Structure-activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 1, 2013, Pages 114-126

  Lee, Ill Young ^a   Gruber, Todd D ^b   Samuels, Amanda ^b   Yun, Minhan ^a   Nam, Bora ^a   Kang, Minseo ^a   Crowley, Kathryn ^b   Winterroth, Benjamin ^b   Boshoff, Helena I ^b   Barry III, Clifton E ^a,b  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Antibacterial; Proton gradient; Salicylanilide; Tuberculosis

Indexed keywords

N (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 2 HYDROXY 5 HYDROXY 5 (1H PYRROL 1 YL)BENZAMIDE; N (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 2 HYDROXY 5 IODO BENZAMIDE; N (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 2 HYDROXYBENZAMIDE; N (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 5 BROMO 2 HYDROXYBENZAMIDE; N (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 5 CHLORO 2 HYDROXYBENZAMIDE; N (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 5 CHLORO 3 CHLOROBENZAMIDE; N (3,5 BIS(TRIFLUOROMETHYL)PHENYL) 5 FLUORO 2 HYDROXYBENZAMIDE; N (3,5 BIS(TRIFLUOROMETHYL)PHENYL)BENZAMIDE; SALICYLANILIDE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CELL KILLING; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; IC 50; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; HUMANS; MACROPHAGES; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PROTONS; SALICYLANILIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBERCULOSIS;

MURINAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 84870874682     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.10.056     Document Type: Article

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