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Volumn 85, Issue 1, 2013, Pages 9-20

Novel lenalidomide-based combinations for treatment of multiple myeloma

Author keywords

Bone resorption; Combination therapies; IMiDs; Lenalidomide; Multiple myeloma; New drugs

Indexed keywords

AURORA KINASE INHIBITOR; AZACITIDINE; BEVACIZUMAB; BORTEZOMIB; CARFILZOMIB; CYCLIN DEPENDENT KINASE INHIBITOR; DACETUZUMAB; DELANZOMIB; DEXAMETHASONE; ELOTUZUMAB; EVEROLIMUS; IXAZOMIB; LENALIDOMIDE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PANOBINOSTAT; PAZOPANIB; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; POLO LIKE KINASE INHIBITOR; PROTEIN KINASE B INHIBITOR; ROMIDEPSIN; SALINOSPORAMIDE A; SORAFENIB; SUNITINIB; TANESPIMYCIN; THALIDOMIDE; TUBACIN; UNINDEXED DRUG; VANDETANIB; VORINOSTAT;

EID: 84870800589     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2012.06.008     Document Type: Review
Times cited : (11)

References (89)
  • 1
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • Kumar S.K., Rajkumar S.V., Dispenzieri A., et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 2008, 111(5):2516-2520.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2516-2520
    • Kumar, S.K.1    Rajkumar, S.V.2    Dispenzieri, A.3
  • 2
    • 34249945940 scopus 로고    scopus 로고
    • Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003
    • Kristinsson S.Y., Landgren O., Dickman P.W., Derolf A.R., Björkholm M. Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003. Journal of Clinical Oncology 2007, 25(15):1993-1999.
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.15 , pp. 1993-1999
    • Kristinsson, S.Y.1    Landgren, O.2    Dickman, P.W.3    Derolf, A.R.4    Björkholm, M.5
  • 3
    • 73349122918 scopus 로고    scopus 로고
    • Relapse/refractory myeloma patients: potential treatment guidelines
    • San Miguel J.F. Relapse/refractory myeloma patients: potential treatment guidelines. Journal of Clinical Oncology 2009, 27(34):5676-5677.
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.34 , pp. 5676-5677
    • San Miguel, J.F.1
  • 4
    • 77957958698 scopus 로고    scopus 로고
    • The potential of immunomodulatory drugs in the treatment of solid tumors
    • Dalgleish A., Galustian C. The potential of immunomodulatory drugs in the treatment of solid tumors. Future Oncology 2010, 6(9):1479-1484.
    • (2010) Future Oncology , vol.6 , Issue.9 , pp. 1479-1484
    • Dalgleish, A.1    Galustian, C.2
  • 7
    • 74249089972 scopus 로고    scopus 로고
    • Mechanism of action of immunomodulatory drugs (IMiDs) in multiple myeloma
    • Quach H., Ritchie D., Stewart A.K., et al. Mechanism of action of immunomodulatory drugs (IMiDs) in multiple myeloma. Leukemia 2010, 24:22-32.
    • (2010) Leukemia , vol.24 , pp. 22-32
    • Quach, H.1    Ritchie, D.2    Stewart, A.K.3
  • 8
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies F.E., Raje N., Hideshima T., et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001, 98(1):210-216.
    • (2001) Blood , vol.98 , Issue.1 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 9
    • 0033168605 scopus 로고    scopus 로고
    • Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha
    • Corral L.G., Haslett P.A., Muller G.W., et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha. Journal of Immunology 1999, 163:380-386.
    • (1999) Journal of Immunology , vol.163 , pp. 380-386
    • Corral, L.G.1    Haslett, P.A.2    Muller, G.W.3
  • 10
    • 0032726481 scopus 로고    scopus 로고
    • Immunomodulation by thalidomide and thalidomide analogues
    • Corral L.G., Kaplan G. Immunomodulation by thalidomide and thalidomide analogues. Annals of the Rheumatic Diseases 1999, 58(Suppl. 1):1107-1113.
    • (1999) Annals of the Rheumatic Diseases , vol.58 , Issue.SUPPL. 1 , pp. 1107-1113
    • Corral, L.G.1    Kaplan, G.2
  • 11
    • 0037093854 scopus 로고    scopus 로고
    • Protective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunity
    • Dredge K., Marriott J.B., Todryk S.M., et al. Protective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunity. Journal of Immunology 2002, 168(10):4914-4919.
