In vitro and in vivo activities of oligodeoxynucleotide-based thrombin inhibitors containing neutral formacetal linkages

Journal of Medicinal Chemistry

Volumn 41, Issue 22, 1998, Pages 4224-4231

  He, Gong Xin ^a   Williams, John P ^a   Postich, Michael J ^a   Swaminathan, S ^a   Shea, Regan G ^a   Terhorst, Terry ^a   Law, Veronica S ^a   Mao, Cheri T ^a   Sueoka, Cathy ^a   Coutré, Steven ^a   Bischofberger, Norbert ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGODEOXYNUCLEOTIDE DERIVATIVE; THROMBIN INHIBITOR;

ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; ISCHEMIC HEART DISEASE; MOLECULAR INTERACTION; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; THROMBOSIS;

ACETALS; ANIMALS; ANTICOAGULANTS; FORMIC ACIDS; HUMANS; INFUSIONS, INTRAVENOUS; MACACA FASCICULARIS; OLIGONUCLEOTIDES; PROTHROMBIN TIME; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 15444352571     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970766i     Document Type: Article

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