메뉴 건너뛰기




Volumn 277, Issue 22, 2010, Pages 4614-4625

Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes

Author keywords

lactalbumin; Cancer; Cell death; ELOA; HAMLET; Lysozyme; Oleate; Oleic acid; Protein folding

Indexed keywords

ALPHA LACTALBUMIN; ANTINEOPLASTIC AGENT; CELL NUCLEUS RECEPTOR; EQUINE LYSOZYME WITH OLEIC ACID; FATTY ACID; HISTONE DEACETYLASE INHIBITOR; HUMAN ALPHA LACTALBUMIN MADE LETHAL TO TUMOR CELLS; OLEIC ACID; PLACEBO; PROTEASOME; UNCLASSIFIED DRUG;

EID: 78049232312     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07890.x     Document Type: Review
Times cited : (69)

References (59)
  • 1
    • 0015859467 scopus 로고
    • Principles that govern the folding of protein chains
    • Anfinsen CB (1973) Principles that govern the folding of protein chains. Science 181, 223-230.
    • (1973) Science , vol.181 , pp. 223-230
    • Anfinsen, C.B.1
  • 3
    • 67650379261 scopus 로고    scopus 로고
    • Can misfolded proteins be beneficial? The HAMLET case
    • Pettersson-Kastberg J et al. (2009) Can misfolded proteins be beneficial? The HAMLET case Ann Med 41, 162-176.
    • (2009) Ann Med , vol.41 , pp. 162-176
    • Pettersson-Kastberg, J.1
  • 12
    • 0024362936 scopus 로고
    • The evolution of lysozyme and alpha-lactalbumin
    • Nitta K & Sugai S (1989) The evolution of lysozyme and alpha-lactalbumin. Eur J Biochem 182, 111-118.
    • (1989) Eur J Biochem , vol.182 , pp. 111-118
    • Nitta, K.1    Sugai, S.2
  • 13
    • 0030800608 scopus 로고    scopus 로고
    • Molecular divergence of lysozymes and alpha-lactalbumin
    • Qasba PK & Kumar S (1997) Molecular divergence of lysozymes and alpha-lactalbumin. Crit Rev Biochem Mol Biol 32, 255-306.
    • (1997) Crit Rev Biochem Mol Biol , vol.32 , pp. 255-306
    • Qasba, P.K.1    Kumar, S.2
  • 15
    • 0030059690 scopus 로고    scopus 로고
    • The molten globule state of alpha-lactalbumin
    • Kuwajima K (1996) The molten globule state of alpha-lactalbumin. FASEB J 10, 102-109.
    • (1996) FASEB J , vol.10 , pp. 102-109
    • Kuwajima, K.1
  • 16
    • 34249666246 scopus 로고    scopus 로고
    • Equine lysozyme: the molecular basis of folding, self-assembly and innate amyloid toxicity
    • Morozova-Roche LA (2007) Equine lysozyme: the molecular basis of folding, self-assembly and innate amyloid toxicity. FEBS Lett 581, 2587-2592.
    • (2007) FEBS Lett , vol.581 , pp. 2587-2592
    • Morozova-Roche, L.A.1
  • 19
    • 0032981136 scopus 로고    scopus 로고
    • Independent nucleation and heterogeneous assembly of structure during folding of equine lysozyme
    • Morozova-Roche LA, Jones JA, Noppe W & Dobson CM (1999) Independent nucleation and heterogeneous assembly of structure during folding of equine lysozyme. J Mol Biol 289, 1055-1073.
    • (1999) J Mol Biol , vol.289 , pp. 1055-1073
    • Morozova-Roche, L.A.1    Jones, J.A.2    Noppe, W.3    Dobson, C.M.4
  • 20
    • 0042744699 scopus 로고    scopus 로고
    • Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration
    • Mališauskas M, Zamotin V, Jass J, Noppe W, Dobson CM & Morozova-Roche LA (2003) Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration. J Mol Biol 330, 879-890.
    • (2003) J Mol Biol , vol.330 , pp. 879-890
    • Mališauskas, M.1    Zamotin, V.2    Jass, J.3    Noppe, W.4    Dobson, C.M.5    Morozova-Roche, L.A.6
  • 21
  • 22
    • 84862855124 scopus 로고    scopus 로고
    • General, Organic, and Biological Chemistry: an Integrated Approach
    • Wiley, Hoboken, NJ.
    • Raymond KW (2008) General, Organic, and Biological Chemistry: an Integrated Approach. Wiley, Hoboken, NJ.
    • (2008)
    • Raymond, K.W.1
  • 23
    • 78049249726 scopus 로고    scopus 로고
    • Human Milk as a Source of Tumor Killing Molecules
    • Lund University, Lund.
    • Mossberg A-K (2010) Human Milk as a Source of Tumor Killing Molecules. Lund University, Lund.
    • (2010)
    • Mossberg, A.1
  • 26
    • 77950648249 scopus 로고    scopus 로고
    • Effect of denaturation of α-lactalbumin on the formation of BAMLET (bovine alpha-lactalbumin made lethal to tumor cells)
    • Lišková K, Kelly AL, Nora OB & Brodkorb A (2010). Effect of denaturation of α-lactalbumin on the formation of BAMLET (bovine alpha-lactalbumin made lethal to tumor cells). J Agric Food Chem 58, 4421-4427.
