Antioxidant potential of selected Spirulina platensis preparations

Phytotherapy Research

Volumn 22, Issue 5, 2008, Pages 627-633

  Dartsch, Peter C ^a  

^a Dartsch Scientific GmbH   (Germany)

Author keywords

Blue green micro algae; Cell culture; Inflammation; Oxidative burst; Oxidative stress; Reactive oxygen species; Spirulina

Indexed keywords

BIOSPIRULINA; CHROMIUM; OXYGEN RADICAL; PLANT EXTRACT; RADICAL; SELENIUM; SPIRUCOMPLEX; SPIRULINA PLATENSIS EXTRACT; SPIRUZINK; SUPEROXIDE; ZINC; ZINKSPIRULINA PLUS ACEROLA;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL BASED TEST ASSAY; CELL CULTURE; CELL FREE SYSTEM; DOSE RESPONSE; DRUG SYNTHESIS; METABOLIC ACTIVATION; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; RECOMMENDED DRUG DOSE; SPIRULINA PLATENSIS;

ANTIOXIDANTS; CELL SURVIVAL; CELL-FREE SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICALS; HL-60 CELLS; HUMANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SPIRULINA; SUPEROXIDES;

ALGAE; CYANOBACTERIA; SPIRULINA; SPIRULINA PLATENSIS;

EID: 44149123079     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2310     Document Type: Article

References (37)

1. Babior BM. 1999. NADPH oxidase: an update. Blood 93: 1464-1476.
2. Belay A, Ota Y, Miyakawa K, Shimamatsu H. 1993. Current knowledge on potential health benefits of Spirulina. J Appl Phycol 5: 235-241.
3. Bhat VB, Madyastha KM. 2001. Scavenging of peroxynitrite by phycocyanin and phycocyanobilin from Spirulina platensis: protection against oxidative damage to DNA. Biochem Biophys Res Commun 285: 262-266.
4. Blinkova LP, Gorobets OB, Baturo AP. 2001. Biological activity of Spirulina (in Russian). Zh Mikrobiol Epidemiol Immunobiol 2: 114-118.
5. Bray TM, Bettger WJ. 1990. The physiological role of zinc as an antioxidant. Free Radic Biol Med 8: 281-291.
6. Chamorro G, Salazar M, Araujo KG, dos Santos CP, Ceballos G, Castillo LF. 2002. Update on the pharmacology of Spirulina (Arthrospira), an unconventional food. (in Spanish). Arch Latinoam Nutr 52: 232-240.
7. Conner EM, Grisham MB. 1996. Inflammation, free radicals, and antioxidants. Nutrition 12: 274-277.
8. Crimi E, Sica V, Williams-lgnarro S et al. 2006. The role of oxidative stress in adult critical care. Free Radic Biol Med 40: 398-406.
9. Dartsch PC. 2006. TIIOS - a sensitive and cell-based test assay for the screening of biologically active substances for their antioxidant potential. Innov Food Tech 32: 72-75.
10. Dartsch PC, Pischel I, Feistel B. 2006. A new natural, botanical based digestive aid called nutrifin digest and its efficacy in promoting cellular processes. Nutracos 5: 2-6.
11. Droge W. 2002. Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95.
12. Forman HJ, Torres M. 2001. Redox signaling in macrophages. Mol Aspects Med 22: 189-216.
13. Hayes JD, McLellan LI. 1999. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defense against oxidative stress. Free Radic Res 31: 273-300.
14. Hensley K, Robinson KA, Gabbiata SP, Salsman S, Floyd RA. 2000. Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 28: 1456-1462.
15. Khan Z, Bhadouria P, Bisen PS. 2005. Nutritional and therapeutic potential of Spirulina. Curr Pharm Biotechnol 6: 373-379.
16. Kuhad A, Tirkey N, Pilkhwal S, Chopra K. 2006a. Renoprotective effect of Spirulina fusiformis on cisplatin-induced oxidative stress and renal dysfunction in rats. Ren Fail 28: 247-254.
17. Kuhad A, Tirkey N, Pilkhwal S, Chopra K. 2006b. Effect of Spirulina, a blue green algae, on gentamycin-induced oxidative stress and renal dysfunction in rats. Fundam Clin Pharmacol 20: 121-128.
18. Kytridis VP, Manetas Y. 2006. Mesophyll versus epidermal anthocyanins as potential in vivo antioxidants: evidence linking the putative antioxidant role to the proximity of oxyradical source. J Exp Bot 57: 2203-2210.
19. Lenaz G, Bovina C, Formiggini G, Parenti Castelli G. 1999. Mitochondria, oxidative stress, and antioxidant defenses. Acta Biochem Pol 46: 1-21.
20. Lu HK, Hsieh CC, Hsu JJ, Yang YK, Chou HN. 2006. Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress. Eur J Appl Physiol 98: 220-226.
21. Meister A. 1992. On the antioxidant effects of ascorbic acid and glutathione. Biochem Pharmacol 44: 1905-1915.
22. Mohan IK, Khan M, Shobha JC et al. 2006. Protection against cisplatin-induced nephrotoxicity by Spirulina in rats. Cancer Chemother Pharmacol 58: 802-808.
23. Nagamine I, Sakurai H, Nguyen HTT et al. 2004. Antioxidant activity of acerola extracts. Czech J Food Sci 22: 155-158.
24. Nagata M. 2005. Inflammatory cells and oxygen radicals. Curr Drug Targets In flamm Allergy 4: 503-504.
25. Oteiza PI, Clegg MS, Zago MP, Keen CL. 2000. Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells. Free Radic Biol Med 28: 1091-1099.
26. Oteiza PI, Olin KL, Fraga CG, Keen CL. 1995. Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. J Nutr 125: 823-829.
27. Peskin AV, Winterbourn CC. 2000. A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1). Clin Chim Acta 293: 157-166.
28. Pinero Estrada JE, Bermejo Bescos P, Villar del Fresno AM. 2001. Antioxidant activity of different fractions of Spirulina platensis protean extract. Farmaco 56: 497-500.
29. Powell SR. 2000. The antioxidant properties of zinc. J Nutr 130: 1447S-1454S.
30. Rice-Evans C. 2001. Flavonoid antioxidants. Curr Med Chem 8: 797-807.
31. Romay C, Armesto J, Remirez D, Gonzalez R, Ledon N, Garcia I. 1998a. Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae. Inflamm Res 47: 36-41.
32. Romay C, Ledon N, Gonzalez R. 1998b. Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation. Inflamm Res 47: 334-338.
33. Takashi H, Mikiya T, Masaki O, Teppei T, Morihiko S. 2000. Antioxidant activities of phycocyanobilin prepared from Spirulina platensis. J Appl Phycol 12: 435-439.
34. Tan AS, Berridge MV. 2000. Superoxide produced by activated neutrophils efficiently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: a simple colorimetric assay for measuring respiratory burst activation and for screening anti-inflammatory agents. J Immunol Meth 238: 59-68.
35. Terman A, Brunk UT. 2006. Oxidative stress, accumulation of biological 'garbage' and aging. Antioxid Redox Signal 8: 197-2004.
36. Teufelhofer O, Weiss R-M, Parzefall W et al. 2003. Promyelocyte HL60 cells express NADPH oxidase and are excellent targets in a rapid spectrophotometry microplate assay for extracellular superoxide. Toxicol Sci 76: 376-383.
37. Upasani CD, Balaraman R. 2003. Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats. Phytother Res 17: 330-334.