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Volumn 344, Issue 6, 2012, Pages 486-490

Reactive oxygen species: The 2-edged sword of osteoarthritis

Author keywords

Chondrocyte differentiation; Ionic homeostasis; Osteoarthritis; Reactive oxygen species

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

EID: 84870956140     PISSN: 00029629     EISSN: 15382990     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e3182579dc6     Document Type: Review
Times cited : (98)

References (69)
  • 1
    • 38149052992 scopus 로고    scopus 로고
    • Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
    • Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheumatism 2008;58: 26-35.
    • (2008) Arthritis Rheumatism , vol.58 , pp. 26-35
    • Lawrence, R.C.1    Felson, D.T.2    Helmick, C.G.3
  • 2
    • 0034304209 scopus 로고    scopus 로고
    • The increasing impact of arthritis on public health
    • Elders MJ. The increasing impact of arthritis on public health. J Rheumatol Suppl 2000;60: 6-8.
    • (2000) J Rheumatol Suppl , vol.60 , pp. 6-8
    • Elders, M.J.1
  • 4
    • 77955812504 scopus 로고    scopus 로고
    • Is osteoarthritis a disease involving only cartilage or other articular tissues?
    • Martel-Pelletier J, Pelletier JP. Is osteoarthritis a disease involving only cartilage or other articular tissues? Eklem Hastalik Cerrahisi 2010; 21: 2-14.
    • (2010) Eklem Hastalik Cerrahisi , vol.21 , pp. 2-14
    • Martel-Pelletier, J.1    Pelletier, J.P.2
  • 5
    • 0242663593 scopus 로고    scopus 로고
    • Cyclic tensile stretch loaded on bovine chondrocytes causes depolymerization of hyaluronan: Involvement of reactive oxygen species
    • Yamazaki K, Fukuda K, Matsukawa M, et al. Cyclic tensile stretch loaded on bovine chondrocytes causes depolymerization of hyaluronan: involvement of reactive oxygen species. Arthritis Rheum 2003;48: 3151-58.
    • (2003) Arthritis Rheum , vol.48 , pp. 3151-3158
    • Yamazaki, K.1    Fukuda, K.2    Matsukawa, M.3
  • 6
    • 0347088927 scopus 로고    scopus 로고
    • Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression
    • Kurz B, Lemke A, Kehn M, et al. Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression. Arthritis Rheum 2004;50: 123-30.
    • (2004) Arthritis Rheum , vol.50 , pp. 123-130
    • Kurz, B.1    Lemke, A.2    Kehn, M.3
  • 7
    • 0028587756 scopus 로고
    • Oxygen-derived species: Their relation to human disease and environmental stress
    • Halliwell B, Cross CE. Oxygen-derived species: their relation to human disease and environmental stress. Env Health Perspect 1994; 102: 5-12.
    • (1994) Env Health Perspect , vol.102 , pp. 5-12
    • Halliwell, B.1    Cross, C.E.2
  • 8
    • 4244087065 scopus 로고
    • Reactive oxygen species in living systems: Source, biochemistry, and role in human disease
    • Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 1991;91: 14S-22S.
    • (1991) Am J Med , vol.91
    • Halliwell, B.1
  • 9
    • 0036088349 scopus 로고    scopus 로고
    • Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function
    • Jackson MJ, Papa S, Bolanos J, et al. Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function. Mol Aspects Med 2002;23: 209-85.
    • (2002) Mol Aspects Med , vol.23 , pp. 209-285
    • Jackson, M.J.1    Papa, S.2    Bolanos, J.3
  • 10
    • 22944448999 scopus 로고    scopus 로고
    • Inflammatory cells and oxygen radicals
    • Nagata M. Inflammatory cells and oxygen radicals. Curr Drug Targets Inflamm Allergy 2005;4: 503-04.
