메뉴 건너뛰기




Volumn 88, Issue 4, 2012, Pages 279-291

Lenalidomide in multiple myeloma: Current experimental and clinical data

Author keywords

Immunomodulatory drugs; Lenalidomide; Multiple myeloma; Osteoclastogenesis

Indexed keywords

BORTEZOMIB; CARFILZOMIB; CLARITHROMYCIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DACETUZUMAB; DEXAMETHASONE; DOXORUBICIN; ELOTUZUMAB; GRANULOCYTE COLONY STIMULATING FACTOR; I KAPPA B; LENALIDOMIDE; MELPHALAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLACEBO; PREDNISONE; THALIDOMIDE; VINCRISTINE;

EID: 84858283875     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2011.01735.x     Document Type: Review
Times cited : (18)

References (72)
  • 3
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
    • Richardson PG, Schlossman RL, Weller E, et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002;100:3063-7.
    • (2002) Blood , vol.100 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.L.2    Weller, E.3
  • 4
    • 19944430437 scopus 로고    scopus 로고
    • Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application
    • Hayashi T, Hideshima T, Akiyama M, et al. Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application. Br J Haematol 2005;128:192-203.
    • (2005) Br J Haematol , vol.128 , pp. 192-203
    • Hayashi, T.1    Hideshima, T.2    Akiyama, M.3
  • 5
    • 0034331194 scopus 로고    scopus 로고
    • Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
    • Hideshima T, Chauhan D, Shima Y, et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 2000;96:2943-50.
    • (2000) Blood , vol.96 , pp. 2943-2950
    • Hideshima, T.1    Chauhan, D.2    Shima, Y.3
  • 8
    • 54049156803 scopus 로고    scopus 로고
    • Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
    • Breitkreutz J, Raab MS, Vallet S, et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia 2006;22:1925-32.
    • (2006) Leukemia , vol.22 , pp. 1925-1932
    • Breitkreutz, J.1    Raab, M.S.2    Vallet, S.3
  • 9
    • 63849262026 scopus 로고    scopus 로고
    • Bone resorbing cells in multiple myeloma: osteoclasts, myeloma cell polycaryons or both?
    • Silvestris F, Ciavarella S, De Matteo M, Tucci M, Dammacco F. Bone resorbing cells in multiple myeloma: osteoclasts, myeloma cell polycaryons or both? Oncologist 2009;14:264-75.
    • (2009) Oncologist , vol.14 , pp. 264-275
    • Silvestris, F.1    Ciavarella, S.2    De Matteo, M.3    Tucci, M.4    Dammacco, F.5
  • 10
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Roodman GD. Mechanisms of bone metastasis. N Engl J Med 2004;350:1655-64.
    • (2004) N Engl J Med , vol.350 , pp. 1655-1664
    • Roodman, G.D.1
  • 13
    • 78650310780 scopus 로고    scopus 로고
    • Epithelial plasticity, cancer stem cells and bone metastasis formation
    • Van Der Pluijm G. Epithelial plasticity, cancer stem cells and bone metastasis formation. Bone 2011;48:37-43.
    • (2011) Bone , vol.48 , pp. 37-43
    • Van Der Pluijm, G.1
  • 15
    • 0003234481 scopus 로고    scopus 로고
    • Results of phase I study of CC-5013 for the treatment of multiple myeloma (MM) patients who relapse after high dose chemotherapy (HDCT)
    • Zangari M, Tricot G, Zeldis J, Eddlemon P, Saghafifar F, Barlogie B. Results of phase I study of CC-5013 for the treatment of multiple myeloma (MM) patients who relapse after high dose chemotherapy (HDCT). Blood (ASH Annual Meeting Abstracts) 2001;98:775.
