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Volumn 12, Issue 5, 2012, Pages 560-567

Possible role of GLP-1 and its agonists in the treatment of type 1 diabetes mellitus

Author keywords

GLP 1; Glucagon; Glycemic control; Insulin; Type 1 diabetesmellitus

Indexed keywords

ARGININE; C PEPTIDE; EXENDIN 4; GASTRIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCAGON LIKE PEPTIDE 2; GLUCOSE; INSULIN; LISOFYLLINE; LYMPHOCYTE ANTIBODY; PLACEBO;

EID: 84870787581     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-012-0291-6     Document Type: Article
Times cited : (13)

References (78)
  • 1
    • 84944484435 scopus 로고
    • Mechanism of pancreatic secretion
    • Bayliss WM, Starling EH. Mechanism of pancreatic secretion. J Physiol. 1902;28:235-334.
    • (1902) J Physiol , vol.28 , pp. 235-334
    • Bayliss, W.M.1    Starling, E.H.2
  • 2
    • 0000103499 scopus 로고
    • Is a duodenal hormone involved in carbohydrate metabolism?
    • Loew ER, Gray JS, Ivy AC. Is a duodenal hormone involved in carbohydrate metabolism? Am J Physiol. 1940;129:659-63.
    • (1940) Am J Physiol , vol.129 , pp. 659-663
    • Loew, E.R.1    Gray, J.S.2    Ivy, A.C.3
  • 3
    • 15044356921 scopus 로고
    • The effect of duodenal instillation of hydrochloric acid upon the fasting blood sugar of dogs
    • Loew ER, Gray JS, Ivy AC. The effect of duodenal instillation of hydrochloric acid upon the fasting blood sugar of dogs. Am J Physiol. 1939;126:270-6.
    • (1939) Am J Physiol , vol.126 , pp. 270-276
    • Loew, E.R.1    Gray, J.S.2    Ivy, A.C.3
  • 4
    • 15044366202 scopus 로고
    • The effect of acid stimulation of the duodenum upon experimental hyperglycemia and utilization of glucose
    • Loew ER, Gray JS, Ivy AC. The effect of acid stimulation of the duodenum upon experimental hyperglycemia and utilization of glucose. Am J Physiol. 1940;128:298-308.
    • (1940) Am J Physiol , vol.128 , pp. 298-308
    • Loew, E.R.1    Gray, J.S.2    Ivy, A.C.3
  • 5
    • 33845344395 scopus 로고
    • Plasma insulin responses to oral and intravenous glucose administration
    • Elrick H, Stimmler L, Hlad CJ, Arai Y. Plasma insulin responses to oral and intravenous glucose administration. J Clin Endocrinol Metab. 1964;24:1076-82.
    • (1964) J Clin Endocrinol Metab , vol.24 , pp. 1076-1082
    • Elrick, H.1    Stimmler, L.2    Hlad, C.J.3    Arai, Y.4
  • 6
    • 0002294149 scopus 로고
    • New interpretation of oral glucose tolerance
    • Mcintryre N, Holdsworth CD, Turner DA. New interpretation of oral glucose tolerance. Lancet. 1964;II:20-1.
    • (1964) Lancet , vol.2 , pp. 20-21
    • McIntryre, N.1    Holdsworth, C.D.2    Turner, D.A.3
  • 7
    • 0015015451 scopus 로고
    • A gastric inhibitory polypeptide. I. The amino acid composition and the tryptic peptides
    • Brown JC. A gastric inhibitory polypeptide. I. The amino acid composition and the tryptic peptides. Can J Biochem. 1971;49:255-61.
    • (1971) Can J Biochem , vol.49 , pp. 255-261
    • Brown, J.C.1
  • 8
    • 0015103223 scopus 로고
    • A gastric inhibitory polypeptide. II. The complete amino acid sequence
    • Brown JC, Dryburgh Jr. A gastric inhibitory polypeptide. II. The complete amino acid sequence. Can J Biochem. 1971;49:867-72.
