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Volumn 21, Issue 26, 2012, Pages 5443-5455

A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN A; FIBROBLAST GROWTH FACTOR RECEPTOR 3; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE DERIVATIVE; PEPTIDE P3; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

EID: 84870849268     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds390     Document Type: Article
Times cited : (41)

References (59)
  • 1
    • 34347222589 scopus 로고    scopus 로고
    • Roles of epidermal growth factor family in the regulation of postnatal somatic growth
    • Xian, C.J. (2007) Roles of epidermal growth factor family in the regulation of postnatal somatic growth. Endocr. Rev., 28, 284-296.
    • (2007) Endocr. Rev. , vol.28 , pp. 284-296
    • Xian, C.J.1
  • 2
    • 0027964261 scopus 로고
    • Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
    • Shiang, R., Thompson, L.M., Zhu, Y.Z., Church, D.M., Fielder, T.J., Bocian, M., Winokur, S.T. and Wasmuth, J.J. (1994) Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell, 78, 335-342.
    • (1994) Cell , vol.78 , pp. 335-342
    • Shiang, R.1    Thompson, L.M.2    Zhu, Y.Z.3    Church, D.M.4    Fielder, T.J.5    Bocian, M.6    Winokur, S.T.7    Wasmuth, J.J.8
  • 3
    • 0030773251 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 and the human chondrodysplasias
    • Horton, W.A. (1997) Fibroblast growth factor receptor 3 and the human chondrodysplasias. Curr. Opin. Pediatr., 9, 437-442.
    • (1997) Curr. Opin. Pediatr. , vol.9 , pp. 437-442
    • Horton, W.A.1
  • 4
    • 0029912958 scopus 로고    scopus 로고
    • Common mutations in the fibroblast growth factor receptor 3 (FGFR 3) gene account for achondroplasia, hypochondroplasia, and thanatophoric dwarfism
    • Bonaventure, J., Rousseau, F., Legeai-Mallet, L., Le Merrer, M., Munnich, A. and Maroteaux, P. (1996) Common mutations in the fibroblast growth factor receptor 3 (FGFR 3) gene account for achondroplasia, hypochondroplasia, and thanatophoric dwarfism. Am. J. Med. Genet., 63, 148-154.
    • (1996) Am. J. Med. Genet. , vol.63 , pp. 148-154
    • Bonaventure, J.1    Rousseau, F.2    Legeai-Mallet, L.3    Le Merrer, M.4    Munnich, A.5    Maroteaux, P.6
  • 7
    • 0032413011 scopus 로고    scopus 로고
    • Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
    • Naski, M.C., Colvin, J.S., Coffin, J.D. and Ornitz, D.M. (1998) Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development, 125, 4977-4988.
    • (1998) Development , vol.125 , pp. 4977-4988
    • Naski, M.C.1    Colvin, J.S.2    Coffin, J.D.3    Ornitz, D.M.4
  • 8
    • 0033456159 scopus 로고    scopus 로고
    • Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis
    • Chen, L., Adar, R., Yang, X., Monsonego, E.O., Li, C., Hauschka, P.V., Yayon, A. and Deng, C.X. (1999) Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. J. Clin. Invest., 104, 1517-1525.
    • (1999) J. Clin. Invest. , vol.104 , pp. 1517-1525
    • Chen, L.1    Adar, R.2    Yang, X.3    Monsonego, E.O.4    Li, C.5    Hauschka, P.V.6    Yayon, A.7    Deng, C.X.8
  • 9
    • 0037097976 scopus 로고    scopus 로고
    • FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    • Ornitz, D.M. and Marie, P.J. (2002) FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes. Dev., 16, 1446-1465.
    • (2002) Genes. Dev. , vol.16 , pp. 1446-1465
    • Ornitz, D.M.1    Marie, P.J.2
  • 10
    • 0032938128 scopus 로고    scopus 로고
    • A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors
    • Li, C., Chen, L., Iwata, T., Kitagawa, M., Fu, X.Y. and Deng, C.X. (1999) A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum. Mol. Genet., 8, 35-44.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 35-44
    • Li, C.1    Chen, L.2    Iwata, T.3    Kitagawa, M.4    Fu, X.Y.5    Deng, C.X.6
  • 11
    • 0030896404 scopus 로고    scopus 로고
    • Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
    • Su, W.C., Kitagawa, M., Xue, N., Xie, B., Garofalo, S., Cho, J., Deng, C., Horton, W.A. and Fu, X.Y. (1997) Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature, 386, 288-292.
