Electrostatic interactions play an essential role in the binding of oleic acid with α-lactalbumin in the HAMLET-like complex: A study using charge-specific chemical modifications

Proteins: Structure, Function and Bioinformatics

Volumn 81, Issue 1, 2013, Pages 1-17

  Xie, Yongjing ^a   Min, Soyoung ^a   Harte, Níal P ^a   Kirk, Hannah ^a   O'Brien, John E ^a   Voorheis, H Paul ^a   Svanborg, Catharina ^b   Hun Mok, K ^a,b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b LUND UNIVERSITY   (Sweden)

Author keywords

lactalbumin; Charge specific; Chemical modification; Electrostatic interaction; HAMLET BAMLET; Lysine; Oleic acid oleate; Partially unfolded folded; Protein unfolding; Protein fatty acid complex

Indexed keywords

ALPHA LACTALBUMIN; ANTINEOPLASTIC AGENT; HOMOARGININE; HUMAN ALPHA LACTALBUMIN MADE LETHAL TO TUMOR CELLS LIKE COMPLEX; HYBRID PROTEIN; LYSINE; OLEIC ACID; UNCLASSIFIED DRUG;

ACETYLATION; AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL DESTRUCTION; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; CITRACONYLATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; ELECTRICITY; FLUORESCENCE ANALYSIS; GUANIDINATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LIPID INTERACTION; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; PROTEIN UNFOLDING; STATIC ELECTRICITY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTALBUMIN; LYSINE; MODELS, MOLECULAR; OLEIC ACIDS; PROTEIN CONFORMATION; PROTEIN UNFOLDING; SPECTROMETRY, FLUORESCENCE; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84871132663     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24141     Document Type: Article

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