    • (1971) Can J Biochem , vol.49 , pp. 867-872
    • Brown, J.C.1    Dryburgh, J.R.2
  • 9
    • 0014811685 scopus 로고
    • Further purification of a polypeptide demonstrating enterogastrone activity
    • Brown JC, Mutt V, Pederson RA. Further purification of a polypeptide demonstrating enterogastrone activity. J Physiol. 1970; 209:57-64.
    • (1970) J Physiol , vol.209 , pp. 57-64
    • Brown, J.C.1    Mutt, V.2    Pederson, R.A.3
  • 10
    • 0015791989 scopus 로고
    • Stimulation of insulin secretion by gastric inhibitory polypeptide in man
    • Dupreo J, Ross SA, Watson D, Brown JC. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab. 1973;37:826-28.
    • (1973) J Clin Endocrinol Metab , vol.37 , pp. 826-828
    • Dupreo, J.1    Ross, S.A.2    Watson, D.3    Brown, J.C.4
  • 11
    • 0020535282 scopus 로고
    • Exon duplication and divergence in the human preproglucagon gene
    • Bell GI, Sanchez-Pescador R, Laybourn PJ, Najarian RC. Exon duplication and divergence in the human preproglucagon gene. Nature. 1983;304:368-71. (Pubitemid 13072761)
    • (1983) Nature , vol.304 , Issue.5924 , pp. 368-371
    • Bell, G.I.1    Sanchez Pescador, R.2    Laybourn, P.J.3    Najarian, R.C.4
  • 12
    • 0022389280 scopus 로고
    • Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets
    • DOI 10.1007/BF00291980
    • Schmidt WE, Siegel EG, Creutzfeldt W. Glucagonlike peptide-1 but not glucagon-like-peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia. 1985;28:704-7. (Pubitemid 16226411)
    • (1985) Diabetologia , vol.28 , Issue.9 , pp. 704-707
    • Schmidt, W.E.1    Siegel, E.G.2    Creutzfeldt, W.3
  • 13
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • Mojsov S, Weir GC, Habener JF. Insulinotropin glucagon-like peptide-1 (7-36): co-encoded in the glucagons gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest. 1987;79:616-19. (Pubitemid 17009701)
    • (1987) Journal of Clinical Investigation , vol.79 , Issue.2 , pp. 616-619
    • Mojsov, S.1    Weir, G.C.2    Habener, J.F.3
  • 14
    • 0035512742 scopus 로고    scopus 로고
    • Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
    • Meier JJ, Hucking K, Holst JJ, Deacon CF, Schmiegel WH, Nauck MA. Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes. 2001;50:2497-504. (Pubitemid 33642767)
    • (2001) Diabetes , vol.50 , Issue.7-12 , pp. 2497-2504
    • Meier, J.J.1    Hucking, K.2    Holst, J.J.3    Deacon, C.F.4    Schmiegel, W.H.5    Nauck, M.A.6
  • 15
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type- 2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest. 1993;91:301-7. (Pubitemid 23037285)
    • (1993) Journal of Clinical Investigation , vol.91 , Issue.1 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 18
    • 0035095031 scopus 로고    scopus 로고
    • Monounsaturated fatty acid diets improve glycemic tolerance through increased secretion of glucagon-like peptide-1
    • DOI 10.1210/en.142.3.1148
    • Rocca AS, Lagreca J, Kalitsky J, Brubaker PL. Monounsaturated fatty acid diets improve glycemic tolerance through increased secretion of glucagon-like peptide-1. Endocrinology. 2001;142:1148-55. (Pubitemid 32202825)
    • (2001) Endocrinology , vol.142 , Issue.3 , pp. 1148-1155
    • Rocca, A.S.1    Lagreca, J.2    Kalitsky, J.3    Brubaker, P.L.4
  • 19
    • 0037371203 scopus 로고    scopus 로고
    • Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes
    • Thomsen C, Storm H, Holst JJ, Hermansen K. Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes. Am J Clin Nutr. 2003;77:605-11. (Pubitemid 36258569)
    • (2003) American Journal of Clinical Nutrition , vol.77 , Issue.3 , pp. 605-611
    • Thomsen, C.1    Storm, H.2    Holst, J.J.3    Hermansen, K.4
  • 20
    • 0016755040 scopus 로고
    • The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat
    • Sakurai H, Dobbs RE, Unger RH. The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat. Diabetologia. 1975;11:427-30.
