J 7:881-882
50. Duman BS, Tanakol R, Erensoy N, Ozturk M, Yilmazer S (2004) Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women. Med Princ Pract 13:260-266
51. Li YL, Yang YH, Li DF, Cai XZ, Li ZW (2000) Vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal women. J Tianjin Med Univ 3:263-264
52. Yanagi H, Tomura S, Kawanami K, Hosokawa M, Tanaka M, Kobayashi K, Tsuchiya S, Amagai H, Hayashi K (1996) Vitamin D receptor gene polymorphisms are associated with osteoporosis in Japanese women. J Clin Endocrinol Metab 1:4179-4181
53. Lisker R, Lopez MA, Jasqui S, Ponce DLRS, Correa-Rotter R, Sanchez S, Mutchinick OM (2003) Association of vitamin D receptor polymorphisms with osteoporosis in Mexican postmenopausal women. Hum Biol 75:399-403
54. Borjas-Fajardo L, Zambrano M, Fernandez E, Pineda L, Machin A, de Romero P, Zabala W, Sanchez MA, Chacin JA, Delgado W (2003) Analysis of Bsm I polymorphism of the vitamin D receptor (VDR) gene in Venezuelan female patients living in the state of Zulia with osteoporosis. Invest Clin 44:275-282
55. Quevedo LI, Martinez BM, Castillo NM, Rivera FN (2008) Vitamin D receptor gene polymorphisms and risk of hip fracture in Chilean elderly women. Rev Med Chil 136:475-481
56. Ramalho AC, Lazaretti-Castro M, Hauache O, Kasamatsu T, Brandao C, Reis AF, Takata E, Cafalli F, Tavares F, Gimeno SG, Vieira JG (1998) Fractures of the proximal femur: correlation with vitamin D receptor gene polymorphism. Braz J Med Biol Res 31:921-927
57. Yasovanthi J, Venkata KK, Sri MK, Pulla RB, Ajeya KP, Sesha CM, Aruna P, Narasimulu G, Jyothy A (2011) Association of vitamin D receptor gene polymorphisms with BMD and their effect on 1, 25-dihydroxy vitamin D3 levels in pre- and postmenopausal South Indian women from Andhra Pradesh. Clin Chim Acta 412:541-544
58. Ousley AM, Castillo HS, Duraj-Thatte A, Doyle DF, Azizi B (2011) A human vitamin D receptor mutant activated by cholecalciferol. J Steroid Biochem Mol Biol 125:202-210
59. Cooper GS, Umbach DM (1996) Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis. J Bone Miner Res 11:1841-1849
60. Thakkinstian A, D'Este C, Eisman J, Nguyen T, Attia J (2004) Meta-analysis of molecular association studies: vitamin D receptor gene polymorphisms and BMD as a case study. J Bone Miner Res 19:419-428
61. Zintzaras E, Rodopoulou P, Koukoulis GN (2006) BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and the risk of osteoporosis: a meta-analysis. Dis Markers 22:317-326
62. Fang Y, Rivadeneira F, van Meurs JB, Pols HA, Ioannidis JP, Uitterlinden AG (2006) Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis. Bone 39:938-945
63. Ji GR, Yao M, Sun CY, Li ZH, Han Z (2010) BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: a meta-analysis. Bone 47:681-686
64. Uitterlinden AG, Ralston SH, Brandi ML, Carey AH, Grinberg D, Langdahl BL, Lips P, Lorenc R, Obermayer-Pietsch B, Reeve J, Reid DM, Amedei A, Bassiti A, Bustamante M, Husted LB, Diez-Perez A, Dobnig H, Dunning AM, Enjuanes A, Fahrleitner-Pammer A, Fang Y, Karczmarewicz E, Kruk M, van Leeuwen JP, Mavilia C, van Meurs JB, Mangion J, McGuigan FE, Pols HA, Renner W, Rivadeneira F, van Schoor NM, Scollen S, Sherlock RE, Ioannidis JP (2006) The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med 145:255-264