Design, synthesis, and biological activities of closantel analogues: Structural promiscuity and its impact on onchocerca volvulus

Journal of Medicinal Chemistry

Volumn 54, Issue 11, 2011, Pages 3963-3972

  Garner, Amanda L ^a,b   Gloeckner, Christian ^a,b   Tricoche, Nancy ^c   Zakhari, Joseph S ^a,b   Samje, Moses ^d   Cho Ngwa, Fidelis ^d   Lustigman, Sara ^c   Janda, Kim D ^a,b  

^a Department of Chemistry ^*  (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c NEW YORK BLOOD CENTER   (United States)

^d UNIVERSITY OF BUEA   (Cameroon)

Author keywords

[No Author keywords available]

Indexed keywords

CHITINASE; CLOSANTEL; IONOPHORE; SALICYLANILIDE DERIVATIVE;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LARVAL STAGE; MOLTING; NEMATODE; NEMATODE LIFE CYCLE STAGE; NONHUMAN; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHITINASE; DRUG DESIGN; ENZYME INHIBITORS; EPITHELIAL CELLS; FILARICIDES; HAPLORHINI; HEK293 CELLS; HUMANS; IONOPHORES; LARVA; MOLECULAR STRUCTURE; MOLTING; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; ONCHOCERCIASIS, OCULAR; PROTONS; SALICYLANILIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79958153399     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200364n     Document Type: Article

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