    • (1975) Diabetologia , vol.11 , pp. 427-430
    • Sakurai, H.1    Dobbs, R.E.2    Unger, R.H.3
  • 21
    • 0016826560 scopus 로고
    • Glucose, insulin, pancreatic glucagon and glucagon-like immunoreactive materials in the plasma of normal and diabetic children. Effect of the initial insulin treatment
    • Matsuyama T, Hoffman WH, Dunbar JC, Foa NL, Foa PP. Glucose, insulin, pancreatic glucagon and glucagon-like immunoreactive materials in the plasma of normal and diabetic children. Effect of the initial insulin treatment. Horm Metab Res. 1975; 7:452-6.
    • (1975) Horm Metab Res , vol.7 , pp. 452-456
    • Matsuyama, T.1    Hoffman, W.H.2    Dunbar, J.C.3    Foa, N.L.4    Foa, P.P.5
  • 22
    • 0031034854 scopus 로고    scopus 로고
    • Rapid oscillations in plasma glucagon-like peptide-1 (GLP-1) in humans: Cholinergic control of GLP-1 secretion via muscarinic receptors
    • DOI 10.1210/jc.82.3.786
    • Balks HJ, Holst JJ. Von Zur Muhlen A, Brabant G. Rapid oscillations in plasma glucagon-like peptide-1 (GLP-1) in humans: cholinergic control of GLP-1 secretion via muscarinic receptors. J Clin Endocrinol Metab. 1997;82:786-90. (Pubitemid 27106588)
    • (1997) Journal of Clinical Endocrinology and Metabolism , vol.82 , Issue.3 , pp. 786-790
    • Balks, H.J.1    Holst, J.J.2    Von Zur Muhlen, A.3    Brabant, G.4
  • 23
    • 0028791530 scopus 로고
    • Regulation of glucagon-like peptide-1-(7-36) amide, peptide YY, and neurotensin secretion by neurotransmitters and gut hormones in the isolated vascularly perfused rat ileum
    • Dumoulin V, Dakka T, Plaisancie P, Chayvialle JA, Cuber JC. Regulation of glucagon-like peptide-1-(7-36) amide, peptide YY, and neurotensin secretion by neurotransmitters and gut hormones in the isolated vascularly perfused rat ileum. Endocrinology. 1995;136:5182-88.
