The basal body gene, RPGRIP1L, is a candidate tumour suppressor gene in human hepatocellular carcinoma

European Journal of Cancer

Volumn 45, Issue 11, 2009, Pages 2041-2049

  Lin, Ya Wen ^a   Yan, Ming De ^b   Shih, Yu Lueng ^a   Hsieh, Chung Bao ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Hepatocellular carcinoma; RPGRIP1L gene; Tumour suppressor gene

Indexed keywords

GENOMIC DNA; PROTEIN MAD2; SECURIN; SURVIVIN;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CHROMOSOME 16Q; CLINICAL ARTICLE; COLONY FORMATION; DNA EXTRACTION; DOWN REGULATION; GENE OVEREXPRESSION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MUTATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA INTERFERENCE; RPGRIP1L GENE; TUMOR GENE; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 16; CLONING, MOLECULAR; DNA MUTATIONAL ANALYSIS; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; LOSS OF HETEROZYGOSITY; MOLECULAR SEQUENCE DATA; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

EID: 67649510223     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2009.04.012     Document Type: Article

References (30)

1. Bosch F.X., Ribes J., Cleries R., and Diaz M. Epidemiology of hepatocellular carcinoma. Clin Liver Dis 9 2 (2005) 191-211
2. Buendia M.A. Genetic alterations in hepatoblastoma and hepatocellular carcinoma: common and distinctive aspects. Med Pediatr Oncol 39 5 (2002) 530-535
3. El-Serag H.B. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 127 5 Suppl. 1 (2004) S27-S34
4. Farazi P.A., and DePinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6 9 (2006) 674-687
5. Nagai H., Pineau P., Tiollais P., Buendia M.A., and Dejean A. Comprehensive allelotyping of human hepatocellular carcinoma. Oncogene 14 24 (1997) 2927-2933
6. Lin Y.W., Sheu J.C., Huang G.T., et al. Chromosomal abnormality in hepatocellular carcinoma by comparative genomic hybridisation in Taiwan. Eur J Cancer 35 4 (1999) 652-658
7. Lin Y.W., Lee I.N., Chen C.H., et al. Deletion mapping of chromosome 16q24 in hepatocellular carcinoma in Taiwan and mutational analysis of the 17-beta-HSD gene localized to the region. Int J Cancer 93 1 (2001) 74-79
8. Sheu J.C., Lin Y.W., Chou H.C., et al. Loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in Taiwan. Br J Cancer 80 3-4 (1999) 468-476
9. Laurent-Puig P., Legoix P., Bluteau O., et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 120 7 (2001) 1763-1773
10. Shih Y.L., Shyu R.Y., Hsieh C.B., et al. Promoter methylation of the secreted frizzled-related protein 1 gene SFRP1 is frequent in hepatocellular carcinoma. Cancer 107 3 (2006) 579-590
11. Jou Y.S., Lee C.S., Chang Y.H., et al. Clustering of minimal deleted regions reveals distinct genetic pathways of human hepatocellular carcinoma. Cancer Res 64 9 (2004) 3030-3036
12. De Souza A.T., Hankins G.R., Washington M.K., Fine R.L., Orton T.C., and Jirtle R.L. Frequent loss of heterozygosity on 6q at the mannose 6- phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene 10 9 (1995) 1725-1729
13. Fujimoto Y., Hampton L.L., Wirth P.J., Wang N.J., Xie J.P., and Thorgeirsson S.S. Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China [see comments]. Cancer Res 54 1 (1994) 281-285
14. Elo J.P., Harkonen P., Kyllonen A.P., Lukkarinen O., and Vihko P. Three independently deleted regions at chromosome arm 16q in human prostate cancer allelic loss at 16q241-q24.2 is associated with aggressive behaviour of the disease, recurrent growth, poor differentiation of the tumour and poor prognosis for the patient. Br J Cancer 79 1 (1999) 156-160
15. Nose H., Imazeki F., Ohto M., and Omata M. P53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan. Cancer 72 2 (1993) 355-360
16. Yeh S.H., Chen P.J., Chen H.L., Lai M.Y., Wang C.C., and Chen D.S. Frequent genetic alterations at the distal region of chromosome 1p in human hepatocellular carcinomas. Cancer Res 54 15 (1994) 4188-4192
17. Yeh S.H., Chen P.J., Lai M.Y., and Chen D.S. Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma: association with elevated alpha-fetoprotein production. Gastroenterology 110 1 (1996) 184-192
18. Yeh S.H., Chen P.J., Shau W.Y., et al. Chromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma. Gastroenterology 121 3 (2001) 699-709
19. Cleton-Jansen A.M., Moerland E.W., Kuipers-Dijkshoorn N.J., et al. At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer. Genes Chromosomes Cancer 9 2 (1994) 101-107
20. Lin Y.W., Lee H.S., Chen C.H., Huang G.T., Lee P.H., and Sheu J.C. Clonality analysis of multiple hepatocellular carcinomas by loss of heterozygosity pattern determined by chromosomes 16q and 13q. J Gastroenterol Hepatol 20 4 (2005) 536-546
21. Suzuki H., Komiya A., Emi M., et al. Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate cancers. Genes Chromosomes Cancer 17 4 (1996) 225-233
22. Bednarek A.K., Laflin K.J., Daniel R.L., Liao Q., Hawkins K.A., and Aldaz C.M. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q233-24.1, a region frequently affected in breast cancer. Cancer Res 60 8 (2000) 2140-2145
23. Arts H.H., Doherty D., van Beersum S.E., et al. Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome. Nat Genet 39 7 (2007) 882-888
24. Delous M., Baala L., Salomon R., et al. The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nat Genet 39 7 (2007) 875-881
25. van Deursen J.M. Rb loss causes cancer by driving mitosis mad. Cancer Cell 11 1 (2007) 1-3
26. Sotillo R., Hernando E., Diaz-Rodriguez E., et al. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11 1 (2007) 9-23 [Epub 2006 Dec 28]
27. Shih YL, Hsieh CB, Lai HC, et al. SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway. 2007;121(5):1028-35.
28. Lee A.Y., He B., You L., et al. Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Oncogene 23 39 (2004) 6672-6676
29. Kops G.J., Weaver B.A., and Cleveland D.W. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 5 10 (2005) 773-785
30. Weaver B.A., Silk A.D., Montagna C., Verdier-Pinard P., and Cleveland D.W. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11 1 (2007) 25-36