    • (2001) Blood (ASH Annual Meeting Abstracts) , vol.98 , pp. 775
    • Zangari, M.1    Tricot, G.2    Zeldis, J.3    Eddlemon, P.4    Saghafifar, F.5    Barlogie, B.6
  • 16
    • 33646560823 scopus 로고    scopus 로고
    • A multicenter, single-arm, open-label study to evaluate the efficacy and safety of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma; preliminary results
    • Richardson P, Jagannath S, Hussein M, et al. A multicenter, single-arm, open-label study to evaluate the efficacy and safety of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma; preliminary results. Blood (ASH Annual Meeting Abstracts) 2005;106:1565.
    • (2005) Blood (ASH Annual Meeting Abstracts) , vol.106 , pp. 1565
    • Richardson, P.1    Jagannath, S.2    Hussein, M.3
  • 17
    • 33750607347 scopus 로고    scopus 로고
    • A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
    • Richardson PG, Blood E, Mitsiades CS, et al. A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Blood 2006;108:3458-64.
    • (2006) Blood , vol.108 , pp. 3458-3464
    • Richardson, P.G.1    Blood, E.2    Mitsiades, C.S.3
  • 18
    • 43049096682 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexamethasone for relapsed multiple myeloma in North America
    • Weber DM, Chen C, Niesvizky R, et al. Lenalidomide plus high-dose dexamethasone for relapsed multiple myeloma in North America. N Engl J Med 2007;22:357.
    • (2007) N Engl J Med , vol.22 , pp. 357
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 19
    • 33748940534 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexamethasone provides improved overall survival compared to high-dose dexamethasone alone for relapsed or refractory multiple myeloma (MM): results of a North American phase III study (MM-009), 2006 ASCO Annual Meeting Proceedings Part I
    • Weber DM, Chen C, Niesvizky R, Wang M, Belch A, Stadtmauer E, Yu Z, Olesnyckyj M, Zeldis J, Knight R. Lenalidomide plus high-dose dexamethasone provides improved overall survival compared to high-dose dexamethasone alone for relapsed or refractory multiple myeloma (MM): results of a North American phase III study (MM-009), 2006 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2006;24(18 Suppl):7521.
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL. , pp. 7521
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3    Wang, M.4    Belch, A.5    Stadtmauer, E.6    Yu, Z.7    Olesnyckyj, M.8    Zeldis, J.9    Knight, R.10
  • 20
    • 36349023319 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
    • Dimopoulos M, Spencer A, Attal M, et al. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. New Engl J Med 2007;357:2123-32.
    • (2007) New Engl J Med , vol.357 , pp. 2123-2132
    • Dimopoulos, M.1    Spencer, A.2    Attal, M.3
  • 21
    • 43049086661 scopus 로고    scopus 로고
    • Lenalidomide in the treatment of multiple myeloma: a review
    • Armoiry X, Aulagner G, Facon T. Lenalidomide in the treatment of multiple myeloma: a review. J Clin Pharm Ther 2008;33:219-26.
    • (2008) J Clin Pharm Ther , vol.33 , pp. 219-226
    • Armoiry, X.1    Aulagner, G.2    Facon, T.3
  • 22
    • 70450230539 scopus 로고    scopus 로고
    • Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
    • Dimopoulos MA, Chen C, Spencer A, et al. Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma. Leukemia 2009;23:2147-52.
    • (2009) Leukemia , vol.23 , pp. 2147-2152
    • Dimopoulos, M.A.1    Chen, C.2    Spencer, A.3
  • 23
    • 77957774888 scopus 로고    scopus 로고
    • Better quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcomes in patients with relapsed or refractory multiple myeloma
    • Harousseau JL, Dimopoulos MA, Wang M, et al. Better quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcomes in patients with relapsed or refractory multiple myeloma. Haematologica 2010;95:1738-44.
    • (2010) Haematologica , vol.95 , pp. 1738-1744
    • Harousseau, J.L.1    Dimopoulos, M.A.2    Wang, M.3
  • 24
    • 79953716823 scopus 로고    scopus 로고
    • Effects of lenalidomide and dexamethasone treatment duration on survival in patients with relapsed or refractory multiple myeloma treated with lenalidomide and dexamethasone
    • San-Miguel JF, Dimopoulos MA, Stadtmauer EA, et al. Effects of lenalidomide and dexamethasone treatment duration on survival in patients with relapsed or refractory multiple myeloma treated with lenalidomide and dexamethasone. Clin Lymphoma Myeloma Leuk 2011;11:38-43.