    • (1995) Endocrinology , vol.136 , pp. 5182-5188
    • Dumoulin, V.1    Dakka, T.2    Plaisancie, P.3    Chayvialle, J.A.4    Cuber, J.C.5
  • 24
    • 0019446118 scopus 로고
    • Chromatographic pattern of extrapancreatic glucagon and glucagon-like immunoreactivity before and during stimulation by epinephrine and participation of glucagon in epinephrine-induced hepatic glucose overproduction
    • Lickley HL, Kemmer FW, Gray DE, et al. Chromatographic pattern of extrapancreatic glucagons and glucagon-like immunoreactivity before and during stimulation by epinephrine and participation of glucagons in epinephrine-induced hepatic glucose overproduction. Surgery. 1981;90:186-94. (Pubitemid 11047229)
    • (1981) Surgery , vol.90 , Issue.2 , pp. 186-194
    • Lickley, H.L.A.1    Kemmer, F.W.2    Gray, D.E.3
  • 27
    • 0019122810 scopus 로고
    • Insulin secretory reserve in insulin dependent patients at time of diagnosis and the first 180 days of insulin treatment
    • Madsbad S, Krarup T, Regeur L, Faber OK, Binder C. Insulin secretory reserve in insulin dependent patients at time of diagnosis and the first 180 days of insulin treatment. Acta Endocrinol (Copenh). 1980;95:359-63. (Pubitemid 11211731)
    • (1980) Acta Endocrinologica , vol.95 , Issue.3 , pp. 359-363
    • Madsbad, S.1    Krarup, T.2    Regeur, L.3
  • 28
    • 0020659187 scopus 로고
    • Prevalence of residual B cell function and its metabolic consequences in type 1 (insulin-dependent) diabetes
    • Madsbad S. Prevalence of residual B cell function and its metabolic consequences in Type 1 (insulin-dependent) diabetes. Diabetologia. 1983;24:141-7. (Pubitemid 13147816)
    • (1983) Diabetologia , vol.24 , Issue.3 , pp. 141-147
    • Madsbad, S.1
  • 29
    • 0028883204 scopus 로고
    • Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM
    • Dinneen S, Alzaid A, Turk D, Rizza R. Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM. Diabetologia. 1995;38:337-43.
    • (1995) Diabetologia , vol.38 , pp. 337-343
    • Dinneen, S.1    Alzaid, A.2    Turk, D.3    Rizza, R.4
  • 30
    • 0036224872 scopus 로고    scopus 로고
    • Impaired β-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose
    • Greenbaum CJ, Prigeon RL, D'Alessio DA. Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose. Diabetes. 2002;51:951-7. (Pubitemid 34438336)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 951-957
    • Greenbaum, C.J.1    Prigeon, R.L.2    D'Alessio, D.A.3
  • 31
    • 0033765237 scopus 로고    scopus 로고
    • Effect of nutrient ingestion on glucagon-like peptide 1 (7-36 amide) secretion in human type 1 and type 2 diabetes
    • Lugari R, Dell'Anna C, Ugolotti D, et al. Effect of nutrient ingestion on glucagon-like peptide 1 (7-36 amide) secretion in human type 1 and type 2 diabetes. Horm Metab Res. 2000; 32:424-8.
    • (2000) Horm Metab Res , vol.32 , pp. 424-428
    • Lugari, R.1    Dell'Anna, C.2    Ugolotti, D.3
  • 33
    • 77952755033 scopus 로고    scopus 로고
    • Elevated serum DPP4 activity in type 1 diabetes mellitus: A direct comparison
    • Varga T, Firneisz G, Nagy G, Somogyi A. Elevated serum DPP4 activity in type 1 diabetes mellitus: a direct comparison. Orv Hetil 2010 151: 899-902.
    • (2010) Orv Hetil , vol.151 , pp. 899-902
    • Varga, T.1    Firneisz, G.2    Nagy, G.3    Somogyi, A.4
  • 34
    • 0029954211 scopus 로고    scopus 로고
    • Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide i (7-36) amide in type i diabetic patients
    • Creutzfeldt WO, Kleine N, Willms B, Orskov C, Holst JJ, Nauck MA. Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I (7-36) amide in type I diabetic patients. Diabetes Care. 1996;19:580-6.
    • (1996) Diabetes Care , vol.19 , pp. 580-586
    • Creutzfeldt, W.O.1    Kleine, N.2    Willms, B.3    Orskov, C.4    Holst, J.J.5    Nauck, M.A.6
  • 35
    • 16344374278 scopus 로고    scopus 로고
    • Glucagon-like peptide 1(GLP-1) in biology and pathology
    • DOI 10.1002/dmrr.538
    • Meier JJ, Nauck MA. Glucagon-like peptide 1(GLP-1) in biology and pathology. Diabetes Metab Res Rev. 2005;21:91-117. (Pubitemid 40467658)
    • (2005) Diabetes/Metabolism Research and Reviews , vol.21 , Issue.2 , pp. 91-117
    • Meier, J.J.1    Nauck, M.A.2
  • 36
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus
    • GutniakM, Orskov C, Holst JJ, Ahren B, Efendic S. Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus. N Engl J Med. 1992; 326:1316-22.
