Grape-Seed Proanthocyanidin Extract as Suppressors of Bone Destruction in Inflammatory Autoimmune Arthritis

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Park, Jin Sil ^a   Park, Mi Kyung ^a   Oh, Hye Joa ^a   Woo, Yun Ju ^a   Lim, Mi Ae ^a   Lee, Jong Ho ^c   Ju, Ji Hyeon ^a   Jung, Young Ok ^b   Lee, Zang Hee ^c   Park, Sung Hwan ^a   Kim, Ho Youn ^a   Cho, Mi La ^a,d   Min, Jun Ki ^a  

^a The Catholic University of Korea   (South Korea)

^b Hallym University   (South Korea)

^c Seoul National University   (South Korea)

^d The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; GRAPE SEED PROANTHOCYANIDIN EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; BONE DESTRUCTION; CELL ACTIVITY; CELL DIFFERENTIATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; DRUG EFFICACY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS;

ACID PHOSPHATASE; ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BASE SEQUENCE; BONE AND BONES; BONE RESORPTION; CELL DIFFERENTIATION; CELLS, CULTURED; DNA PRIMERS; GRAPE SEED EXTRACT; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MALE; MICE; MICE, INBRED DBA; OSTEOBLASTS; OSTEOCLASTS; PROANTHOCYANIDINS; REAL-TIME POLYMERASE CHAIN REACTION;

MUS; VITACEAE;

EID: 84870906320     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051377     Document Type: Article

References (43)

