Ghrelin, motilin, insulin concentration in healthy infants in the first months of life: Relation to fasting time and anthropometry

Clinical Endocrinology

Volumn 65, Issue 2, 2006, Pages 158-162

  Savino, F ^a,b   Grassino, E C ^a   Fissore, M F ^a   Guidi, C ^a   Liguori, S A ^a   Silvestro, L ^a   Oggero, R ^a   Miniero, R ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; INSULIN; MOTILIN;

ANTHROPOMETRY; ARTICLE; BLOOD SAMPLING; BODY HEIGHT; BODY WEIGHT; CORRELATION ANALYSIS; DIET RESTRICTION; FEMALE; HEAD CIRCUMFERENCE; HORMONE DETERMINATION; HUMAN; HUMAN EXPERIMENT; INFANT; INFANT FEEDING; MALE; NORMAL HUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; RADIOIMMUNOASSAY; TERM BIRTH;

ANTHROPOMETRY; APPETITE REGULATION; BODY HEIGHT; BODY WEIGHT; BOTTLE FEEDING; BREAST FEEDING; CEPHALOMETRY; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FASTING; FEMALE; GHRELIN; HUMANS; INFANT; INSULIN; MALE; MOTILIN; MULTIVARIATE ANALYSIS; PEPTIDE HORMONES;

EID: 33746044264     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2006.02561.x     Document Type: Article

References (38)

