Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast

Breast Cancer Research

Volumn 12, Issue 6, 2010, Pages

  Kennedy, Stephanie ^a   Geradts, Joseph ^b   Bydlon, Torre ^a   Brown, J Quincy ^a   Gallagher, Jennifer ^b   Junker, Marlee ^a   Barry, William ^c   Ramanujam, Nimmi ^a   Wilke, Lee ^d  

^a Duke University   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; HEMOGLOBIN;

ADIPOSE TISSUE; ARTICLE; BREAST; BREAST CANCER; CANCER RECURRENCE; CANCER RISK; CANCER SCREENING; CELL HETEROGENEITY; CONTROLLED STUDY; DIAGNOSIS; FEMALE; HUMAN; HUMAN TISSUE; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; MENOPAUSE; OBSERVATIONAL STUDY; PARTIAL MASTECTOMY; POSTMENOPAUSE; RANK SUM TEST; SPECTROSCOPY; BREAST TUMOR; METHODOLOGY; MINIMAL RESIDUAL DISEASE; PATHOLOGY; TUMOR RECURRENCE;

BETA CAROTENE; BREAST; BREAST NEOPLASMS; FEMALE; HEMOGLOBINS; HUMANS; MENOPAUSE; NEOPLASM RECURRENCE, LOCAL; NEOPLASM, RESIDUAL; SPECTRUM ANALYSIS;

EID: 78650871046     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2770     Document Type: Article

References (47)

