HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53

Experimental and Molecular Pathology

Volumn 94, Issue 1, 2013, Pages 103-108

  Ghosh, Anil ^a   Lai, Cecilia ^a   McDonald, Sarah ^a   Suraweera, Nirosha ^a   Sengupta, Neel ^a   Propper, David ^b   Dorudi, Sina ^a   Silver, Andrew ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Activated PI3K AKT; HSP27; HSP72; KRAS; Oncogene induced senescence (OIS); TP53

Indexed keywords

HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 72; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER SURVIVAL; CODON; COLON CANCER; COLORECTAL CANCER; CONTROLLED STUDY; DISTANT METASTASIS; ENZYME ACTIVATION; FEMALE; GENE MUTATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; ONCOGENE K RAS; PRIMARY TUMOR; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECTUM CANCER; TUMOR DIFFERENTIATION;

ADULT; AGED; AGED, 80 AND OVER; CELL AGING; COLORECTAL NEOPLASMS; ENZYME ACTIVATION; FEMALE; GENES, RAS; HSP27 HEAT-SHOCK PROTEINS; HSP72 HEAT-SHOCK PROTEINS; HUMANS; MALE; MIDDLE AGED; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84870858502     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2012.09.001     Document Type: Article

References (42)

1. Abubaker J., et al. Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population. Oncogene 2008, 27:3539-3545.
2. Andreyev H.J., et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. British Journal of Cancer 2001, 85:692-696.
3. Bai Y.X., et al. Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma. World Journal of Gastroenterology 2007, 13:3883-3885.
4. Barault L., et al. Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. International Journal of Cancer 2008, 122:2255-2259.
5. Bukau B., et al. Molecular chaperones and protein quality control. Cell 2006, 125:443-451.
6. Castellano E., Downward J. RAS interaction with PI3K: more than just another effector pathway. Genes Cancer 2011, 2:261-274.
7. Charette S.J., et al. Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Molecular and Cellular Biology 2000, 20:7602-7612.
8. Ciocca D.R., Calderwood S.K. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress & Chaperones 2005, 10:86-103.
9. Collado M., et al. Tumour biology: senescence in premalignant tumours. Nature 2005, 436:642.
10. Evans C.G., et al. Heat shock protein 70 (hsp70) as an emerging drug target. Journal of Medicinal Chemistry 2010, 53:4585-4602.
11. Gabai V.L., et al. Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Molecular and Cellular Biology 2009, 29:559-569.
12. Halazonetis T.D., et al. An oncogene-induced DNA damage model for cancer development. Science 2008, 319:1352-1355.
13. Hartl F.U., Hayer-Hartl M. Converging concepts of protein folding in vitro and in vivo. Nature Structural and Molecular Biology 2009, 16:574-581.
14. Hwang T.S., et al. Differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in colorectal cancer. Journal of Gastroenterology and Hepatology 2003, 18:690-700.
15. Kanagasabai R., et al. Hsp27 protects adenocarcinoma cells from UV-induced apoptosis by Akt and p21-dependent pathways of survival. Molecular Cancer Research 2010, 8:1399-1412.
16. Kanazawa Y., et al. Expression of heat shock protein (Hsp) 70 and Hsp 40 in colorectal cancer. Medical Oncology 2003, 20:157-164.
17. Kennedy A.L., et al. Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Molecular Cell 2011, 42:36-49.
18. Kindas-Mugge I., Trautinger F. Increased expression of the M(r) 27,000 heat shock protein (hsp27) in in vitro differentiated normal human keratinocytes. Cell Growth & Differentiation 1994, 5:777-781.
19. Kocsis J., et al. Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis. Cell Stress & Chaperones 2010, 15:143-151.
20. Lazaris A.C., et al. Heat shock protein 70 and HLA-DR molecules tissue expression. Prognostic implications in colorectal cancer. Diseases of the Colon and Rectum 1995, 38:739-745.
21. Levine A.J. p53, the cellular gatekeeper for growth and division. Cell 1997, 88:323-331.
22. Massey A.J., et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemotherapy and Pharmacology 2010, 66:535-545.
23. Mearow K.M., et al. Stress-mediated signaling in PC12 cells - the role of the small heat shock protein, Hsp27, and Akt in protecting cells from heat stress and nerve growth factor withdrawal. Journal of Neurochemistry 2002, 83:452-462.
24. Milicevic Z.T., et al. Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma-immunohistochemistry and Western blot analysis. Neoplasma 2007, 54:37-45.
25. O'Callaghan-Sunol C., et al. Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Research 2007, 67:11779-11788.
26. Patel H., et al. Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma. International Journal of Cancer 2007, 121:2668-2673.
27. Pei H.P., et al. Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer. Zhonghua Wei Chang Wai Ke Za Zhi 2010, 13:213-215.
28. Rousseau S., et al. Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. Journal of Biological Chemistry 2000, 275:10661-10672.
29. Samuels Y., Velculescu V.E. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 2004, 3:1221-1224.
30. Sherman M. Major heat shock protein Hsp72 controls oncogene-induced senescence. Annals of the New York Academy of Sciences 2010, 1197:152-157.
31. Shotar A.M. P53 and heat shock protein 70 expressions in colorectal adenocarcinoma. Saudi Medical Journal 2005, 26:1602-1606.
32. Sun X.F., et al. Heat shock protein 72/73 in relation to cytoplasmic p53 expression and prognosis in colorectal adenocarcinomas. International Journal of Cancer 1997, 74:600-604.
33. Tsuruta M., et al. Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer. Oncology Reports 2008, 20:1165-1172.
34. Tuna B., et al. PS2 and HSP70 expression in rectal adenocarcinomas: an immunohistochemical investigation of 45 cases. Applied Immunohistochemistry & Molecular Morphology 2006, 14:31-36.
35. Tweedle E.M., et al. Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer. Gut 2010, 59:1501-1510.
36. Velho S., et al. The prevalence of PIK3CA mutations in gastric and colon cancer. European Journal of Cancer 2005, 41:1649-1654.
37. Vidaurreta M., et al. Colorectal carcinoma prognosis can be predicted by alterations in gene p53 exons 5 and 8. International Journal of Colorectal Disease 2008, 23:581-586.
38. Wang X.P., et al. Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma. World Journal of Gastroenterology 2005, 11:1056-1059.
39. Yaglom J.A., et al. High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways. Cancer Research 2007, 67:2373-2381.
40. Yu Z., et al. Clinical significance of HSP27 expression in colorectal cancer. Molecular Medicine Reports 2010, 3:953-958.
41. Zhang W.L., et al. Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics. Ai Zheng 2009, 28:612-618.
42. Zhao L., et al. Differential proteomic analysis of human colorectal carcinoma cell lines metastasis-associated proteins. Journal of Cancer Research and Clinical Oncology 2007, 133:771-782.