Spirulina (Arthrospira) protects against valproic acid-induced neural tube defects in mice

Journal of Medicinal Food

Volumn 15, Issue 12, 2012, Pages 1103-1108

  Escalona Cardoso, Gerardo N ^a   Paniagua Castro, Norma ^a   Pérez Pastén, Ricardo ^a   Chamorro Cevallos, Germán ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Antioxidant activity; Reactive oxygen species; Spirulina

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE; SPIRULINA EXTRACT; SUPEROXIDE DISMUTASE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; EXENCEPHALY; FETUS; GESTATIONAL AGE; MALE; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROPHYLAXIS; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTIOXIDANTS; FEMALE; FETUS; LIPID PEROXIDATION; MICE; MICE, INBRED ICR; NEURAL TUBE DEFECTS; OXIDATIVE STRESS; PREGNANCY; SPIRULINA; TERATOGENS; VALPROIC ACID;

ARTHROSPIRA; MUS; SPIRULINA;

EID: 84871195408     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.0057     Document Type: Article

References (38)

1. Kennedy D, Koren G: Valproic acid use in psychiatry: Issues in treating women of reproductive age. J Psychiatry Neurosci 1998;23:223-228. (Pubitemid 28502672)
2. Gerstner T, Buesing D, Longin E, Bendl C, Wenzel D, Scheid B, et al.: Valproic acid induced encephalopathy - 19 new cases in Germany from 1994 to 2003 - A side effect associated to VPAtherapy not only in young children. Seizure 2006;15:443-448. (Pubitemid 44207882)
3. Vidya M, Subramian P: Effects of a-ketoglutarate on antioxidants and lipid peroxidation products in rats treated with sodium valproate. J Appl Biomed 2006;4:141-146. (Pubitemid 44803324)
4. Deeb SA, Mountaery KA, Arshaduddin M, Tariq M: Vitamin E decreases valproic acid induced neural tube defects in mice. Neurosci Lett 2000;292:179-182.
5. Campanella L, Crescentini G, Avino P: Chemical composition and nutritional evaluation of some natural and commercial food products based on Spirulina. Analusis 1999:23:533-540.
6. Premkumar K, Abraham SK, Santhiya ST, Ramesh A: Protective effect of Spirulina fusiformis on chemical-Induced genotoxocity in mice. Fitoterapia 2004;75:24-31. (Pubitemid 38010400)
7. Dartsch PC. Antioxidant potential of selected Spirulina plantensis preparations. Phytother Res 2008;22:627-633. (Pubitemid 351716550)
8. Romay C, Armesto J, Remirez D, Gonza'lez R, Ledon N, Garci'a I: Antioxidant and anti-Inflammatory properties of C-Phycocianin from blue-Gren algae. Inflamm Res 1998;47:36-41. (Pubitemid 28048114)
9. Zhan-Ping Z, Lu-Ning L, Xiu-Lang C, Jin-Xia W, Min C, Yu-Zhong Z, et al.: Factor that effect antioxidant activity of cphycocyianins from Spirulina platensis. J Food Biochem 2005;29:313-322.
10. Upasani CD, Balarman R: Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats. J Morphol 2003;27:285-294.
11. Paniagua-Castro N, Escalona-Cardoso G, Herna'ndez-Navarro D, Pe'rez-Paste'n R, Chamorro-Cevallos G: Spirulina (Athrospira) protects against cadmium-Induced teratogenic damage in mice. J Med Food 2011;14:1-7.
12. Kapoor R, Mehta U: Effect of supplementation of blue green alga (Spirulina) on outcome of pregnancy in rats. Plant Foods Hum Nutr 1993;43:29-35.
13. Kapoor R, Mehta U: Utilization of beta-Carotene from Spirulina platensis by rats. Plant Foods Hum Nutr 1993:43:1-7.
14. Chamorro-Cevallos G, Garduño-Siciliano L, Barron BL, Madrigal-Bujaidar E, Cruz-Vega DE, Pages N: Chemoprotective effect of Spirulina (Arthrospira) against cyclophosphamide-Induced mutagenicity in mice. Food Chem Toxicol 2008;46:567-574.
15. Peters PW: Double staining of fetal skeletons for cartilage and bone. In: Methods in Prenatal Toxicology: Evaluation of Embryonic Effects in Experimental Animals, 1st edition (Newbert D, Merker HJ, Kwasigroch TF, eds.). Teratology Workshop, April 1977, Berlin. Thieme, Stuttgart, Germany, 1977, pp. 153-154.
16. Wilson JG: Environment and Birth Defects. Academic Press, New York, 1973.
17. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantitites of protein utilizing the principle of protein-Dye binding. Anal Biochem 1976;72:248-254.
18. Ornoy A: Review. Neuroteratogens in man: An overview with special emphasis on the teratogenicity of antiepileptic drugs in pregnancy. Reprod Toxicol 2006;22:214-226. (Pubitemid 43994382)
19. Hrubec TC, Yan M, Ye K, Salafia CM, Holladay SD: Valproic acid-Induced fetal malformations are reduced by maternal inmmune stimulation with granulocyte-macrophage colony-Stimulating factor or interferon-C. Anat Rec 2006;288A:1303-1369.
20. Ceylan S, Duru S, Ceylan S: Vaproic acid sodium-Induced spina bifida occulta in the rat. Neurosurg Rev 2001;24:31-34. (Pubitemid 32825984)
21. Aluclu MU, Tuncer MC, Guzel A, Aluclu MA, Akkus M: The effects of valproic acid on sciatic nerve of fetal rats and protective effects of folic acid and vitamin E. Int Morphol 2009;27:285-294.
22. Jergil M, Kultima K, Gustafson AL, Dencker L, Sugson M: Valproic acid-Induced deregulation in vitro of genes associated in vivo with neural tube defects. Toxicol Sci 2009;108:132-148.
23. Stodgell CJ, Ingram JL, O'Bara M, Tisdale BK, Nau H, Rodier PM: Induction of the homeotic gene Hoxa 1 through valproic acid's teratogenic mechanism of action. Neurotoxicol Teratol 2006;28:617-624. (Pubitemid 44708585)
24. Halliwell B, Gutteridge JMC: Free Radicals in Biology and Medicine, 4th edition. Oxford University Press, New York, 2007, pp. 380-387.
25. Dawson J, Raymod A, Winn LM: Folic acid and pantothenic acid protection against valproic acid-Induced neural tube defects in CD-1mice. Toxicol Appl Pharmacol 2006;211:124-132. (Pubitemid 43238306)
26. Zhang B, Wang X, Nazarali AJ: Ascorbic acid reverses valproic acid-Induced inhibition of Hoxa2 and maintains glutathione homeostasis in mouse embryos in culture. Cell Mol Neurobiol 2010;30:137-148.
27. Pippenger CE, Meng X, Van Lente F, Rothner AD: Valproate therapy depresses GSH-Px and SOD enzyme activity a possible mechanism for VPA induced idiosyncratic drug toxicity. Clin Chem 1989;35:1173.
28. Tong V, Wei Teng X, Chang TKH, Abbott FS: Valproic acid II: Effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-Depleted rat hepatocytes. Toxicol Sci 2005;86:436-443. (Pubitemid 41418656)
29. Dennery PA: Effects of oxidative stress on embryonic development. Birth Defects Res C Embryo Today 2007;81:155-162. (Pubitemid 350086244)
30. Onroy A: Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reprod Toxicol 2007;24:31-41.
31. Ornoy A: Review. Valproic acid in pregnancy: How much are we endangering the embryo and fetus? Reprod Toxicol 2009;28: 1-10.
32. Aktas A, Nergiz Y, Akkus M, Nasir Y: The effects of valproic acid on renal corpuscle of pregnant rats and protective role of folic acid and vitamin E. Afr J Biotechnol 2010;9:5605-5610.
33. Schwarz B: Spirulina. La Microalga Milagrosa Para Su Bienestar, 2nd edition. PPL Impresores, Quito, Ecuador, 2008.
34. Patel A, Mishra S, Ghosh PK: Antioxidant potential of Cphycocyanin isolated from cyanobacterial species. Lyngbya, Phormidiu and Spirulina spp. Indian J Biochem Biophys 2006;43: 25-31. (Pubitemid 44475384)
35. Bermejo P, Piñero E, Villar MA: Iron-Chelating ability and antioxidant properties of phycocyanin isolated from a protean extract of Spirulina platensis. Food Chem 2008;110: 436-445.
36. Viana M, Aruoma OI, Herrera E, Bonet B: Oxidative damage in pregnant diabetic rats and their embryos. Free Radic Biol Med 2000;29:1115-1121.
37. Kovacic P, Jacintho JD: Reproductive Toxins: Pervasive theme of oxidative stress and electron transfer. Curr Med Chem 2001;8:863-892. (Pubitemid 32427914)
38. Assayed ME, Khalaf AA, Salem HA: Protective effects of garlic extract and vitamin C against in vivo cypermethrin-Induced teratogenic effects in rat offspring. Food Chem Toxicol 2010;48: 3153-3158.