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Volumn 7, Issue 12, 2012, Pages

Dynamics of Tumor Hypoxia in Response to Patupilone and Ionizing Radiation

Author keywords

[No Author keywords available]

Indexed keywords

EPOTHILONE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LUCIFERASE; OXYGEN;

EID: 84870942768     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051476     Document Type: Article
Times cited : (14)

References (52)
  • 2
    • 0038176480 scopus 로고    scopus 로고
    • Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction
    • Wachsberger P, Burd R, Dicker AP, (2003) Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction. Clin Cancer Res 9: 1957-1971.
    • (2003) Clin Cancer Res , vol.9 , pp. 1957-1971
    • Wachsberger, P.1    Burd, R.2    Dicker, A.P.3
  • 3
    • 33745216415 scopus 로고    scopus 로고
    • Ionizing radiation antagonizes tumor hypoxia induced by antiangiogenic treatment
    • Riesterer O, Honer M, Jochum W, Oehler C, Ametamey S, et al. (2006) Ionizing radiation antagonizes tumor hypoxia induced by antiangiogenic treatment. Clin Cancer Res 12: 3518-3524.
    • (2006) Clin Cancer Res , vol.12 , pp. 3518-3524
    • Riesterer, O.1    Honer, M.2    Jochum, W.3    Oehler, C.4    Ametamey, S.5
  • 4
    • 34748851338 scopus 로고    scopus 로고
    • Hypoxia modulation and radiosensitization by the novel dual EGFR and VEGFR inhibitor AEE788 in spontaneous and related allograft tumor models
    • Oehler-Janne C, Jochum W, Riesterer O, Broggini-Tenzer A, Caravatti G, et al. (2007) Hypoxia modulation and radiosensitization by the novel dual EGFR and VEGFR inhibitor AEE788 in spontaneous and related allograft tumor models. Mol Cancer Ther 6: 2496-2504.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2496-2504
    • Oehler-Janne, C.1    Jochum, W.2    Riesterer, O.3    Broggini-Tenzer, A.4    Caravatti, G.5
  • 5
    • 14644387529 scopus 로고    scopus 로고
    • Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo
    • Hofstetter B, Vuong V, Broggini-Tenzer A, Bodis S, Ciernik IF, et al. (2005) Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo. Clin Cancer Res 11: 1588-1596.
    • (2005) Clin Cancer Res , vol.11 , pp. 1588-1596
    • Hofstetter, B.1    Vuong, V.2    Broggini-Tenzer, A.3    Bodis, S.4    Ciernik, I.F.5
  • 6
    • 63149182838 scopus 로고    scopus 로고
    • Role of the microenvironment for radiosensitization by patupilone
    • Bley CR, Jochum W, Orlowski K, Furmanova P, Vuong V, et al. (2009) Role of the microenvironment for radiosensitization by patupilone. Clin Cancer Res 15: 1335-1342.
    • (2009) Clin Cancer Res , vol.15 , pp. 1335-1342
    • Bley, C.R.1    Jochum, W.2    Orlowski, K.3    Furmanova, P.4    Vuong, V.5
  • 7
    • 0033950286 scopus 로고    scopus 로고
    • Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group trial
    • Bonomi P, Kim K, Fairclough D, Cella D, Kugler J, et al. (2000) Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group trial. J Clin Oncol 18: 623-631.
    • (2000) J Clin Oncol , vol.18 , pp. 623-631
    • Bonomi, P.1    Kim, K.2    Fairclough, D.3    Cella, D.4    Kugler, J.5
  • 8
    • 0034175066 scopus 로고    scopus 로고
    • Taxanes for breast cancer: an evidence-based review of randomized phase II and phase III trials
    • discussion 41-32
    • Sparano JA (2000) Taxanes for breast cancer: an evidence-based review of randomized phase II and phase III trials. Clin Breast Cancer 1: 32-40; discussion 41-32.
    • (2000) Clin Breast Cancer , vol.1 , pp. 32-40
    • Sparano, J.A.1
  • 9
    • 3843053396 scopus 로고    scopus 로고
    • The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography
    • Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, et al. (2004) The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. Science 305: 866-869.