    • (2005) Curr Drug Targets Inflamm Allergy , vol.4 , pp. 503-504
    • Nagata, M.1
  • 11
    • 77954466425 scopus 로고    scopus 로고
    • Extracellular/microenvironmental redox state
    • Chaiswing L, Oberley TD. Extracellular/microenvironmental redox state. Antioxid Redox Signal 2010;13: 449-65.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 449-465
    • Chaiswing, L.1    Oberley, T.D.2
  • 12
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • St-Pierre J, Buckingham JA, Roebuck SJ, et al. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 2002;277: 44784-790.
    • (2002) J Biol Chem , vol.277 , pp. 44784-44790
    • St-Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3
  • 13
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 2003;552: 335-44.
    • (2003) J Physiol , vol.552 , pp. 335-344
    • Turrens, J.F.1
  • 14
    • 65349123514 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function
    • Stowe DF, Camara AK. Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function. Antioxid Redox Signal 2009;11: 1373-414.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1373-1414
    • Stowe, D.F.1    Camara, A.K.2
  • 15
    • 76049083966 scopus 로고    scopus 로고
    • Reactive oxygen species, cellular redox systems, and apoptosis
    • Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010;48: 749-62.
    • (2010) Free Radic Biol Med , vol.48 , pp. 749-762
    • Circu, M.L.1    Aw, T.Y.2
  • 16
    • 10644262971 scopus 로고    scopus 로고
    • The Nox family of NAD(P)H oxidases: Host defense and beyond
    • Geiszt M, Leto TL. The Nox family of NAD(P)H oxidases: host defense and beyond. J Biol Chem 2004;279: 51715-718.
    • (2004) J Biol Chem , vol.279 , pp. 51715-51718
    • Geiszt, M.1    Leto, T.L.2
  • 17
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007;87: 245-313.
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 18
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 2004;4: 181-89.
    • (2004) Nat Rev Immunol , vol.4 , pp. 181-189
    • Lambeth, J.D.1
  • 19
    • 0037076798 scopus 로고    scopus 로고
    • Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: Regulation by angiotensin II
    • Touyz RM, Chen X, Tabet F, et al. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II. Circ Res 2002;90: 1205-13.
    • (2002) Circ Res , vol.90 , pp. 1205-1213
    • Touyz, R.M.1    Chen, X.2    Tabet, F.3
  • 20
    • 33748755208 scopus 로고    scopus 로고
    • A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation
    • Hidalgo C, Sanchez G, Barrientos G, et al. A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation. J Biol Chem 2006; 281: 26473-82.
    • (2006) J Biol Chem , vol.281 , pp. 26473-26482
    • Hidalgo, C.1    Sanchez, G.2    Barrientos, G.3
  • 22
    • 23844540597 scopus 로고    scopus 로고
    • Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats
    • Gomez-Cabrera MC, Borras C, Pallardo FV, et al. Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol 2005;567: 113-20.
    • (2005) J Physiol , vol.567 , pp. 113-120
    • Gomez-Cabrera, M.C.1    Borras, C.2    Pallardo, F.V.3
  • 23
    • 33748771233 scopus 로고    scopus 로고
    • Reactive oxygen species: Toxic molecules or spark of life?
    • Magder S. Reactive oxygen species: toxic molecules or spark of life? Crit Care 2006;10: 208.
    • (2006) Crit Care , vol.10 , pp. 208
    • Magder, S.1
  • 24
    • 0027979484 scopus 로고
    • Transient mitochondrial transcript level decay in oxidative stressed chondrocytes
    • Vincent F, Corral-Debrinski M, Adolphe M. Transient mitochondrial transcript level decay in oxidative stressed chondrocytes. J Cell Physiol 1994;158: 128-32.
    • (1994) J Cell Physiol , vol.158 , pp. 128-132
    • Vincent, F.1    Corral-Debrinski, M.2    Adolphe, M.3
  • 25
    • 71649086310 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species in normal physiological processes
    • Pourova J, Kottova M, Voprsalova M, et al. Reactive oxygen and nitrogen species in normal physiological processes. Acta Physiol 2010; 198: 15-35.
