Update on genetic markers of quinine resistance in plasmodium falciparum

Molecular and Biochemical Parasitology

Volumn 177, Issue 2, 2011, Pages 77-82

  Okombo, John ^a   Ohuma, Eric ^a   Picot, Stephane ^b   Nzila, Alexis ^a,c  

^a KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^b UNIVERSITÉ LYON 1   (France)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Drug resistance; Malaria; Microsatellite; Pfcrt; Pfmdr1; Pfnhe; Quinine

Indexed keywords

BENFLUMETOL; CARRIER PROTEINS AND BINDING PROTEINS; CHLOROQUINE; HALOFANTRINE; MEFLOQUINE; MEMBRANE PROTEIN; PYRIMETHAMINE; QUININE; SODIUM PROTON EXCHANGE PROTEIN 1; TRANSPORTER PROTEIN PFCRT; TRANSPORTER PROTEIN PFMDR1; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; BIOCHEMISTRY; CODON; CROSS RESISTANCE; DRUG ABSORPTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG STRUCTURE; GENE DOSAGE; GENE MUTATION; GENETIC MARKER; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFUSION; LOADING DRUG DOSE; MALARIA; MAXIMUM PLASMA CONCENTRATION; MICROSATELLITE MARKER; MUTANT; NONHUMAN; NUCLEOTIDE REPEAT; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; TREATMENT DURATION;

AFRICA; ANTIMALARIALS; ASIA, SOUTHEASTERN; DRUG RESISTANCE; GENETIC MARKERS; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; QUININE;

PLASMODIUM FALCIPARUM;

EID: 79953897600     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2011.01.012     Document Type: Review

References (54)