    • (2004) Science , vol.305 , pp. 866-869
    • Nettles, J.H.1    Li, H.2    Cornett, B.3    Krahn, J.M.4    Snyder, J.P.5
  • 11
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • Bollag DM, McQueney PA, Zhu J, Hensens O, Koupal L, et al. (1995) Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 55: 2325-2333.
    • (1995) Cancer Res , vol.55 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3    Hensens, O.4    Koupal, L.5
  • 12
    • 0034678986 scopus 로고    scopus 로고
    • Epothilones and related structures-a new class of microtubule inhibitors with potent in vivo antitumor activity
    • Altmann KH, Wartmann M, O'Reilly T, (2000) Epothilones and related structures-a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim Biophys Acta 1470: M79-91.
    • (2000) Biochim Biophys Acta , vol.1470
    • Altmann, K.H.1    Wartmann, M.2    O'Reilly, T.3
  • 13
    • 77950520462 scopus 로고    scopus 로고
    • Management of advanced breast cancer with the epothilone B analog, ixabepilone
    • Gradishar W, (2009) Management of advanced breast cancer with the epothilone B analog, ixabepilone. Drug Des Devel Ther 3: 163-171.
    • (2009) Drug Des Devel Ther , vol.3 , pp. 163-171
    • Gradishar, W.1
  • 14
    • 77953561380 scopus 로고    scopus 로고
    • Phase I trial using patupilone (epothilone B) and concurrent radiotherapy for central nervous system malignancies
    • Fogh S, Machtay M, Werner-Wasik M, Curran WJ Jr, Bonanni R, et al. (2010) Phase I trial using patupilone (epothilone B) and concurrent radiotherapy for central nervous system malignancies. Int J Radiat Oncol Biol Phys 77: 1009-1016.
    • (2010) Int J Radiat Oncol Biol Phys , vol.77 , pp. 1009-1016
    • Fogh, S.1    Machtay, M.2    Werner-Wasik, M.3    Curran Jr., W.J.4    Bonanni, R.5
  • 15
    • 80052417101 scopus 로고    scopus 로고
    • Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor Group
    • Stupp R, Tosoni A, Bromberg JE, Hau P, Campone M, et al. (2011) Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor Group. Ann Oncol 22: 2144-2149.
    • (2011) Ann Oncol , vol.22 , pp. 2144-2149
    • Stupp, R.1    Tosoni, A.2    Bromberg, J.E.3    Hau, P.4    Campone, M.5
  • 16
    • 77957374075 scopus 로고    scopus 로고
    • Microtubule-binding agents: a dynamic field of cancer therapeutics
    • Dumontet C, Jordan MA, (2010) Microtubule-binding agents: a dynamic field of cancer therapeutics. Nat Rev Drug Discov 9: 790-803.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 790-803
    • Dumontet, C.1    Jordan, M.A.2
  • 17
    • 82055198578 scopus 로고    scopus 로고
    • Clinical activity of patupilone in patients with pretreated advanced/metastatic colon cancer: results of a phase I dose escalation trial
    • Melichar B, Casado E, Bridgewater J, Bennouna J, Campone M, et al. (2011) Clinical activity of patupilone in patients with pretreated advanced/metastatic colon cancer: results of a phase I dose escalation trial. Br J Cancer 105: 1646-1653.
    • (2011) Br J Cancer , vol.105 , pp. 1646-1653
    • Melichar, B.1    Casado, E.2    Bridgewater, J.3    Bennouna, J.4    Campone, M.5
  • 18
    • 33749578369 scopus 로고    scopus 로고
    • 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules
    • Kamath K, Okouneva T, Larson G, Panda D, Wilson L, et al. (2006) 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol Cancer Ther 5: 2225-2233.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2225-2233
    • Kamath, K.1    Okouneva, T.2    Larson, G.3    Panda, D.4    Wilson, L.5
  • 19
    • 0345275866 scopus 로고    scopus 로고
    • Gene expression and mitotic exit induced by microtubule-stabilizing drugs
    • Chen JG, Yang CP, Cammer M, Horwitz SB, (2003) Gene expression and mitotic exit induced by microtubule-stabilizing drugs. Cancer Res 63: 7891-7899.
    • (2003) Cancer Res , vol.63 , pp. 7891-7899
    • Chen, J.G.1    Yang, C.P.2    Cammer, M.3    Horwitz, S.B.4
  • 20
    • 0030020158 scopus 로고    scopus 로고
    • Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
    • Jordan MA, Wendell K, Gardiner S, Derry WB, Copp H, et al. (1996) Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 56: 816-825.