    • (2010) Acta Physiol , vol.198 , pp. 15-35
    • Pourova, J.1    Kottova, M.2    Voprsalova, M.3
  • 26
    • 34147210988 scopus 로고    scopus 로고
    • Hydrogen peroxide sensing and signaling
    • Veal EA, Day AM, Morgan BA. Hydrogen peroxide sensing and signaling. Mol Cell 2007;26: 1-14.
    • (2007) Mol Cell , vol.26 , pp. 1-14
    • Veal, E.A.1    Day, A.M.2    Morgan, B.A.3
  • 27
    • 79957597757 scopus 로고    scopus 로고
    • Mitochondria in innate immune responses
    • West AP, Shadel GS, Ghosh S. Mitochondria in innate immune responses. Nat Rev Immunol 2011;11: 389-402.
    • (2011) Nat Rev Immunol , vol.11 , pp. 389-402
    • West, A.P.1    Shadel, G.S.2    Ghosh, S.3
  • 28
    • 49449116792 scopus 로고    scopus 로고
    • Oxidative innate immune defenses by Nox/Duox family NADPH oxidases
    • Rada B, Leto TL. Oxidative innate immune defenses by Nox/Duox family NADPH oxidases. Contrib Microbiol 2008;15: 164-87.
    • (2008) Contrib Microbiol , vol.15 , pp. 164-187
    • Rada, B.1    Leto, T.L.2
  • 29
    • 4644316472 scopus 로고    scopus 로고
    • Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: New role for the NADPH oxidase in host defense
    • Rothfork JM, Timmins GS, Harris MN, et al. Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense. Proc Natl Acad Sci U S A 2004; 101: 13867-872.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13867-13872
    • Rothfork, J.M.1    Timmins, G.S.2    Harris, M.N.3
  • 30
    • 36348990865 scopus 로고    scopus 로고
    • Oxygen and reactive oxygen species in articular cartilage: Modulators of ionic homeostasis
    • Gibson JS, Milner PI, White R, et al. Oxygen and reactive oxygen species in articular cartilage: modulators of ionic homeostasis. Pflugers Arch 2008;455: 563-73.
    • (2008) Pflugers Arch , vol.455 , pp. 563-573
    • Gibson, J.S.1    Milner, P.I.2    White, R.3
  • 31
    • 0029091894 scopus 로고
    • Control of matrix synthesis in isolated bovine chondrocytes by extracellular and intracellular pH
    • Wilkins RJ, Hall AC. Control of matrix synthesis in isolated bovine chondrocytes by extracellular and intracellular pH. J Cell Physiol 1995; 164: 474-81.
    • (1995) J Cell Physiol , vol.164 , pp. 474-481
    • Wilkins, R.J.1    Hall, A.C.2
  • 32
    • 0034665367 scopus 로고    scopus 로고
    • Surviving in a matrix: Membrane transport in articular chondrocytes
    • Wilkins RJ, Browning JA, Ellory JC. Surviving in a matrix: membrane transport in articular chondrocytes. J Memb Biol 2000;177: 95-108.
    • (2000) J Memb Biol , vol.177 , pp. 95-108
    • Wilkins, R.J.1    Browning, J.A.2    Ellory, J.C.3
  • 33
    • 11144244420 scopus 로고    scopus 로고
    • Effect of sodium bicarbonate on extracellular pH, matrix accumulation, and morphology of cultured articular chondrocytes
    • Waldman SD, Couto DC, Omelon SJ, et al. Effect of sodium bicarbonate on extracellular pH, matrix accumulation, and morphology of cultured articular chondrocytes. Tissue Eng 2004;10: 1633-40.
