A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague-Dawley rats

Toxicology

Volumn 267, Issue 1-3, 2010, Pages 154-158

  Kim, Kui Jin ^a   Lee, Ok Hwan ^a   Lee, Hee Hyun ^a   Lee, Boo Yong ^a  

^a CHA University   (South Korea)

Author keywords

Fucoidan; Oral toxicity; Safety; Sulfated polysaccharide

Indexed keywords

FUCOIDIN; POLYSACCHARIDE SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; BLOOD EXAMINATION; BODY WEIGHT; CONTROLLED STUDY; DRUG DOSE INCREASE; FEMALE; HISTOPATHOLOGY; MALE; NONHUMAN; OPHTHALMOSCOPY; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RAT; REPEATED DRUG DOSE; SAFETY; SEAWEED; SPRAGUE DAWLEY RAT; TOXICITY TESTING; UNDARIA; UNDARIA PINNATIFIDA; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; ANTICOAGULANTS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; BIOLOGICAL MARKERS; BODY WEIGHT; DRINKING; EATING; FEMALE; FIBRINOLYTIC AGENTS; MALE; ORGAN SIZE; POLYSACCHARIDES; RATS; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS; UNDARIA;

RATTUS; UNDARIA PINNATIFIDA;

EID: 71849086789     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.11.007     Document Type: Article

References (16)

1. Beress A., Wassermann O., Tahhan S., Bruhn T., Beress L., Kraiselburd E.N., Gonzalez L.V., de Motta G.E., and Chavez P.I. A new procedure for the isolation of anti-HIV compounds (polysaccharides and polyphenols) from the marine alga Fucus vesiculosus. J. Nat. Prod. 56 (1993) 478-488
2. Gavrilova E.A., Barbanova I.I., Usov A.I., Efimov V.S., and Smirnov A.I. The anticoagulant activity of fucoidans. Eksp. Klin. Farmakol. 60 (1997) 42-44
3. Gideon T.P., and Rengasamy R. Toxicological evaluation of fucoidan from Cladosiphon okamuranus. J. Med. Food 11 (2008) 638-642
4. Hayakawa K., and Nagamine T. Effect of fucoidan on the biotinidase kinetics in human hepatocellular carcinoma. Anticancer Res. 29 (2009) 1211-1217
5. Koyanagi S., Tanigawa N., Nakagawa H., Soeda S., and Shimeno H. Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities. Biochem. Pharmacol. 65 (2003) 173-179
6. Lee J.B., Hayashi K., Hashimoto M., Nakano T., and Hayashi T. Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu). Chem. Pharm. Bull. (Tokyo) 52 (2004) 1091-1094
7. Li N., Zhang Q., and Song J. Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats. Food Chem. Toxicol. 43 (2005) 421-426
8. Nishino T., Aizu Y., and Nagumo T. Antithrombin activity of a fucan sulfate from the brown seaweed Ecklonia kurome. Thromb. Res. 62 (1991) 765-773
9. Patankar M.S., Oehninger S., Barnett T., Williams R.L., and Clark G.F. A revised structure for fucoidan may explain some of its biological activities. J. Biol. Chem. 268 (1993) 21770-21776
10. Pereira M.S., Mulloy B., and Mourao P.A. Structure and anticoagulant activity of sulfated fucans. Comparison between the regular, repetitive, and linear fucans from echinoderms with the more heterogeneous and branched polymers from brown algae. J. Biol. Chem. 274 (1999) 7656-7667
11. Preeprame S., Hayashi K., Lee J.B., Sankawa U., and Hayashi T. A novel antivirally active fucan sulfate derived from an edible brown alga, Sargassum horneri. Chem. Pharm. Bull. (Tokyo) 49 (2001) 484-485
12. Religa P., Kazi M., Thyberg J., Gaciong Z., Swedenborg J., and Hedin U. Fucoidan inhibits smooth muscle cell proliferation and reduces mitogen-activated protein kinase activity. Eur. J. Vasc. Endovasc. Surg. 20 (2000) 419-426
13. Riou D., Colliec-Jouault S., Pinczon du Sel D., Bosch S., Siavoshian S., Le Bert V., Tomasoni C., Sinquin C., Durand P., and Roussakis C. Antitumor and antiproliferative effects of a fucan extracted from Ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. Anticancer Res. 16 (1996) 1213-1218
14. Teruya T., Konishi T., Uechi S., Tamaki H., and Tako M. Anti-proliferative activity of oversulfated fucoidan from commercially cultured Cladosiphon okamuranus TOKIDA in U937 cells. Int. J. Biol. Macromol. 41 (2007) 221-226
15. Trinchero J., Ponce N.M., Cordoba O.L., Flores M.L., Pampuro S., Stortz C.A., Salomon H., and Turk G. Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis. Phytother. Res. 23 (2009) 707-712
16. Zhuang C., Itoh H., Mizuno T., and Ito H. Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii). Biosci. Biotechnol. Biochem. 59 (1995) 563-567