    • (1992) N Engl J Med , vol.326 , pp. 1316-1322
    • Gutniakm Orskov, C.1    Holst, J.J.2    Ahren, B.3    Efendic, S.4
  • 37
    • 0029033945 scopus 로고
    • Glucagon-like peptide i reduces postprandial glycemic excursions in IDDM
    • Dupre J, Behme MT, Hramiak IM, et al. Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM. Diabetes. 1995;44:626-30.
    • (1995) Diabetes , vol.44 , pp. 626-630
    • Dupre, J.1    Behme, M.T.2    Hramiak, I.M.3
  • 38
    • 0031035778 scopus 로고    scopus 로고
    • Subcutaneous glucagon-like peptide I combined with insulin normalizes postcibal glycemic excursions in IDDM
    • Dupre J, Behme MT, Hramiak IM, McDonald TJ. Subcutaneous glucagon-like peptide I combined with insulin normalizes postcibal glycemic excursions in IDDM. Diabetes Care. 1997;20:381-4. (Pubitemid 27098228)
    • (1997) Diabetes Care , vol.20 , Issue.3 , pp. 381-384
    • Dupre, J.1    Behme, M.T.2    Hramiak, I.M.3    Mcdonald, T.J.4
  • 39
    • 1842598583 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 improved glycemic control in type 1 diabetes
    • Behme MT, Dupre J, McDonald TJ. Glucagon-like peptide 1 improved glycemic control in type 1 diabetes. BMC Endocr Disord. 2003;10:1-9.
    • (2003) BMC Endocr Disord , vol.10 , pp. 1-9
    • Behme, M.T.1    Dupre, J.2    McDonald, T.J.3
  • 41
    • 77952758235 scopus 로고    scopus 로고
    • Effect of GLP-1 on alfa and beta-cell function in c-peptide negative type 1 diabetic patients
    • Kielgast A, Madsbad H. Effect of GLP-1 on alfa and beta-cell function in c-peptide negative type 1 diabetic patients. J Clin Endocrin Metab 2010;95(5):2492-6.
    • (2010) J Clin Endocrin Metab , vol.95 , Issue.5 , pp. 2492-2496
    • Kielgast, A.1    Madsbad, H.2
  • 46
    • 0031731228 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on the kinetics of glycogen synthase a in hepatocytes from normal and diabetic rats
    • DOI 10.1210/en.139.6.2811
    • Lopez-Delgado MI, Morales M, Villanueva-Penacarrillo ML, Malaisse WJ, Valverde I. Effects of glucagon-like peptide 1 on the kinetics of glycogen synthase a in hepatocytes from normal and diabetic rats. Endocrinology. 1998;139:2811-17. (Pubitemid 28512390)
    • (1998) Endocrinology , vol.139 , Issue.6 , pp. 2811-2817
    • Lopez-Delgado, M.I.1    Morales, M.2    Villanueva-Penacarrillo, M.L.3    Malaisse, W.J.4    Valverde, I.5
  • 47
    • 0042668287 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes
    • DOI 10.2337/diacare.26.3.837
    • Meneilly GS, McIntosh CH, Pederson RA, et al. Effect of glucagonlike peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes. Diabetes Care. 2003;26:837-42. (Pubitemid 36929352)
    • (2003) Diabetes Care , vol.26 , Issue.3 , pp. 837-842
    • Meneilly, G.S.1    McIntosh, C.H.S.2    Pederson, R.A.3    Habener, J.F.4    Ehlers, M.R.W.5    Egan, J.M.6    Elahi, D.7
  • 48
    • 0035123797 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-1(7-36)-amide on initial splanchnic glucose uptake and insulin action in humans with type 1 diabetes
    • Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk FW, et al. Effect of glucagon-like peptide-1(7-36)-amide on initial splanchnic glucose uptake and insulin action in humans with type 1 diabetes. Diabetes. 2001;50:565-72. (Pubitemid 32195221)
    • (2001) Diabetes , vol.50 , Issue.3 , pp. 565-572