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , pp. 38-43
    • San-Miguel, J.F.1    Dimopoulos, M.A.2    Stadtmauer, E.A.3
  • 25
    • 79960725350 scopus 로고    scopus 로고
    • Phase III intergroup study of lenalidomide versus placebo maintenance therapy following single autologous stem cell transplant (ASCT) for multiple myeloma (MM): CALGB ECOG BMT-CTN 100104
    • McCarthy P, Owzar K, Anderson K, et al. Phase III intergroup study of lenalidomide versus placebo maintenance therapy following single autologous stem cell transplant (ASCT) for multiple myeloma (MM): CALGB ECOG BMT-CTN 100104. Haematologica 2011;96(S1):S23.
    • (2011) Haematologica , vol.96 , Issue.S1
    • McCarthy, P.1    Owzar, K.2    Anderson, K.3
  • 26
    • 80053246543 scopus 로고    scopus 로고
    • Maintenance treatment with lenalidomide after transplantation for myeloma: analysis of secondary malignancies within the IFM 2005-02 trial
    • Attal M, Olivier P, Cances Lauwers V, et al. Maintenance treatment with lenalidomide after transplantation for myeloma: analysis of secondary malignancies within the IFM 2005-02 trial. Haematologica 2011;96(S1):S23.
    • (2011) Haematologica , vol.96 , Issue.S1
    • Attal, M.1    Olivier, P.2    Cances Lauwers, V.3
  • 27
    • 79957447588 scopus 로고    scopus 로고
    • A phase 3 study evaluating the efficacy and safety of lenalidomide combined with melphalan and prednisone in patients ≥65years with newly diagnosed multiple myeloma (NDMM): continuous use of lenalidomide vs fixed-duration regimens
    • Palumbo A, Delforge M, Catalano J, et al. A phase 3 study evaluating the efficacy and safety of lenalidomide combined with melphalan and prednisone in patients ≥65years with newly diagnosed multiple myeloma (NDMM): continuous use of lenalidomide vs fixed-duration regimens. Blood (ASH Annual Meeting Abstracts) 2010;116:622.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 622
    • Palumbo, A.1    Delforge, M.2    Catalano, J.3
  • 28
    • 84555171507 scopus 로고    scopus 로고
    • Incidence of second primary malignancy (SPM) in melphalan-prednisone-lenalidomide combination followed by lenalidomide maintenance (MPR-R) in newly diagnosed multiple myeloma patients (pts) age 65 or older
    • Palumbo A, Delforge M, Catalano J, Hajek R, Kropff M, Petrucci MT, Yu Z, Mei JM, Dimopoulos MA. Incidence of second primary malignancy (SPM) in melphalan-prednisone-lenalidomide combination followed by lenalidomide maintenance (MPR-R) in newly diagnosed multiple myeloma patients (pts) age 65 or older. J Clin Oncol 2011;29:8007.
    • (2011) J Clin Oncol , vol.29 , pp. 8007
    • Palumbo, A.1    Delforge, M.2    Catalano, J.3    Hajek, R.4    Kropff, M.5    Petrucci, M.T.6    Yu, Z.7    Mei, J.M.8    Dimopoulos, M.A.9
  • 29
    • 58149384555 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapse or refractory multiple myeloma regardless of prior thalidomide exposure
    • Wang M, Dimopoulos MA, Chen C, et al. Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapse or refractory multiple myeloma regardless of prior thalidomide exposure. Blood 2008;112:4445-51.
    • (2008) Blood , vol.112 , pp. 4445-4451
    • Wang, M.1    Dimopoulos, M.A.2    Chen, C.3
  • 30
    • 66149109580 scopus 로고    scopus 로고
    • Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom)
    • Knop S, Gerecke C, Liebisch P, et al. Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom). Blood 2009;113:4137-43.