    • (2002) Journal of Immunology , vol.168 , Issue.10 , pp. 4914-4919
    • Dredge, K.1    Marriott, J.B.2    Todryk, S.M.3
  • 12
    • 10744231369 scopus 로고    scopus 로고
    • Immunomodulatory drug costimulates T cells via the B7-CD28 pathway
    • LeBlanc R., Hideshima T., Catley L.P., et al. Immunomodulatory drug costimulates T cells via the B7-CD28 pathway. Blood 2004, 103(5):1787-1790.
    • (2004) Blood , vol.103 , Issue.5 , pp. 1787-1790
    • LeBlanc, R.1    Hideshima, T.2    Catley, L.P.3
  • 13
    • 0038476461 scopus 로고    scopus 로고
    • Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs
    • Schafer P.H., Gandhi A.K., Loveland M.A., et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. Journal of Pharmacology and Experimental Therapeutics 2003, 305(3):1222-1232.
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.305 , Issue.3 , pp. 1222-1232
    • Schafer, P.H.1    Gandhi, A.K.2    Loveland, M.A.3
  • 14
    • 0032100486 scopus 로고    scopus 로고
    • Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset
    • Haslett P.A., Corral L.G., Albert M., Kaplan G. Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset. Journal of Experimental Medicine 1998, 187:1885-1892.
    • (1998) Journal of Experimental Medicine , vol.187 , pp. 1885-1892
    • Haslett, P.A.1    Corral, L.G.2    Albert, M.3    Kaplan, G.4
  • 15
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells
    • Wu L., Adams M., Carter T., et al. Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells. Clinical Cancer Research 2008, 14:4650-4657.
    • (2008) Clinical Cancer Research , vol.14 , pp. 4650-4657
    • Wu, L.1    Adams, M.2    Carter, T.3
  • 16
    • 19944430437 scopus 로고    scopus 로고
    • Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application
    • Hayashi T., Hideshima T., Akiyama M., et al. Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application. British Journal of Haematology 2005, 128:192-203.
    • (2005) British Journal of Haematology , vol.128 , pp. 192-203
    • Hayashi, T.1    Hideshima, T.2    Akiyama, M.3
  • 17
    • 52549088421 scopus 로고    scopus 로고
    • Immunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation
    • Zhu D., Corral L.G., Fleming Y.W., Stein B. Immunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation. Cancer Immunology, Immunotherapy 2008, 57(12):1849-1859.
    • (2008) Cancer Immunology, Immunotherapy , vol.57 , Issue.12 , pp. 1849-1859
    • Zhu, D.1    Corral, L.G.2    Fleming, Y.W.3    Stein, B.4
  • 18
    • 83455220035 scopus 로고    scopus 로고
    • IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer versus multiple myeloma effect
    • Benson D.M., Bakan C.E., Zhang S., et al. IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer versus multiple myeloma effect. Blood 2011, 118(24):6387-6391.
    • (2011) Blood , vol.118 , Issue.24 , pp. 6387-6391
    • Benson, D.M.1    Bakan, C.E.2    Zhang, S.3
  • 19
    • 77957701558 scopus 로고    scopus 로고
    • The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal antibody anti-PD-1 antibody
    • Benson D.M., Bakan C.E., Mishra A., et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal antibody anti-PD-1 antibody. Blood 2010, 116(13):2286-2294.
    • (2010) Blood , vol.116 , Issue.13 , pp. 2286-2294
    • Benson, D.M.1    Bakan, C.E.2    Mishra, A.3
  • 20
    • 67349107194 scopus 로고    scopus 로고
    • The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells
    • Galustian C., Meyer B., Labarthe M.C., et al. The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunology, Immunotherapy 2009, 58(7):1033-1045.
    • (2009) Cancer Immunology, Immunotherapy , vol.58 , Issue.7 , pp. 1033-1045
    • Galustian, C.1    Meyer, B.2    Labarthe, M.C.3
  • 21
    • 30144444962 scopus 로고    scopus 로고
    • Dysfunctional T regulatory cells in multiple myeloma
    • Prabhala R.H., Neri P., Bae J.E., et al. Dysfunctional T regulatory cells in multiple myeloma. Blood 2006, 107(1):301-304.
    • (2006) Blood , vol.107 , Issue.1 , pp. 301-304
    • Prabhala, R.H.1    Neri, P.2    Bae, J.E.3
  • 22
    • 58849093606 scopus 로고    scopus 로고
    • CD4(+)CD25(+)FoxP3(+) regulatory T cells are increased whilst CD3(+)CD4(-)CD8(-) alphabeta TCR (+) double negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden
    • Feyler S., von Lilienfeld-Toal M., Jarmin S., et al. CD4(+)CD25(+)FoxP3(+) regulatory T cells are increased whilst CD3(+)CD4(-)CD8(-) alphabeta TCR (+) double negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden. British Journal of Haematology 2009, 144(5):686-695.