    • (1996) Cancer Res , vol.56 , pp. 816-825
    • Jordan, M.A.1    Wendell, K.2    Gardiner, S.3    Derry, W.B.4    Copp, H.5
  • 21
    • 0034949714 scopus 로고    scopus 로고
    • Screening of natural compounds for inhibitory activity on colon cancer cell migration
    • Ogasawara M, Matsubara T, Suzuki H, (2001) Screening of natural compounds for inhibitory activity on colon cancer cell migration. Biol Pharm Bull 24: 720-723.
    • (2001) Biol Pharm Bull , vol.24 , pp. 720-723
    • Ogasawara, M.1    Matsubara, T.2    Suzuki, H.3
  • 23
    • 3042661957 scopus 로고    scopus 로고
    • Role of cell cycle in mediating sensitivity to radiotherapy
    • Pawlik TM, Keyomarsi K, (2004) Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 59: 928-942.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 928-942
    • Pawlik, T.M.1    Keyomarsi, K.2
  • 24
    • 0030220881 scopus 로고    scopus 로고
    • Therapeutic potential of paclitaxel-radiation treatment of a murine ovarian carcinoma
    • Milas L, Saito Y, Hunter N, Milross CG, Mason KA, (1996) Therapeutic potential of paclitaxel-radiation treatment of a murine ovarian carcinoma. Radiother Oncol 40: 163-170.
    • (1996) Radiother Oncol , vol.40 , pp. 163-170
    • Milas, L.1    Saito, Y.2    Hunter, N.3    Milross, C.G.4    Mason, K.A.5
  • 25
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • Wenger RH, Stiehl DP, Camenisch G, (2005) Integration of oxygen signaling at the consensus HRE. Sci STKE 2005: re12.
    • (2005) Sci STKE , vol.2005
    • Wenger, R.H.1    Stiehl, D.P.2    Camenisch, G.3
  • 26
    • 0036320934 scopus 로고    scopus 로고
    • Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
    • Wenger RH, (2002) Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J 16: 1151-1162.
    • (2002) FASEB J , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 27
    • 69549138474 scopus 로고    scopus 로고
    • Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events
    • Lehmann S, Stiehl DP, Honer M, Dominietto M, Keist R, et al. (2009) Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events. Proc Natl Acad Sci U S A 106: 14004-14009.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14004-14009
    • Lehmann, S.1    Stiehl, D.P.2    Honer, M.3    Dominietto, M.4    Keist, R.5
  • 28
    • 34447565882 scopus 로고    scopus 로고
    • The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts
    • Harada H, Kizaka-Kondoh S, Itasaka S, Shibuya K, Morinibu A, et al. (2007) The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts. Biochem Biophys Res Commun 360: 791-796.
    • (2007) Biochem Biophys Res Commun , vol.360 , pp. 791-796
    • Harada, H.1    Kizaka-Kondoh, S.2    Itasaka, S.3    Shibuya, K.4    Morinibu, A.5
  • 29
    • 34547650866 scopus 로고    scopus 로고
    • Transcriptional and post-translational regulatory system for hypoxia specific gene expression using the erythropoietin enhancer and the oxygen-dependent degradation domain
    • Kim HA, Kim K, Kim SW, Lee M, (2007) Transcriptional and post-translational regulatory system for hypoxia specific gene expression using the erythropoietin enhancer and the oxygen-dependent degradation domain. J Control Release 121: 218-224.
    • (2007) J Control Release , vol.121 , pp. 218-224
    • Kim, H.A.1    Kim, K.2    Kim, S.W.3    Lee, M.4
  • 30
    • 25444465116 scopus 로고    scopus 로고
    • Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function
    • Escuin D, Kline ER, Giannakakou P, (2005) Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer Res 65: 9021-9028.
    • (2005) Cancer Res , vol.65 , pp. 9021-9028
    • Escuin, D.1    Kline, E.R.2    Giannakakou, P.3
  • 31
    • 36949007159 scopus 로고    scopus 로고
    • Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1alpha
    • Lu Y, Liang K, Li X, Fan Z, (2007) Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1alpha. Mol Cancer 6: 63.