    • (2009) Blood , vol.113 , pp. 4137-4143
    • Knop, S.1    Gerecke, C.2    Liebisch, P.3
  • 31
    • 33845350847 scopus 로고    scopus 로고
    • Lenalidomide and pegylated liposomal -based chemotherapy for relapsed or refractory multiple myeloma: safety and efficacy
    • Baz R, Walker E, Karam MA, et al. Lenalidomide and pegylated liposomal -based chemotherapy for relapsed or refractory multiple myeloma: safety and efficacy. Ann Oncol 2006;17:1766-71.
    • (2006) Ann Oncol , vol.17 , pp. 1766-1771
    • Baz, R.1    Walker, E.2    Karam, M.A.3
  • 32
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • Richardson PG, Weller E, Jagannath S, et al. Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. J Clin Oncol 2009;27:5713-9.
    • (2009) J Clin Oncol , vol.27 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3
  • 33
    • 77957996812 scopus 로고    scopus 로고
    • Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies
    • Dimopoulos MA, Kastritis E, Christoulas D, et al. Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies. Leukemia 2010;24:1769-78.
    • (2010) Leukemia , vol.24 , pp. 1769-1778
    • Dimopoulos, M.A.1    Kastritis, E.2    Christoulas, D.3
  • 34
    • 73349122918 scopus 로고    scopus 로고
    • Relapse/refractory myeloma patient: potential treatment guidelines
    • San Miguel JF. Relapse/refractory myeloma patient: potential treatment guidelines. J Clin Oncol 2009;27:5676-7.
    • (2009) J Clin Oncol , vol.27 , pp. 5676-5677
    • San Miguel, J.F.1
  • 35
    • 77952429928 scopus 로고    scopus 로고
    • Lenalidomide, melphalan, prednisone and thalidomide (RMPT) for relapsed/refractory multiple myeloma
    • Palumbo A, Larocca A, Falco P, et al. Lenalidomide, melphalan, prednisone and thalidomide (RMPT) for relapsed/refractory multiple myeloma. Leukemia 2010;24:1037-42.
    • (2010) Leukemia , vol.24 , pp. 1037-1042
    • Palumbo, A.1    Larocca, A.2    Falco, P.3
  • 36
    • 27744492561 scopus 로고    scopus 로고
    • Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
    • Rajkumar SV, Hayman SR, Lacy MQ, et al. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood 2005;106:4050-3.
    • (2005) Blood , vol.106 , pp. 4050-4053
    • Rajkumar, S.V.1    Hayman, S.R.2    Lacy, M.Q.3
  • 37
    • 41349122600 scopus 로고    scopus 로고
    • Superiority of lenalidomide (len) plus high-dose dexamethasone (HD) compared to HD alone as treatment of newly-diagnosed multiple myeloma (NDMM): results of the randomized, double-blinded, placebo-controlled SWOG trial S0232
    • Zonder JA, Crowley J, Hussein MA, Bolejack V, Moore DF, Whittenberger BF, Abidi MH, Durie BGM, Barlogie B. Superiority of lenalidomide (len) plus high-dose dexamethasone (HD) compared to HD alone as treatment of newly-diagnosed multiple myeloma (NDMM): results of the randomized, double-blinded, placebo-controlled SWOG trial S0232. Blood 2007;110:77.
    • (2007) Blood , vol.110 , pp. 77
    • Zonder, J.A.1    Crowley, J.2    Hussein, M.A.3    Bolejack, V.4    Moore, D.F.5    Whittenberger, B.F.6    Abidi, M.H.7    Durie, B.G.M.8    Barlogie, B.9
  • 38
    • 34548138921 scopus 로고    scopus 로고
    • Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma
    • Kumar S, Dispenzieri A, Lacy MQ, et al. Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma. Leukemia 2007;21:2035-42.
    • (2007) Leukemia , vol.21 , pp. 2035-2042
    • Kumar, S.1    Dispenzieri, A.2    Lacy, M.Q.3
  • 39
    • 76249096571 scopus 로고    scopus 로고
    • How I treat multiple myeloma in younger patients
    • Stewart KA, Richardson PG, San Miguel JF. How I treat multiple myeloma in younger patients. Blood 2009;114:5436-43.