    • (2009) British Journal of Haematology , vol.144 , Issue.5 , pp. 686-695
    • Feyler, S.1    von Lilienfeld-Toal, M.2    Jarmin, S.3
  • 23
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
    • Richardson P.G., Schlossman R.L., Weller E., et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002, 100:3063-3067.
    • (2002) Blood , vol.100 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.L.2    Weller, E.3
  • 24
    • 0035958517 scopus 로고    scopus 로고
    • The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications
    • Hideshima T., Chauhan D., Schlossman R., Richardson P., Anderson K.C. The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene 2001, 20(33):4519-4527.
    • (2001) Oncogene , vol.20 , Issue.33 , pp. 4519-4527
    • Hideshima, T.1    Chauhan, D.2    Schlossman, R.3    Richardson, P.4    Anderson, K.C.5
  • 25
    • 10344264979 scopus 로고    scopus 로고
    • Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner
    • Payvandi F., Wu L., Haley M., et al. Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cellular Immunology 2004, 230(2):81-88.
    • (2004) Cellular Immunology , vol.230 , Issue.2 , pp. 81-88
    • Payvandi, F.1    Wu, L.2    Haley, M.3
  • 26
    • 52949102543 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise
    • Bernard M.P., Bancos S., Sime P.J., Phipps R.P. Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. Current Pharmaceutical Design 2008, 14(21):2051-2060.
    • (2008) Current Pharmaceutical Design , vol.14 , Issue.21 , pp. 2051-2060
    • Bernard, M.P.1    Bancos, S.2    Sime, P.J.3    Phipps, R.P.4
  • 27
    • 23044449530 scopus 로고    scopus 로고
    • A multicenter phase II trial of thalidomide and celecoxib for patients with relapsed and refractory multiple myeloma
    • Prince H.M., Mileshkin L., Roberts A., et al. A multicenter phase II trial of thalidomide and celecoxib for patients with relapsed and refractory multiple myeloma. Clinical Cancer Research 2005, 11(15):5504-5514.
    • (2005) Clinical Cancer Research , vol.11 , Issue.15 , pp. 5504-5514
    • Prince, H.M.1    Mileshkin, L.2    Roberts, A.3
  • 28
    • 27644591608 scopus 로고    scopus 로고
    • Properties of thalidomide and its analogues: implications for anticancer therapy
    • Teo S.K. Properties of thalidomide and its analogues: implications for anticancer therapy. AAPS Journal 2005, 7(1):E14-E19.
    • (2005) AAPS Journal , vol.7 , Issue.1
    • Teo, S.K.1
  • 29
    • 0037021257 scopus 로고    scopus 로고
    • Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects
    • Dredge K., Marriott J.B., Macdonald C.D., et al. Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects. British Journal of Cancer 2002, 87(10):1166-1172.
    • (2002) British Journal of Cancer , vol.87 , Issue.10 , pp. 1166-1172
    • Dredge, K.1    Marriott, J.B.2    Macdonald, C.D.3
  • 30
    • 79953300083 scopus 로고    scopus 로고
    • Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma
    • De Luisi A., Ferrucci A., Coluccia A.M.L., et al. Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma. Clinical Cancer Research 2011, 17(7):1935-1946.
    • (2011) Clinical Cancer Research , vol.17 , Issue.7 , pp. 1935-1946
    • De Luisi, A.1    Ferrucci, A.2    Coluccia, A.M.L.3
  • 31
    • 20144375457 scopus 로고    scopus 로고
    • Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro
    • Dredge K., Horsfall R., Robinson S.P., et al. Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro. Microvascular Research 2005, 69(1-2):56-63.
    • (2005) Microvascular Research , vol.69 , Issue.1-2 , pp. 56-63
    • Dredge, K.1    Horsfall, R.2    Robinson, S.P.3
  • 33
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
    • Hideshima T., Chauhan D., Shima Y., et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 2000, 96(9):2943-2950.
    • (2000) Blood , vol.96 , Issue.9 , pp. 2943-2950
    • Hideshima, T.1    Chauhan, D.2    Shima, Y.3
  • 34
    • 0037262242 scopus 로고    scopus 로고
    • Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo
    • Lentzsch S., LeBlanc R., Podar K., et al. Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo. Leukemia 2003, 17(1):41-44.