1. T.S. Kaufman, and E.A. Ruveda The quest for quinine: those who won the battles and those who won the war Angew Chem Int Ed Engl 44 2005 854 885 (Pubitemid 40239012)
2. WHO (2010). Guidelines for the treatment of malaria, second edition. In: http://www.who.int/malaria/publications/atoz/9789241547925/en/index.html. WHO, entry 12 January 2011, p. 18.
3. J. Achan, J.K. Tibenderana, and D. Kyabayinze Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial BMJ 339 2009 b2763
4. I. Adam, D.M. Ali, W. Noureldien, and M.I. Elbashir Quinine for the treatment of chloroquine-resistant Plasmodium falciparum malaria in pregnant and non-pregnant Sudanese women Ann Trop Med Parasitol 99 2005 427 429 (Pubitemid 40874263)
5. A.A. Adegnika, L.P. Breitling, and S.T. Agnandji Effectiveness of quinine monotherapy for the treatment of Plasmodium falciparum infection in pregnant women in Lambarene, Gabon Am J Trop Med Hyg 73 2005 263 266 (Pubitemid 41278694)
6. P.J. de Vries, N.N. Bich, and H. Van Thien Combinations of artemisinin and quinine for uncomplicated falciparum malaria: efficacy and pharmacodynamics Antimicrob Agents Chemother 44 2000 1302 1308 (Pubitemid 30228309)
7. R. McGready, E.A. Ashley, and E. Moo A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy J Infect Dis 192 2005 846 853 (Pubitemid 41193082)
8. G. Praygod, A. de Frey, and M. Eisenhut Artemisinin derivatives versus quinine in treating severe malaria in children: a systematic review Malar J 7 2008 210
9. K.L. Jones, S. Donegan, and D.G. Lalloo Artesunate versus quinine for treating severe malaria Cochrane Database Syst Rev 2007 CD005967
10. A.M. Checkley, and C.J. Whitty Artesunate, artemether or quinine in severe Plasmodium falciparum malaria Expert Rev Anti Infect Ther 5 2007 199 204 (Pubitemid 46681739)
11. A.M. Dondorp, C.I. Fanello, and I.C. Hendriksen Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial Lancet 376 2010 1647 1657
12. A.M. Dondorp, F. Nosten, and P. Yi Artemisinin resistance in Plasmodium falciparum malaria N Engl J Med 361 2009 455 467
13. S. Krishna, and N.J. White Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications Clin Pharmacokinet 30 1996 263 299
14. H.Y. Myint, P. Tipmanee, and F. Nosten A systematic overview of published antimalarial drug trials Trans R Soc Trop Med Hyg 98 2004 73 81 (Pubitemid 38111554)
15. I. Adam, I. Salih, and M.I. Elbashir Quinine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Sudan Trans R Soc Trop Med Hyg 99 2005 736 738 (Pubitemid 41150669)
16. W. Supanaranond, T.M. Davis, and S. Pukrittayakamee Disposition of oral quinine in acute falciparum malaria Eur J Clin Pharmacol 40 1991 49 52
17. W. Fungladda, E.R. Honrado, and K. Thimasarn Compliance with artesunate and quinine + tetracycline treatment of uncomplicated falciparum malaria in Thailand Bull World Health Organ 76 Suppl. 1 1998 59 66 (Pubitemid 128685315)
18. A. Yeka, J. Achan, U. D'Alessandro, and A.O. Talisuna Quinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy an appropriate public health policy Lancet Infect Dis 9 2009 448 452
19. P.E. Kofoed, F. Lopes, and P. Johansson Low-dose quinine for treatment of Plasmodium falciparum malaria in Guinea-Bissau Trans R Soc Trop Med Hyg 93 1999 547 549 (Pubitemid 29495847)
20. A. Nzila, and L. Mwai In vitro selection of Plasmodium falciparum drug-resistant parasite lines J Antimicrob Chemother 65 2009 390 398
21. F. Pettinelli, M.E. Pettinelli, and P. Eldin de Pecoulas Short report: high prevalence of multidrug-resistant Plasmodium falciparum malaria in the French territory of Mayotte Am J Trop Med Hyg 70 2004 635 637 (Pubitemid 38802392)
22. H. Tinto, C. Rwagacondo, and C. Karema In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda Trans R Soc Trop Med Hyg 100 2006 509 514
23. L.K. Basco, and J. Le Bras In vitro activity of pyronaridine against African strains of Plasmodium falciparum Ann Trop Med Parasitol 86 1992 447 454 (Pubitemid 23040784)
24. P. Brasseur, J. Kouamouo, R. Moyou-Somo, and P. Druilhe Multi-drug resistant falciparum malaria in Cameroon in 1987-1988: II. Mefloquine resistance confirmed in vivo and in vitro and its correlation with quinine resistance Am J Trop Med Hyg 46 1992 8 14
25. F. Simon, J. Le Bras, and G. Charmot Severe chloroquine-resistant falciparum malaria in Gabon with decreased sensitivity to quinine Trans R Soc Trop Med Hyg 80 1986 996 997
26. M. Warsame, W.H. Wernsdorfer, D. Payne, and A. Bjorkman Susceptibility of Plasmodium falciparum in vitro to chloroquine, mefloquine, quinine and sulfadoxine/pyrimethamine in Somalia: relationships between the responses to the different drugs Trans R Soc Trop Med Hyg 85 1991 565 569
