Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: Studies in a UK population

Bone

Volumn 18, Issue 3, 1996, Pages 249-252

  Houston, L A ^c   Grant, S F A ^c   Reid, D M ^c   Ralston, Stuart H ^a,b  

^a ABERDEEN ROYAL INFIRMARY   (United Kingdom)

^b Osteoporosis Research Unit   (United Kingdom)

^c NONE

Author keywords

Bone density; Genotype; Osteoporosis; Vertebral fracture; Vitamin D receptor

Indexed keywords

RECEPTOR SUBTYPE; VITAMIN D; VITAMIN RECEPTOR;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE MINERAL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FEMUR NECK; GENOTYPE; HIP; HUMAN; LUMBAR SPINE; NORMAL HUMAN; OSTEOPOROSIS; POSTMENOPAUSE; PREMENOPAUSE; UNITED KINGDOM; VERTEBRA FRACTURE;

EID: 0029870079     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/8756-3282(95)00483-1     Document Type: Article

References (21)

1. Cooper, C. and Melton, L. J. Vertebral fractures. Br Med J 304:793-794; 1992.
2. Eisman, J. A. Vitamin D receptor gene alleles and osteoporosis: An affirmative view. J Bone Miner Res 10:1289-1293: 1995.
3. Evans, R. A., Marel, G. M., Lancaster, E. K., Kos, S., Evans, M., and Wong, S. Y. P. Bone mass is low in relatives of osteoporotic patients. Ann Intern Med 109:870-873; 1988.
4. Ferrari, S., Rizzoli, R., Chevally, T., Slosman, D., Eisman, J. A., and Bonjour, J. Vitamin D receptor gene polymorphisms and change in lumbar spine bone mineral density. Lancet 345:423-424; 1995.
5. Fleet, J. C., Harris, S. S., Wood, R. J., and Dawson-Hughes, B. The Bsm-I vitamin D receptor restriction length polymorphism (BB) predicts low bone density in premenopausal black and white women. J Bone Miner Res 10:985-990; 1995.
6. Garnero, P., Borel, O., Sornay-Rendu, E., and Delmas, P. D. Vitamin D Receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women. J Bone Miner Res 10:1283-1288; 1995.
7. Garton, M., Martin, J., Stewart, A., Krukowski, Z., Matheson, N., Robins, S., Loveridge, N., and Reid, D. Changes in bone mass and metabolism after surgery for primary hyperparathyroidism. Clin Endocrinol 42:493-500; 1995.
8. Godden, D. J., Ross, S., Abdalla, M., McMurray, D., Douglas, A., Oldman, D., Friend, J. A. R., Legge, J. S., and Douglas, J. G. Outcome of wheeze in childhood: symptoms and pulmonary function 25 years later. Am J Resp Crit Care Med 149:106-112; 1994.
9. Hustmyer, F. G., Peacock, M., Hui, S., Johnston, C. C., and Christian, J. Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J Clin Invest 94:2130-2134; 1994.
10. Kanis, J. A., Melton, L. J., Christiansen, C., Johnston, C. C., and Khaltaev, N. The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141; 1994.
11. Krall, E. A., Parry, P., Lichter, J. B., and Dawson-Hughes, B. Vitamin D receptor alleles and rates of bone loss: influence of years since menopause and calcium intake. J Bone Miner Res 10:978-984; 1995.
12. Kwok, S. and Higuchi, R. Avoiding false positives with PCR. Nature 339:237-238; 1989.
13. Lander, E. S. and Schork, N. J. Genetic dissection of complex traits. Science 265:2037-2048; 1994.
14. Looney, J. E., Yoon, H., Fisher, M., Farley, S. M., Farley, J. R., Wergedal, J. E., and Baylink, D. J. Lack of high prevalence of the BB vitamin D receptor genotype in severely osteoporotic women. J Clin Endocrinol Metab 80:2158-2162; 1995.
15. Melhus, H., Kindmark, A., Amer, S., Wilen, B., Lindh, E., and Ljunghall, S. Vitamin D receptor genotypes in osteoporosis. Lancet 344:949-950; 1994.
16. Morrison, N. A., Qi, J. C., Tokita, A., Kelly, P., Crofts, L., Nguyen, T. V., Sambrook, P. N., and Eisman, J. A. Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287; 1994.
17. Mundy, G. R. Boning up on genes. Nature 367:216-217; 1994.
18. Peacock, M. Vitamin D receptor gene alleles and osteoporosis: a contrasting view. J Bone Miner Res 10:1294-1297; 1995.
19. Pocock, N. A., Eisman, J. A., Hopper, J. L., Yeates, M. G., Sambrook, P. N., and Eberl, S. Genetic determinants of bone mass in adults: A twin study. J Clin Invest 80:706-710; 1987.
20. Spector, T. D., Keen, R. W., Arden, N. K., Morrison, N. A., Major, P. J., Nguyen, T. V., Kelly, P. J., Baker, J. R., Sambrook, P. N., Lanchbury, J. S., and Eisman, J. A. Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain. Br Med J 310:1357-1360; 1995.
21. Uitterlinden, A. G., Pols, H. A. P., van Daele, P. L. A., Algra, D., Hofman, A., Birkenhager, J. C., and van Leeuwen, J. P. T. M. Vitamin D receptor genotype is associated with bone mineral density in humans [abstract]. Calcif Tissue Int 56::474; 1995.