    • (2003) Leukemia , vol.17 , Issue.1 , pp. 41-44
    • Lentzsch, S.1    LeBlanc, R.2    Podar, K.3
  • 35
    • 0037097595 scopus 로고    scopus 로고
    • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications
    • Mitsiades N., Mitsiades C.S., Poulaki V., et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002, 99(12):4524-4530.
    • (2002) Blood , vol.99 , Issue.12 , pp. 4524-4530
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 36
    • 28844472902 scopus 로고    scopus 로고
    • Lenalidomide and thalidomide: mechanisms of action - similarities and differences
    • Anderson K.C. Lenalidomide and thalidomide: mechanisms of action - similarities and differences. Seminars in Hematology 2005, 42:S3-S8.
    • (2005) Seminars in Hematology , vol.42
    • Anderson, K.C.1
  • 37
    • 77950644007 scopus 로고    scopus 로고
    • Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function
    • Gandhi A.K., Kang J., Capone L., et al. Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function. Current Cancer Drug Targets 2010, 10(2):155-167.
    • (2010) Current Cancer Drug Targets , vol.10 , Issue.2 , pp. 155-167
    • Gandhi, A.K.1    Kang, J.2    Capone, L.3
  • 38
    • 70349739288 scopus 로고    scopus 로고
    • Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism
    • Escoubet-Lozach L., Lin I.L., Jensen-Pergakes K., et al. Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism. Cancer Research 2009, 69(18):7347-7356.
    • (2009) Cancer Research , vol.69 , Issue.18 , pp. 7347-7356
    • Escoubet-Lozach, L.1    Lin, I.L.2    Jensen-Pergakes, K.3
  • 39
    • 54049156803 scopus 로고    scopus 로고
    • Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
    • Breitkreutz I., Raab M.S., Vallet S., et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia 2008, 22(10):1925-1932.
    • (2008) Leukemia , vol.22 , Issue.10 , pp. 1925-1932
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3
  • 40
    • 33645736007 scopus 로고    scopus 로고
    • Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1
    • Anderson G., Gries M., Kurihara N., et al. Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1. Blood 2006, 107:3098-3105.
    • (2006) Blood , vol.107 , pp. 3098-3105
    • Anderson, G.1    Gries, M.2    Kurihara, N.3
  • 41
    • 63849262026 scopus 로고    scopus 로고
    • Bone resorbing cells in multiple myeloma: osteoclasts myeloma cell polykaryons, or both?
    • Silvestris F., Ciavarella S., De Matteo M., Tucci M., Dammacco F. Bone resorbing cells in multiple myeloma: osteoclasts myeloma cell polykaryons, or both?. Oncologist 2009, 14(3):264-275.
    • (2009) Oncologist , vol.14 , Issue.3 , pp. 264-275
    • Silvestris, F.1    Ciavarella, S.2    De Matteo, M.3    Tucci, M.4    Dammacco, F.5
  • 43
    • 79956110813 scopus 로고    scopus 로고
    • Biological aspects of altered bone remodeling in multiple myeloma and possibilities of pharmacological intervention
    • Kupisiewicz K. Biological aspects of altered bone remodeling in multiple myeloma and possibilities of pharmacological intervention. Danish Medical Bulletin 2011, 58(5):B4277.
    • (2011) Danish Medical Bulletin , vol.58 , Issue.5
    • Kupisiewicz, K.1
  • 44
    • 78649714233 scopus 로고    scopus 로고
    • Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies
    • Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Reviews 2010, 24(S1):27-32.
    • (2010) Blood Reviews , vol.24 , Issue.S1 , pp. 27-32
    • Morgan, G.1
  • 46
    • 52049104695 scopus 로고    scopus 로고
    • CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma
    • Hsi E.D., Steinle R., Balasa B., et al. CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma. Clinical Cancer Research 2008, 14(9):2775-2784.
    • (2008) Clinical Cancer Research , vol.14 , Issue.9 , pp. 2775-2784
    • Hsi, E.D.1    Steinle, R.2    Balasa, B.3
  • 47
    • 66149133630 scopus 로고    scopus 로고
    • CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells
    • Tai Y.T., Soydan E., Song W., et al. CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells. Blood 2009, 113(18):4309-4318.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4309-4318
    • Tai, Y.T.1    Soydan, E.2    Song, W.3
  • 48
    • 51649083849 scopus 로고    scopus 로고
    • Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
    • Tai Y.T., Dillon M., Song W., et al. Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. Blood 2008, 112(4):1329-1337.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1329-1337
    • Tai, Y.T.1    Dillon, M.2    Song, W.3
  • 49
    • 84863919927 scopus 로고    scopus 로고
    • Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma
    • [E-pub ahead of print]
    • Lonial S., Vij R., Harousseau J.L., et al. Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma. Journal of Clinical Oncology 2012, [E-pub ahead of print].