1. Cancer Facts and Figures 2009. , http://www.cancer.org/Research/CancerFactsFigures/cancer-facts-figures-2009
2. Waljee JF, Hu ES, Newman LA, Alderman AK. Predictors of re-excision among women undergoing breast-conserving surgery for cancer. Ann Surg Oncol 2008, 15:1297-1303. 10.1245/s10434-007-9777-x, 18259820.
3. Soucy G, Belanger J, Leblanc G, Sideris L, Drolet P, Mitchell A, Leclerc YE, Dufresne MP, Beaudet J, Dube P. Surgical margins in breast-conservation operations for invasive carcinoma: does neoadjuvant chemotherapy have an impact?. J Am Coll Surg 2008, 206:1116-1121. 10.1016/j.jamcollsurg.2007.12.025, 18501808.
4. Lee MC, Rogers K, Griffith K, Diehl KA, Breslin TM, Cimmino VM, Chang AE, Newman LA, Sabel MS. Determinants of breast conservation rates: reasons for mastectomy at a comprehensive cancer center. Breast J 2009, 15:34-40. 10.1111/j.1524-4741.2008.00668.x, 19141132.
5. Morrow M, Jagsi R, Alderman AK, Griggs JJ, Hawley ST, Hamilton AS, Graff JJ, Katz SJ. Surgeon recommendations and receipt of mastectomy for treatment of breast cancer. JAMA 2009, 302:1551-1556. 10.1001/jama.2009.1450, 19826024.
6. Dunne C, Burke JP, Morrow M, Kell MR. Effect of margin status on local recurrence after breast conservation and radiation therapy for ductal carcinoma in situ. J Clin Oncol 2009, 27:1615-1620. 10.1200/JCO.2008.17.5182, 19255332.
7. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, Godwin J, Gray R, Hicks C, James S, MacKinnon E, McGale P, McHugh T, Peto R, Taylor C, Wang Y. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 366:2087-2106.
8. Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker MK, Gallagher J, Barry WT, Geradts J, Ramanujam N. Rapid noninvasive optical imaging of tissue composition in breast tumor margins. Am J Surg 2009, 198:566-574. 10.1016/j.amjsurg.2009.06.018, 19800470, 2764289.
9. Singletary SE. Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy. American Journal of Surgery 2002, 184:383-393. 10.1016/S0002-9610(02)01012-7, 12433599.
10. Cabioglu N, Hunt KK, Sahin AA, Kuerer HM, Babiera GV, Singletary SE, Whitman GJ, Ross MI, Ames FC, Feig BW, Buchholz TA, Meric-Bernstam F. Role for intraoperative margin assessment in patients undergoing breast-conserving surgery. Ann Surg Oncol 2007, 14:1458-1471. 10.1245/s10434-006-9236-0, 17260108.
11. Jacobs L. Positive margins: the challenge continues for breast surgeons. Ann Surg Oncol 2008, 15:1271-1272. 10.1245/s10434-007-9766-0, 2277448, 18320287.
12. Balch GC, Mithani SK, Simpson JF, Kelley MC. Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy. Am Surg 2005, 71:22-27. discussion 27-28.
13. Valdes EK, Boolbol SK, Cohen JM, Feldman SM. Intra-operative touch preparation cytology; does it have a role in re-excision lumpectomy?. Ann Surg Oncol 2007, 14:1045-1050. 10.1245/s10434-006-9263-x, 17206481.
14. Cox CE, Ku NN, Reintgen DS, Greenberg HM, Nicosia SV, Wangensteen S. Touch preparation cytology of breast lumpectomy margins with histologic correlation. Archives of Surgery 1991, 126:490-493.
15. Olson TP, Harter J, Munoz A, Mahvi DM, Breslin T. Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence. Ann Surg Oncol 2007, 14:2953-2960. 10.1245/s10434-007-9437-1, 17674109.
16. Cendan JCCD, Copeland EM. Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins. J Am Coll Surg 2005, 201:194-198. 10.1016/j.jamcollsurg.2005.03.014, 16038815.
17. Weber S, Storm FK, Stitt J, Mahvi DM. The role of frozen section analysis of margins during breast conservation surgery. Cancer J Sci Am 1997, 3:273-277.
18. Pleijhuis RG, Graafland M, de Vries J, Bart J, de Jong JS, van Dam GM. Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions. Ann Surg Oncol 2009, 16:2717-2730. 10.1245/s10434-009-0609-z, 2749177, 19609829.
19. Camp ER, McAuliffe PF, Gilroy JS, Morris CG, Lind DS, Mendenhall NP, Copeland EM. Minimizing local recurrence after breast conserving therapy using intraoperative shaved margins to determine pathologic tumor clearance. J Am Coll Surg 2005, 201:855-861. 10.1016/j.jamcollsurg.2005.06.274, 16310688.
20. Nguyen FT, Zysk AM, Chaney EJ, Kotynek JG, Oliphant UJ, Bellafiore FJ, Rowland KM, Johnson PA, Boppart SA. Intraoperative evaluation of breast tumor margins with optical coherence tomography. Cancer Res 2009, 69:8790-8796. 10.1158/0008-5472.CAN-08-4340, 2782920, 19910294.
21. Giuliano AE, Boolbol S, Degnim A, Kuerer H, Leitch AM, Morrow M. Society of Surgical Oncology: position statement on prophylactic mastectomy. Approved by the Society of Surgical Oncology Executive Council, March 2007. Ann Surg Oncol 2007, 14:2425-2427. 10.1245/s10434-007-9447-z, 17597344.
22. Bigio IJ, Bown SG, Briggs G, Kelley C, Lakhani S, Pickard D, Ripley PM, Rose IG, Saunders C. Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results. J Biomed Opt 2000, 5:221-228. 10.1117/1.429990, 10938787.
23. Haka AS, Volynskaya Z, Gardecki JA, Nazemi J, Shenk R, Wang N, Dasari RR, Fitzmaurice M, Feld MS. Diagnosing breast cancer using Raman spectroscopy: prospective analysis. J Biomed Opt 2009, 14:054023. 10.1117/1.3247154, 2774977, 19895125.
24. Keller MD, Majumder SK, Kelley MC, Meszoely IM, Boulos FI, Olivares GM, Mahadevan-Jansen A. Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis. Lasers Surg Med 42:15-23. 10.1002/lsm.20865, 20077490.
