Advancing Optical Imaging for Breast Margin Assessment: An Analysis of Excisional Time, Cautery, and Patent Blue Dye on Underlying Sources of Contrast

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Bydlon, Torre M ^a   Barry, William T ^b   Kennedy, Stephanie A ^a   Brown, J Quincy ^a,c   Gallagher, Jennifer E ^d   Wilke, Lee G ^e   Geradts, Joseph ^d   Ramanujam, Nimmi ^a,c  

^a Duke University   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c Zenalux   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; HEMOGLOBIN; ISOSULFAN BLUE;

ARTICLE; BREAST CANCER; BREAST SURGERY; BREAST TUMOR MARGIN; CAUTERIZATION; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; EX VIVO STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; INTRAOPERATIVE PERIOD; KINETICS; LIGHT SCATTERING; LIPID ANALYSIS; MONTE CARLO METHOD; ONCOLOGICAL PARAMETERS; OPERATION DURATION; PARTIAL MASTECTOMY; PHANTOM; POSTOPERATIVE PERIOD; REFLECTOMETRY; SENTINEL LYMPH NODE; SPECTROSCOPY; STAINING; SURGICAL APPROACH; SURGICAL TECHNIQUE; TISSUE DISTRIBUTION;

BREAST NEOPLASMS; CAUTERY; COLORING AGENTS; FEMALE; HUMANS; MASTECTOMY; MASTECTOMY, SEGMENTAL; OPTICAL IMAGING; ROSANILINE DYES;

EID: 84870873222     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051418     Document Type: Article

References (70)

