Ghrelin and obestatin in infants, lactating mothers and breast milk

Hormone Research in Paediatrics

Volumn 78, Issue 5-6, 2012, Pages 297-303

  Savino, F ^a   Benetti, S ^a   Lupica, M M ^a   Petrucci, E ^a   Palumeri, E ^a   Di Montezemolo, L Cordero ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Ghrelin; Human milk; Lactating mothers; Obestatin; Term infants

Indexed keywords

ADULT; CROSS-SECTIONAL STUDIES; FEMALE; GHRELIN; HUMANS; INFANT; INFANT FORMULA; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; LACTATION; MILK, HUMAN; SKINFOLD THICKNESS;

GHRELIN; OBESTATIN;

ANTHROPOMETRIC PARAMETERS; ARTICLE; BLOOD SAMPLING; BREAST FEEDING; BREAST MILK; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; INFANT; LACTATION; MALE; MILK LEVEL; PRIORITY JOURNAL;

EID: 84871183614     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000345876     Document Type: Article

References (35)

1. Seim I, Walpole C, Amorim L, Josh P, Herington A, Chopin L: The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease. Mol Cell Endocrinol 2011; 340: 111-117.
2. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growthhormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
3. Zizzari P, Hassouna R, Grouselle D, Epelbaum J, Tolle V: Physiological roles of preproghrelin-derived peptides in GH secretion and feeding. Peptides 2011; 32: 2274-2282.
4. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, et al: Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310: 996-999.
5. Savino F, Petrucci E, Nanni G: Adiponectin: an intriguing hormone for paediatricians. Acta Paediatr 2008; 97: 701-705.
6. Ariysu H, Takaya K, Tagami T: Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 2001; 86: 4753-4758.
7. Lacquaniti A, Donato V, Chirico V, Buemi A, Buemi M: Obestatin: an interesting but controversial gut hormone. Ann Nutr Metab 2011; 59: 193-199.
8. Grönberg M, Tsolakis AV, Magnusson L, Janson ET, Saras J: Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands. J Histochem Cytochem 2008; 56: 793-801.
9. Aydin S, Aydin S, Ozkan Y, Kumru S: Ghrelin is present in human colostrum, transitional and mature milk. Peptides 2006; 27: 878-82.
10. Aydin S, Ozkan Y, Erman F, Gurates B, Kilic N, Colak R, et al: Presence of obestatin in breast milk: relationship among obestatin, ghrelin, and leptin in lactating women. Nutrition 2008; 24: 689-693.
11. Savino F, Liguori SA, Petrucci E, Lupica MM, Fissore MF, Oggero R, Silvestro L: Evaluation of leptin in breast milk, lactating mothers and their infants. Eur J Clin Nutr 2010; 64: 972-977.
12. Savino F, Lupica MM, Liguori SA, Fissore MF, Silvestro L: Ghrelin and feeding behaviour in preterm infants. Early Hum Dev 2012; 88(suppl 1):S51-S55.
13. Savino F, Liguori SA, Fissore MF, Oggero R: Breast milk hormones and their protective effect on obesity. Int J Pediatr Endocrinol 2009; 2009: 327505.
14. Chiesa C, Osborn JF, Haass C, Natale F, Spinelli M, Scapillati E, et al: Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry? Clin Chem 2008; 54: 550-558.
15. Savino F, Fissore MF, Liguori SA, Grassino EC, Guidi C, Oggero R, et al: Serum ghrelin concentration, fasting time and feeding in infants. J Pediatr Endocrinol Metab 2007; 20: 1027-1033.
16. Fidanc K, Meral C, Süleymanolu S, Pirgon ö, Karademir F, Aydnöz S, et al: Ghrelin levels and postnatal growth in healthy infants 0-3 months of age. J Clin Res Pediatr Endocrinol 2010; 2: 34-38.
17. Savino F, Grassino EC, Fissore MF, Guidi C, Liguori SA, Silvestro L, Oggero R, Miniero R: Ghrelin, motilin, insulin concentration in healthy infants in the first months of life: relation to fasting time and anthropometry. Clin Endocrinol (Oxf) 2006; 65: 158-162.