    • (2009) Blood , vol.114 , pp. 5436-5443
    • Stewart, K.A.1    Richardson, P.G.2    San Miguel, J.F.3
  • 40
    • 18544390035 scopus 로고    scopus 로고
    • Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis
    • Koh KR, Janz M, Mapara MY, Lemke B, Stirling D, Dörken B, Zenke M, Lentzsch S. Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis. Blood 2005;105:3833-40.
    • (2005) Blood , vol.105 , pp. 3833-3840
    • Koh, K.R.1    Janz, M.2    Mapara, M.Y.3    Lemke, B.4    Stirling, D.5    Dörken, B.6    Zenke, M.7    Lentzsch, S.8
  • 41
    • 70349260793 scopus 로고    scopus 로고
    • Mobilization in myeloma revisited: IMWG consensus perspectives on stem cell collection following initial therapy with thalidomide-, lenalidomide-, or bortezomib-containing regimens
    • Kumar S, Giralt S, Stadtmauer EA, et al. Mobilization in myeloma revisited: IMWG consensus perspectives on stem cell collection following initial therapy with thalidomide-, lenalidomide-, or bortezomib-containing regimens. Blood 2009;114:1729-35.
    • (2009) Blood , vol.114 , pp. 1729-1735
    • Kumar, S.1    Giralt, S.2    Stadtmauer, E.A.3
  • 42
    • 67349243088 scopus 로고    scopus 로고
    • Impairment of filgrastim-induced stem cell mobilization after prior lenalidomide in patients with multiple myeloma
    • Popat U, Saliba R, Thandi R, et al. Impairment of filgrastim-induced stem cell mobilization after prior lenalidomide in patients with multiple myeloma. Biol Blood Marrow Transplant 2009;15:718-23.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 718-723
    • Popat, U.1    Saliba, R.2    Thandi, R.3
  • 43
    • 80054018501 scopus 로고    scopus 로고
    • Stem cell mobilization in patients with newly diagnosed multiple myeloma after lenalidomide induction therapy
    • Cavallo F, Bringhen S, Milone G, et al. Stem cell mobilization in patients with newly diagnosed multiple myeloma after lenalidomide induction therapy. Leukemia 2011;25:1627-31.
    • (2011) Leukemia , vol.25 , pp. 1627-1631
    • Cavallo, F.1    Bringhen, S.2    Milone, G.3
  • 44
    • 85027917175 scopus 로고    scopus 로고
    • Stem cell collection in patients with multiple myeloma: impact of induction therapy and mobilization regimen
    • Nazha A, Cook R, Vogl DT, et al. Stem cell collection in patients with multiple myeloma: impact of induction therapy and mobilization regimen. Bone Marrow Transplant 2011;46:59-63.
    • (2011) Bone Marrow Transplant , vol.46 , pp. 59-63
    • Nazha, A.1    Cook, R.2    Vogl, D.T.3
  • 45
    • 79952536052 scopus 로고    scopus 로고
    • Plerixafor (Mozobil) for stem cell mobilization in patients with multiple myeloma previously treated with lenalidomide
    • Micallef IN, Ho AD, Klein LM, Marulkar S, Gandhi PJ, McSweeney PA. Plerixafor (Mozobil) for stem cell mobilization in patients with multiple myeloma previously treated with lenalidomide. Bone Marrow Transplant 2011;46:350-5.
    • (2011) Bone Marrow Transplant , vol.46 , pp. 350-355
    • Micallef, I.N.1    Ho, A.D.2    Klein, L.M.3    Marulkar, S.4    Gandhi, P.J.5    McSweeney, P.A.6
  • 46
    • 73249146496 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial
    • Rajkumar SV, Jacobus S, Callander NS, Fonseca R, Vesole DH, Williams ME, Abonour R, Siegel DS, Katz M, Greipp PR. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial. Lancet Oncol 2010;11:29-37.