1. Jacobs L, (2008) Positive margins: the challenge continues for breast surgeons. Ann Surgical Oncology 15: 1271-1272.
2. Lee MC, Rogers K, Griffith K, Diehl KA, Breslin TM, et al. (2009) Determinants of breast conservation rates: reasons for mastectomy at a comprehensive cancer center. Breast J 15: 34-40.
3. Cancer Facts and Figures 2009. Available: http://www.cancer.org/research/cancerfactsfigures/cancerfactsfigures/cancer-facts-figures-2009. Accessed 2012 Nov 8.
4. Sanchez C, Brem RF, McSwain AP, Rapelyea JA, Torrente J, et al. (2010) Factors associated with re-excision in patients with early-stage breast cancer treated with breast conservation therapy. Am Surg 76: 331-334.
5. Mann RM, Loo CE, Wobbes T, Bult P, Barentsz JO, et al. (2010) The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breast. Breast Cancer Res Treat 119: 415-422.
6. Balch GC, Mithani SK, Simpson JF, Kelley MC (2005) Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy. Am Surg 71: 22-27; discussion 27-28.
7. Mendez JE, Lamorte WW, de Las Morenas A, Cerda S, Pistey R, et al. (2006) Influence of breast cancer margin assessment method on the rates of positive margins and residual carcinoma. Am J Surg 192: 538-540.
8. Huston TL, Pigalarga R, Osborne MP, Tousimis E, (2006) The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery. Am J Surg 192: 509-512.
9. Kobbermann A, Unzeitig A, Xie XJ, Yan J, Euhus D, et al. (2010) Impact of Routine Cavity Shave Margins on Breast Cancer Re-excision Rates. Ann Surg Oncol.
10. McCahill LE, Single RM, Aiello Bowles EJ, Feigelson HS, James TA, et al. (2012) Variability in reexcision following breast conservation surgery. JAMA 307: 467-475.
11. Kunos C, Latson L, Overmoyer B, Silverman P, Shenk R, et al. (2006) Breast conservation surgery achieving > = 2 mm tumor-free margins results in decreased local-regional recurrence rates. Breast Journal 12: 28-36.
12. Elkhuizen PHM, van de Vijver MJ, Hermans J, Zonderland HM, van de Velde CJH, et al. (1998) Local recurrence after breast-conserving therapy for invasive breast cancer: High incidence in young patients and association with poor survival. International Journal of Radiation Oncology Biology Physics 40: 859-867.
13. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, et al. (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366: 2087-2106.
14. Guidi AJ, Connolly JL, Harris JR, Schnitt SJ, (1997) The relationship between shaved margin and inked margin status in breast excision specimens. Cancer 79: 1568-1573.
15. Creager AJ, Shaw JA, Young PR, Geisinger KR, (2002) Intraoperative evaluation of lumpectomy margins by imprint cytology with histologic correlation: a community hospital experience. Arch Pathol Lab Med 126: 846-848.
16. Chagpar A, Yen T, Sahin A, Hunt KK, Whitman GJ, et al. (2003) Intraoperative margin assessment reduces reexcision rates in patients with ductal carcinoma in situ treated with breast-conserving surgery. Am J Surg 186: 371-377.
17. Cox CE, Ku NN, Reintgen DS, Greenberg HM, Nicosia SV, et al. (1991) Touch Preparation Cytology of Breast Lumpectomy Margins with Histologic Correlation. Archives of Surgery 126: 490-493.
18. Singletary SE, (2002) Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy. American Journal of Surgery 184: 383-393.
19. Saarela AO, Paloneva TK, Rissanen TJ, Kiviniemi HO, (1997) Determinants of positive histologic margins and residual tumor after lumpectomy for early breast cancer: a prospective study with special reference to touch preparation cytology. J Surg Oncol 66: 248-253.
20. Valdes EK, Boolbol SK, Cohen JM, Feldman SM, (2007) Intra-operative touch preparation cytology; does it have a role in re-excision lumpectomy? Ann Surg Oncol 14: 1045-1050.
21. Klimberg VS, Westbrook KC, Korourian S, (1998) Use of touch preps for diagnosis and evaluation of surgical margins in breast cancer. Ann Surg Oncol 5: 220-226.
22. Johnson AT, Henry-Tillman R, Klimberg VS, (2001) Breast conserving surgery: optimizing local control in the breast with the assessment of margins. Breast Dis 12: 35-41.
23. Cendan JC, Coco D, Copeland EM, 3rd (2005) Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins. J Am Coll Surg 201: 194-198.