    • (2012) Journal of Clinical Oncology
    • Lonial, S.1    Vij, R.2    Harousseau, J.L.3
  • 50
    • 84858295098 scopus 로고    scopus 로고
    • Phase 2 study of elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma
    • Richardson P., Moreau P., Jakubowiak A., et al. Phase 2 study of elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma. Haematologica 2011, 96(S1):S106.
    • (2011) Haematologica , vol.96 , Issue.S1
    • Richardson, P.1    Moreau, P.2    Jakubowiak, A.3
  • 51
    • 80051772478 scopus 로고    scopus 로고
    • Dacetuzumab (SGN-40), lenalidomide, and weekly dexamethasone in relapsed or refractory multiple myeloma: multiple responses observed in a phase Ib study
    • ASH annual meeting abstracts
    • Agura E., Niesvizky R., Matous J., et al. Dacetuzumab (SGN-40), lenalidomide, and weekly dexamethasone in relapsed or refractory multiple myeloma: multiple responses observed in a phase Ib study. Blood 2009, 114:2870.
    • (2009) Blood , vol.114 , pp. 2870
    • Agura, E.1    Niesvizky, R.2    Matous, J.3
  • 52
    • 79251581902 scopus 로고    scopus 로고
    • Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab
    • van der Veer M.S., de Weers M., van Kessel B., et al. Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab. Haematologica 2011, 96(2):284-290.
    • (2011) Haematologica , vol.96 , Issue.2 , pp. 284-290
    • van der Veer, M.S.1    de Weers, M.2    van Kessel, B.3
  • 53
    • 84870854229 scopus 로고    scopus 로고
    • A phase I trial of IPH-2101, a novel anti-inhibitory KIR antibody, in patients with multiple myeloma
    • Benson D., Bakan C., Hofmeister C., et al. A phase I trial of IPH-2101, a novel anti-inhibitory KIR antibody, in patients with multiple myeloma. Haematologica 2011, 96(S1):S87.
    • (2011) Haematologica , vol.96 , Issue.S1
    • Benson, D.1    Bakan, C.2    Hofmeister, C.3
  • 55
    • 77952313238 scopus 로고    scopus 로고
    • Cancer-testis antigens MAGE-C1/CT7 and MAGE-A3 promote the survival of multiple myeloma cells
    • Atanackovic D., Hildebrandt Y., Jadczak A., et al. Cancer-testis antigens MAGE-C1/CT7 and MAGE-A3 promote the survival of multiple myeloma cells. Haematologica 2010, 95(5):785-793.
    • (2010) Haematologica , vol.95 , Issue.5 , pp. 785-793
    • Atanackovic, D.1    Hildebrandt, Y.2    Jadczak, A.3
  • 57
    • 84865813072 scopus 로고    scopus 로고
    • Lenalidomide decreases PD-1 expression, depletes regulatory T-cells and improves cellular response to a multiple myeloma/dendritic cell fusion vaccine in vitro
    • ASH annual meeting abstracts
    • Luptakova K., Glotzbecker B., Mills H., et al. Lenalidomide decreases PD-1 expression, depletes regulatory T-cells and improves cellular response to a multiple myeloma/dendritic cell fusion vaccine in vitro. Blood 2010, 116:492.
    • (2010) Blood , vol.116 , pp. 492
    • Luptakova, K.1    Glotzbecker, B.2    Mills, H.3
  • 58
    • 56449107803 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab combined with low dose dexamethasone and lenalidomide (BEV/REV/DEX) for relapsed or refractory myeloma (MM)
    • ASH annual meeting abstracts
    • Raschko M., Markovina S., Miyamoto S., et al. Phase II trial of bevacizumab combined with low dose dexamethasone and lenalidomide (BEV/REV/DEX) for relapsed or refractory myeloma (MM). Blood 2007, 110:1173.
    • (2007) Blood , vol.110 , pp. 1173
    • Raschko, M.1    Markovina, S.2    Miyamoto, S.3
  • 59
    • 80052269008 scopus 로고    scopus 로고
    • The addition of bevacizumab (B) to lenalidomide and low dose dexamethasone does not significantly increase response in relapsed or refractory multiple myeloma (NCI#7317)
    • ASH annual meeting abstracts
    • Callander N.S., Markovina S., Juckett M.B., et al. The addition of bevacizumab (B) to lenalidomide and low dose dexamethasone does not significantly increase response in relapsed or refractory multiple myeloma (NCI#7317). Blood 2009, 114:3885.
