A defect in ATP-citrate lyase links acetyl-CoA production, virulence factor elaboration and virulence in Cryptococcus neoformans

Molecular Microbiology

Volumn 86, Issue 6, 2012, Pages 1404-1423

  Griffiths, Emma J ^a   Hu, Guanggan ^a   Fries, Bettina ^b   Caza, Mélissa ^a   Wang, Joyce ^a   Gsponer, Joerg ^c   Gates Hollingsworth, Marcellene A ^d   Kozel, Thomas R ^d   De Repentigny, Louis ^e   Kronstad, James W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE CITRATE LYASE; CITRIC ACID; FLUCONAZOLE; GLUCOSE; VIRULENCE FACTOR;

ACL1 GENE; AMINO ACID SEQUENCE; ANIMAL CELL; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; CULTURE MEDIUM; DISEASE MODEL; ENZYME SYNTHESIS; FEMALE; FUNGAL GENE; FUNGAL METABOLISM; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS MUTANT; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE;

ACETYL COENZYME A; AMINO ACID SEQUENCE; ANIMALS; ATP CITRATE (PRO-S)-LYASE; CELL LINE; CITRIC ACID; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; CULTURE MEDIA; DISEASE MODELS, ANIMAL; GLUCOSE; INDEL MUTATION; MACROPHAGES; MICE; MICROBIAL VIABILITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; VIRULENCE; VIRULENCE FACTORS;

FILOBASIDIELLA NEOFORMANS; MURINAE;

EID: 84870978868     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12065     Document Type: Article

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