24. Olson TP, Harter J, Munoz A, Mahvi DM, Breslin T, (2007) Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence. Ann Surg Oncol 14: 2953-2960.
25. Sauter ER, Hoffman JP, Ottery FD, Kowalyshyn MJ, Litwin S, et al. (1994) Is frozen section analysis of reexcision lumpectomy margins worthwhile? Margin analysis in breast reexcisions. Cancer 73: 2607-2612.
26. Weber S, Storm FK, Stitt J, Mahvi DM, (1997) The role of frozen section analysis of margins during breast conservation surgery. Cancer J Sci Am 3: 273-277.
27. Noguchi M, Minami M, Earashi M, Taniya T, Miyazaki II, et al. (1995) Pathologic Assessment of Surgical Margins on Frozen and Permanent Sections in Breast Conserving Surgery. Breast Cancer 2: 27-33.
28. Pleijhuis RG, Graafland M, de Vries J, Bart J, de Jong JS, et al. (2009) Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions. Ann Surg Oncol 16: 2717-2730.
29. Cabioglu N, Hunt KK, Sahin AA, Kuerer HM, Babiera GV, et al. (2007) Role for intraoperative margin assessment in patients undergoing breast-conserving surgery. Ann Surg Oncol 14: 1458-1471.
30. Bigio IJ, Bown SG, Briggs G, Kelley C, Lakhani S, et al. (2000) Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results. J Biomed Opt 5: 221-228.
31. Keller MD, Majumder SK, Mahadevan-Lansen A, (2009) Spatially offset Raman spectroscopy of layered soft tissues. Optics Letters 34: 926-928.
32. Haka AS, Volynskaya Z, Gardecki JA, Nazemi J, Shenk R, et al. (2009) Diagnosing breast cancer using Raman spectroscopy: prospective analysis. J Biomed Opt 14: 054023.
33. Nguyen FT, Zysk AM, Chaney EJ, Kotynek JG, Oliphant UJ, et al. (2009) Intraoperative evaluation of breast tumor margins with optical coherence tomography. Cancer Res 69: 8790-8796.
34. Nachabe R, Evers DJ, Hendriks BH, Lucassen GW, van der Voort M, et al. (2011) Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods. J Biomed Opt 16: 087010.
35. Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, et al. (2009) Rapid noninvasive optical imaging of tissue composition in breast tumor margins. Am J Surg 198: 566-574.
36. Brown J, Bydlon T, Richards L, Yu B, Kennedy S, et al. (2010) Optical assessment of tumor resection margins in the breast. IEEE Journal on Selected Topics in Quantum Electronics: accepted.
37. Zhu C, Palmer GM, Breslin TM, Xu F, Ramanujam N, (2005) Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer. J Biomed Opt 10: 024032.
38. Zhu C, Palmer GM, Breslin TM, Harter J, Ramanujam N, (2008) Diagnosis of breast cancer using fluorescence and diffuse reflectance spectroscopy: a Monte-Carlo-model-based approach. J Biomed Opt 13: 034015.
39. Palmer GM, Ramanujam N, (2006) A Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms. Appl Opt 45: 1062-1071.
40. Palmer GM, Zhu C, Breslin TM, Xu F, Gilchrist KW, et al. (2006) A Monte Carlo-based inverse model for calculating tissue optical properties. Part II: Application to breast cancer diagnosis. Appl Opt 45: 1072-1078.
41. Brown JQ, Wilke LG, Geradts J, Kennedy SA, Palmer GM, et al. (2009) Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo. Cancer Res 69: 2919-2926.
42. Keller MD, Majumder SK, Kelley MC, Meszoely IM, Boulos FI, et al. (2012) Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis. Lasers Surg Med 42: 15-23.
43. Kennedy S, Geradts J, Bydlon T, Brown JQ, Gallagher J, et al. (2010) Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast. Breast Cancer Research 12: R91.
44. Bydlon TM, Kennedy SA, Richards LM, Brown JQ, Yu B, et al. (2010) Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins. Opt Express 18: 8058-8076.
45. Brown JQ, Bydlon TM, Richards LM, Bing Y, Kennedy SA, et al. (2010) Optical Assesssment of Tumor Resection Margins in the Breast. Selected Topics in Quantum Electronics, IEEE Journal of 16: 530-544.
46. Bender JE, Vishwanath K, Moore LK, Brown JQ, Chang V, et al. (2009) A robust Monte Carlo model for the extraction of biological absorption and scattering in vivo. IEEE Trans Biomed Eng 56: 960-968.
47. Ruidiaz ME, Cortes-Mateos MJ, Sandoval S, Martin DT, Wang-Rodriguez J, et al. (2011) Quantitative comparison of surgical margin histology following excision with traditional electrosurgery and a low-thermal-injury dissection device. J Surg Oncol 104: 746-754.