    • (2007) Mol Cancer , vol.6 , pp. 63
    • Lu, Y.1    Liang, K.2    Li, X.3    Fan, Z.4
  • 32
    • 36749029349 scopus 로고    scopus 로고
    • Significance of HIF-1-active cells in angiogenesis and radioresistance
    • Harada H, Kizaka-Kondoh S, Li G, Itasaka S, Shibuya K, et al. (2007) Significance of HIF-1-active cells in angiogenesis and radioresistance. Oncogene 26: 7508-7516.
    • (2007) Oncogene , vol.26 , pp. 7508-7516
    • Harada, H.1    Kizaka-Kondoh, S.2    Li, G.3    Itasaka, S.4    Shibuya, K.5
  • 33
    • 78651338243 scopus 로고    scopus 로고
    • Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression
    • Carbonaro M, O'Brate A, Giannakakou P, (2011) Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression. J Cell Biol 192: 83-99.
    • (2011) J Cell Biol , vol.192 , pp. 83-99
    • Carbonaro, M.1    O'Brate, A.2    Giannakakou, P.3
  • 34
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
    • Moeller BJ, Cao Y, Li CY, Dewhirst MW, (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441.
    • (2004) Cancer Cell , vol.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3    Dewhirst, M.W.4
  • 35
    • 0028849274 scopus 로고
    • p21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • Waldman T, Kinzler KW, Vogelstein B, (1995) p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 55: 5187-5190.
    • (1995) Cancer Res , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 36
    • 78651069389 scopus 로고    scopus 로고
    • Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent
    • Chao SK, Lin J, Brouwer-Visser J, Smith AB 3rd, Horwitz SB, et al (2010) Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent. Proc Natl Acad Sci U S A 108: 391-396.
    • (2010) Proc Natl Acad Sci U S A , vol.108 , pp. 391-396
    • Chao, S.K.1    Lin, J.2    Brouwer-Visser, J.3    Smith 3rd, A.B.4    Horwitz, S.B.5
  • 37
    • 30444445382 scopus 로고    scopus 로고
    • Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production
    • Safran M, Kim WY, O'Connell F, Flippin L, Gunzler V, et al. (2006) Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci U S A 103: 105-110.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 105-110
    • Safran, M.1    Kim, W.Y.2    O'Connell, F.3    Flippin, L.4    Gunzler, V.5
  • 38
    • 79960342262 scopus 로고    scopus 로고
    • Regulation of VEGF-expression by patupilone and ionizing radiation in lung adenocarcinoma cells
    • Rohrer Bley C, Orlowski K, Furmanova P, McSheehy PM, Pruschy M, (2011) Regulation of VEGF-expression by patupilone and ionizing radiation in lung adenocarcinoma cells. Lung Cancer 73: 294-301.
    • (2011) Lung Cancer , vol.73 , pp. 294-301
    • Rohrer Bley, C.1    Orlowski, K.2    Furmanova, P.3    McSheehy, P.M.4    Pruschy, M.5
  • 39
    • 34047272690 scopus 로고    scopus 로고
    • Regulation of HIF-1alpha stability through S-nitrosylation
    • Li F, Sonveaux P, Rabbani ZN, Liu S, Yan B, et al. (2007) Regulation of HIF-1alpha stability through S-nitrosylation. Mol Cell 26: 63-74.
    • (2007) Mol Cell , vol.26 , pp. 63-74
    • Li, F.1    Sonveaux, P.2    Rabbani, Z.N.3    Liu, S.4    Yan, B.5
  • 40
    • 33747660292 scopus 로고    scopus 로고
    • Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system
    • Stiehl DP, Wirthner R, Koditz J, Spielmann P, Camenisch G, et al. (2006) Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system. J Biol Chem 281: 23482-23491.
    • (2006) J Biol Chem , vol.281 , pp. 23482-23491
    • Stiehl, D.P.1    Wirthner, R.2    Koditz, J.3    Spielmann, P.4    Camenisch, G.5
  • 41
    • 80052770432 scopus 로고    scopus 로고
    • The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells
    • Oehler C, von Bueren AO, Furmanova P, Broggini-Tenzer A, Orlowski K, et al. (2011) The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol 13: 1000-1010.