27. A.C. Uhlemann, and S. Krishna Antimalarial multi-drug resistance in Asia: mechanisms and assessment Curr Top Microbiol Immunol 295 2005 39 53 (Pubitemid 41236510)
28. V. Andriantsoanirina, D. Menard, and S. Rabearimanana Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa Am J Trop Med Hyg 82 2010 782 787
29. W. Chaijaroenkul, R. Wisedpanichkij, and K. Na-Bangchang Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate Acta Trop 113 2010 190 194
30. S.L. Nsobya, M. Kiggundu, and S. Nanyunja In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda Antimicrob Agents Chemother 54 2010 1200 1206
31. C.P. Sanchez, W.D. Stein, and M. Lanzer Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum Trends Parasitol 23 2007 332 339 (Pubitemid 46935568)
32. S.G. Valderramos, and D.A. Fidock Transporters involved in resistance to antimalarial drugs Trends Pharmacol Sci 27 2006 594 601 (Pubitemid 44572395)
33. C.J. Woodrow, and S. Krishna Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significance Cell Mol Life Sci 63 2006 1586 1596 (Pubitemid 44252173)
34. V. Lakshmanan, P.G. Bray, and D. Verdier-Pinard A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance EMBO J 24 2005 2294 2305 (Pubitemid 41032582)
35. A.B. Sidhu, D. Verdier-Pinard, and D.A. Fidock Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations Science 298 2002 210 213
36. M.T. Ferdig, R.A. Cooper, and J. Mu Dissecting the loci of low-level quinine resistance in malaria parasites Mol Microbiol 52 2004 985 997 (Pubitemid 38916169)
37. M.B. Reed, K.J. Saliba, S.R. Caruana, K. Kirk, and A.F. Cowman Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum Nature 403 2000 906 909 (Pubitemid 30130994)
38. J. Okombo, S.M. Kiara, and J. Rono In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya Antimicrob Agents Chemother 54 2010 3302 3307
39. A.L. Pickard, C. Wongsrichanalai, and A. Purfield Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1 Antimicrob Agents Chemother 47 2003 2418 2423 (Pubitemid 36919439)
40. R.N. Price, A.C. Uhlemann, and A. Brockman Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number Lancet 364 2004 438 447 (Pubitemid 39036891)
41. R.N. Price, A.C. Uhlemann, and M. van Vugt Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria Clin Infect Dis 42 2006 1570 1577
42. T.J. Anderson, S. Nair, and H. Qin Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance Antimicrob Agents Chemother 49 2005 2180 2188 (Pubitemid 40734444)
43. A.B. Sidhu, A.C. Uhlemann, and S.G. Valderramos Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin J Infect Dis 194 2006 528 535 (Pubitemid 44162666)
44. J. Mu, M.T. Ferdig, and X. Feng Multiple transporters associated with malaria parasite responses to chloroquine and quinine Mol Microbiol 49 2003 977 989 (Pubitemid 36981343)
45. M. Henry, S. Briolant, and A. Zettor Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine Antimicrob Agents Chemother 53 2009 1926 1930
46. T.N. Bennett, J. Patel, M.T. Ferdig, and P.D. Roepe Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance Mol Biochem Parasitol 153 2007 48 58 (Pubitemid 46517676)
47. A. Bosia, D. Ghigo, and F. Turrini Kinetic characterization of Na+/H+ antiport of Plasmodium falciparum membrane J Cell Physiol 154 1993 527 534 (Pubitemid 23076321)
48. L.J. Nkrumah, P.M. Riegelhaupt, and P. Moura Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE Mol Biochem Parasitol 165 2009 122 131
49. K.J. Saliba, and K. Kirk pH regulation in the intracellular malaria parasite Plasmodium falciparum. H(+) extrusion via a V-type H(+)-ATPase J Biol Chem 274 1999 33213 33219 (Pubitemid 129511618)
50. N.J. Spillman, R.J. Allen, and K. Kirk Acid extrusion from the intraerythrocytic malaria parasite is not via a Na(+)/H(+) exchanger Mol Biochem Parasitol 162 2008 96 99
51. P.D. Roepe, and M.T. Ferdig P. falciparum Na(+)/H(+) exchanger (PfNHE) function and quinine resistance (QNR) [Reply to: Spillman et al. "Acid extrusion from the intraerythrocytic malaria parasite is not via a Na(+)/H(+) exchanger" Mol. Biochem. Parasitol. 2008 162 (1) 96-99] Mol Biochem Parasitol 166 2009 1 2
52. N.J. Spillman, R.J.W. Allen, and K. Kirk Na+-dependent acid efflux from P. falciparum: PfNHE or residual nigericin Mol Biochem Parasitol 166 2009 3
53. F.N Baliraine, S.L. Nsobya, and J. Achan Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda Antimicrob Agents Chemother 2010 [Epub ahead of print]
54. H. Meng, R. Zhang, and H. Yang In vitro Sensitivity of Plasmodium falciparum Clinical Isolates from the China-Myanmar Border Area to Quinine and Association with Polymorphism in the Na+/H+ Exchanger Antimicrob Agents Chemother 54 2010 4306 4313