The association between common vitamin D receptor gene variations and osteoporosis: A participant-level meta-analysis

Annals of Internal Medicine

Volumn 145, Issue 4, 2006, Pages 255-264

  Uitterlinden, André G ^a   Ralston, Stuart H ^b   Brandi, Maria Luisa ^c   Carey, Alisoun H ^d   Grinberg, Daniel ^e   Langdahl, Bente L ^f   Lips, Paul ^g   Lorenc, Roman ^h   Obermayer Pietsxch, Barbara ⁱ   Reeve, Jonathan ^j   Reid, David M ^k   Amedei, Antonietta ^c   Bassiti, Amelia ^k   Bustamante, Mariona ^e   Husted, Lise Bjerre ^f   Diez Perez, Adolfo ^e   Dobnig, Harald ⁱ   Dunning, Alison M ^j   Enjuanes, Anna ^e   Fahrleitner Pammer, Astrid ⁱ   Fang, Yue ^a   Karczmarewicz, Elzbieta ^h   Kruk, Marcin ^h   Van Leeuwen, Johannes P T M ^a   Mavilia, Carmelo ^c   Van Meurs, Joyce B J ^a   Mangion, Jon ^d   McGuigan, Fiona E A ^k   Pols, Huibert A P ^a   Renner, Wilfried ⁱ   Rivadeneira, Fernando ^a   Van Schoor, Natasja M ^g   Scollen, Serena ^j   Sherlock, Rachael E ^d   Ioannidis, John P A ^l,m   Parsons, Claire ⁿ   Bear, Stuart ⁿ   Farmer, Rosie ⁿ   Lukaszkiewicz, J ⁿ   Bilinski, P ⁿ   Czerwinski, E ⁿ   Lewinski, A ⁿ   Marcinowska Suchowierska, E ⁿ   Milewicz, A ⁿ   Spaczynski, M ⁿ   Jaworski, M ⁿ   Nuti, R ⁿ   Grazio, S ⁿ   Miazgowski, T ⁿ   Boonen, R ⁿ   Masaryk, P ⁿ   Stepan, J J ⁿ   Lopes Vaz, A ⁿ   Cannata, J ⁿ   Weber, K ⁿ   Benevolenskaya, L I ⁿ   Todd, C ⁿ   Khaw, K T ⁿ   Da Silva, J ⁿ   Bhalla, A ⁿ   Poor, G ⁿ   Bruges Armas, J ⁿ   Lyritis, G ⁿ   O'Neill, T W ⁿ   Lunt, M ⁿ   Compston, Juliet ^o   Cooper, Cyrus ^p   Duncan, Emma ^q   Keen, Richard ^r   McLellan, Alastair ^s   Wass, John ^q   Dekema, Ebbo ⁿ   Van Essen, Huub ⁿ   Pluijm, Saskia ⁿ   Bravenboer, Natalie ⁿ   Hofman, Albert ⁿ   Van Duijn, Cornelia M ⁿ   De Jong, Paulus J ⁿ   Breteler, Monique M ⁿ   Stricker, Bruno H ⁿ   Witteman, Jacqueline C ⁿ   more..

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF FLORENCE   (Italy)

^d Oxagen Limited   (United Kingdom)

^e UNIVERSITY OF BARCELONA   (Spain)

^f AARHUS UNIVERSITY HOSPITAL   (Denmark)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^h CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

ⁱ MEDICAL UNIVERSITY OF GRAZ   (Austria)

^j UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^k UNIVERSITY OF ABERDEEN   (United Kingdom)

^l INSTITUTE OF COMPUTER SCIENCE   (Greece)

^m UNIVERSITY OF IOANNINA   (Greece)

ⁿ University of Ioannina School of Medicine ^*

^o UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^p UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^q NUFFIELD ORTHOPAEDIC CENTRE   (United Kingdom)

^r UNIVERSITY COLLEGE LONDON   (United Kingdom)

^s UNIVERSITY OF GLASGOW   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR FOK1; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; CDX2 PROTEIN, HUMAN; ENDODEOXYRIBONUCLEASE APAI; ENDODEOXYRIBONUCLEASE BSMI; ENDODEOXYRIBONUCLEASE FOKI; ENDODEOXYRIBONUCLEASE TAQI; HOMEODOMAIN PROTEIN; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ALLELE; APAI GENE; ARTICLE; BONE DENSITY; BSMI GENE; CLINICAL TRIAL; DATA BASE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMUR NECK; FOKI GENE; FRACTURE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LUMBAR SPINE; META ANALYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SYSTEMATIC REVIEW; TAQI GENE; VERTEBRA FRACTURE; ADULT; AGED; FEMALE; GENETICS; MALE; MIDDLE AGED; MULTICENTER STUDY; PROMOTER REGION; PROSPECTIVE STUDY;

ADULT; AGED; BONE DENSITY; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; FEMALE; FRACTURES, BONE; GENOTYPE; HAPLOTYPES; HOMEODOMAIN PROTEINS; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROSPECTIVE STUDIES; RECEPTORS, CALCITRIOL;

EID: 33747115419     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-145-4-200608150-00005     Document Type: Article

References (34)

1. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, et al. Prediction of bone density from vitamin D receptor alleles. Nature. 1994;367:284-7. Erratum in: Nature 1997 May 1;387:106.
2. Uitterlinden AG, Pols HA, Burger H, Huang Q, Van Daele PL, Van Duijn CM, et al. A large-scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density. J Bone Miner Res. 1996;11:1241-8.
3. Cooper GS, Umbach DM. Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis. J Bone Miner Res. 1996;11:1841-9.
4. Thakkinstian A, D'Este C, Eisman J, Nguyen T, Attia J. Meta-analysis of molecular association studies: vitamin D receptor gene polymorphisms and BMD as a case study. J Bone Miner Res. 2004;19:419-28.
5. Gong G, Stern HS, Cheng SC, Fong N, Mordeson J, Deng HW, et al. The association of bone mineral density with vitamin D receptor gene polymorphisms. Osteoporos Int. 1999;9:55-64.
6. Arai H, Miyamoto KI, Yoshida M, Yamamoto H, Taketani Y, Morita K, et al. The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene. J Bone Miner Res. 2001;16:1256-64.
7. Fang Y, van Meurs JB, Bergink AP, Hofman A, van Duijn CM, van Leeuwen JP, et al. Cdx-2 polymorphism in the promoter region of the human vitamin D receptor gene determines susceptibility to fracture in the elderly. J Bone Miner Res. 2003;18:1632-41.
8. Gross C, Eccleshall TR, Malloy PJ, Villa ML, Marcus R, Feldman D. The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res. 1996;11:1850-5.
9. Ioannidis JP, Ralston SH, Bennett ST, Brandi ML, Grinberg D, Karassa FB, et al. Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA. 2004;292:2105-14.
10. Burger H, de Laet CE, van Daele PL, Weel AE, Witteman JC, Hofman A, et al. Risk factors for increased bone loss in an elderly population: the Rotterdam Study. Am J Epidemiol. 1998;147:871-9.
11. Torgerson DJ, Thomas RE, Campbell MK, Reid DM. Randomized trial of osteoporosis screening. Use of hormone replacement therapy and quality-of-life results. Arch Intern Med. 1997;157:2121-5.
12. Pluijm SM, van Essen HW, Bravenboer N, Uitterlinden AG, Smit JH, Pols HA, et al. Collagen type I alpha1 Sp1 polymorphism, osteoporosis, and intervertebral disc degeneration in older men and women. Ann Rheum Dis. 2004;63:71-7.
13. Ismail AA, O'Neill TW, Cooper C, Finn JD, Bhalla AK, Cannata JB, et al. Mortality associated with vertebral deformity in men and women: results from the European Prospective Osteoporosis Study (EPOS). Osteoporos Int. 1998;8:291-7.
14. Ralston SH, Galwey N, MacKay I, Albagha OM, Cardon L, Compston JE, et al. Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study. Hum Mol Genet. 2005;14:943-51.
15. Kudlacek S, Schneider B, Peterlik M, Leb G, Klaushofer K, Weber K, et al. Normative data of bone mineral density in an unselected adult Austrian population. Eur J Clin Invest. 2003;33:332-9.
16. McCloskey EV, Spector TD, Eyres KS, Fern ED, O'Rourke N, Vasikaran S, et al. The assessment of vertebral deformity: a method for use in population studies and clinical trials. Osteoporos Int. 1993;3:138-47.
17. Reid DM, Mackay I, Wilkinson S, Miller C, Schuette DG, Compston J, et al. Cross-calibration of dual-energy X-ray densitometers for a large, multi-center genetic study of osteoporosis. Osteoporos Int. 2006;17:125-32.
18. Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet. 2003;73:1162-9.
19. McCulloch CE, Searle SR. Generalized, Linear, and Mixed Models. New York: Wiley; 2001.
20. Pettiti D. Meta-Analysis, Decision Analysis and Cost-Effectiveness Analysis. Oxford: Oxford Univ Pr; 1999.
21. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-60.
22. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-88.
23. Rousset F, Raymond M. Testing heterozygote excess and deficiency. Genetics. 1995;140:1413-9.
24. Fang Y, van Meurs JB, d'Alesio A, Jhamai M, Zhao H, Rivadeneira F, et al. Promoter and 3′-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam study. Am J Hum Genet. 2005;77:807-23.
25. Rebbeck TR, Spitz M, Wu X. Assessing the function of genetic variants in candidate gene association studies. Nat Rev Genet. 2004;5:589-97.
26. Little J, Khoury MJ. Mendelian randomisation: a new spin or real progress? Lancet. 2003;362:930-1.
27. Ralston SH, Uitterlinden AG, Brandi ML, Balcells S, Langdahl BL, Lips P, et al. Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study. PLoS Med. 2006;3:e90.
28. Ioannidis JP, Trikalinos TA, Ntzani EE, Contopoulos-Ioannidis DG. Genetic associations in large versus small studies: an empirical assessment. Lancet. 2003;361:567-71.
29. Little J, Khoury MJ, Bradley L, Clyne M, Gwinn M, Lin B, et al. The human genome project is complete. How do we develop a handle for the pump? [Editorial] Am J Epidemiol. 2003;157:667-73.
30. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet. 2001;29:306-9.
31. Ioannidis JP. Genetic associations: false or true? Trends Mol Med. 2003;9:135-8.
32. Ioannidis JP. Why most published research findings are false. PLoS Med. 2005;2:e124.
33. Pan Z, Trikalinos TA, Kavvoura FK, Lau J, Ioannidis JP. Local literature bias in genetic epidemiology: an empirical evaluation of the Chinese literature. PLoS Med. 2005;2:e334.
34. Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst. 2004;96:434-42.