    • (2004) Tissue Eng , vol.10 , pp. 1633-1640
    • Waldman, S.D.1    Couto, D.C.2    Omelon, S.J.3
  • 34
    • 49749153485 scopus 로고    scopus 로고
    • Cytosolic free Ca2+ concentration exhibits a characteristic temporal pattern during in vitro cartilage differentiation: A possible regulatory role of calcineurin in Ca-signalling of chondrogenic cells
    • Matta C, Fodor J, Szijgyarto Z, et al. Cytosolic free Ca2+ concentration exhibits a characteristic temporal pattern during in vitro cartilage differentiation: a possible regulatory role of calcineurin in Ca-signalling of chondrogenic cells. Cell Calcium 2008;44: 310-23.
    • (2008) Cell Calcium , vol.44 , pp. 310-323
    • Matta, C.1    Fodor, J.2    Szijgyarto, Z.3
  • 35
    • 0442323624 scopus 로고    scopus 로고
    • Mechanisms contributing to intracellular pH homeostasis in an immortalised human chondrocyte cell line
    • Browning JA, Wilkins RJ. Mechanisms contributing to intracellular pH homeostasis in an immortalised human chondrocyte cell line. Comp Biochem Physiol A Mol Integr Physiol 2004;137: 409-18.
    • (2004) Comp Biochem Physiol A Mol Integr Physiol , vol.137 , pp. 409-418
    • Browning, J.A.1    Wilkins, R.J.2
  • 36
    • 33244466790 scopus 로고    scopus 로고
    • Electrophysiological demonstration of Na+/Ca2+ exchange in bovine articular chondrocytes
    • Sanchez JC, Powell T, Staines HM, et al. Electrophysiological demonstration of Na+/Ca2+ exchange in bovine articular chondrocytes. Biorheology 2006;43: 83-94.
    • (2006) Biorheology , vol.43 , pp. 83-94
    • Sanchez, J.C.1    Powell, T.2    Staines, H.M.3
  • 37
    • 33747331902 scopus 로고    scopus 로고
    • Electrophysiological demonstration of voltage- activated H+ channels in bovine articular chondrocytes
    • Sanchez JC, Powell T, Staines HM, et al. Electrophysiological demonstration of voltage- activated H+ channels in bovine articular chondrocytes. Cell Physiol Biochem 2006;18: 85-90.
    • (2006) Cell Physiol Biochem , vol.18 , pp. 85-90
    • Sanchez, J.C.1    Powell, T.2    Staines, H.M.3
  • 38
    • 0042164893 scopus 로고    scopus 로고
    • Molecular and functional identification of the Na(+)/H(+) exchange isoforms NHE1 and NHE3 in isolated bovine articular chondrocytes
    • Tattersall A, Meredith D, Furla P, et al. Molecular and functional identification of the Na(+)/H(+) exchange isoforms NHE1 and NHE3 in isolated bovine articular chondrocytes. Cell Physiol Biochem 2003;13: 215-22.
    • (2003) Cell Physiol Biochem , vol.13 , pp. 215-222
    • Tattersall, A.1    Meredith, D.2    Furla, P.3
  • 39
    • 10444289817 scopus 로고    scopus 로고
    • Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: A modeling study
    • Zhou S, Cui Z, Urban JP. Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling study. Arthritis Rheum 2004;50: 3915-24.
    • (2004) Arthritis Rheum , vol.50 , pp. 3915-3924
    • Zhou, S.1    Cui, Z.2    Urban, J.P.3
  • 40
    • 33750952921 scopus 로고    scopus 로고
    • The effect of O2 tension on pH homeostasis in equine articular chondrocytes
    • Milner PI, Fairfax TP, Browning JA, et al. The effect of O2 tension on pH homeostasis in equine articular chondrocytes. Arthritis Rheum 2006;54: 3523-32.
    • (2006) Arthritis Rheum , vol.54 , pp. 3523-3532
    • Milner, P.I.1    Fairfax, T.P.2    Browning, J.A.3
  • 41
    • 77951245417 scopus 로고    scopus 로고
    • The effect of oxygen tension on calcium homeostasis in bovine articular chondrocytes
    • White R, Gibson JS. The effect of oxygen tension on calcium homeostasis in bovine articular chondrocytes. J Orthop Surg Res 2010;5: 27.