    • (2010) J Agric Food Chem , vol.58 , pp. 4421-4427
    • Lišková, K.1    Kelly, A.L.2    Nora, O.B.3    Brodkorb, A.4
  • 29
    • 67349213968 scopus 로고    scopus 로고
    • Cytotoxic aggregates of α-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells
    • Zhang M, Yang F Jr, Yang F, Chen J, Zheng C-Y & Liang Y (2009) Cytotoxic aggregates of α-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells. Chem Biol Interact 180, 131-142.
    • (2009) Chem Biol Interact , vol.180 , pp. 131-142
    • Zhang, M.1    Yang Jr, F.2    Yang, F.3    Chen, J.4    Zheng, C.5    Liang, Y.6
  • 30
    • 0037584357 scopus 로고    scopus 로고
    • Multimeric α-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei
    • Hakansson A, Andreasson J, Zhivotovsky B, Karpman D, Orrenius S & Svanborg C (1999) Multimeric α-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei. Exp Cell Res 246, 451-460.
    • (1999) Exp Cell Res , vol.246 , pp. 451-460
    • Hakansson, A.1    Andreasson, J.2    Zhivotovsky, B.3    Karpman, D.4    Orrenius, S.5    Svanborg, C.6
  • 31
    • 70450224072 scopus 로고    scopus 로고
    • α-Lactalbumin, engineered to be non-native and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding
    • Pettersson-Kastberg J, Mossberg AK, Trulsson M, Yong YJ, Min S, Lim Y, O'Brien JE, Svanborg C & Mok KH (2009) α-Lactalbumin, engineered to be non-native and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding. J Mol Biol 394, 994-1010.
    • (2009) J Mol Biol , vol.394 , pp. 994-1010
    • Pettersson-Kastberg, J.1    Mossberg, A.K.2    Trulsson, M.3    Yong, Y.J.4    Min, S.5    Lim, Y.6    O'Brien, J.E.7    Svanborg, C.8    Mok, K.H.9
  • 34
    • 10744223979 scopus 로고    scopus 로고
    • α-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human α-lactalbumin made lethal to tumor cells)
    • Svensson M, Fast J, Mossberg AK, Düringer C, Gustafsson L, Hallgren O, Brooks CL, Berliner L, Linse S & Svanborg C (2003) α-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human α-lactalbumin made lethal to tumor cells). Protein Sci 12, 2794-2804.
    • (2003) Protein Sci , vol.12 , pp. 2794-2804
    • Svensson, M.1    Fast, J.2    Mossberg, A.K.3    Düringer, C.4    Gustafsson, L.5    Hallgren, O.6    Brooks, C.L.7    Berliner, L.8    Linse, S.9    Svanborg, C.10
  • 35
    • 0344201898 scopus 로고    scopus 로고
    • Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells)
    • Svensson M, Mossberg AK, Pettersson J, Linse S & Svanborg C (2003) Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells). Protein Sci 12, 2805-2814.
    • (2003) Protein Sci , vol.12 , pp. 2805-2814
    • Svensson, M.1    Mossberg, A.K.2    Pettersson, J.3    Linse, S.4    Svanborg, C.5
  • 37
    • 27444437672 scopus 로고    scopus 로고
    • Interaction of bovine α-lactalbumin with fatty acids as determined by partition equilibrium and fluorescence spectroscopy
    • Barbana C, Pérez MD, Sánchez L, Dalgalarrondo M, Chobert JM, Haertle T & Calvo M (2006) Interaction of bovine α-lactalbumin with fatty acids as determined by partition equilibrium and fluorescence spectroscopy. Int Dairy J 16, 18-25.
    • (2006) Int Dairy J , vol.16 , pp. 18-25
    • Barbana, C.1    Pérez, M.D.2    Sánchez, L.3    Dalgalarrondo, M.4    Chobert, J.M.5    Haertle, T.6    Calvo, M.7
  • 38
    • 33747773827 scopus 로고    scopus 로고
    • Structural changes of α-lactalbumin induced by low pH and oleic acid
    • Yang F Jr, Zhang M, Chen J & Liang Y (2006) Structural changes of α-lactalbumin induced by low pH and oleic acid. Biochim Biophys Acta 1764, 1389-1396.
    • (2006) Biochim Biophys Acta , vol.1764 , pp. 1389-1396
    • Yang Jr, F.1    Zhang, M.2    Chen, J.3    Liang, Y.4
  • 40
    • 77951767673 scopus 로고    scopus 로고
    • The interaction of equine lysozyme:oleic acic complexes with lipid membranes suggests a cargo off-loading mechanism
    • Nielsen SB, Wilhelm K, Vad B, Schleucher J, Morozova-Roche LA & Otzen D (2010). The interaction of equine lysozyme:oleic acic complexes with lipid membranes suggests a cargo off-loading mechanism. J Mol Biol 398, 351-361.
