A single residue within the V5 region of HIV-1 envelope facilitates viral escape from the broadly neutralizing monoclonal antibody VRC01

Journal of Biological Chemistry

Volumn 287, Issue 51, 2012, Pages 43170-43179

  Guo, Dongxing ^a   Shi, Xuanling ^b   Arledge, Kelly C ^b   Song, Dingka ^b   Jiang, Liwei ^b   Fu, Lili ^b   Gong, Xinqi ^c   Zhang, Senyan ^c   Wang, Xinquan ^c   Zhang, Linqi ^a,b  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b Tsinghua University   (China)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE RESIDUE; BINDING AFFINITIES; CRITICAL DETERMINANT; ENVELOPE GLYCOPROTEINS; KEY FACTORS; N-LINKED GLYCOSYLATION; RESISTANT STRAINS; SENSITIVITY PROFILES; SIDE-CHAINS; SINGLE ALANINE SUBSTITUTIONS; SINGLE RESIDUE; STERIC HINDRANCES; STRUCTURAL MODELING;

AMINO ACIDS; BINDING ENERGY; ESTERIFICATION; GLYCOSYLATION; MODEL STRUCTURES; MONOCLONAL ANTIBODIES;

CLONING;

ASPARAGINE; ASPARAGINE 460; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY VRCO1; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; VIRUS ENVELOPE; VIRUS NEUTRALIZATION; VIRUS RESISTANCE; VIRUS STRAIN;

AMINO ACID SEQUENCE; AMINO ACIDS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD4; ASPARAGINE; GENOTYPE; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP160; HIV-1; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84871173025     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.399402     Document Type: Article

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