    • Vella, A.1    Shah, P.2    Basu, R.3    Basu, A.4    Camilleri, M.5    Schwenk, F.W.6    Holst, J.J.7    Rizza, R.A.8
  • 49
    • 0036035521 scopus 로고    scopus 로고
    • Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans
    • DOI 10.1007/s00125-002-0924-4
    • Vella A, Shah P, Reed AS, Adkins AS, Basu R, Rizza RA. Lack of effect of exendin-4 and glucagon-like peptide-1-(7-36)-amide on insulin action in nondiabetic humans. Diabetologia. 2002;45:1410-15. (Pubitemid 35244894)
    • (2002) Diabetologia , vol.45 , Issue.10 , pp. 1410-1415
    • Vella, A.1    Shah, P.2    Reed, A.3    Adkins, A.4    Basu, R.5    Rizza, R.6
  • 50
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • DOI 10.1053/j.gastro.2007.03.054, PII S001650850700580X
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132:2131-57. (Pubitemid 46711096)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 51
    • 2542479899 scopus 로고    scopus 로고
    • Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    • DOI 10.1210/en.2004-0015
    • Brubaker PL, Drucker DJ. Minireview. Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology. 2004;145:2653-9. (Pubitemid 38686211)
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 2653-2659
    • Brubaker, P.L.1    Drucker, D.J.2
  • 52
    • 4344675057 scopus 로고    scopus 로고
    • Therapeutic strategies based on glucagon-like peptide 1
    • DOI 10.2337/diabetes.53.9.2181
    • Deacon CF. Therapeutic strategies based on glucagon-like peptide. Diabetes. 2004;53:2181-9. (Pubitemid 39145569)
    • (2004) Diabetes , vol.53 , Issue.9 , pp. 2181-2189
    • Deacon, C.F.1
  • 53
    • 0037357951 scopus 로고    scopus 로고
    • GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells
    • DOI 10.1002/dmrr.357
    • Egan JM, Bulotta A, Hui H, Perfetti R. GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab Res Rev. 2003;19:115-23. (Pubitemid 36417195)
    • (2003) Diabetes/Metabolism Research and Reviews , vol.19 , Issue.2 , pp. 115-123
    • Egan, J.M.1    Bulotta, A.2    Hui, H.3    Perfetti, R.4
  • 54
  • 55
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • DOI 10.1038/nm1196-1254
    • Scrocchi LA, Brown TJ, MacLusky N, Brubaker PL, Auerbach AB, Joyner AL, et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med. 1996;2:1254-8. (Pubitemid 26375413)
    • (1996) Nature Medicine , vol.2 , Issue.11 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    MacLusky, N.3    Brubaker, P.L.4    Auerbach, A.B.5    Joyner, A.L.6    Drucker, D.J.7
  • 56
    • 0031789874 scopus 로고    scopus 로고
    • Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: Implications for basal intracellular cyclic adenosine 3',5'-monophosphate levels and β-cell glucose competence
    • DOI 10.1210/en.139.11.4448
    • Serre V, Dolci W, Schaerer E, Scrocchi L, Drucker D, Efrat S, et al. Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: implications for basal intracellular cyclic adenosine 3,5-monophosphate levels and beta-cell glucose competence. Endocrinology. 1998;139:4448-54. (Pubitemid 28487758)
    • (1998) Endocrinology , vol.139 , Issue.11 , pp. 4448-4454
    • Serre, V.1    Dolci, W.2    Schaerer, E.3    Scrocchi, L.4    Drucker, D.5    Efrat, S.6    Thorens, B.7
  • 58
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells
    • Fehmann HC, Habener JF. Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology. 1992;130:159-66.
