Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum

Malaria Journal

Volumn 11, Issue , 2012, Pages

  Bohórquez, Elaine B ^a   Chua, Michael ^b   Meshnick, Steven R ^c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c University of North Carolina at Chapel Hill   (United States)

Author keywords

Copy number; Pfmdr1; Plasmodium falciparum; Quinine

Indexed keywords

HEMOZOIN; QUININE;

ARTICLE; CELL CYCLE PROGRESSION; CELL VACUOLE; CELLULAR DISTRIBUTION; COPY NUMBER VARIATION; DRUG DISTRIBUTION; DRUG MECHANISM; FLUORESCENCE MICROSCOPY; NONHUMAN; PARASITE CULTIVATION; PLASMODIUM FALCIPARUM; TIME LAPSE IMAGING;

ANTIMALARIALS; DRUG RESISTANCE; GENE DOSAGE; MICROSCOPY, FLUORESCENCE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTANT PROTEINS; PLASMODIUM FALCIPARUM; QUININE; TIME-LAPSE IMAGING; VACUOLES;

EID: 84870949960     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-11-350     Document Type: Article

References (34)

1. Three hundred and fifty years of the peruvian fever bark. Bruce-Chwatt LJ, Br Med J (Clin Res Ed) 1988 296 1486 1487 10.1136/bmj.296.6635.1486
2. Quinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy: an appropriate public health policy? Yeka A, Achan J, D'Alessandro U, Talisuna AO, Lancet Infect Dis 2009 9 448 452 10.1016/S1473-3099(09)70109-4 19555904
3. WHO, World malaria report World Health Organization, Geneva 2010
4. Update on genetic markers of quinine resistance in Plasmodium falciparum. Okombo J, Ohuma E, Picot S, Nzila A, Mol Biochem Parasitol 2011 177 77 82 10.1016/j.molbiopara.2011.01.012 21295079
5. Artemisinin derivatives versus quinine for cerebral malaria in african children: a systematic review. Kyu HH, Fernandez E, Bull World Health Organ 2009 87 896 904 10.2471/BLT.08.060327 20454480
6. Antimalarial drugs and their actions. Peters W, Postgrad Med J 1973 49 573 583 10.1136/pgmj.49.574.573 4596545
7. Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites. Slater AF, Cerami A, Nature 1992 355 167 169 10.1038/355167a0 1729651
8. Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment). Egan TJ, Ross DC, Adams PA, FEBS Lett 1994 352 54 57 10.1016/0014-5793(94)00921-X 7925942
9. Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: evidence for quinine resistance. Zalis MG, Pang L, Silveira MS, Milhous WK, Wirth DF, Am J Trop Med Hyg 1998 58 630 637 9598453
10. pfmdr1 Mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in plasmodium falciparum. Sidhu AB, Valderramos SG, Fidock DA, Mol Microbiol 2005 57 913 926 10.1111/j.1365-2958.2005.04729.x 16091034
11. Probing the multifactorial basis of plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Nkrumah LJ, Riegelhaupt PM, Moura P, Johnson DJ, Patel J, Hayton K, Ferdig MT, Wellems TE, Akabas MH, Fidock DA, Mol Biochem Parasitol 2009 165 122 131 10.1016/j.molbiopara.2009.01.011 19428659
12. Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. Sidhu AB, Uhlemann AC, Valderramos SG, Valderramos JC, Krishna S, Fidock DA, J Infect Dis 2006 194 528 535 10.1086/507115 16845638
13. Pgh1 Modulates sensitivity and resistance to multiple antimalarials in plasmodium falciparum. Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF, Nature 2000 403 906 909 10.1038/35002615 10706290
14. Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mu J, Ferdig MT, Feng X, Joy DA, Duan J, Furuya T, Subramanian G, Aravind L, Cooper RA, Wootton JC, Xiong M, Su XZ, Mol Microbiol 2003 49 977 989 10.1046/j.1365-2958.2003.03627.x 12890022
15. Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. Cowman AF, Galatis D, Thompson JK, Proc Natl Acad Sci U S A 1994 91 1143 1147 10.1073/pnas.91.3.1143 8302844
16. Monitoring of in vitro susceptibilities and molecular markers of resistance of plasmodium falciparum isolates from thai-myanmar border to chloroquine, quinine, mefloquine and artesunate. Chaijaroenkul W, Wisedpanichkij R, Na-Bangchang K, Acta Trop 2010 113 190 194 10.1016/j.actatropica.2009.10.016 19879850
17. Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant plasmodium falciparum malaria. Price RN, Uhlemann AC, van Vugt M, Brockman A, Hutagalung R, Nair S, Nash D, Singhasivanon P, Anderson TJ, Krishna S, White NJ, Nosten F, Clin Infect Dis 2006 42 1570 1577 10.1086/503423 16652314
18. Mefloquine resistance in plasmodium falciparum and increased pfmdr1 gene copy number. Price RN, Uhlemann AC, Brockman A, McGready R, Ashley E, Phaipun L, Patel R, Laing K, Looareesuwan S, White NJ, Nosten F, Krishna S, Lancet 2004 364 438 447 10.1016/S0140-6736(04)16767-6 15288742
19. Resistance to antimalarials in southeast asia and genetic polymorphisms in pfmdr1. Pickard AL, Wongsrichanalai C, Purfield A, Kamwendo D, Emery K, Zalewski C, Kawamoto F, Miller RS, Meshnick SR, Antimicrob Agents Chemother 2003 47 2418 2423 10.1128/AAC.47.8.2418-2423.2003 12878499
20. Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance? Anderson TJ, Nair S, Qin H, Singlam S, Brockman A, Paiphun L, Nosten F, Antimicrob Agents Chemother 2005 49 2180 2188 10.1128/AAC.49.6.2180-2188. 2005 15917511
21. Quinine sulfate as a fluorescence quantum yield standard. Fletcher AN, Photochem Photobiol 1969 9 439 444 10.1111/j.1751-1097.1969.tb07311.x 5771430
22. Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia. Lim P, Alker AP, Khim N, Shah NK, Incardona S, Doung S, Yi P, Bouth DM, Bouchier C, Puijalon OM, Meshnick SR, Wongsrichanalai C, Fandeur T, Le Bras J, Ringwald P, Ariey F, Malar J 2009 8 11 10.1186/1475-2875-8-11 19138391
23. Cultivation of malarial parasites. Trager W, Jensen JB, Nature 1978 273 621 622 10.1038/273621a0 351412
24. Methods in malaria research Malaria Research and Reference Reagent Resource Center (MR4)/American Type Culture Collection (ATCC), Manassas, VA 2008
25. Tetraethylthiuram disulfide (antabuse) inhibits the human malaria parasite plasmodium falciparum. Scheibel LW, Adler A, Trager W, Proc Natl Acad Sci U S A 1979 76 5303 5307 10.1073/pnas.76.10.5303 388434
26. The diamidine DB75 targets the nucleus of plasmodium falciparum. Purfield AE, Tidwell RR, Meshnick SR, Malar J 2009 8 104 10.1186/1475-2875-8-104 19442305
27. Antimalarial exposure delays plasmodium falciparum intra-erythrocytic cycle and drives drug transporter genes expression. Veiga MI, Ferreira PE, Schmidt BA, Ribacke U, Bjorkman A, Tichopad A, Gil JP, PLoS One 2010 5 12408 10.1371/journal.pone.0012408 20811640
28. The historical aspects of sunscreens. Urbach F, J Photochem Photobiol B 2001 64 99 104 10.1016/S1011-1344(01)00202-0 11744395
29. Iron(III) protoporphyrin IX complexes of the antimalarial cinchona alkaloids quinine and quinidine. de Villiers KA, Gildenhuys J, le Roex T, ACS Chem Biol 2012 7 666 671 10.1021/cb200528z 22276975
30. The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization. Pisciotta JM, Coppens I, Tripathi AK, Scholl PF, Shuman J, Bajad S, Shulaev V, Sullivan DJ Jr, Biochem J 2007 402 197 204 10.1042/BJ20060986 17044814
31. Solution structures of antimalarial drug-haem complexes. Leed A, DuBay K, Ursos LM, Sears D, De Dios AC, Roepe PD, Biochemistry 2002 41 10245 10255 10.1021/bi020195i 12162739
32. Quinoline antimalarials decrease the rate of beta-hematin formation. Egan TJ, Ncokazi KK, J Inorg Biochem 2005 99 1532 1539 10.1016/j.jinorgbio.2005.04. 013 15927260
33. Interference with haemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols. Correa Soares JB, Menezes D, Vannier-Santos MA, Ferreira-Pereira A, Almeida GT, Venancio TM, Verjovski-Almeida S, Zishiri VK, Kuter D, Hunter R, Egan TJ, Oliveira MF, PLoS Negl Trop Dis 2009 3 477 10.1371/journal.pntd.0000477 19597543
34. The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-haem complex. Alumasa JN, Gorka AP, Casabianca LB, Comstock E, de Dios AC, Roepe PD, J Inorg Biochem 2011 105 467 475 10.1016/j.jinorgbio.2010.08.011 20864177