18. Soriano-Guillén L, Barrios V, Chowen JA, Sánchez I, Vila S, Quero J, et al: Ghrelin levels from fetal life through early adulthood: relationship with endocrine and metabolic and anthropometric measures. J Pediatr 2004; 144: 30-35.
19. Thompson NM, Gill DA, Davies R, Loveridge N, Houston PA, Robinson IC, et al: Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 2004; 145: 234-242.
20. Kierson JA, Dimatteo DM, Locke RG, Mackley AB, Spear ML: Ghrelin and cholecystokinin in term and preterm human breast milk. Acta Paediatr 2006; 95: 991-995.
21. Savino F, Fissore MF, Liguori SA, Oggero R: Can hormones contained in mothers' milk account for the beneficial effect of breastfeeding on obesity in children? Clin Endocrinol (Oxf) 2009; 71: 757-765.
22. Savino F, Petrucci E, Lupica MM, Nanni GE, Oggero R: Assay of ghrelin concentration in infant formulas and breast milk. World J Gastroenterol 2011; 17: 1971-1975.
23. Wang X, Ni S, Xu Y, Liang L, Du L, Gu W: Effects of long-term high-hat/high-energy and high-protein diets on insulin and ghrelin expression in developing rats. Endocr Res 2012; 37: 97-109.
24. Savino F, Fissore MF, Grassino EC, Nanni GE, Oggero R, Silvestro L: Ghrelin, leptin and IGF-I levels in breast-fed and formulafed infants in the first years of life. Acta Paediatr 2005; 94: 531-537.
25. Savino F, Liguori SA, Fissore MF, Oggero R, Silvestro L, Miniero R: Serum ghrelin concentration and weight gain in healthy term infants in the first year of life. J Pediatr Gastroenterol Nutr 2005; 41: 653-659.
26. Vester BM, Belsito KR, Swanson KS: Serum metabolites, ghrelin and leptin are modified by age and/or diet in weanling kittens fed either a high-or moderate-protein diet. Anim Sci J 2012; 83: 426-433.
27. Takeshita E, Matsuura B, Dong M, Miller LJ, Matsui H, Onji M: Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract. J Gastroenterol 2006; 41: 223-230.
28. Cesur G, Ozguner F, Yilmaz N, Dundar B: The relationship between ghrelin and adiponectin levels in breast milk and infant serum and growth of infants during early postnatal life. J Physiol Sci 2012; 62: 185-190.
29. Zizzari P, Longchamps R, Epelbaum J, Bluet-Pajot MT: Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology 2007; 148: 1648-1653.
30. Chen CY, Tsai CY, Lee WJ, Liaw WJ, Chiang CH, Ho ST, et al: Intracerebroventricular O-n-octanoylated ghrelin and its splice variant-induced feeding is blocked by insulin, independent of obestatin or CRF receptor, in satiated rats. Nutrition 2012; 28: 812-820.
31. Hertzog MA: Considerations in determining sample size for pilot studies. Res Nurs Health 2008; 31: 180-191.
32. Granata R, Gallo D, Luque RM, Baragli A, Scarlatti F, Grande C, et al: Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation. FASEB J 2012; 26: 3393-3411.
33. Song Z, Verhulst PJ, Ansari Z, Thijs T, Depoortere I, Everaert N, et al: Peripheral "chicken" obestatin administration does not affect feed intake and gut muscle contractility of meat-type and layer-type chicks (Gallus gallus domesticus). Regul Pept 2012; 177: 60-67.
34. Koletzko B, Brands B, Demmelmair H, Early Nutrition Programming Project: The Early Nutrition Programming Project (EARNEST): 5 y of successful multidisciplinary collaborative research. Am J Clin Nutr 2011; 94(suppl 6):1749S-1753S.
35. Tarry-Adkins JL, Ozanne SE: Mechanisms of early life programming: current knowledge and future directions. Am J Clin Nutr 2011; 94(suppl 6):1765S-1771S.