    • (2010) J Orthop Surg Res , vol.5 , pp. 27
    • White, R.1    Gibson, J.S.2
  • 42
    • 70349572887 scopus 로고    scopus 로고
    • Rapid effects of hypoxia on H+ homeostasis in articular chondrocytes
    • Gibson JS, McCartney D, Sumpter J, et al. Rapid effects of hypoxia on H+ homeostasis in articular chondrocytes. Pflugers Arch 2009;458: 1085-92.
    • (2009) Pflugers Arch , vol.458 , pp. 1085-1092
    • Gibson, J.S.1    McCartney, D.2    Sumpter, J.3
  • 43
    • 34250005379 scopus 로고    scopus 로고
    • The role of mitochondrial reactive oxygen species in pH regulation in articular chondrocytes
    • Milner PI, Wilkins RJ, Gibson JS. The role of mitochondrial reactive oxygen species in pH regulation in articular chondrocytes. Osteoarthritis Cartilage 2007;15: 735-42.
    • (2007) Osteoarthritis Cartilage , vol.15 , pp. 735-742
    • Milner, P.I.1    Wilkins, R.J.2    Gibson, J.S.3
  • 44
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg HM. Developmental regulation of the growth plate. Nature 2003;423: 332-6.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 45
    • 35748954326 scopus 로고    scopus 로고
    • Endochondral ossification: How cartilage is converted into bone in the developing skeleton
    • Mackie EJ, Ahmed YA, Tatarczuch L, et al. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol 2008;40: 46-62.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 46-62
    • MacKie, E.J.1    Ahmed, Y.A.2    Tatarczuch, L.3
  • 46
    • 35848958601 scopus 로고    scopus 로고
    • Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation
    • Adams SL, Cohen AJ, Lassova L. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. J Cell Physiol 2007;213: 635-41.
    • (2007) J Cell Physiol , vol.213 , pp. 635-641
    • Adams, S.L.1    Cohen, A.J.2    Lassova, L.3
  • 47
    • 28844441670 scopus 로고    scopus 로고
    • Reactive oxygen species as signaling molecules in cardiovascular differentiation of embryonic stem cells and tumor-induced angiogenesis
    • Sauer H, Wartenberg M. Reactive oxygen species as signaling molecules in cardiovascular differentiation of embryonic stem cells and tumor-induced angiogenesis. Antioxid Redox Signal 2005;7: 1423-34.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1423-1434
    • Sauer, H.1    Wartenberg, M.2
  • 48
    • 33644936885 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated regulation of the Na+-H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers
    • Akram S, Teong HF, Fliegel L, et al. Reactive oxygen species-mediated regulation of the Na+-H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers. Cell Death Differ 2006;13: 628-41.
    • (2006) Cell Death Differ , vol.13 , pp. 628-641
    • Akram, S.1    Teong, H.F.2    Fliegel, L.3
  • 49
    • 65649128653 scopus 로고    scopus 로고
    • Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2
    • Xiao Q, Luo Z, Pepe AE, et al. Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2. Am J Physiol Cell Physiol 2009;296: C711-23.
    • (2009) Am J Physiol Cell Physiol , vol.296
    • Xiao, Q.1    Luo, Z.2    Pepe, A.E.3
  • 50
    • 77950523031 scopus 로고    scopus 로고
    • Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage
    • Ji AR, Ku SY, Cho MS, et al. Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage. Exp Mol Med 2010;42: 175-86.
    • (2010) Exp Mol Med , vol.42 , pp. 175-186
    • Ji, A.R.1    Ku, S.Y.2    Cho, M.S.3
  • 51
    • 34447263031 scopus 로고    scopus 로고
    • Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification
    • Morita K, Miyamoto T, Fujita N, et al. Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification. J Exp Med 2007;204: 1613-23.
