Vitamin D receptor genotypes and intestinal calcium absorption in postmenopausal women

Calcified Tissue International

Volumn 61, Issue 6, 1997, Pages 460-463

  Gennari, L ^a   Becherini, L ^a   Masi, L ^a   Gonnelli, S ^b   Cepollaro, C ^b   Martini, S ^b   Mansani, R ^a   Brandi, M L ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Intestinal Ca absorption; Osteoporosis genetics; Postmenopausal women; Strontium chloride; VDR genotypes

Indexed keywords

CALCIUM; VITAMIN D RECEPTOR;

ADULT; ALLELE; ARTICLE; BONE MASS; CALCIUM ABSORPTION; CALCIUM HOMEOSTASIS; FEMALE; GENE LOCUS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INTESTINE ABSORPTION; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL;

AGED; ALKALINE PHOSPHATASE; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BONE DENSITY; CALCIFEDIOL; CALCITRIOL; CALCIUM; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FEMUR; GENOTYPE; HUMANS; INTESTINAL ABSORPTION; ITALY; MIDDLE AGED; PARATHYROID HORMONE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POSTMENOPAUSE; RECEPTORS, CALCITRIOL; STRONTIUM;

EID: 0030714142     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900368     Document Type: Article

References (29)

1. Hansen MA, Hassager C, Jensen SB, Christiansen C (1992) Is heritability a risk factor for postmenopausal osteoporosis? J Bone Miner Res 7(9): 1037-1043
2. Seeman E, Hopper JL, Bach LA, Cooper ME, Parkinson E, McKay J, Jerums G (1989) Reduced bone mass in daughters of women with osteoporosis. N Engl J Med 320:554-558
3. Eisman JA, Kelly P, Morrison N A, Tokita A, Pocock NA, Yeoman R, Ristelli J, Birmingham J, Sambrook PN (1992) Genetic and environmental interaction on bone mass. In: Cohn DV, Gennari C, Tashijan AH (eds) Calcium-regulating hormones. Elsevier Science Publisher B.V., pp 376-383
4. Morrison NA, Cheng JQI, Akifumi T, Kelly PJ, Krofts L, Nguyen TV, Sambrook PN, Eisman JA (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287
5. Hustmyer FG, Peacock M, Hui S, Johnston CC, Christian JC (1994) Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J Clin Invest 94:2130-2134
6. Garnero P, Borel O, Sornay-Rendu E, Arlot ME, Delmas PD (1996) Vitamin D receptor gene polymorphisms are not related to bone turnover, rate of bone loss and bone mass in postmenopausal women: the OFELY study. J Bone Miner Res 11:827-834
7. Looney JE, Yoon HK, Fischer M, Farley SM, Farley JR, Wergedal JE, Baylink DJ (1995) Lack of a high prevalence of the BB vitamin D receptor genotype in severely osteoporotic women. J Clin Endocrinol Metab 80:2158-2162
8. Houston LA, Grant SPA, Reid DM, Ralston SH (1996) Vitamin D receptor polymorphism, bone mineral density and osteoporotic vertebral fracture: studies in a UK population. Bone 18:249-252
9. Uitterlinden AG, Pols HAP, Burger H, Huang Q, Van Daele PEA, Van Duijn CMV, Hofman A, Birkenhager JC, Van Leeuwen JPTM (1996) A large-scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density. J Bone Miner Res 11:1241-1248
10. 47Ca absorption in postmenopausal osteoporosis. J Clin Invest 44:1960-1967
11. Riggs BL, Melton LJ (1986) Involutional osteoporosis. N Engl J Med 314:1676-1686
12. Ebeling PR, Sandgren ME, Di Magno EP, Eane AW, De Luca HF, Riggs BL (1992) Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25 dihydroxyvitamin D3 and intestinal VDR concentration in normal women. J Clin Endocrinol Metab 75:176-182
13. Gallagher JC (1990) The pathogenesis of osteoporosis. Bone Miner 9(3):215-227
14. Morris HA, Need AG, Horowitz M, O'Loughlin PD, Nordin BEC (1991) Calcium absorption in normal and osteoporotic postmenopausal women. Calcif Tissue Int 49:240-243
15. Francis RM, Peacock M, Taylor GA, Storer JH, Nordin BEC (1984) Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites on the bowel. Clin Sci 66:103-107
16. Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, De Luca HF (1979) Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. J Clin Invest 64:729-736
17. Gennari C, Agnusdei D, Nardi P, Civitelli R (1990) Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women. J Clin Endocrinol Metab 71(5): 1288-1293
18. Dawson Hughes B, Harris SS, Finneran S (1995) Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. J Clin Endocrinol Metab 80: 3657-3661
19. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141
20. Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503
21. Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf TM, Haussler MR, Pike JW, Shine J, O'Malley BW (1988) Cloning and expression of full length cDNA encoding human VDR. Proc Natl Acad Sci USA 85:3294-3298
22. Reid IR, Pybus J, Lim TMT, Hannon S, Ibbertson HK (1986) The assessment of intestinal calcium absorption using stable strontium. Calcif Tissue Int 38:303-305
23. Marshall DH, Nordin BEC (1969) Kinetic analysis of plasma radioactivity after oral ingestion of radiocalcium. Nature 222: 797
24. Fleet JC, Harris SS, Wood RJ, Dawson-Hughes B (1995) The BSM I vitamin D receptor restriction fragment length polymorphism (BB) predicts low bone density in premenopausal black and white women. J Bone Miner Res 10(6):985-990
25. Tokita A, Watanabe T, Miura Y, Tawa T, Yabuta K, Mathumoto H, Yamamori S, Morrison N A, Eisman JA (1995) Vitamin D receptor gene RFLP and bone mineral density in Japanese (abstract). Bone 16(S1):83S
26. Lim SK, Park YS, Park JM, Song YD, Lee EJ, Kim KR, Lee HL, Huh KB (1995) Lack of association between vitamin D receptor genotypes and osteoporosis in Korean. J Clin Endocrinol Metab 80:3677-3681
27. Gennari C, Montagnani M (1990) Role of nutrition in the pathogenesis of osteoporosis. In: Fabris F, Pernigotti L, Ferrario E (eds) Sedentary life and nutrition. Raven Press Ltd, New York, pp 109-118
28. Morrison NA, Cheng QJ, Tokita A, Sambrook P, Kelly P, Eisman JA (1995) Genetic susceptibility and resistance to osteoporosis and the vitamin D receptor gene (abstract 14). Bone 16(S1):83S
29. Gennari L, Becherini L, Masi L, Gonnelli S, Cepollaro C, Martini S, Mansani R, Montagnani A, Brandi ML (1996) Vitamin D and estrogen receptor genotypes in postmenopausal women: influences on BMD and intestinal calcium absorption (abstract T660). J Bone Miner Res 11(S1):S464