48. Majumder SK, Keller MD, Boulos FI, Kelley MC, Mahadevan-Jansen A, (2008) Comparison of autofluorescence, diffuse reflectance, and Raman spectroscopy for breast tissue discrimination. J Biomed Opt 13: 054009.
49. Keller MD, Majumder SK, Kelley MC, Meszoely IM, Boulos FI, et al. (2010) Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis. Lasers Surg Med 42: 15-23.
50. Volynskaya Z, Haka AS, Bechtel KL, Fitzmaurice M, Shenk R, et al. (2008) Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy. Journal of Biomedical Optics 13:-.
51. Bigio IJ, Brown SG, Briggs G, Kelley C, Lakhani S, et al. (2000) Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results. Journal of Biomedical Optics 5: 221-228.
52. Ghosh N, et al. (2001) Measurement of optical transport properties of normal and malignant human breast tissue. Applied Optics 40: 176-184.
53. Laughney AM, Krishnaswamy V, Garcia-Allende PB, Conde OM, Wells WA, et al. (2010) Automated classification of breast pathology using local measures of broadband reflectance. J Biomed Opt 15: 066019.
54. Optical Properties Spectra. Available: http://omlc.ogi.edu/spectra/. Accessed 2012 Nov 8.
55. Breslin TM, Xu F, Palmer GM, Zhu C, Gilchrist KW, et al. (2004) Autofluorescence and diffuse reflectance properties of malignant and benign breast tissues. Ann Surg Oncol 11: 65-70.
56. Palmer GM, Zhu CF, Breslin TM, Xu FS, Gilchrist KW, et al. (2003) Comparison of multiexcitation fluorescence and diffuse reflectance spectroscopy for the diagnosis of breast cancer (March 2003). Ieee Transactions on Biomedical Engineering 50: 1233-1242.
57. Palmer GM, Zhu CF, Breslin TM, Xu FS, Gilchrist KW, et al. (2006) Monte Carlo-based inverse model for calculating tissue optical properties. Part II: Application to breast cancer diagnosis. Applied Optics 45: 1072-1078.
58. Zhu C, Breslin TM, Harter J, Ramanujam N, (2008) Model based and empirical spectral analysis for the diagnosis of breast cancer. Opt Express 16: 14961-14978.
59. Zhu CF, Palmer GM, Breslin TM, Harter J, Ramanujam N, (2006) Diagnosis of breast cancer using diffuse reflectance spectroscopy: Comparison of a Monte Carlo versus partial least squares analysis based feature extraction technique. Lasers in Surgery and Medicine 38: 714-724.
60. Spinelli L, Torricelli A, Pifferi A, Taroni P, Danesini GM, et al. (2004) Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography. J Biomed Opt 9: 1137-1142.
61. Cerussi AE, Berger AJ, Bevilacqua F, Shah N, Jakubowski D, et al. (2001) Sources of absorption and scattering contrast for near-infrared optical mammography. Acad Radiol 8: 211-218.
62. Shah N, Cerussi AE, Eker C, Espinoza J, Butler J, et al. (2001) Noninvasive functional optical spectroscopy of human breast tissue. PNAS 98: 4420-4425.
63. Pogue BW, Poplack SP, McBride TO, Wells WA, Osterman KS, et al. (2001) Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast. Radiology 218: 261-266.
64. Pogue B, Jiang S, Dehghani H, Kogel C, Soho S, et al. (2004) Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes. J Biomed Opt 9: 541-552.
65. Palmer GM, Zhu C, Breslin TM, Xu F, Gilchrist KW, et al. (2003) Comparison of multiexcitation fluorescence and diffuse reflectance spectroscopy for the diagnosis of breast cancer (March 2003). IEEE Trans Biomed Eng 50: 1233-1242.
66. Demos SG, Vogel AJ, Gandjbakhche AH, (2006) Advances in optical spectroscopy and imaging of breast lesions. J Mammary Gland Biol Neoplasia 11: 165-181.
67. Haka AS, Volynskaya Z, Gardecki JA, Nazemi J, Lyons J, et al. (2006) In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy. Cancer Res 66: 3317-3322.
68. Haka AS, Shafer-Peltier KE, Fitzmaurice M, Crowe J, Dasari RR, et al. (2005) Diagnosing breast cancer by using Raman spectroscopy. Proceedings of the National Academy of Sciences of the United States of America 102: 12371-12376.
69. Hsiung PL, Phatak DR, Chen Y, Aguirre AD, Fujimoto JG, et al. (2007) Benign and malignant lesions in the human breast depicted with ultrahigh resolution and three-dimensional optical coherence tomography. Radiology 244: 865-874.
70. Zysk AM, Boppart SA, (2006) Computational methods for analysis of human breast tumor tissue in optical coherence tomography images. J Biomed Opt 11: 054015.