ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

Nature Immunology

Volumn 14, Issue 1, 2013, Pages 27-33

  Lin, Amy E ^a,b   Ebert, Gregor ^c   Ow, Yongkai ^b   Preston, Simon P ^c,d   Toe, Jesse G ^c,d   Cooney, James P ^c   Scott, Hamish W ^c   Sasaki, Masato ^b   Saibil, Samuel D ^a,b,d   Dissanayake, Dilan ^b,d   Kim, Raymond H ^a,b   Wakeham, Andrew ^b   You Ten, Annick ^b   Shahinian, Arda ^b   Duncan, Gordon ^b   Silvester, Jennifer ^b   Ohashi, Pamela S ^a,b,e   Mak, Tak W ^a,b,e   Pellegrini, Marc ^c,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN ARIH2; TRANSCRIPTION FACTOR RELA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CELL NUCLEUS; CONTROLLED STUDY; DENDRITIC CELL; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; HEMATOPOIETIC STEM CELL; IMMUNOPATHOLOGY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; WEANING;

ANIMALS; CELLS, CULTURED; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; EMBRYONIC DEVELOPMENT; HEMATOPOIESIS; HUMANS; IMMUNE SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; MULTIPLE ORGAN FAILURE; NF-KAPPA B; TRANSCRIPTIONAL ACTIVATION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84871212540     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2478     Document Type: Article

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