    • (2009) Blood , vol.114 , pp. 3885
    • Callander, N.S.1    Markovina, S.2    Juckett, M.B.3
  • 60
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • Weber D.M., Chen C., Niesvizky R., et al. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. New England Journal of Medicine 2007, 357(21):2133-2142.
    • (2007) New England Journal of Medicine , vol.357 , Issue.21 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 61
    • 80053483270 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment: focus on angiogenesis
    • Fan F., Schimming A., Jaeger D., Podar K. Targeting the tumor microenvironment: focus on angiogenesis. Journal of Oncology 2012, 2012:281261.
    • (2012) Journal of Oncology , vol.2012 , pp. 281261
    • Fan, F.1    Schimming, A.2    Jaeger, D.3    Podar, K.4
  • 62
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • Richardson P.G., Weller E., Jagannath S., et al. Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. Journal of Clinical Oncology 2009, 27(34):5713-5719.
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.34 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3
  • 63
    • 77957996812 scopus 로고    scopus 로고
    • Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies
    • Dimopoulos M.A., Kastritis E., Christoulas D., et al. Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies. Leukemia 2010, 24(10):1769-1778.
    • (2010) Leukemia , vol.24 , Issue.10 , pp. 1769-1778
    • Dimopoulos, M.A.1    Kastritis, E.2    Christoulas, D.3
  • 64
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson P.G., Weller E., Lonial S., et al. Lenalidomide, bortezomib and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010, 116(5):679-686.
    • (2010) Blood , vol.116 , Issue.5 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 65
    • 84870803871 scopus 로고    scopus 로고
    • Phase 1b/2 dose-ranging study of carfilzomib (cfz) in combination with lenalidomide (len) and dexamethasone (lodex) in relapsed-refractory multiple myeloma (R/R MM)
    • Niesvizky R., Bensinger W., Martin T., et al. Phase 1b/2 dose-ranging study of carfilzomib (cfz) in combination with lenalidomide (len) and dexamethasone (lodex) in relapsed-refractory multiple myeloma (R/R MM). Haematologica 2011, 96(S1):S91.
    • (2011) Haematologica , vol.96 , Issue.S1
    • Niesvizky, R.1    Bensinger, W.2    Martin, T.3
  • 66
    • 84870857055 scopus 로고    scopus 로고
    • ®), and low dose dexamethasone is highly active in newly diagnosed multiple myeloma (MM): phase I/II MMRC study
    • ®), and low dose dexamethasone is highly active in newly diagnosed multiple myeloma (MM): phase I/II MMRC study. Haematologica 2011, 96(S1):S106.
    • (2011) Haematologica , vol.96 , Issue.S1
    • Jakubowiak, A.J.1    Dytfeld, D.2    Griffith, K.3
  • 67
    • 84864557601 scopus 로고    scopus 로고
    • Tumor-specific histone signature and DNA methylation in multiple myeloma and leukemia cells
    • Foltankova V., Legartova S., Kozubek S., Bartova E. Tumor-specific histone signature and DNA methylation in multiple myeloma and leukemia cells. Neoplasma 2012, 59(4):450-462.
    • (2012) Neoplasma , vol.59 , Issue.4 , pp. 450-462
    • Foltankova, V.1    Legartova, S.2    Kozubek, S.3    Bartova, E.4
  • 68
    • 78651350825 scopus 로고    scopus 로고
    • The DAC system and associations with multiple myeloma
    • Ocio E.M., San Miguel J.F. The DAC system and associations with multiple myeloma. Investigational New Drugs 2010, 28(S1):S28-S35.
    • (2010) Investigational New Drugs , vol.28 , Issue.S1
    • Ocio, E.M.1    San Miguel, J.F.2
  • 69
    • 77952306482 scopus 로고    scopus 로고
    • In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma
    • Ocio E.M., Vilanova D., Atadja P., et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica 2010, 95(5):794-803.
    • (2010) Haematologica , vol.95 , Issue.5 , pp. 794-803
    • Ocio, E.M.1    Vilanova, D.2    Atadja, P.3
  • 70
    • 79960663588 scopus 로고    scopus 로고
    • Phase Ib study of oral panobinostat (LBH589) plus lenalidomide (LEN) plus dexamethasone (DEX) in patients (Pts) with relapsed (Rel) or rel and refractory (Ref) multiple myeloma (MM)
    • Mateos M., Spencer A., Taylor K., et al. Phase Ib study of oral panobinostat (LBH589) plus lenalidomide (LEN) plus dexamethasone (DEX) in patients (Pts) with relapsed (Rel) or rel and refractory (Ref) multiple myeloma (MM). Journal of Clinical Oncology 2010, 28(15S):8030.
