Evaluation of leptin in breast milk, lactating mothers and their infants

European Journal of Clinical Nutrition

Volumn 64, Issue 9, 2010, Pages 972-977

  Savino, F ^a   Liguori, S A ^a   Petrucci, E ^a   Lupica, M M ^a   Fissore, M F ^a   Oggero, R ^a   Silvestro, L ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

breast milk; infants; leptin; mothers

Indexed keywords

LEPTIN;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD LEVEL; BODY HEIGHT; BODY MASS; BODY WEIGHT; BREAST FEEDING; BREAST MILK; CHILD GROWTH; FEMALE; GESTATIONAL AGE; HUMAN; INFANT; LACTATION; MATERNAL BLOOD; MILK LEVEL; NORMAL HUMAN; RADIOIMMUNOASSAY;

ADULT; BODY MASS INDEX; BODY WEIGHT; BREAST FEEDING; CROSS-SECTIONAL STUDIES; FEMALE; GESTATIONAL AGE; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; LACTATION; LEPTIN; MALE; MILK, HUMAN; MOTHERS;

EID: 77956338307     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2010.105     Document Type: Article

References (38)

1. Agostoni C, Braegger C, Decsi T, Kolacek S, Koletzko B, Michaelsen KF et al. (2009). Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 49, 112-125.
2. Barrenetxe J, Villaro AC, Guembe L, Pascual I, Munoz-Navas M, Barber A et al. (2002). Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes. Gut 50, 797-802.
3. Bartok CJ, Ventura AK (2009). Mechanisms underlying the association between breastfeeding and obesity. Int J Pediatr Obes 4, 196-204.
4. Bielicki J, Huch R, von Mandach U (2004). Time-course of leptin levels in term and preterm human milk. Eur J Endocrinol 15, 271-276.
5. Bonnet M, Gourdou I, Leroux C, Chilliard Y, Djiane J (2002). Leptin expression in the ovine mammary gland: putative sequential involvement of adipose, epithelial and myoepithelial cells during pregnancy and lactation. J Anim Sci 80, 723-728.
6. Bouret SG, Simerly RB (2006). Developmental programming of hypothalamic feeding circuits. Clin Genet 70, 295-301.
7. Bronsky J, Karpisek M, Bronska E, Pechova M, Jancikova B, Kotolova H et al. (2006). Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: proteins newly identified in human breast milk. Clin Chem 52, 1763-1770.
8. Casabiell X, Pineiro V, Tom MA, Peinto R, Dieguez C, Casanueva FF (1997). Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake. J Clin Endocrinol Metab 82, 4270-4273.
9. Chan JL, Mantzoros CS (2005). Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet 366, 74-85.
10. Cinti S, de Matteis R, Ceresi E, Pico C, Oliver J, Oliver P et al. (2001). Leptin in the human stomach. Gut 49, 155.
11. Demmelmailr H, von Rosen J, Koletzko B (2006). Long-term consequences of early nutrition. Early Hum Dev 82, 567-574.
12. Faroooqi IS, O'Rahilly S (2009). Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 89 (Suppl), 980S-984S.
13. Houseknecht KL, McGuire MK, Portocarrero CP, McGuire MA, Beerman K (1997). Leptin is present in human milk and is related to maternal plasma leptin concentration and adiposity. Biochem Biophys Res Commun 240, 742-747.
14. Huang L, Li C (2000). Leptin: a multifunctional hormone. Cell Res 10, 81-92.
15. Ilcol YO, Hizli ZB, Ozkan T (2006). Leptin concentration in breast milk and its relationship to duration of lactation and hormonal status. Int Breastfeed J 1, 21.
16. Koletzko B, von Kries R, Monasterolo RC, Subias JE, Scaglioni S, Giovannini M et al. (2009). Infant feeding and later obesity risk. Adv Exp Med Biol 646, 15-29.
17. Lammert A, Kiess W, Bottner A, Glasow A, KratzschJ (2001). Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 283, 982-988.
18. Lonnerdal B (2003). Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr 77, 1537S-1543S.
19. Lonnerdal B, Havel PJ (2000). Serum leptin concentrations in infants: effects of diet, sex, and adiposity. Am J Clin Nutr 72, 484-489.
20. Lyle RE, Kincaid SC, Bryant JC, Prince AM, McGehee RE Jr. (2001). Human milk contains detectable levels of immunoreactive leptin. Adv Exp Med Biol 501, 87-92.
21. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H et al. (1997). Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3, 1029-1033.
22. Miralles O, Sanchez J, Palou A, Pico C (2006). A physiological role of breast milk leptin in body weight control in developing infants. Obesity 14, 1371-1377.
23. Palou A, Pico C (2009). Leptin intake during lactation prevents obesity and affects food intake and food preferences in later life. Appetite 52, 249-252.
24. Pico C, Sanchez J, Oliver P, Miralles O, Ceresi E, Palou A (2007). Role of leptin present in maternal milk in the control of energy balance during the post-natal period. Genes Nutr 2, 139-141.
25. Resto M, O'Connor D, Leef K, Funanage V, Spear M, Locke R (2001). Leptin levels in preterm human breast milk and infant formula. Pediatrics 108, E15.
26. Sanchez J, Priego T, Palou M, Tobaruela A, Palou A, Pico C (2008). Oral supplementation with physiological doses of leptin during lactation in rats improves insulin sensitivity and affects food preferences later in life. Endocrinology 149, 733-740.
27. Savino F, Fissore MF, Grassino EC, Nanni GE, Oggero R, Silvestro L (2005). Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life. Acta Paediatr 94, 531-537.
28. Savino F, Fissore MF, Liguori SA, Oggero R (2009). Can hormones contained in mothers' milk account for the beneficial effect of breast-feeding on obesity in children? Clin Endocrinol 71, 757-765.
29. Savino F, Liguori SA, Lupica MM, Fissore MF, Oggero R (2006). Leptin levels in breast-fed infants. Clin Endocrinol 64, 597-598.
30. Shekhawat PS, Garland JS, Shivpuri C, Mick GJ, Sasidharan P, Pelz CJ et al. (1998). Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids. Pediatr Res 43, 338-343.
31. Singhal A, Lanigan J (2007). Breastfeeding, early growth and later obesity. Obes Rev 8 (Suppl 1), 51-54.
32. Smith-Kirwin SM, O'Connor DM, De Johnston J, Lancey ED, Hassink SG, Funanage VL (1998). Leptin expression in human mammary epithelial cells and breast milk. J Clin Endocrinol Metab 83, 1810-1813.
33. Stocker CJ, Cawthorne MA (2008). The influence of leptin on early life programming of obesity. Trends Biotechnol 26, 545-551.
34. Ucar B, Kirel B, Bor O, Kilic FS, Dogruel N, Aydogdu SD et al. (2000). Breast milk leptin concentrations in initial and terminal milk samples: relationships to maternal and infant plasma leptin concentrations, adiposity, serum glucose, insulin, lipid and lipoprotein levels. J Pediatr Endocrinol Metab 13, 149-156.
35. Uysal FK, Onal EE, Aral YZ, Adam B, Dilmen U, Ardicoglu Y (2002). Breast milk leptin: its relationship to maternal and infant adiposity. Clin Nutr 21, 157-160.
36. Wagner CL, Taylor SN, Johnson D (2008). Host factors in amniotic fluid and breast milk that contribute to gut maturation. Clin Rev Allergy Immunol 34, 191-204.
37. Weyermann M, Beermann C, Brenner H, Rothenbacher D (2006). Adiponectin and leptin in maternal serum, cord blood, and breast milk. Clin Chem 52, 2095-2102.
38. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.