Immunogenicity of well-characterized synthetic Plasmodium falciparum multiple antigen peptide conjugates

Infection and Immunity

Volumn 69, Issue 8, 2001, Pages 4884-4890

  Joshi, M B ^a   Gam, A A ^a   Boykins, R A ^a   Kumar, S ^a   Sacci, J ^a   Hoffman, S L ^a   Nakasi, H L ^a   Kenney, R T ^a  

^a IOMAI Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; EPITOPE; IMMUNOGLOBULIN G; MALARIA VACCINE; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOASSAY; IMMUNOFLUORESCENCE TEST; IMMUNOGENICITY; MALARIA; MEROZOITE; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SPLEEN CELL; SPOROZOITE; STRAIN DIFFERENCE; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIBODY SPECIFICITY; ANTIGENS, PROTOZOAN; CELL DIVISION; CELLS, CULTURED; FEMALE; INTERFERON TYPE II; MALARIA VACCINES; MALARIA, FALCIPARUM; MEROZOITE SURFACE PROTEIN 1; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PEPTIDES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SPLEEN; T-LYMPHOCYTES; VACCINES, CONJUGATE;

EID: 0034921323     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.8.4884-4890.2001     Document Type: Article

References (52)

1. Immunogenicity of chimeric multiple antigen peptides based on Plasmodium falciparum antigens: Impact of epitope orientation
2. Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine
3. Synthesis and construction of a novel multiple peptide conjugate system: Strategy for a subunit vaccine design
4. Progress in the development of malaria vaccines: Context and constraints
5. 4)beta 1-Cer] and cholesterol-3-sulfate and its dependence on disulfide bond formation between cysteines in region II
6. Characterization of Plasmodium yoelii monoclonal antibodies directed against stage-specific sporozoite antigens
7. Immunization with a multiple antigen peptide containing defined B- and T-cell epitopes: Production of bactericidal antibodies against group B Neisseria meningitidis
8. T-cell immunity to peptide epitopes of liver-stage antigen 1 in an area of Papua New Guinea in which malaria is holoendemic
9. Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum
10. The complexity of protective immunity against liver-stage malaria
11. A new synthetic functionalized antigen carrier
12. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
13. Inhibition of development of exoerythrocytic forms of malaria parasites by gamma-interferon
14. The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from as well as at the determinant site
15. Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine
16. Peptide immunization can elicit malaria protein-specific memory, helper but not proliferative T cells
17. A liver-stage-specific antigen of Plasmodium falciparum characterized by gene cloning
18. Immunogenicity of multiple antigen peptides containing Plasmodium vivax CS epitopes in BALB/c mice
19. Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites
20. Toward clinical trials of DNA vaccines against malaria
21. The three major antigens on the surface of Plasmodium falciparum merozoites are derived from a single high molecular weight precursor
22. Merozoite surface protein 1, immune evasion, and vaccines against asexual blood stage malaria
23. Non-CS pre-erythrocytic protective antigens
24. Biology of malarial liver stages: Implications for vaccine design
25. Inhibition of entry of Plasmodium falciparum and P. vivax sporozoites into cultured cells; an in vitro assay of protective antibodies
26. Malaria vaccine development
27. Transmission-blocking vaccines: Uses and current status of development
28. Immunogenicity of Plasmodium falciparum circumsporozoite protein multiple antigen peptide vaccine formulated with different adjuvants
29. Immunization against the murine malaria parasite Plasmodium yoelii using a recombinant protein with adjuvants developed for clinical use
30. Linear and multiple antigen peptides containing defined T and B epitopes of the Plasmodium yoelii circumsporozoite protein: Antibody-mediated protection and boosting by sporozoite infection
31. IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an [L-arginine-dependent effector mechanism
32. Inhibitory activity of interferons and interleukin 1 on the development of Plasmodium falciparum in human hepatocyte cultures
33. Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice
34. The MAP system. A flexible and unambiguous vaccine design of branched peptides
35. Pre-erythrocytic malaria vaccine: Mechanisms of protective immunity and human vaccine trials
36. Plasmodium falciparum polyoximes: Highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein
37. T cell responses to pre-erythrocytic stages of malaria: Role in protection and vaccine development against pre-erythrocytic stages
38. The use of multiple antigen peptides in the analysis and induction of protective immune responses against infectious diseases
39. Phase I trial of the SPf66 malaria vaccine in a malaria-experienced population in Southeast Asia
40. Characterization of conserved T- and B-cell epitopes in Plasmodium falciparum major merozoite surface protein 1
41. Analysis of human T cell clones specific for conserved peptide sequences within malaria proteins. Paucity of clones responsive to intact parasites
42. Plasmodium falciparum CS C-terminal fragment: Preclinical evaluation and phase I clinical studies
43. Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine
44. Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules
45. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria
46. Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system
47. Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria
48. Genetic regulation of protective immune response in congenic strains of mice vaccinated with a subunit malaria vaccine
49. NYVAC-Pf7: A poxvirus-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria
50. Induction of protective polyclonal antibodies by immunization with a Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine
51. Structure of Plasmodium falciparum liver stage antigen-1