Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation

Journal of Medicinal Chemistry

Volumn 55, Issue 23, 2012, Pages 10448-10459

  Tardito, Saverio ^a,b   Barilli, Amelia ^a   Bassanetti, Irene ^a   Tegoni, Matteo ^a   Bussolati, Ovidio ^a   Franchi Gazzola, Renata ^a   Mucchino, Claudio ^a   Marchiò, Luciano ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 QUINOLINOL DERIVATIVE; CASPASE; CLIOQUINOL; CLIOQUINOL COPPER COMPLEX; COPPER COMPLEX; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; UNCLASSIFIED DRUG;

ARTICLE; CELL VACUOLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG STABILITY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME RELEASE; HELA CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; STRUCTURE ACTIVITY RELATION; TUMOR CELL; UMBILICAL VEIN ENDOTHELIAL CELL;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; COPPER; ENZYME ACTIVATION; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; MOLECULAR STRUCTURE; OXYQUINOLINE;

EID: 84871031059     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301053a     Document Type: Article

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