1. Cowley, M.A., Smith, R.G., Diano, S., Tschop, M., Pronchuk, N., Grove, K.L., Strasburger, C.J., Bidlingmaier, M., Esterman, M., Heiman, M.L., Garcia-Segura, L.M., Nillni, E.A., Mendez, P., Low, M.J., Sotonyi, P., Friedman, J.M., Liu, H., Pinto, S., Colmers, W.F., Cone, R.D. & Horvath, T.L. (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates novel hypothalamic circuit regulating energy homeostasis. Neuron, 37, 649-661.
2. Cummings, D.E., Purnell, J.Q., Frayo, R.S., Schmidova, K., Wisse, B.E. & Weigle, D.S. (2001) A preprandial rise in plasma ghrelin levels suggests a role in initiation in humans. Diabetes, 50, 1714-1719.
3. Tschop, M., Wawarta, R., Riepl, R.L., Friedrich, S., Bidlingmaier, M., Landgraf, R. & Folwaczny, C. (2001) Post-prandial decrease of circulating human ghrelin levels. Journal of Endocrinological Investigation, 24, RC 19-21.
4. Schwartz, M.W., Woods, S.C., Porte, D. Jr, Seeley, R.J. & Baskin, D.G. (2000) Central nervous system control of food intake. Nature, 404, 661-671.
5. Tomasetto, C., Karam, S.M., Ribieras, S., Masson, R., Lefèbvre, O., Staub, A., Alexander, G., Chenard, M.P. & Rio, M.C. (2000) Identification and characterization of a novel peptide hormone: the motilin-related peptide. Gastroenterology, 119, 395-405.
6. Asakawa, A., Inui, A., Kaga, T., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimya, M., Niijima, A., Fujino, M.A. & Kasuga, M. (2001) Ghrelin is an appetite stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology, 120, 337-345.
7. Itoh, Z. (1997) Motilin and clinical application. Peptides, 18, 593-608.
8. Feighner, S.D., Tan, C.P., McKee, K.K., Palyha, O.C., Hreniuk, D.L., Pong, S.S., Austin, C.P., Figueroa, D., MacNeil, D., Cascieri, M.A., Nargund, R., Bakshi, R., Abramovitz, M., Stocco, R., Kargman, S., O'Neill, G., Van Der Loeg, L.H.T., Evans, J., Patchett, A.A., Smith, R.G. & Howard, A.D. (1999) Receptor for motilin identified in the human gastrointestinal system. Science, 284, 2184-2188.
9. Xu, L., Depoortere, I., Tomasetto, C., Zandecki, M., Tang, M., Timmermans, J.P. & Peeters, T.L. (2005) Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus. Regulatory Peptides, 124, 119-125.
10. Depoortere, I. (2001) Motilin and motilin receptors: characterization and functional significance. Verhandelingen Koninklijke Academie Voor Geneeskunde van Belgie, 63, 511-529.
11. Wren, A.M., Small, C.J., Abbott, C.R., Dhillo, W.S., Seal, L.J., Choen, M.A., Batterham, R.L., Taheri, S., Stanley, S.A., Ghatei, M.A. & Bloom, S.R. (2001) Ghrelin causes hyperphagia and obesity in rats. Diabetes, 50, 2540-2547.
12. Wren, A.M., Seal, L.J., Choen, M.A., Brynes, A.E., Frost, G.S., Murphy, K.G., Dhillo, W.S., Ghatei, M.A. & Bloom, S.R. (2001) Ghrelin enhances appetite and increases food intake in humans. Journal of Clinical Endocrinology and Metabolism, 86, 5992.
13. Kitamura, S., Yokota, I., Hosoda, H., Totani, Y., Matsuda, J., Naito, E., Ito, M., Kangawa, K. & Kuroda, Y. (2003) Ghrelin concentration in cord and neonatal blood: relation to fetal growth and energy balance. Journal of Clinical Endocrinology and Metabolism, 88, 5473-5477.
14. Soriano Guillen, L., Barrios, V., Chowen, J.A., Sanchez, I., Vila, S., Quero, J. & Argente, J. (2004) Ghrelin levels from fetal life through early adulthood: relationship with endocrine and metabolic and anthropometric measures. Journal of Pediatrics, 144, 30-35.
15. Önal, E.E., Cinaz, P., Atalay, Y., Türkyilmaz, C., Bideci, A., Aktürk, A., Okumus, N., Ünal, S., Koc, E. & Ergenekon, E. (2004) Umbilical cord ghrelin concentrations in small- and appropriate-for-gestational age newborn infants: relationship to anthropometric markers. Journal of Endocrinology, 180, 267-271.
16. Yokota, I., Kitamura, S., Hosoda, H., Kotani, Y. & Kangawa, K. (2005) Concentration of the n-octanoylated active form of ghrelin in fetal and neonatal circulation. Endocrine Journal, 52, 271-276.
17. Ng, P.N., Lee, C.H., Lam, C.W.K., Chan, I.H.S., Wong, E. & Fok, T.F. (2005) Ghrelin in pre-term and term newborns: relations to anthropometry, leptin and insulin. Clinical Endocrinology, 63, 217-222.
18. Savino, F., Liguori, S.A., Fissore, M.F., Oggero, R., Silvestro, L. & Miniero, R. (2005) Serum ghrelin concentration and weight gain in healthy term infants in the first year of life. Journal of Pediatric Gastroenterology and Nutrition, 41, 653-659.
