Widespread changes in synaptic markers as a function of sleep and wakefulness in drosophila

Science

Volumn 324, Issue 5923, 2009, Pages 109-112

  Gilestro, Giorgio F ^a   Tononi, Giulio ^a   Cirelli, Chiara ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRUCHPILOT PROTEIN; CELL PROTEIN; CYSTEIN STRING PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSIN; SYNTAXIN; UNCLASSIFIED DRUG;

COGNITION; FLY; GENETIC ANALYSIS; HOMEOSTASIS; MEMORY; MICROSCOPY; NERVOUS SYSTEM; PROTEIN; SLEEP; WALKING;

ARTICLE; BRAIN; DROSOPHILA; FEMALE; MALE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SLEEP; SLEEP DEPRIVATION; SYNAPSE; WAKEFULNESS;

ANIMALS; BIOLOGICAL CLOCKS; BLOTTING, WESTERN; BRAIN; CIRCADIAN RHYTHM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; HOMEOSTASIS; MALE; MICROSCOPY, CONFOCAL; MODELS, ANIMAL; QA-SNARE PROTEINS; SLEEP; SLEEP DEPRIVATION; SYNAPSES; SYNAPSINS; TUMOR SUPPRESSOR PROTEINS; WAKEFULNESS;

EID: 64249122538     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1166673     Document Type: Article

References (31)

1. C. Cirelli, G. Tononi, PLoS Biol. 6, e216 (2008).
2. V. V. Vyazovskiy, C. Cirelli, M. Pfister-Genskow, U. Faraguna, G. Tononi, Nat. Neurosci. 11, 200 (2008).
3. G. Tononi, C. Cirelli, Sleep Med. Rev. 10, 49 (2006).
4. J. C. Hendricks et al., Neuron 25, 129 (2000).
5. P. J. Shaw, C. Cirelli, R. J. Greenspan, G. Tononi, Science 287, 1834 (2000).
6. R. Huber et al., Sleep 27, 628 (2004).
7. R. Huber, M. F. Ghilardi, M. Massimini, G. Tononi, Nature 430, 78 (2004).
8. I. Ganguly-Fitzgerald, J. Donlea, P. J. Shaw, Science 313, 1775 (2006).
9. Z. Guan, S. Saraswati, B. Adolfsen, J. T. Littleton, Neuron 48, 91 (2005).
10. C. Margulies, T. Tully, J. Dubnau, Curr. Biol. 15, R700 (2005).
11. D. A. Wagh et al., Neuron 49, 833 (2006).
12. K. Chen, D. E. Featherstone, BMC Biol. 3, 1 (2005).
13. See supporting material on Science Online.
14. D. F. Woods, P. J. Bryant, Cell 66, 451 (1991).
15. T. Lahey, M. Gorczyca, X. X. Jia, V. Budnik, Neuron 13, 823 (1994).
16. V. Albornoz et al., Gene Expr. Patterns 8, 443 (2008).
17. V. Budnik et al., Neuron 17, 627 (1996).
18. H. Kazama, A. Nose, T. Morimoto-Tanifuji, Neuroscience 145, 1007 (2007).
19. I. Ehrlich, R. Malinow, J. Neurosci. 24, 916 (2004).
20. A. E. El-Husseini, E. Schnell, D. M. Chetkovich, R. A. Nicoll, D. S. Bredt, Science 290, 1364 (2000).
21. B. R. Klagges et al., J. Neurosci. 16, 3154 (1996).
22. K. L. Schulze, K. Broadie, M. S. Perin, H. J. Bellen, Cell 80, 311 (1995).
23. K. E. Zinsmaier, K. K. Eberle, E. Buchner, N. Walter, S. Benzer, Science 263, 977 (1994).
24. M. Heisenberg, M. Heusipp, C. Wanke, J. Neurosci. 15, 1951 (1995).
25. S. Sachse et al., Neuron 56, 838 (2007).
26. K. I. Mehnert et al., Dev. Neurobiol. 67, 415 (2007).
27. J. Gorska-Andrzejak, A. Keller, T. Raabe, L. Kilianek, E. Pyza, Photochem. Photobiol. Sci. 4, 721 (2005).
28. M. P. Fernandez, J. Berni, M. F. Ceriani, PLoS Biol. 6, e69 (2008).
29. E. Pyza, I. A. Meinertzhagen, J. Neurobiol. 40, 77 (1999).
30. J. M. Donlea, N. Ramanan, P. J. Shaw, Science 324, 105 (2009).
31. Authors' contributions: G.F.G. performed the experiments; G.F.G., G.T., and C.C. designed the experiments; G.T. and C.C. conceived and coordinated the project. All authors wrote the manuscript and read and approved the final version. We thank D. Paasch, D. Denucci, and M. Uy for technical assistance with fly work; M. Pfister-Genskow for help with Western blot analysis; L. Rodenkirch and the UW Keck Laboratory for Biological Imaging for assistance in confocal microscopy; and D. Bushey for discussion and comments on the manuscript. Supported by National Institute of General Medical Sciences grant R01 GM075315 (C.C.) and an NIH Director's Pioneer award (G.T.).