    • (2010) Lancet Oncol , vol.11 , pp. 29-37
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.S.3    Fonseca, R.4    Vesole, D.H.5    Williams, M.E.6    Abonour, R.7    Siegel, D.S.8    Katz, M.9    Greipp, P.R.10
  • 47
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, et al. Lenalidomide, bortezomib and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010;116:679-86.
    • (2010) Blood , vol.116 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 48
    • 35348923502 scopus 로고    scopus 로고
    • Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA-Italian Multiple Myeloma Network
    • Palumbo A, Falco P, Corradini P, et al. Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA-Italian Multiple Myeloma Network. J Clin Oncol 2007;25:4459-65.
    • (2007) J Clin Oncol , vol.25 , pp. 4459-4465
    • Palumbo, A.1    Falco, P.2    Corradini, P.3
  • 49
    • 67650657867 scopus 로고    scopus 로고
    • Melphalan, Prednisone, and Lenalidomide for newly diagnosed myeloma: kinetics of neutropenia and thrombocytopenia and time-to-event results
    • Palumbo A, Falco P, Falcone A, et al. Melphalan, Prednisone, and Lenalidomide for newly diagnosed myeloma: kinetics of neutropenia and thrombocytopenia and time-to-event results. Clin Lymphoma Myeloma 2009;9:145-50.
    • (2009) Clin Lymphoma Myeloma , vol.9 , pp. 145-150
    • Palumbo, A.1    Falco, P.2    Falcone, A.3
  • 50
    • 14944374754 scopus 로고    scopus 로고
    • Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice
    • Ohara T, Morishita T, Suzuki H, Masaoka T, Ishii H, Hibi T. Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice. Anticancer Res 2004;24:3723-30.
    • (2004) Anticancer Res , vol.24 , pp. 3723-3730
    • Ohara, T.1    Morishita, T.2    Suzuki, H.3    Masaoka, T.4    Ishii, H.5    Hibi, T.6
  • 53
    • 38949216066 scopus 로고    scopus 로고
    • Biaxin® [clarithromycin]/Revlimid® [lenalidomide]/dexamethasone combination therapy results in high complete- and overall-response rates in treatment-naïve symptomatic multiple myeloma
    • Niesvizky R, Jayabalan DS, Christos PJ, et al. Biaxin® [clarithromycin]/Revlimid® [lenalidomide]/dexamethasone combination therapy results in high complete- and overall-response rates in treatment-naïve symptomatic multiple myeloma. Blood 2008;111:1101-9.
    • (2008) Blood , vol.111 , pp. 1101-1109
    • Niesvizky, R.1    Jayabalan, D.S.2    Christos, P.J.3
  • 54
    • 77649215631 scopus 로고    scopus 로고
    • Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients
    • Palumbo A, Gay F, Falco P, et al. Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients. J Clin Oncol 2010;28:800-7.
    • (2010) J Clin Oncol , vol.28 , pp. 800-807
    • Palumbo, A.1    Gay, F.2    Falco, P.3
  • 57
    • 77649222186 scopus 로고    scopus 로고
    • Patterns of improved survival in patients with multiple myeloma in the twenty-first century: a population-based study
    • Tueresson I, Velez R, Kristinsson SY, Landgren O. Patterns of improved survival in patients with multiple myeloma in the twenty-first century: a population-based study. J Clin Oncol 2009;28:830-4.
    • (2009) J Clin Oncol , vol.28 , pp. 830-834
    • Tueresson, I.1    Velez, R.2    Kristinsson, S.Y.3    Landgren, O.4
  • 58
    • 0014955268 scopus 로고
    • Multiple myeloma and acute myelomonocytic leukemia
    • Kyle RA, Pierre RV, Bayrd ED. Multiple myeloma and acute myelomonocytic leukemia. N Engl J Med 1970;283:1121-5.
