Biochemically defined HIV-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the CD4-binding site

Journal of Biological Chemistry

Volumn 287, Issue 8, 2012, Pages 5673-5686

  Feng, Yu ^a   McKee, Krisha ^b   Tran, Karen ^a   O'Dell, Sijy ^b   Schmidt, Stephen D ^b   Phogat, Adhuna ^a,d   Forsell, Mattias N ^c   Hedestam, Gunilla B Karlsson ^c   Mascola, John R ^b   Wyatt, Richard T ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIFFERENTIAL BINDING; DIRECT RESPONSE; ENVELOPE GLYCOPROTEINS; IMMUNE RESPONSE; IMMUNOGENS; ISOTHERMAL TITRATION MICROCALORIMETRY; LIGAND BINDING PROPERTIES; NEUTRALIZING ANTIBODIES; RECOMBINANT GLYCOPROTEINS; TRIMERIZATION;

BINDING ENERGY; OLIGOMERS;

ANTIBODIES;

CD4 ANTIBODY; CD4 ANTIGEN; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 140; MONOCLONAL ANTIBODY; MONOMER; NEUTRALIZING ANTIBODY; PROTEIN VARIANT; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN ANTIBODY REACTION; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCHEMISTRY; BIOENGINEERING; BIOPHYSICS; CLADISTICS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOTHERMAL TITRATION MICROCALORIMETRY; LIGAND BINDING; MICROCALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PURIFICATION; PROTEIN STABILITY; SURFACE PLASMON RESONANCE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; ANTIGENS, CD4; BINDING SITES; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; FEMALE; HIV ENVELOPE PROTEIN GP120; HIV-1; KINETICS; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RABBITS; THERMODYNAMICS;

EID: 84857306337     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.317776     Document Type: Article

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