25. Uzgiris EE, Sood A, Bove K, Grimmond B, Lee D, Lomnes S. A multimodal contrast agent for preoperative MR Imaging and intraoperative tumor margin delineation. Technol Cancer Res Treat 2006, 5:301-309.
26. Allweis TM, Kaufman Z, Lelcuk S, Pappo I, Karni T, Schneebaum S, Spector R, Schindel A, Hershko D, Zilberman M, Sayfan J, Berlin Y, Hadary A, Olsha O, Paran H, Gutman M, Carmon M. A prospective, randomized, controlled, multicenter study of a real-time, intraoperative probe for positive margin detection in breast-conserving surgery. Am J Surg 2008, 196:483-489. 10.1016/j.amjsurg.2008.06.024, 18809049.
27. Karni T, Pappo I, Sandbank J, Lavon O, Kent V, Spector R, Morgenstern S, Lelcuk S. A device for real-time, intraoperative margin assessment in breast-conservation surgery. Am J Surg 2007, 194:467-473. 10.1016/j.amjsurg.2007.06.013, 17826057.
28. Pappo I, Spector R, Schindel A, Morgenstern S, Sandbank J, Leider LT, Schneebaum S, Lelcuk S, Karni T. Diagnostic performance of a novel device for real-time margin assessment in lumpectomy specimens. J Surg Res 2010, 160:277-281. 10.1016/j.jss.2009.02.025, 19628225.
29. Volynskaya Z, Haka AS, Bechtel KL, Fitzmaurice M, Shenk R, Wang N, Nazemi J, Dasari RR, Feld MS. Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy. J Biomed Opt 2008, 13:024012. 10.1117/1.2909672, 18465975.
30. Brown JA, Stevenson K, Kim HT, Cutler C, Ballen K, McDonough S, Reynolds C, Herrera M, Liney D, Ho V, Kao G, Armand P, Koreth J, Alyea E, McAfee S, Attar E, Dey B, Spitzer T, Soiffer R, Ritz J, Antin JH, Boussiotis VA. Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis. Blood 2010, 115:4111-4119.
31. Bydlon TM, Kennedy SA, Richards LM, Brown JQ, Yu B, Junker MK, Gallagher J, Geradts J, Wilke LG, Ramanujam N. Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins. Opt Express 2010, 18:8058-8076. 10.1364/OE.18.008058, 2939901, 20588651.
32. Palmer GM, Zhu C, Breslin TM, Xu F, Gilchrist KW, Ramanujam N. Monte Carlo-based inverse model for calculating tissue optical properties. Part II: Application to breast cancer diagnosis. Appl Opt 2006, 45:1072-1078. 10.1364/AO.45.001072, 16512551.
33. Palmer GM, Ramanujam N. Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms. Appl Opt 2006, 45:1062-1071. 10.1364/AO.45.001062, 16512550.
34. Brown JQ, Vishwanath K, Palmer GM, Ramanujam N. Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer. Curr Opin Biotechnol 2009, 20:119-131. 10.1016/j.copbio.2009.02.004, 2742920, 19268567.
35. Liu Q, Zhu CF, Ramanujam N. Experimental validation of Monte Carlo modeling of fluorescence in tissues in the UV-visible spectrum. Journal of Biomedical Optics 2003, 8:223-236. 10.1117/1.1559057, 12683848.
36. Zhu C, Palmer GM, Breslin TM, Harter J, Ramanujam N. Diagnosis of breast cancer using diffuse reflectance spectroscopy: Comparison of a Monte Carlo versus partial least squares analysis based feature extraction technique. Lasers Surg Med 2006, 38:714-724. 10.1002/lsm.20356, 16799981.
37. Brown JQ, Wilke LG, Geradts J, Kennedy SA, Palmer GM, Ramanujam N. Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo. Cancer Res 2009, 69:2919-2926. 10.1158/0008-5472.CAN-08-3370, 2677720, 19293184.
38. Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker MK, Gallagher J, Barry WT, Geradts J, Ramanujam N. Rapid non-invasive optical imaging of tissue composition in breast tumor margins. American Journal of Surgery 2009, 198:566-574. 10.1016/j.amjsurg.2009.06.018, 2764289, 19800470.
39. Zhu C, Palmer GM, Breslin TM, Harter J, Ramanujam N. Diagnosis of breast cancer using fluorescence and diffuse reflectance spectroscopy: a Monte-Carlo-model-based approach. J Biomed Opt 2008, 13:034015. 10.1117/1.2931078, 2791791, 18601560.
40. Ghosh N, Mohanty SK, Majumder SK, Gupta PK. Measurement of optical transport properties of normal and malignant human breast tissue. Appl Opt 2001, 40:176-184. 10.1364/AO.40.000176, 18356989.
41. Pogue BW, Jiang S, Dehghani H, Kogel C, Soho S, Srinivasan S, Song X, Tosteson TD, Poplack SP, Paulsen KD. Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes. J Biomed Opt 2004, 9:541-552. 10.1117/1.1691028, 15189092.
42. Srinivasan S, Pogue BW, Jiang S, Dehghani H, Kogel C, Soho S, Gibson JJ, Tosteson TD, Poplack SP, Paulsen KD. Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography. Proc Natl Acad Sci USA 2003, 100:12349-12354. 10.1073/pnas.2032822100, 218761, 14514888.
43. Suzuki K, Yamashita Y, Ohta K, Kaneko M, Yoshida M, Chance B. Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women. Journal of Biomedical Optics 1996, 1:330-334.
44. Jakubowski DB, Cerussi AE, Bevilacqua F, Shah N, Hsiang D, Butler J, Tromberg BJ. Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study. J Biomed Opt 2004, 9:230-238. 10.1117/1.1629681, 14715078.
45. Tromberg BJ, Shah N, Lanning R, Cerussi A, Espinoza J, Pham T, Svaasand L, Butler J. Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. Neoplasia 2000, 2:26-40. 10.1038/sj.neo.7900082, 1531865, 10933066.
46. Cerussi AE, Berger AJ, Bevilacqua F, Shah N, Jakubowski D, Butler J, Holcombe RF, Tromberg BJ. Sources of absorption and scattering contrast for near-infrared optical mammography. Acad Radiol 2001, 8:211-218. 10.1016/S1076-6332(03)80529-9, 11249084.
47. Cubeddu R, D'Andrea C, Pifferi A, Taroni P, Torricelli A, Valentini G. Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast. Photochem Photobiol 2000, 72:383-391.