    • (1997) Nature , vol.386 , pp. 288-292
    • Su, W.C.1    Kitagawa, M.2    Xue, N.3    Xie, B.4    Garofalo, S.5    Cho, J.6    Deng, C.7    Horton, W.A.8    Fu, X.Y.9
  • 12
    • 0033151612 scopus 로고    scopus 로고
    • FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
    • Sahni, M., Ambrosetti, D.C., Mansukhani, A., Gertner, R., Levy, D. and Basilico, C. (1999) FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes. Dev., 13, 1361-1366.
    • (1999) Genes. Dev. , vol.13 , pp. 1361-1366
    • Sahni, M.1    Ambrosetti, D.C.2    Mansukhani, A.3    Gertner, R.4    Levy, D.5    Basilico, C.6
  • 13
    • 1042289662 scopus 로고    scopus 로고
    • Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype
    • Murakami, S., Balmes, G., McKinney, S., Zhang, Z., Givol, D. and de Crombrugghe, B. (2004) Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes. Dev., 18, 290-305.
    • (2004) Genes. Dev. , vol.18 , pp. 290-305
    • Murakami, S.1    Balmes, G.2    McKinney, S.3    Zhang, Z.4    Givol, D.5    de Crombrugghe, B.6
  • 14
    • 0033951768 scopus 로고    scopus 로고
    • FGFs, heparan sulfate and FGFRs: complex interactions essential for development
    • Ornitz, D.M. (2000) FGFs, heparan sulfate and FGFRs: complex interactions essential for development. Bioessays, 22, 108-112.
    • (2000) Bioessays , vol.22 , pp. 108-112
    • Ornitz, D.M.1
  • 15
    • 66349135677 scopus 로고    scopus 로고
    • Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
    • Qing, J., Du, X., Chen, Y., Chan, P., Li, H., Wu, P., Marsters, S., Stawicki, S., Tien, J., Totpal, K. et al. (2009) Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice. J. Clin. Invest., 119, 1216-1229.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1216-1229
    • Qing, J.1    Du, X.2    Chen, Y.3    Chan, P.4    Li, H.5    Wu, P.6    Marsters, S.7    Stawicki, S.8    Tien, J.9    Totpal, K.10
  • 16
    • 0035815704 scopus 로고    scopus 로고
    • A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells
    • Shimizu, A., Tada, K., Shukunami, C., Hiraki, Y., Kurokawa, T., Magane, N. and Kurokawa-Seo, M. (2001) A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells. J. Biol. Chem., 276, 11031-11040.
    • (2001) J. Biol. Chem. , vol.276 , pp. 11031-11040
    • Shimizu, A.1    Tada, K.2    Shukunami, C.3    Hiraki, Y.4    Kurokawa, T.5    Magane, N.6    Kurokawa-Seo, M.7
  • 18
    • 0034234569 scopus 로고    scopus 로고
    • A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos
    • Iwata, T., Chen, L., Li, C., Ovchinnikov, D.A., Behringer, R.R., Francomano, C.A. and Deng, C.X. (2000) A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum. Mol. Genet., 9, 1603-1613.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1603-1613
    • Iwata, T.1    Chen, L.2    Li, C.3    Ovchinnikov, D.A.4    Behringer, R.R.5    Francomano, C.A.6    Deng, C.X.7
  • 23
    • 0029794956 scopus 로고    scopus 로고
    • Short-term recombinant human growth hormone treatment increases growth rate in achondroplasia
    • Shohat, M., Tick, D., Barakat, S., Bu, X., Melmed, S. and Rimoin, D.L. (1996) Short-term recombinant human growth hormone treatment increases growth rate in achondroplasia. J. Clin. Endocrinol. Metab., 81, 4033-4037.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 4033-4037
    • Shohat, M.1    Tick, D.2    Barakat, S.3    Bu, X.4    Melmed, S.5    Rimoin, D.L.6
  • 26
    • 0034909417 scopus 로고    scopus 로고
    • Limb lengthening in short stature patients
    • Aldegheri, R. and Dall'Oca, C. (2001) Limb lengthening in short stature patients. J. Pediatr. Orthop. B, 10, 238-247.
    • (2001) J. Pediatr. Orthop. B , vol.10 , pp. 238-247
    • Aldegheri, R.1    Dall'Oca, C.2
  • 28
    • 0037861955 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia-genetic short limbed dwarfism
    • Aviezer, D., Golembo, M. and Yayon, A. (2003) Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia-genetic short limbed dwarfism. Curr. Drug Targets, 4, 353-365.