    • (1992) Endocrinology , vol.130 , pp. 159-166
    • Fehmann, H.C.1    Habener, J.F.2
  • 60
    • 0141953908 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 synthetic analogs: New therapeutic agents for use in the treatment of diabetes mellitus
    • DOI 10.2174/0929867033456648
    • Holz GG, Chepurny OG. Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus. Curr Med Chem. 2003;10:2471-83. (Pubitemid 37236400)
    • (2003) Current Medicinal Chemistry , vol.10 , Issue.22 , pp. 2471-2483
    • Holz, G.G.1    Chepurny, O.G.2
  • 61
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: A model of immune dysregulation
    • DOI 10.1146/annurev.immunol.23.021704.115643
    • Anderson MS, Bluestone JA. The NOD mouse. A model of immune dysregulation. Annu Rev Immunol. 2005;23:447-85. (Pubitemid 40563177)
    • (2005) Annual Review of Immunology , vol.23 , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 63
    • 40849102699 scopus 로고    scopus 로고
    • Exendin-4 modulates diabetes onset in nonobese diabetic mice
    • DOI 10.1210/en.2007-1137
    • Hadjiyanni I, Baggio LL, Poussier P, Drucker DJ. Exendin-4 modulates diabetes onset in nonobese diabetic mice. Endocrinology. 2008;149:1338-49. (Pubitemid 351397945)
    • (2008) Endocrinology , vol.149 , Issue.3 , pp. 1338-1349
    • Hadjiyanni, I.1    Baggio, L.L.2    Poussier, P.3    Drucker, D.J.4
  • 64
    • 58149357117 scopus 로고    scopus 로고
    • Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice
    • Suarez-Pinzon WL, Power RF, Yan Y, Wasserfall C, Atkinson M, Rabinovitch A. Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice. Diabetes. 2008;57:3281-8.
    • (2008) Diabetes , vol.57 , pp. 3281-3288
    • Suarez-Pinzon, W.L.1    Power, R.F.2    Yan, Y.3    Wasserfall, C.4    Atkinson, M.5    Rabinovitch, A.6
  • 66
    • 33646163679 scopus 로고    scopus 로고
    • Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes
    • Yang Z, Chen M, Carter JD, et al. Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. Biochem Biophys Res Commun. 2006;344:1017-22.
    • (2006) Biochem Biophys Res Commun , vol.344 , pp. 1017-1022
    • Yang, Z.1    Chen, M.2    Carter, J.D.3
  • 67
    • 3042737844 scopus 로고    scopus 로고
    • Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4
    • DOI 10.2337/diabetes.53.7.1700
    • Ogawa N, List JF, Habener JF, Maki T. Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4. Diabetes. 2004;53:1700-5. (Pubitemid 38857027)
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1700-1705
    • Ogawa, N.1    List, J.F.2    Habener, J.F.3    Maki, T.4
  • 68
    • 77954521533 scopus 로고    scopus 로고
    • Decrease in beta-cell proliferation precedes apoptosis during diabetes development in Bio-Breeding/Worcester rat: Beneficial role of Exendin-4
    • Perez-Arana G, Blandino-Rosano M, Prada-Oliveira A, Aguilar-Diosdado M, Segundo C. Decrease in beta-cell proliferation precedes apoptosis during diabetes development in Bio-Breeding/Worcester rat: beneficial role of Exendin-4. Endocrinology. 2010;151:2538-46.
    • (2010) Endocrinology , vol.151 , pp. 2538-2546
    • Perez-Arana, G.1    Blandino-Rosano, M.2    Prada-Oliveira, A.3    Aguilar-Diosdado, M.4    Segundo, C.5
  • 69
    • 77951252480 scopus 로고    scopus 로고
    • Amelioration of hyperglycemia by intestinal overexpression of GLP-1 in mice
    • Liu MJ, Han J, Lee YS, Park MS, Shin S, Jun HS. Amelioration of hyperglycemia by intestinal overexpression of GLP-1 in mice. J Mol Med. 2010;88:351-8.