    • (2010) J Mol Biol , vol.398 , pp. 351-361
    • Nielsen, S.B.1    Wilhelm, K.2    Vad, B.3    Schleucher, J.4    Morozova-Roche, L.A.5    Otzen, D.6
  • 41
  • 42
    • 1542405871 scopus 로고    scopus 로고
    • Human α-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival
    • Fischer W, Gustafsson L, Mossberg AK, Gronli J, Mork S, Bjerkvig R & Svanborg C (2004) Human α-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Res 64, 2105-2112.
    • (2004) Cancer Res , vol.64 , pp. 2105-2112
    • Fischer, W.1    Gustafsson, L.2    Mossberg, A.K.3    Gronli, J.4    Mork, S.5    Bjerkvig, R.6    Svanborg, C.7
  • 44
    • 84934444496 scopus 로고    scopus 로고
    • Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells)
    • Hallgren O, Aits S, Brest P, Gustafsson L, Mossberg AK, Wullt B & Svanborg C (2008) Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells). Adv Exp Med Biol 606, 217-240.
    • (2008) Adv Exp Med Biol , vol.606 , pp. 217-240
    • Hallgren, O.1    Aits, S.2    Brest, P.3    Gustafsson, L.4    Mossberg, A.K.5    Wullt, B.6    Svanborg, C.7
  • 47
    • 2442575245 scopus 로고    scopus 로고
    • No need to be HAMLET or BAMLET to interact with histones: binding of monomeric α-lactalbumin to histones and basic poly-amino acids
    • Permyakov SE, Pershikova IV, Khokhlova TI, Uversky VN & Permyakov EA (2004) No need to be HAMLET or BAMLET to interact with histones: binding of monomeric α-lactalbumin to histones and basic poly-amino acids. Biochemistry 43, 5575-5582.
    • (2004) Biochemistry , vol.43 , pp. 5575-5582
    • Permyakov, S.E.1    Pershikova, I.V.2    Khokhlova, T.I.3    Uversky, V.N.4    Permyakov, E.A.5
  • 48
    • 0035160316 scopus 로고    scopus 로고
    • A folding variant of human α-lactalbumin induces mitochondrial permeability transition in isolated mitochondria
    • Kohler C, Gogvadze V, Hakansson A, Svanborg C, Orrenius S & Zhivotovsky B (2001) A folding variant of human α-lactalbumin induces mitochondrial permeability transition in isolated mitochondria. Eur J Biochem 268, 186-191.
    • (2001) Eur J Biochem , vol.268 , pp. 186-191
    • Kohler, C.1    Gogvadze, V.2    Hakansson, A.3    Svanborg, C.4    Orrenius, S.5    Zhivotovsky, B.6
  • 50
  • 51
    • 27644484061 scopus 로고    scopus 로고
    • Autophagy: molecular machinery for self-eating
    • Yorimitsu T & Klionsky DJ (2005) Autophagy: molecular machinery for self-eating. Cell Death Differ 12(Suppl. 2), 1542-1552.
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1542-1552
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 52
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: dual roles in life and death?
    • Baehrecke EH (2005) Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 6, 505-510.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 55
    • 34548073069 scopus 로고    scopus 로고
    • Bladder cancers respond to intravesical instillation of HAMLET (human α-lactalbumin made lethal to tumor cells)
    • Mossberg A-K, Wullt B, Gustafsson L, Månsson W, Ljunggren E & Svanborg C (2007) Bladder cancers respond to intravesical instillation of HAMLET (human α-lactalbumin made lethal to tumor cells). Int J Cancer 121, 1352-1359.
    • (2007) Int J Cancer , vol.121 , pp. 1352-1359
    • Mossberg, A.1    Wullt, B.2    Gustafsson, L.3    Månsson, W.4    Ljunggren, E.5    Svanborg, C.6
  • 56
    • 0003703471 scopus 로고
    • Le Hasard et la Necessité
    • Le Seuil, Paris.
    • Monod J (1970) Le Hasard et la Necessité. Le Seuil, Paris.
    • (1970)
    • Monod, J.1
  • 57
    • 33746377894 scopus 로고    scopus 로고
    • Protein misfolding, functional amyloid, and human disease
    • Chiti F & Dobson CM (2006) Protein misfolding, functional amyloid, and human disease. Ann Rev Biochem 75, 333-366.
    • (2006) Ann Rev Biochem , vol.75 , pp. 333-366
    • Chiti, F.1    Dobson, C.M.2
  • 59
    • 19544363062 scopus 로고    scopus 로고
    • Prions as adaptive conduits of memory and inheritance
    • Shorter J & Lindquist S (2005) Prions as adaptive conduits of memory and inheritance. Nat Rev Genet 6, 435-450.
    • (2005) Nat Rev Genet , vol.6 , pp. 435-450
    • Shorter, J.1    Lindquist, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.