RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules

Molecular Biology of the Cell

Volumn 23, Issue 24, 2012, Pages 4807-4819

  Gad, Annica K B ^a   Nehru, Vishal ^a   Ruusala, Aino ^b   Aspenström, Pontus ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FILAMIN A; PROTEIN CDC42; RAC1 PROTEIN; RHO FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOD PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ARTICLE; CELL ADHESION; CELL MIGRATION; CYTOSKELETON; DOWN REGULATION; GOLGI COMPLEX; HUMAN; MICROTUBULE; PRIORITY JOURNAL;

ACTIN-RELATED PROTEIN 2-3 COMPLEX; ACTINS; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CONTRACTILE PROTEINS; COS CELLS; CYTOSKELETAL PROTEINS; CYTOSKELETON; GOLGI APPARATUS; HEK293 CELLS; HUMANS; MALE; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; RHO GTP-BINDING PROTEINS; RNA INTERFERENCE; SEQUENCE HOMOLOGY, AMINO ACID; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84871253887     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-07-0555     Document Type: Article

References (33)

1. Aspenström P, Fransson Å, Saras J (2004). The Rho GTPases have diverse effects on the organization of the actin filament system. Biochem J 377, 327-337.
2. Aspenström P, Olson MF (1995). Yeast two-hybrid system to detect protein-protein interactions with Rho GTPases. Methods Enzymol 256, 228-241.
3. Aspenström P, Ruusala A, Pacholsky D (2007). Taking the Rho GTPases to the next level: the cellular function of the atypical Rho GTPases. Exp Cell Res 313, 3673-3679.
4. Baldassarre M, Razinia Z, Burande CF, Lamsoul I, Lutz PG, Calderwood DA (2009). Filamins regulate cell spreading and initiation of cell migration. PLoS One 4, e7830.
5. Barrios-Rodiles M, et al. (2005). High-throughput mapping of a dynamic signaling network in mammalian cells. Science 307, 1621-1625.
6. Boureux A, Vignal E, Faure S, Fort P (2007). Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol 24, 203-216.
7. Campellone KG, Webb NJ, Znameroski EA, Welch MD (2008). WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. Cell 134, 148-161.
8. Chavrier P, Simins K, Zerial M (1992). The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene 112, 261-264.
9. Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (2001). Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31. Genomics 78, 7-11.
10. Ellis S, Mellor H (2000). The novel Rho-family GTPase Rif regulates coordinated actin-based membrane rearrangements. Curr Biol 10, 1387-1390.
11. Fan L, Pellegrin S, Scott A, Mellor H (2010). The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells. J Cell Sci 123, 1247-1252.
12. Feng Y, Chen MH, Moskowitz IP, Mendonza AM, Vidali L, Nakamura F, Kwiatkowski DJ, Walsh CA (2006). Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci USA 103, 19836-19841.
13. Gad KBA, Aspenström P (2010). Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking. Cell Signal 22, 183-189.
14. Gasman S, Kalaidzidis Y, Zerial M (2003). RhoD regulates endosome dynamics through Diaphanous-related formin and Src kinase. Nat Cell Biol 5, 195-204.
15. Goh WI, Sudhaharan T, Lim KB, Sem KP, Lau CL, Ahmed S (2011). Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors. J Biol Chem 286, 13681-13694.
16. Gorelik R, Yang C, Kameswaran V, Dominguez R, Svitkina T (2011). Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains. Mol Biol Cell 22, 189-201.
17. Hart AW, Morgan JE, Schneider J, West K, McKie L, Bhattacharya S, Jackson IJ, Cross SH (2006). Cardiac malformations and midline skeletal defects in mice lacking filamin A. Hum Mol Genet 15, 2457-2467.
18. Heasman SJ, Ridley AJ (2008). Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9, 690-701.
19. Hota PK, Buck M (2009). Thermodynamic characterization of two homologous protein complexes: association of the semaphoring receptor plexin-B1 Rho GTPase binding domain with Rnd1 and active Rac1. Protein Sci 18, 1060-1071.
20. Hsu C-Y, Chang NC, Lee MW, Lee KH, Sun DS, Lai C, Chang AC (2008). LUZP deficiency affects neural tube closure during brain development. Biochem Biophys Res Commun 376, 466-471.
21. Jaffe AB, Hall A (2005). Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21, 247-269.
22. Kwon M et al. (2008). Functional characterization of Filamin A interacting protein 1-like, a novel candidate for antivascular cancer therapy. Cancer Res 68, 7332-7341.
23. Murphy C, Saffrich R, Grummt M, Gournier H, Rybin V, Rubino M, Auvinen P, Lütcke A, Parton RG, Zerial M (1996). Endosome dynamics regulated by a Rho protein. Nature 384, 427-432.
24. Murphy C, Saffrich R, Olivo-Marin JC, Giner A, Ansorge W, Fotsis T, Zerial M (2001). Dual function of RhoD in vesicular movement and cell motility. Eur J Cell Biol 80, 391-398.
25. Nagano T, Yoneda T, Hatanaka Y, Kubota C, Murakami F, Sato M (2002). Filamin A- interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone. Nat Cell Biol 4, 495-501.
26. Pellegrin S, Mellor H (2005). The Rho family GTPase Rif induces filopodia through mDia2. Curr Biol 15, 129-133.
27. Rottner K, Stradal TE (2011). Actin dynamics and turnover in cell motility. Curr Opin Cell Biol 23, 569-578.
28. Tong Y, Chugha P, Hota PK, Alviani RS, Li M, Tempel W, Shen L, Park H-W, Buck M (2007). Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the Plexin-B1 effector domain. J Biol Chem 282, 37215-37224.
29. Tsubakimoto K, Matsumoto K, Abe H, Ishii J, Amano M, Kaibuchi K, Endo T (1999). Small GTPase RhoD suppresses cell migration and cytokinesis. Oncogene 18, 2431-2440.
30. Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, Kumar R (2002). Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 4, 681-690.
31. Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse. J Neurosci 22, 471-477.
32. Zhou AX, Hartwig JH, Akyürek LM (2010). Filamins in cell signaling, transcription and organ development. Trends Cell Biol 20, 113-123.
33. Zuchero JB, Coutts AS, Quinlan ME, Thangue NB, Mullins RD (2009). p53-cofactor JMY is a multifunctional actin nucleation factor. Nat Cell Biol 11, 4511-459.