    • (2010) J Mol Med , vol.88 , pp. 351-358
    • Liu, M.J.1    Han, J.2    Lee, Y.S.3    Park, M.S.4    Shin, S.5    Jun, H.S.6
  • 70
    • 57149110807 scopus 로고    scopus 로고
    • EuCSGLP-1. What is known, new and controversial about GLP-1? Minutes of the 1st European GLP-1 club meeting, Marseille 28-29 May 2008
    • Burcelin R. EuCSGLP-1. What is known, new and controversial about GLP-1? Minutes of the 1st European GLP-1 club meeting, Marseille 28-29 May 2008. Diabetes Metab. 2008;34(6 Pt 1):627-30.
    • (2008) Diabetes Metab , vol.346 , Issue.PART 1 , pp. 627-630
    • Burcelin, R.1
  • 71
    • 41849097354 scopus 로고    scopus 로고
    • Beta-cell mass in diabetes: A realistic therapeutic target?
    • Meier JJ. Beta-cell mass in diabetes: a realistic therapeutic target? Diabetologia. 2008;51(5):703-13.
    • (2008) Diabetologia , vol.51 , Issue.5 , pp. 703-713
    • Meier, J.J.1
  • 72
    • 34249032122 scopus 로고    scopus 로고
    • Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth
    • DOI 10.1196/annals.1394.018, How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis
    • Roep BO. Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth. Ann NY Acad Sci. 2007;1103:1-10. (Pubitemid 46791118)
    • (2007) Annals of the New York Academy of Sciences , vol.1103 , pp. 1-10
    • Roep, B.O.1
  • 73
    • 12744259876 scopus 로고    scopus 로고
    • Beta-cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1
    • Li Y, Cao X, Li LX, Brubaker PL, Edlund H, Drucker DJ. Beta-cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Diabetes. 2005;54:482-91.
    • (2005) Diabetes , vol.54 , pp. 482-491
    • Li, Y.1    Cao, X.2    Li, L.X.3    Brubaker, P.L.4    Edlund, H.5    Drucker, D.J.6
  • 74
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA, et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. 2000;49:741-8. (Pubitemid 30339989)
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Bonner-Weir, S.5    Habener, J.F.6    Egan, J.M.7
  • 75
    • 33644844361 scopus 로고    scopus 로고
    • In vivo treatment with glucagon-like peptide 1 promotes the graft function of fetal islet-like cell clusters in transplanted mice
    • DOI 10.1016/j.biocel.2005.08.005, PII S1357272505002554, Diabetes: New Research and Novel Therapies
    • Suen PM, Li K, Chan JC, Leung PS. In vivo treatment with glucagon-like peptide 1 promotes the graft function of fetal isletlike cell clusters in transplanted mice. Int J Biochem Cell Biol. 2006;38:951-60. (Pubitemid 43363424)
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , Issue.5-6 , pp. 951-960
    • Suen, P.M.1    Li, K.2    Chan, J.C.N.3    Leung, P.S.4
  • 76
    • 49849105507 scopus 로고    scopus 로고
    • The use of exenatide in islet transplant recipients with chronic allograft dysfunction: Safety, efficacy and metabolic effects
    • Froud T, Faradji RN, Pileggi A, et al. The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy and metabolic effects. Transplantation. 2008;86:36-45.
    • (2008) Transplantation , vol.86 , pp. 36-45
    • Froud, T.1    Faradji, R.N.2    Pileggi, A.3
  • 78
    • 58849144338 scopus 로고    scopus 로고
    • Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanercept
    • Faradji RN, Tharavanij T, Messinger S, et al. Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanercept. Transplantation. 2008;27(86):1658-65.
    • (2008) Transplantation , vol.27 , Issue.86 , pp. 1658-1665
    • Faradji, R.N.1    Tharavanij, T.2    Messinger, S.3


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