    • (2003) Curr. Drug Targets , vol.4 , pp. 353-365
    • Aviezer, D.1    Golembo, M.2    Yayon, A.3
  • 30
    • 20444414924 scopus 로고    scopus 로고
    • Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells
    • Ozasa, A., Komatsu, Y., Yasoda, A., Miura, M., Sakuma, Y., Nakatsuru, Y., Arai, H., Itoh, N. and Nakao, K. (2005) Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells. Bone, 36, 1056-1064.
    • (2005) Bone , vol.36 , pp. 1056-1064
    • Ozasa, A.1    Komatsu, Y.2    Yasoda, A.3    Miura, M.4    Sakuma, Y.5    Nakatsuru, Y.6    Arai, H.7    Itoh, N.8    Nakao, K.9
  • 31
    • 0035263614 scopus 로고    scopus 로고
    • A Ser(365)- Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia
    • Chen, L., Li, C., Qiao, W., Xu, X. and Deng, C. (2001) A Ser(365)-Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Hum. Mol. Genet., 10, 457-465.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 457-465
    • Chen, L.1    Li, C.2    Qiao, W.3    Xu, X.4    Deng, C.5
  • 33
    • 34250018251 scopus 로고    scopus 로고
    • PTH has the potential to rescue disturbed bone growth in achondroplasia
    • Ueda, K., Yamanaka, Y., Harada, D., Yamagami, E., Tanaka, H. and Seino, Y. (2007) PTH has the potential to rescue disturbed bone growth in achondroplasia. Bone, 41, 13-18.
    • (2007) Bone , vol.41 , pp. 13-18
    • Ueda, K.1    Yamanaka, Y.2    Harada, D.3    Yamagami, E.4    Tanaka, H.5    Seino, Y.6
  • 34
    • 34548371795 scopus 로고    scopus 로고
    • RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
    • Shukla, V., Coumoul, X., Wang, R.H., Kim, H.S. and Deng, C.X. (2007) RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat. Genet., 39, 1145-1150.
    • (2007) Nat. Genet. , vol.39 , pp. 1145-1150
    • Shukla, V.1    Coumoul, X.2    Wang, R.H.3    Kim, H.S.4    Deng, C.X.5
  • 35
    • 22244488749 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs: barriers and developments
    • Hamman, J.H., Enslin, G.M. and Kotze, A.F. (2005) Oral delivery of peptide drugs: barriers and developments. BioDrugs, 19, 165-177.
    • (2005) BioDrugs , vol.19 , pp. 165-177
    • Hamman, J.H.1    Enslin, G.M.2    Kotze, A.F.3
  • 36
    • 28044461993 scopus 로고    scopus 로고
    • Strategies to improve oral drug bioavailability
    • Gomez-Orellana, I. (2005) Strategies to improve oral drug bioavailability. Expert Opin. Drug Deliv., 2, 419-433.
    • (2005) Expert Opin. Drug Deliv. , vol.2 , pp. 419-433
    • Gomez-Orellana, I.1
  • 38
    • 0031596591 scopus 로고    scopus 로고
    • Efficacy of thymosin alpha1 in patients with chronic hepatitis B: a randomized, controlled trial
    • Chien, R.N., Liaw, Y.F., Chen, T.C., Yeh, C.T. and Sheen, I.S. (1998) Efficacy of thymosin alpha1 in patients with chronic hepatitis B: a randomized, controlled trial. Hepatology, 27, 1383-1387.
    • (1998) Hepatology , vol.27 , pp. 1383-1387
    • Chien, R.N.1    Liaw, Y.F.2    Chen, T.C.3    Yeh, C.T.4    Sheen, I.S.5
  • 39
    • 0029880651 scopus 로고    scopus 로고
    • Toward cell-targeting gene therapy vectors: selection of cell-binding peptides from random peptide-presenting phage libraries
    • Barry, M.A., Dower, W.J. and Johnston, S.A. (1996) Toward cell-targeting gene therapy vectors: selection of cell-binding peptides from random peptide-presenting phage libraries. Nat. Med., 2, 299-305.
    • (1996) Nat. Med. , vol.2 , pp. 299-305
    • Barry, M.A.1    Dower, W.J.2    Johnston, S.A.3
  • 40
    • 0025112794 scopus 로고
    • Searching for peptide ligands with an epitope library
    • Scott, J.K. and Smith, G.P. (1990) Searching for peptide ligands with an epitope library. Science, 249, 386-390.