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.15 S , pp. 8030
    • Mateos, M.1    Spencer, A.2    Taylor, K.3
  • 71
    • 79960690495 scopus 로고    scopus 로고
    • Phase I study of combined vorinostat (V), lenalidomide (L), and dexamethasone (D) in patients (pts) with relapsed or refractory multiple myeloma (MM)
    • Richardson P.G., Weber D.M., Mitsiades C.S., et al. Phase I study of combined vorinostat (V), lenalidomide (L), and dexamethasone (D) in patients (pts) with relapsed or refractory multiple myeloma (MM). Journal of Clinical Oncology 2010, 28(15S):8031.
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.15 S , pp. 8031
    • Richardson, P.G.1    Weber, D.M.2    Mitsiades, C.S.3
  • 72
    • 84859637209 scopus 로고    scopus 로고
    • Interest of the association azacitidine-lenalidomide as frontline therapy in high-risk myelodysplasia or acute myeloid leukemia with complex karyotype
    • Scherman E., Malak S., Perot C., Gorin N.C., Rubio M.T., Isnard F. Interest of the association azacitidine-lenalidomide as frontline therapy in high-risk myelodysplasia or acute myeloid leukemia with complex karyotype. Leukemia 2012, 26(4):822-824.
    • (2012) Leukemia , vol.26 , Issue.4 , pp. 822-824
    • Scherman, E.1    Malak, S.2    Perot, C.3    Gorin, N.C.4    Rubio, M.T.5    Isnard, F.6
  • 73
    • 78650405873 scopus 로고    scopus 로고
    • Demonstration of additional benefit in adding lenalidomide to azacitidine in patients with higher-risk myelodysplastic syndromes
    • Sekeres M.A., O'Keefe C., List A.F., et al. Demonstration of additional benefit in adding lenalidomide to azacitidine in patients with higher-risk myelodysplastic syndromes. American Journal of Hematology 2011, 86(1):102-103.
    • (2011) American Journal of Hematology , vol.86 , Issue.1 , pp. 102-103
    • Sekeres, M.A.1    O'Keefe, C.2    List, A.F.3
  • 74
    • 79959610128 scopus 로고    scopus 로고
    • Utility of mTOR inhibition in hematologic malignancies
    • Younes A., Samad N. Utility of mTOR inhibition in hematologic malignancies. Oncologist 2011, 16(6):730-741.
    • (2011) Oncologist , vol.16 , Issue.6 , pp. 730-741
    • Younes, A.1    Samad, N.2
  • 75
    • 10244260355 scopus 로고    scopus 로고
    • Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma
    • Raje N., Kumar S., Hideshima T., et al. Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma. Blood 2004, 104(13):4188-4193.
    • (2004) Blood , vol.104 , Issue.13 , pp. 4188-4193
    • Raje, N.1    Kumar, S.2    Hideshima, T.3
  • 76
    • 78649705825 scopus 로고    scopus 로고
    • Results of a phase I study of RAD001 in combination with lenalidomide in patients with relapsed or refractory multiple myeloma
    • ASCO annual meeting proceedings
    • Mahindra A.K., Richardson P.G., Hari P., et al. Results of a phase I study of RAD001 in combination with lenalidomide in patients with relapsed or refractory multiple myeloma. Journal of Clinical Oncology 2010, 15S:8032.
    • (2010) Journal of Clinical Oncology , vol.15 S , pp. 8032
    • Mahindra, A.K.1    Richardson, P.G.2    Hari, P.3
  • 77
    • 80052756653 scopus 로고    scopus 로고
    • Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein
    • Hofmeister C.C., Yang X., Pichiorri F., et al. Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein. Journal of Clinical Oncology 2011, 29(25):3427-3434.
    • (2011) Journal of Clinical Oncology , vol.29 , Issue.25 , pp. 3427-3434
    • Hofmeister, C.C.1    Yang, X.2    Pichiorri, F.3
  • 78
    • 84856020250 scopus 로고    scopus 로고
    • Evidence does not support clinically significant lenalidomide-CCI-779 interaction via P-glycoprotein
    • Chen N., Kassera C., Kumar G., Palmisano M. Evidence does not support clinically significant lenalidomide-CCI-779 interaction via P-glycoprotein. Journal of Clinical Oncology 2012, 30(3):340-341.
