Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women

Medical Principles and Practice

Volumn 13, Issue 5, 2004, Pages 260-266

  Duman, Belgin Süsleyici ^a   Tanakol, Refik ^b   Erensoy, Nevin ^b   Öztürk, Melek ^b   Yilmazer, Selma ^b,c  

^a KADIR HAS UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Bone mineral density; Menopause; Osteoporosis; Vitamin D receptor gene polymorphism

Indexed keywords

OSTEOCALCIN; VITAMIN D RECEPTOR;

ADULT; ALLELE; ARTICLE; BLOOD LEVEL; BONE DENSITY; BONE METABOLISM; BONE MINERAL; BONE TURNOVER; CONTROLLED STUDY; FEMALE; FEMUR NECK; GENE LOCUS; GENETIC MARKER; GENOTYPE; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; OSTEOPOROSIS; POSTMENOPAUSE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION;

BODY MASS INDEX; BONE DENSITY; BONE REMODELING; CALCIUM; CASE-CONTROL STUDIES; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; FEMALE; GENOTYPE; HUMANS; HYDROXYPROLINE; OSTEOCALCIN; OSTEOPOROSIS, POSTMENOPAUSAL; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, CALCITRIOL; TURKEY;

EID: 4444380659     PISSN: 10117571     EISSN: None     Source Type: Journal    
DOI: 10.1159/000079524     Document Type: Article

References (34)

1. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S: Genetic determinants of bone mass in adults. J Clin Invest 1987;80:706-710.
2. Christian JC, Yu PL, Slemenda CW, Johnston CC: Heritability of bone mass: A longitudinal study in aging male twins. Am J Hum Genet 1989;44:429-433.
3. Smith DM, Nance WE, Kang KW, Christian JC, Johnston CC Jr: Genetic factors in determining bone mass. J Clin Invest 1973;52:2800-2808.
4. Dequeker J, Nijs J, Verstraeten A, Geusens P, Gevers G: Genetic determinants of bone mineral content at the spine and radius: A twin study. Bone 1987;8:207-209.
5. Kelly PJ, Hopper JL, Macaskill GT, Pocock NA, Sambrook PN, Eisman JA: Genetic factors in bone turnover. J Clin Endocrinol Metab 1991;72:808-813.
6. Lutz J: Bone mineral, serum calcium and dietary intakes of mother/daughter pairs. Am J Clin Nutr 1986;44:99-106.
7. Seeman E, Hopper JL, Bach LA, Cooper ME, Parkinson E, McKay J, Jerums G: Reduced bone mass in daughters of women with osteoporosis. N Engl J Med 1989;320:554-558.
8. Morrison NA, Yeoman R, Kelly PJ, Eisman JA: Contribution of trans-acting factor alleles to normal physiological variability: Vitamin D receptor gene polymorphism and circulating osteocalcin. Proc Natl Acad Sci USA 1992;89:6665-6669.
9. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA: Prediction of bone density from vitamin D receptor alleles. Nature 1994;367:284-287.
10. Eisman JA, Morrison NA, Kelly PJ, Sambrook PN, Howard G, Qi J, Tokita A, Crofts L, Nguyen TV, Birmingham J: Genetics of osteoporosis and vitamin D receptor alleles. Calcif Tissue Int 1995;56:S48-49.
11. Peacock M: Vitamin D receptor gene alleles and osteoporosis: A contrasting view. J Bone Miner Res 1995;10:1294-1297.
12. Yamagata Z, Miyamura T, Iijima S, Asaka A, Sasaki M, Kato J, Koizumi K: Vitamin D receptor gene polymorphism and bone mineral density in healthy Japanese women. Lancet 1994;344:1027.
13. Krall EA, Parry P, Lichter JB, Dawson-Hughes B: Vitamin D receptor alleles and rates of bone loss: Influences of years since menopause and calcium intake. J Bone Miner Res 1995;10:978-984.
14. Ferrari S, Rizzoli R, Chevalley T, Slosman D, Eisman JA, Bonjour J-P: Vitamin D receptor gene polymorphisms and chance in lumbar spine bone mineral density. Lancet 1995;345:423-424.
15. Spector TD, Keen RW, Arden NK, Morrison NA, Major PJ, Nguyen TV, Kelly PJ, Baker JR, Sambrook PN, Lanchbury JS, Eisman JA: Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: A twin study in Britain. BMJ 1995;310:1357-1360.
16. Fleet JC, Harris SS, Wood RJ, Dawson-Hughes B: The BsmI vitamin D receptor restriction fragment length polymorphism (BB) predicts low bone density in premenopausal black and white women. J Bone Miner Res 1995;10:985-990.
17. Riggs BL, Nguyen TV, Melton LJ 3rd, Morrison NA, O'Fallon WM, Kelly PJ, Egan KS, Sambrook PN, Muhs JM, Eisman JA: The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal osteoporotic women. J Bone Miner Res 1995;10:991-996.
18. Garnero P, Borel O, Sornay-Rendu E, Delmas PD: Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women. J Bone Miner Res 1995;10:1283-1288.
19. Keen RW, Major PJ, Lanchbury JS, Spector TD: Vitamin D receptor gene polymorphism and bone loss. Lancet 1995;345:990.
20. Looney J, Yoon HK, Fischer SM, Farley SM, Farley JR, Wegedal JE, Baylink DJ: Lack of a high prevalence of the BB vitamin D receptor genotype in severely osteoporotic women. J Clin Endocrinol Metab 1995;80:2158-2162.
21. Kroger H, Mahonen A, Ryhanen S, Turunen AM, Alhava E, Maenpaa P: Vitamin D receptor genotypes and bone mineral density. Lancet 1995;345:1238.
22. Lim SK, Park YS, Park JM, Song YD, Lee EJ, Kim KR, Lee HC, Huh KB: Lack of association between vitamin D receptor genotypes and osteoporosis in Koreans. J Clin Endocrinol Metab 1995;80:3677-3681.
23. Hustmyer FG, Peacock M, Hui S, Johnston CC, Christian J: Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J Clin Invest 1994;94:2130-2134.
24. Parfitt A: Vitamin D receptor genotypes in osteoporosis. Lancet 1994;344:1580.
25. Shiraki M, Eguchi H, Aoki C, Shiraki Y: Can allelic variations in vitamin D receptor gene predict bone densities and serum osteocalcin level in Japanese women. Bone 1995;16(suppl1):84S.
26. Ho KC, Pang C: Automated analysis of urinary hydroxyproline. Clin Chim Acta 1989;185:191-196.
27. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from nucleated cells. Nucleic Acids Res 1998;16:1215.
28. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA: Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988;239:487-491.
29. Jones G, Nguyen TV, Sambrook PN, Kelly PJ, Eisman JA: Progressive loss of bone in the femoral neck in elderly people: Longitudinal findings from the Dubbo osteoporosis epidemiology study. Br Med J 1994;309:691-695.
30. Poggi M, Aterini S, Nicastro L, Chiarugi V, Ruggiero M, Pacini S, Gulisaro M: Lack of association between body weight, bone mineral density and vitamin D receptor gene polymorphism in normal and osteoporotic women. Dis Markers 1999;15:221-227.
31. Sheehan D, Bennett T, Cashman KD: An assessment of genetic markers as predictors of bone turnover in healthy adults. J Endocrinol Invest 2001;24:236-245.
32. Dawson-Hughes B, Harris SS, Finneran S: Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotypes. J Clin Endocrinol Metab 1995;80:3657-3661.
33. Kirschner MA, Samojlik E, Drejka M, Szmal E, Schneider G, Ertel N: Androgen-estrogen metabolism in women with upper body versus lower body obesity. J Clin Endocrinol Metab 1990;70:473-479.
34. Vandevyver C, Wylin T, Cassiman J, Raus J, Geusens P: Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. J Bone Miner Res 1997;12:241-247.