    • (1990) Science , vol.249 , pp. 386-390
    • Scott, J.K.1    Smith, G.P.2
  • 41
    • 0032557555 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia
    • Legeai-Mallet, L., Benoist-Lasselin, C., Delezoide, A.L., Munnich, A. and Bonaventure, J. (1998) Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia. J. Biol. Chem., 273, 13007-13014.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13007-13014
    • Legeai-Mallet, L.1    Benoist-Lasselin, C.2    Delezoide, A.L.3    Munnich, A.4    Bonaventure, J.5
  • 42
    • 14644394929 scopus 로고    scopus 로고
    • Cell responses to FGFR3 signalling: growth, differentiation and apoptosis
    • L'Hote, C.G. and Knowles, M.A. (2005) Cell responses to FGFR3 signalling: growth, differentiation and apoptosis. Exp. Cell Res., 304, 417-431.
    • (2005) Exp. Cell Res. , vol.304 , pp. 417-431
    • L'Hote, C.G.1    Knowles, M.A.2
  • 43
    • 38449096256 scopus 로고    scopus 로고
    • FGF signaling: its role in bone development and human skeleton diseases
    • Su, N., Du, X. and Chen, L. (2008) FGF signaling: its role in bone development and human skeleton diseases. Front. Biosci., 13, 2842-2865.
    • (2008) Front. Biosci. , vol.13 , pp. 2842-2865
    • Su, N.1    Du, X.2    Chen, L.3
  • 44
    • 0029917507 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    • Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A. and Leder, P. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell, 84, 911-921.
    • (1996) Cell , vol.84 , pp. 911-921
    • Deng, C.1    Wynshaw-Boris, A.2    Zhou, F.3    Kuo, A.4    Leder, P.5
  • 45
    • 0029928791 scopus 로고    scopus 로고
    • Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
    • Colvin, J.S., Bohne, B.A., Harding, G.W., McEwen, D.G. and Ornitz, D.M. (1996) Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat. Genet., 12, 390-397.
    • (1996) Nat. Genet. , vol.12 , pp. 390-397
    • Colvin, J.S.1    Bohne, B.A.2    Harding, G.W.3    McEwen, D.G.4    Ornitz, D.M.5
  • 46
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16 3;q32. 3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    • Chesi, M., Nardini, E., Brents, L.A., Schrock, E., Ried, T., Kuehl, W.M. and Bergsagel, P.L. (1997) Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat. Genet., 16, 260-264.
    • (1997) Nat. Genet. , vol.16 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3    Schrock, E.4    Ried, T.5    Kuehl, W.M.6    Bergsagel, P.L.7
  • 54
    • 77952523094 scopus 로고    scopus 로고
    • Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis
    • Su, N., Sun, Q., Li, C., Lu, X., Qi, H., Chen, S., Yang, J., Du, X., Zhao, L., He, Q. et al. (2010) Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. Hum. Mol. Genet., 19, 1199-1210.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 1199-1210
    • Su, N.1    Sun, Q.2    Li, C.3    Lu, X.4    Qi, H.5    Chen, S.6    Yang, J.7    Du, X.8    Zhao, L.9    He, Q.10
  • 55
    • 0029875398 scopus 로고    scopus 로고
    • Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor
    • Shukunami, C., Shigeno, C., Atsumi, T., Ishizeki, K., Suzuki, F. and Hiraki, Y. (1996) Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor. J. Cell Biol., 133, 457-468.
    • (1996) J. Cell Biol. , vol.133 , pp. 457-468
    • Shukunami, C.1    Shigeno, C.2    Atsumi, T.3    Ishizeki, K.4    Suzuki, F.5    Hiraki, Y.6
  • 56
    • 33646789792 scopus 로고    scopus 로고
    • Novel early target genes of parathyroid hormone-related peptide in chondrocytes
    • Hoogendam, J., Parlevliet, E., Miclea, R., Lowik, C.W., Wit, J.M. and Karperien, M. (2006) Novel early target genes of parathyroid hormone-related peptide in chondrocytes. Endocrinology, 147, 3141-3152.
    • (2006) Endocrinology , vol.147 , pp. 3141-3152
    • Hoogendam, J.1    Parlevliet, E.2    Miclea, R.3    Lowik, C.W.4    Wit, J.M.5    Karperien, M.6
  • 57
    • 0022552896 scopus 로고
    • Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
    • Farndale, R.W., Buttle, D.J. and Barrett, A.J. (1986) Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim. Biophys. Acta, 883, 173-177.
    • (1986) Biochim. Biophys. Acta , vol.883 , pp. 173-177
    • Farndale, R.W.1    Buttle, D.J.2    Barrett, A.J.3
  • 59
    • 0019126423 scopus 로고
    • Differential staining of cartilage and bone in whole mouse fetuses by Alcian blue and alizarin red S
    • McLeod, M.J. (1980) Differential staining of cartilage and bone in whole mouse fetuses by Alcian blue and alizarin red S. Teratology, 22, 299-301.
    • (1980) Teratology , vol.22 , pp. 299-301
    • McLeod, M.J.1


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