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.3 , pp. 340-341
    • Chen, N.1    Kassera, C.2    Kumar, G.3    Palmisano, M.4
  • 79
    • 33646577479 scopus 로고    scopus 로고
    • Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
    • Hideshima T., Catley L., Yasui H., et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood 2006, 107(10):4053-4062.
    • (2006) Blood , vol.107 , Issue.10 , pp. 4053-4062
    • Hideshima, T.1    Catley, L.2    Yasui, H.3
  • 80
    • 52649101930 scopus 로고    scopus 로고
    • Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors
    • David E., Sinha R., Chen J., Sun S.Y., Kaufman J.L., Lonial S. Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors. Clinical Cancer Research 2008, 14(16):5090-5098.
    • (2008) Clinical Cancer Research , vol.14 , Issue.16 , pp. 5090-5098
    • David, E.1    Sinha, R.2    Chen, J.3    Sun, S.Y.4    Kaufman, J.L.5    Lonial, S.6
  • 81
    • 60349129511 scopus 로고    scopus 로고
    • A multiple myeloma research consortium (MMRC) multicenter phase I trial of perifosine (KRX-0401) in combination with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma (MM): updated results
    • ASH annual meeting abstracts
    • Jakubowiak A., Zimmerman T., Alsina M., et al. A multiple myeloma research consortium (MMRC) multicenter phase I trial of perifosine (KRX-0401) in combination with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma (MM): updated results. Blood 2007, 110:1169.
    • (2007) Blood , vol.110 , pp. 1169
    • Jakubowiak, A.1    Zimmerman, T.2    Alsina, M.3
  • 82
    • 84865833457 scopus 로고    scopus 로고
    • Final phase I results of perifosine in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma (MM)
    • ASH annual meeting abstracts
    • Jakubowiak A.J., Richardson P.G., Zimmermen T.D., et al. Final phase I results of perifosine in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma (MM). Blood 2010, 116:3064.
    • (2010) Blood , vol.116 , pp. 3064
    • Jakubowiak, A.J.1    Richardson, P.G.2    Zimmermen, T.D.3
  • 84
    • 79551615800 scopus 로고    scopus 로고
    • The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy
    • Hsu A.K., Quach H., Tai T., et al. The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood 2011, 117(5):1605-1613.
    • (2011) Blood , vol.117 , Issue.5 , pp. 1605-1613
    • Hsu, A.K.1    Quach, H.2    Tai, T.3
  • 85
    • 77950644007 scopus 로고    scopus 로고
    • Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor cell growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function
    • Gandhi A.K., Kang J., Capone L., et al. Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor cell growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function. Current Cancer Drug Targets 2010, 10(2):155-167.
    • (2010) Current Cancer Drug Targets , vol.10 , Issue.2 , pp. 155-167
    • Gandhi, A.K.1    Kang, J.2    Capone, L.3
  • 86
    • 79551641781 scopus 로고    scopus 로고
    • How " immunomodulatory" are IMiDs?
    • Mitsiades C.S. How " immunomodulatory" are IMiDs?. Blood 2011, 117(5):1440-1441.
    • (2011) Blood , vol.117 , Issue.5 , pp. 1440-1441
    • Mitsiades, C.S.1
  • 87
    • 77952314963 scopus 로고    scopus 로고
    • Novel drugs for the treatment of multiple myeloma
    • Bladè J., Cibeira M.T., Rosiñol L. Novel drugs for the treatment of multiple myeloma. Haematologica 2010, 95(5):702-704.
    • (2010) Haematologica , vol.95 , Issue.5 , pp. 702-704
    • Bladè, J.1    Cibeira, M.T.2    Rosiñol, L.3
  • 88
    • 84860741220 scopus 로고    scopus 로고
    • Lenalidomide in myeloma - a high-maintenance friend
    • Badros A.Z. Lenalidomide in myeloma - a high-maintenance friend. New England Journal of Medicine 2012, 366(19):1836-1838.
    • (2012) New England Journal of Medicine , vol.366 , Issue.19 , pp. 1836-1838
    • Badros, A.Z.1
  • 89
    • 70450230539 scopus 로고    scopus 로고
    • Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
    • Dimopoulos M.A., Chen C., Spencer A., et al. Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma. Leukemia 2009, 23(11):2147-2152.
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 2147-2152
    • Dimopoulos, M.A.1    Chen, C.2    Spencer, A.3


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