    • (2011) Neuro Oncol , vol.13 , pp. 1000-1010
    • Oehler, C.1    von Bueren, A.O.2    Furmanova, P.3    Broggini-Tenzer, A.4    Orlowski, K.5
  • 42
    • 3042719231 scopus 로고    scopus 로고
    • Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer
    • Nordsmark M, Overgaard J, (2004) Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer. Acta Oncol 43: 396-403.
    • (2004) Acta Oncol , vol.43 , pp. 396-403
    • Nordsmark, M.1    Overgaard, J.2
  • 44
    • 0023932431 scopus 로고
    • Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
    • Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, et al. (1988) Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 14: 831-838.
    • (1988) Int J Radiat Oncol Biol Phys , vol.14 , pp. 831-838
    • Gatenby, R.A.1    Kessler, H.B.2    Rosenblum, J.S.3    Coia, L.R.4    Moldofsky, P.J.5
  • 45
    • 0032585864 scopus 로고    scopus 로고
    • Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix
    • Knocke TH, Weitmann HD, Feldmann HJ, Selzer E, Potter R, (1999) Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix. Radiother Oncol 53: 99-104.
    • (1999) Radiother Oncol , vol.53 , pp. 99-104
    • Knocke, T.H.1    Weitmann, H.D.2    Feldmann, H.J.3    Selzer, E.4    Potter, R.5
  • 46
    • 33645079888 scopus 로고    scopus 로고
    • An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    • Le QT, Chen E, Salim A, Cao H, Kong CS, et al. (2006) An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res 12: 1507-1514.
    • (2006) Clin Cancer Res , vol.12 , pp. 1507-1514
    • Le, Q.T.1    Chen, E.2    Salim, A.3    Cao, H.4    Kong, C.S.5
  • 47
    • 79955729281 scopus 로고    scopus 로고
    • Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts
    • Yaromina A, Kroeber T, Meinzer A, Boeke S, Thames H, et al. (2011) Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts. Int J Radiat Oncol Biol Phys 80: 1205-1213.
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , pp. 1205-1213
    • Yaromina, A.1    Kroeber, T.2    Meinzer, A.3    Boeke, S.4    Thames, H.5
  • 48
    • 79953190404 scopus 로고    scopus 로고
    • Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice
    • Goldman SJ, Chen E, Taylor R, Zhang S, Petrosky W, et al. (2011) Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice. PLoS One 6: e18269.
    • (2011) PLoS One , vol.6
    • Goldman, S.J.1    Chen, E.2    Taylor, R.3    Zhang, S.4    Petrosky, W.5
  • 49
    • 11244287240 scopus 로고    scopus 로고
    • Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry
    • Dubois L, Landuyt W, Haustermans K, Dupont P, Bormans G, et al. (2004) Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry. Br J Cancer 91: 1947-1954.
    • (2004) Br J Cancer , vol.91 , pp. 1947-1954
    • Dubois, L.1    Landuyt, W.2    Haustermans, K.3    Dupont, P.4    Bormans, G.5
  • 50
    • 53149098943 scopus 로고    scopus 로고
    • Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation
    • Hlushchuk R, Riesterer O, Baum O, Wood J, Gruber G, et al. (2008) Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation. Am J Pathol 173: 1173-1185.
    • (2008) Am J Pathol , vol.173 , pp. 1173-1185
    • Hlushchuk, R.1    Riesterer, O.2    Baum, O.3    Wood, J.4    Gruber, G.5
  • 51
    • 27744607653 scopus 로고    scopus 로고
    • Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure
    • Ferretti S, Allegrini PR, O'Reilly T, Schnell C, Stumm M, et al. (2005) Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure. Clin Cancer Res 11: 7773-7784.
    • (2005) Clin Cancer Res , vol.11 , pp. 7773-7784
    • Ferretti, S.1    Allegrini, P.R.2    O'Reilly, T.3    Schnell, C.4    Stumm, M.5
  • 52
    • 57149104637 scopus 로고    scopus 로고
    • In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy
    • Viola RJ, Provenzale JM, Li F, Li CY, Yuan H, et al. (2008) In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy. AJR Am J Roentgenol 191: 1779-1784.
    • (2008) AJR Am J Roentgenol , vol.191 , pp. 1779-1784
    • Viola, R.J.1    Provenzale, J.M.2    Li, F.3    Li, C.Y.4    Yuan, H.5


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