    • (2007) J Exp Med , vol.204 , pp. 1613-1623
    • Morita, K.1    Miyamoto, T.2    Fujita, N.3
  • 52
    • 78650045955 scopus 로고    scopus 로고
    • Reactive oxygen species generated by NADPH oxidase 2 and 4 are required for chondrogenic differentiation
    • Kim KS, Choi HW, Yoon HE, et al. Reactive oxygen species generated by NADPH oxidase 2 and 4 are required for chondrogenic differentiation. J Biol Chem 2010;285: 40294-302.
    • (2010) J Biol Chem , vol.285 , pp. 40294-40302
    • Kim, K.S.1    Choi, H.W.2    Yoon, H.E.3
  • 53
    • 33847191703 scopus 로고    scopus 로고
    • Antioxidant to treat osteoarthritis: Dream or reality?
    • Henrotin Y, Kurz B. Antioxidant to treat osteoarthritis: dream or reality? Curr Drug Targets 2007;8: 347-57.
    • (2007) Curr Drug Targets , vol.8 , pp. 347-357
    • Henrotin, Y.1    Kurz, B.2
  • 54
    • 22644441306 scopus 로고    scopus 로고
    • Oxygen and reactive oxygen species in cartilage degradation: Friends or foes?
    • Henrotin Y, Kurz B, Aigner T. Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthritis Cartilage 2005;13: 643-54.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 643-654
    • Henrotin, Y.1    Kurz, B.2    Aigner, T.3
  • 55
    • 0035071327 scopus 로고    scopus 로고
    • Telomere erosion and senescence in human articular cartilage chondrocytes
    • Martin JA, Buckwalter JA. Telomere erosion and senescence in human articular cartilage chondrocytes. J Gerontol A Biol Sci Med Sci 2001;56: B172-79.
    • (2001) J Gerontol A Biol Sci Med Sci , vol.56
    • Martin, J.A.1    Buckwalter, J.A.2
  • 56
    • 26444473434 scopus 로고    scopus 로고
    • Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: Oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
    • Yudoh K, Nguyen T, Nakamura H, et al. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis Res Ther 2005;7: R380-91.
    • (2005) Arthritis Res Ther , vol.7
    • Yudoh, K.1    Nguyen, T.2    Nakamura, H.3
  • 57
    • 79955893457 scopus 로고    scopus 로고
    • Oxidative stress induces senescence in chondrocytes
    • Brandl A, Hartmann A, Bechmann V, et al. Oxidative stress induces senescence in chondrocytes. J Orthop Res 2011;29: 1114-20.
    • (2011) J Orthop Res , vol.29 , pp. 1114-1120
    • Brandl, A.1    Hartmann, A.2    Bechmann, V.3
  • 58
    • 0031837375 scopus 로고    scopus 로고
    • Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis
    • Hashimoto S, Takahashi K, Amiel D, et al. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 1998;41: 1266-74.
    • (1998) Arthritis Rheum , vol.41 , pp. 1266-1274
    • Hashimoto, S.1    Takahashi, K.2    Amiel, D.3
  • 59
    • 0028830920 scopus 로고
    • Chondrocyte apoptosis induced by nitric oxide
    • Blanco FJ, Ochs RL, Schwarz H, et al. Chondrocyte apoptosis induced by nitric oxide. Am J Pathol 1995;146: 75-85.
    • (1995) Am J Pathol , vol.146 , pp. 75-85
    • Blanco, F.J.1    Ochs, R.L.2    Schwarz, H.3
  • 60
    • 3242681888 scopus 로고    scopus 로고
    • The spread of cell death from impact damaged cartilage: Lack of evidence for the role of nitric oxide and caspases
    • Clements KM, Burton-Wurster N, Lust G. The spread of cell death from impact damaged cartilage: lack of evidence for the role of nitric oxide and caspases. Osteoarthritis Cartilage 2004;12: 577-85.
    • (2004) Osteoarthritis Cartilage , vol.12 , pp. 577-585
    • Clements, K.M.1    Burton-Wurster, N.2    Lust, G.3
  • 61
    • 0036171665 scopus 로고    scopus 로고
    • Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species
    • Del Carlo M Jr, Loeser RF. Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum 2002;46: 394-403.