19. Phillipps, A.F. (2005) Ghrelin, energy balance and weight in infants: the chicken or the egg? Journal of Pediatric Gastroenterology and Nutrition, 41, 575-577.
20. Tschop, M., Weyer, C., Tataranni, P.A., Devanarayan, V., Ravussin, E. & Heiman, M.L. (2001) Ciculating ghrelin levels are decreased in human obesity. Diabetes, 50, 707-709.
21. Cuntz, U., Fruhauf, E., Wawarta, R., Tschop, M., Folwaczny, C., Riepl, R., Lehnert, P., Fichter, M. & Otto, B. (2002) A role for the novel weight-regulating hormone ghrelin in anorexia nervosa. American Clinical Laboratory, 21, 22-23.
22. McLaughlin, T., Abbasi, F., Lamendola, C., Frayo, R.S. & Cummings, D.E. (2004) Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls. Journal of Clinical Endocrinology and Metabolism, 89, 1630-1635.
23. Saad, M.F., Bernaba, B., Hwu, C.M., Jinagouda, S., Fahmi, S., Kogosov, E. & Boyadjian, R. (2002) Insulin regulates plasma ghrelin concentration. Journal of Clinical Endocrinology and Metabolism, 87, 3997-4000.
24. Date, Y., Nakazato, M., Hashiguchi, S., Dezaki, K., Mondal, M.S., Hosoda, H., Kojima, M., Kangawa, K., Arima, T., Matsuo, H., Yada, I. & Matsukura, S. (2002) Ghrelin is present in pancreatic α cells of humans and rats and stimulates insulin secretion. Diabetes, 51, 124-129.
25. Shiiya, T., Nakazato, M., Mizuta, M., Date, Y., Mondal, M.S., Tanaka, M., Nozoe, S.I., Hosoda, H., Kangawa, K. & Matsukura, S. (2002) Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. Journal of Clinical Endocrinology and Metabolism, 87, 240-244.
26. Schaller, G., Schmidt, A., Pleiner, J., Woloszczuk, W., Wolzt, M. & Luger, A. (2003) Plasma ghrelin concentrations are not regulated by glucose or insuline: a double-blind, placebo-controlled crossover clamp study. Diabetes, 52, 16-20.
27. Bacha, F. & Arslanian, S.A. (2005) Ghrelin suppression in overweight children: a manifestation of insulin resistance? Journal of Clinical Endocrinology and Metabolism, 90, 2725-2730.
28. Bellone, S., Castellino, N., Broglio, F., Rapa, A., Vivenza, D., Radetti, G., Bellone, J., Gottero, C., Ghigo, E. & Bona, G. (2004) Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding. Journal of Clinical Endocrinology and Metabolism, 89, 1662-1665.
29. Purnell, J.Q., Weigle, D.S., Breen, P.A. & Cummings, D.E. (2003) Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans. Journal of Clinical Endocrinology and Metabolism, 88, 5747-5752.
30. Bellone, S., Rapa, A., Vivenza, D., Vercellotti, A., Petri, A., Radetti, G., Bellone, J., Broglio, F., Ghigo, E. & Bona, G. (2003) Circulating ghrelin levels in newborns are not associated to gender, body weight and hormonal parameters but depend on the type of delivery. Journal of Endocrinological Investigation, 26, RC9-11.
31. Chanoine, J.P., Yeung, L.P.K., Wong, A.C.K. & Birmingham, C.L. (2002) Immunoreactive ghrelin in human cord blood: relation to anthropometry, leptin, and growth hormone. Journal of Pediatric Gastroenterology and Nutrition, 35, 282-286.
32. Mahmoud, E.L., Bernirschke, K., Vaucher, Y.E. & Poitras, P. (1988) Motilin levels in term neonates who have passed meconium prior to birth. Journal of Pediatric Gastroenterology and Nutrition, 7, 95-99.
33. Janik, J.S., Track, N.S. & Filler, M.N. (1982) Motilin, human pancreatic polypeptide, gastrin, and insulin plasma concentrations in fasted children. Journal of Pediatrics, 101, 51-56.
34. Lucas, A., Adrian, T.E., Christofides, N., Bloom, S.R. & Aynsley-Green, A. (1980) Plasma motilin, gastrin, and enteroglucagon and feeding in human newborn. Archives of Disease in Childhood, 55, 673-677.
35. Morriss, F.H. (1991) Neonatal gastrointestinal motility and enteral feeding. Seminars in Perinatology, 15, 478-481.
36. Shulman, D.I. & Kanarek, K. (1993) Gastrin, motilin, insulin, and insuline-like growth factor-I concentrations in very-low-birth-weight infants receiving enteral or parenteral nutrition. Journal of Parenteral and Enteral Nutrition, 17, 130-133.
37. Koldovsky, O. (1969) Development of the Functions of the Small Intestine in Mammals and Man. Basel: Karger.
38. Asakawa, A., Inui, A., Momose, K., Ueno, N., Fujino, M.A. & Kasuga, M. (1998) Motilin increases food intake in mice. Peptides, 19, 987-990.