1. Gravallese EM, Manning C, Tsay A, Naito A, Pan C, et al. (2000) Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum 43: 250-258.
2. Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, et al. (1999) Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402: 304-309.
3. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, et al. (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20: 345-357.
4. Firestein GS, (2003) Evolving concepts of rheumatoid arthritis. Nature 423: 356-361.
5. Jimi E, Akiyama S, Tsurukai T, Okahashi N, Kobayashi K, et al. (1999) Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J Immunol 163: 434-442.
6. Roodman GD, (2004) Mechanisms of bone metastasis. N Engl J Med 350: 1655-1664.
7. Tanaka Y, Okada Y, Nakamura T, (2003) Inter- and intracellular signaling in secondary osteoporosis. J Bone Miner Metab 21: 61-66.
8. Tanaka Y, Nakayamada S, Okada Y, (2005) Osteoblasts and osteoclasts in bone remodeling and inflammation. Curr Drug Targets Inflamm Allergy 4: 325-328.
9. Schett G, (2007) Cells of the synovium in rheumatoid arthritis. Osteoclasts. Arthritis Res Ther 9: 203.
10. Takayanagi H, Iizuka H, Juji T, Nakagawa T, Yamamoto A, et al. (2000) Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum 43: 259-269.
11. Gengenbacher M, Sebald HJ, Villiger PM, Hofstetter W, Seitz M, (2008) Infliximab inhibits bone resorption by circulating osteoclast precursor cells in patients with rheumatoid arthritis and ankylosing spondylitis. Ann Rheum Dis 67: 620-624.
12. Seriolo B, Paolino S, Sulli A, Ferretti V, Cutolo M, (2006) Bone metabolism changes during anti-TNF-alpha therapy in patients with active rheumatoid arthritis. Ann N Y Acad Sci 1069: 420-427.
13. Chabaud M, Miossec P, (2001) The combination of tumor necrosis factor alpha blockade with interleukin-1 and interleukin-17 blockade is more effective for controlling synovial inflammation and bone resorption in an ex vivo model. Arthritis Rheum 44: 1293-1303.
14. Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE, (2005) Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol 46: 445-451.
15. Sano T, Oda E, Yamashita T, Naemura A, Ijiri Y, et al. (2005) Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed. Thromb Res 115: 115-121.
16. Shafiee M, Carbonneau MA, Urban N, Descomps B, Leger CL, (2003) Grape and grape seed extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production. A comparison to other extracts or compounds. Free Radic Res 37: 573-584.
17. Gabetta B, Fuzzati N, Griffini A, Lolla E, Pace R, et al. (2000) Characterization of proanthocyanidins from grape seeds. Fitoterapia 71: 162-175.
18. Ross JA, Kasum CM, (2002) Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22: 19-34.
19. Martini M, Formigli L, Tonelli P, Giannelli M, Amunni F, et al. (1998) Effects of ipriflavone on perialveolar bone formation. Calcif Tissue Int 63: 312-319.
20. Yamaguchi M, Jie Z, (2001) Effect of polyphenols on calcium content and alkaline phosphatase activity in rat femoral tissues in vitro. Biol Pharm Bull 24: 1437-1439.
21. Sies H, (1993) Strategies of antioxidant defense. Eur J Biochem 215: 213-219.
22. Barnett ML, Kremer JM, St Clair EW, Clegg DO, Furst D, et al. (1998) Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 41: 290-297.
23. Ju JH, Cho ML, Moon YM, Oh HJ, Park JS, et al. (2008) IL-23 induces receptor activator of NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model. J Immunol 181: 1507-1518.
24. Lee SE, Chung WJ, Kwak HB, Chung CH, Kwack KB, et al. (2001) Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK. J Biol Chem 276: 49343-49349.
25. Chae HJ, Kim SC, Chae SW, An NH, Kim HH, et al. (2001) Blockade of the p38 mitogen-activated protein kinase pathway inhibits inducible nitric oxide synthase and interleukin-6 expression in MC3T3E-1 osteoblasts. Pharmacol Res 43: 275-283.
26. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31: 315-324.
27. Cho ML, Kim WU, Min SY, Min DJ, Min JK, et al. (2002) Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes. Arthritis Rheum 46: 42-51.
28. Johnson EB, Hammer RE, Herz J, (2005) Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet 14: 3523-3538.
29. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, et al. (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3: 889-901.
30. Mulero MC, Aubareda A, Schluter A, Perez-Riba M, (2007) RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression. Biochim Biophys Acta 1773: 330-341.
31. Smits P, Li P, Mandel J, Zhang Z, Deng JM, et al. (2001) The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell 1: 277-290.
32. Page G, Miossec P, (2005) RANK and RANKL expression as markers of dendritic cell-T cell interactions in paired samples of rheumatoid synovium and lymph nodes. Arthritis Rheum 52: 2307-2312.
33. Wu YB, Zheng CJ, Qin LP, Sun LN, Han T, et al. (2009) Antiosteoporotic activity of anthraquinones from Morinda officinalis on osteoblasts and osteoclasts. Molecules 14: 573-583.
34. Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, et al. (2005) A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 106: 852-859.
35. Cho ML, Heo YJ, Park MK, Oh HJ, Park JS, et al. (2009) Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis. Immunol Lett 124: 102-110.
36. Park MK, Park JS, Cho ML, Oh HJ, Heo YJ,et al. Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3(+) regulatory and IL-17(+) pathogenic T cell in autoimmune arthritis. Immunol Lett.
37. Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, et al. (2006) Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 203: 2673-2682.
38. Zhang FL, Gao HQ, Shen L, (2007) Inhibitory effect of GSPE on RAGE expression induced by advanced glycation end products in endothelial cells. J Cardiovasc Pharmacol 50: 434-440.
39. Steinbeck MJ, Appel WH Jr, Verhoeven AJ, Karnovsky MJ, (1994) NADPH-oxidase expression and in situ production of superoxide by osteoclasts actively resorbing bone. J Cell Biol 126: 765-772.
40. Vasange M, Liu B, Welch CJ, Rolfsen W, Bohlin L, (1997) The flavonoid constituents of two Polypodium species (Calaguala) and their effect on the elastase release in human neutrophils. Planta Med 63: 511-517.
41. Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, et al. (1997) Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem 272: 22053-22058.
42. Ishikawa M, Maki K, Tofani I, Kimura K, Kimura M, (2005) Grape seed proanthocyanidins extract promotes bone formation in rat's mandibular condyle. Eur J Oral Sci 113: 47-52.
43. Bonnelye E, Chabadel A, Saltel F, Jurdic P, (2008) Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 42: 129-138.