    • (2002) Arthritis Rheum , vol.46 , pp. 394-403
    • Del Carlo Jr., M.1    Loeser, R.F.2
  • 62
    • 57349106464 scopus 로고    scopus 로고
    • Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes
    • Grishko VI, Ho R, Wilson GL, et al. Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes. Osteoarthritis Cartilage 2009;17: 107-13.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 107-113
    • Grishko, V.I.1    Ho, R.2    Wilson, G.L.3
  • 63
    • 0033939459 scopus 로고    scopus 로고
    • Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization
    • Johnson K, Jung A, Murphy A, et al. Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization. Arthritis Rheum 2000;43: 1560-70.
    • (2000) Arthritis Rheum , vol.43 , pp. 1560-1570
    • Johnson, K.1    Jung, A.2    Murphy, A.3
  • 64
    • 0041571728 scopus 로고    scopus 로고
    • The combination of insulinlike growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes
    • Loeser RF, Pacione CA, Chubinskaya S. The combination of insulinlike growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes. Arthritis Rheum 2003;48: 2188-96.
    • (2003) Arthritis Rheum , vol.48 , pp. 2188-2196
    • Loeser, R.F.1    Pacione, C.A.2    Chubinskaya, S.3
  • 65
    • 70450274965 scopus 로고    scopus 로고
    • Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways
    • Yin W, Park JI, Loeser RF. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem 2009;284: 31972-81.
    • (2009) J Biol Chem , vol.284 , pp. 31972-31981
    • Yin, W.1    Park, J.I.2    Loeser, R.F.3
  • 66
    • 79955066683 scopus 로고    scopus 로고
    • Matrix metalloproteinase-13 expression in IL- 1beta-treated chondrocytes by activation of the p38 MAPK/c-Fos/ AP-1 and JAK/STAT pathways
    • Lim H, Kim HP. Matrix metalloproteinase-13 expression in IL- 1beta-treated chondrocytes by activation of the p38 MAPK/c-Fos/ AP-1 and JAK/STAT pathways. Arch Pharm Res 2011;34: 109-17.
    • (2011) Arch Pharm Res , vol.34 , pp. 109-117
    • Lim, H.1    Kim, H.P.2
  • 67
    • 0036159161 scopus 로고    scopus 로고
    • Matrix metalloproteinases as therapeutic targets in arthritic diseases: Bull's-eye or missing the mark?
    • Mengshol JA, Mix KS, Brinckerhoff CE. Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark? Arthritis Rheum 2002;46: 13-20.
    • (2002) Arthritis Rheum , vol.46 , pp. 13-20
    • Mengshol, J.A.1    Mix, K.S.2    Brinckerhoff, C.E.3
  • 68
    • 34047196182 scopus 로고    scopus 로고
    • Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: Regulation by interleukin-1beta and tumour necrosis factor-alpha
    • Chenevier-Gobeaux C, Lemarechal H, Bonnefont-Rousselot D, et al. Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha. Inflamm Res 2006;55: 483-90.
    • (2006) Inflamm Res , vol.55 , pp. 483-490
    • Chenevier-Gobeaux, C.1    Lemarechal, H.2    Bonnefont-Rousselot, D.3
  • 69
    • 79951949669 scopus 로고    scopus 로고
    • Involvement of H-Ras and reactive oxygen species in proinflammatory cytokine-induced matrix metalloproteinase-13 expression in human articular chondrocytes
    • Ahmad R, Sylvester J, Ahmad M, et al. Involvement of H-Ras and reactive oxygen species in proinflammatory cytokine-induced matrix metalloproteinase-13 expression in human articular chondrocytes. Arch Biochem Biophys 2011;507: 350-55.
    • (2011) Arch Biochem Biophys , vol.507 , pp. 350-355
    • Ahmad, R.1    Sylvester, J.2    Ahmad, M.3


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