The Predictive Potential of Molecular Detection in the Nonmetastatic Ewing Family of Tumors

Cancer

Volumn 100, Issue 5, 2004, Pages 1053-1058

  Avigad, Smadar ^a,b   Cohen, Ian J ^b   Zilberstein, Julia ^a   Liberzon, Ella ^a   Goshen, Yacov ^b   Ash, Shifra ^b   Meller, Isaac ^a   Kollender, Yehuda ^a   Issakov, Josephine ^a   Zaizov, Rina ^a,b   Yaniv, Isaac ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

Author keywords

Chimeric transcript; Ewing sarcoma; Prediction; Recurrence

Indexed keywords

TUMOR MARKER;

ADOLESCENT; ADULT; ARTICLE; BONE MARROW; BONE TUMOR; CHILD; CHIMERA; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; EWING SARCOMA; FOLLOW UP; HUMAN; INFANT; MINIMAL RESIDUAL DISEASE; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR NECROSIS; TUMOR RECURRENCE;

ADOLESCENT; ADULT; AGE DISTRIBUTION; BONE MARROW; BONE NEOPLASMS; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; DNA PRIMERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCIDENCE; MALE; MOLECULAR BIOLOGY; NEOPLASM CIRCULATING CELLS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; SAMPLING STUDIES; SARCOMA, EWING'S; SEX DISTRIBUTION; SURVIVAL ANALYSIS; TRANSCRIPTION, GENETIC;

EID: 10744233322     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.20059     Document Type: Article

References (21)

1. Ginsberg JP, Woo SY, Johnson ME, et al. Ewing sarcoma family of tumors: Ewing's sarcoma of bone and soft tissue and the peripheral primitive neuroectodermal tumors. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology (4th edition). Philadelphia: Lippincott-Raven, 2002:973-1016.
2. Delattre O, Zucman J, Melot T, et al. The Ewing family of tumors - a subgroup of small round cell tumors defined by specific chimeric transcripts. N Engl J Med. 1994;331:294-299.
3. Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet. 1994;6:146-151.
4. Jeon IS, Davis JN, Braun BS, et al. A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene. 1995;10:1229-1234.
5. Kaneko Y, Yoshida K, Handa M, et al. Fusion of an ETS-family gene, E1AF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy. Genes Chromosomes Cancer. 1996;15:115-121.
6. Peter M, Couturier J, Pacquement H, et al. A new member of the ETS family fused to EWS in Ewing tumors. Oncogene. 1997;14:1159-1164.
7. Ginzberg JP, de Alava E, Ladanyi M, et al. EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma. J Clin Oncol. 1999;17:1809-1814.
8. Naito N, Kawai A, Ouchida M, et al. A reverse transcriptase polymerase chain reaction assay in the diagnosis of soft tissue sarcomas. Cancer. 2000;89:1992-1998.
9. Zoubek A, Pfleiderer C, Salzer-Kuntschik M, et al. Variability of EWS chimeric transcripts in Ewing tumours: a comparison of clinical and molecular data. Br J Cancer. 1994;70:908-913.
10. Pfleiderer C, Zoubek A, Gruber B, et al. Detection of tumour cells in peripheral blood and bone marrow from Ewing tumour patients by RT-PCR. Int J Cancer. 1995;64:135-139.
11. Peter M, Magdelenat H, Michon J, et al. Sensitive detection of occult Ewing's cells by the reverse transcriptase-polymerase chain reaction. Br J Cancer. 1995;72:96-100.
12. West DC, Grier HE, Swallow MM, Demetri GD, Granowetter L, Sklar J. Detection of circulating tumor cells in patients with Ewing's sarcoma and peripheral primitive neuroectodermal tumor. J Clin Oncol. 1997;15:583-588.
13. Zoubek A, Ladenstein R, Windhager R, et al. Predictive potential of testing for bone marrow involvement in Ewing tumor patients by RT-PCR: a preliminary evaluation. Int J Cancer. 1998;79:56-60.
14. Fagnou C, Michon J, Peter M, et al. Presence of tumor cells in bone marrow but not in blood is associated with adverse prognosis in patients with Ewing's tumor. J Clin Oncol. 1998;16:1707-1711.
15. Schleiermacher G, Peter M, Oberlin O, et al. Increased risk of systemic relapses associated with bone marrow micrometastasis and circulating tumor cells in localized Ewing tumor. J Clin Oncol. 2003;21:85-91.
16. de Alava E, Lozano MD, Patino A, Sierrasesumaga L, Pardo-Mindan FJ. Ewing family tumors: potential prognostic value of reverse-transcriptase polymerase chain reaction detection of minimal residual disease in peripheral blood samples. Diagn Mol Pathol. 1998;7:152-157.
17. Zucman J, Melot T, Desmaze C, et al. Combinatorial generation of variable fusion proteins in the Ewing family of tumours. EMBO J. 1993;12:4481-4487.
18. Zoubek A, Dockhorn-Dworniczak B, Delattre O, et al. Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients? J Clin Oncol. 1996;14:1245-1251.
19. de Alava E, Kawai A, Healy JH, et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J Clin Oncol. 1998;16:1248-1255.
20. van Dongen JJ, Seriu T, Panzer-Grumayer ER, et al. Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood. Lancet. 1998;352:1731-1738.
21. Biondi A, Valsecchi MG, Seriu T, et al. Molecular detection of minimal residual disease is a strong predictive factor of relapse in childhood B-lineage acute lymphoblastic leukemia with medium risk features. A case control study of the International BFM Study Group. Leukemia. 2000;14:1939-1943.