    • (1970) N Engl J Med , vol.283 , pp. 1121-1125
    • Kyle, R.A.1    Pierre, R.V.2    Bayrd, E.D.3
  • 59
    • 0023198180 scopus 로고
    • A comparison of the incidence of the myelodysplastic syndrome and acute myeloid leukaemia following melphalan and cyclophosphamide treatment for myelomatosis. A report to the Medical Research Council's working party on leukaemia in adults
    • Cuzick J, Erskine S, Edelman D, Galton DA. A comparison of the incidence of the myelodysplastic syndrome and acute myeloid leukaemia following melphalan and cyclophosphamide treatment for myelomatosis. A report to the Medical Research Council's working party on leukaemia in adults. Br J Cancer 1987;55:523-9.
    • (1987) Br J Cancer , vol.55 , pp. 523-529
    • Cuzick, J.1    Erskine, S.2    Edelman, D.3    Galton, D.A.4
  • 61
    • 79551646037 scopus 로고    scopus 로고
    • Associations between multiple myeloma and other malignancies
    • Landgren O, Polliack A, Tadmor T. Associations between multiple myeloma and other malignancies. Leuk Lymphoma 2011;52:161-2.
    • (2011) Leuk Lymphoma , vol.52 , pp. 161-162
    • Landgren, O.1    Polliack, A.2    Tadmor, T.3
  • 64
    • 79960663588 scopus 로고    scopus 로고
    • Phase Ib study of oral panobinostat (LBH589) plus lenalidomide (LEN) plus dexamethasone (DEX) in patients (Pts) with relapsed (Rel) or rel and refractory (Ref) multiple myeloma (MM)
    • Mateos M, Spencer A, Taylor K, Lonial S, De La Rubia J, Facon T, Bengoudifa B, Hazell K, Bourquelot M, San-Miguel JF. Phase Ib study of oral panobinostat (LBH589) plus lenalidomide (LEN) plus dexamethasone (DEX) in patients (Pts) with relapsed (Rel) or rel and refractory (Ref) multiple myeloma (MM). J Clin Oncol 2010;28(15 Suppl):8030.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL. , pp. 8030
    • Mateos, M.1    Spencer, A.2    Taylor, K.3    Lonial, S.4    De La Rubia, J.5    Facon, T.6    Bengoudifa, B.7    Hazell, K.8    Bourquelot, M.9    San-Miguel, J.F.10
  • 65
    • 0038784379 scopus 로고    scopus 로고
    • CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling
    • Tai YT, Podar K, Mitsiades N, et al. CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling. Blood 2003;101:2762-9.
    • (2003) Blood , vol.101 , pp. 2762-2769
    • Tai, Y.T.1    Podar, K.2    Mitsiades, N.3
  • 68
    • 84858284550 scopus 로고    scopus 로고
    • Phase I study of elotuzumab plus lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma
    • Lonial S, Vij R, Facon T, et al. Phase I study of elotuzumab plus lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma. Haematologica 2011;96(S1):S103.
    • (2011) Haematologica , vol.96 , Issue.S1
    • Lonial, S.1    Vij, R.2    Facon, T.3
  • 69
    • 84858295098 scopus 로고    scopus 로고
    • Phase 2 study of elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma
    • Richardson P, Moreau P, Jakubowiak A, et al. Phase 2 study of elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma. Haematologica 2011;96(S1):S106.
    • (2011) Haematologica , vol.96 , Issue.S1
    • Richardson, P.1    Moreau, P.2    Jakubowiak, A.3
  • 70
  • 72
    • 77954660886 scopus 로고    scopus 로고
    • Bortezomib, dexamethasone, cyclophosphamide and lenalidomide combination for newly diagnosed multiple myeloma: phase 1 results from the multicenter EVOLUTION study
    • Kumar S, Flinn IW, Noga SJ, et al. Bortezomib, dexamethasone, cyclophosphamide and lenalidomide combination for newly diagnosed multiple myeloma: phase 1 results from the multicenter EVOLUTION study. Leukemia 2010;24:1350-6.
    • (2010) Leukemia , vol.24 , pp. 1350-1356
    • Kumar, S.1    Flinn, I.W.2    Noga, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.