Finding the way into the brain without MCT8

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 12, 2012, Pages 4362-4365

  Visser, W Edward ^a   Visser, Theo J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DIIODOTHYRONINE; LIOTHYRONINE; MONOCARBOXYLATE TRANSPORTER 8; ORGANIC ANION TRANSPORTER 1; PROPYLTHIOURACIL; SEX HORMONE BINDING GLOBULIN; THYROID HORMONE; THYROTROPIN; THYROXINE; THYROXINE DEIODINASE;

ALLAN HERNDON DUDLEY SYNDROME; BRAIN REGION; COGNITIVE DEFECT; EDITORIAL; GENE; GENE MUTATION; HORMONE TRANSPORT; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; MCT8 GENE; MEDICAL DECISION MAKING; MENTAL RETARDATION MALFORMATION SYNDROME; MYELINATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSYCHOMOTOR RETARDATION; THYROID FUNCTION TEST; TREATMENT OUTCOME;

DIIODOTHYRONINES; HUMANS; MALE; MENTAL RETARDATION, X-LINKED; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE HYPOTONIA; MUSCULAR ATROPHY; PROPIONATES;

EID: 84870763379     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3759     Document Type: Editorial

References (23)

1. Dratman MB, Futaesaku Y, Crutchfield FL, Berman N, Payne B, Sar M, Stumpf WE 1982 Iodine-125-labeled triiodothyronine in rat brain: evidence for localization in discrete neural systems. Science 215:309-312 (Pubitemid 12177531)
2. Visser WE, Friesema EC, Visser TJ 2011 Minireview: thyroid hormone transporters: the knowns and the unknowns. Mol Endocrinol 25:1-14
3. Friesema EC, Jansen J, Jachtenberg JW, Visser WE, Kester MH, Visser TJ 2008 Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10. Mol Endocrinol 22:1357-1369 (Pubitemid 351786996)
4. Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH 2006 Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol Endocrinol 20:2761-2772 (Pubitemid 44833533)
5. Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barrett TG, Mancilla EE, Svensson J, Kester MH, Kuiper GG, Balkassmi S, Uitterlinden AG, Koehrle J, Rodien P, Halestrap AP, Visser TJ 2004 Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 364:1435-1437 (Pubitemid 39370719)
6. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S 2004 A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74:168-175 (Pubitemid 38085248)
7. Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE 2005 Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. Am J Hum Genet 77:41-53 (Pubitemid 40848035)
8. Roberts LM, Woodford K, Zhou M, Black DS, Haggerty JE, Tate EH, Grindstaff KK, Mengesha W, Raman C, Zerangue N 2008 Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. Endocrinology 149:6251-6261
9. Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S 2006 Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology 147:4036-4043 (Pubitemid 44268357)
10. Trajkovic M, Visser TJ, Mittag J, Horn S, Lukas J, Darras VM, Raivich G, Bauer K, Heuer H 2007 Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8. J Clin Invest 117:627-635 (Pubitemid 46348521)
11. Ceballos A, Belinchon MM, Sanchez-Mendoza E, Grijota-Martinez C, Dumitrescu AM, Refetoff S, Morte B, Bernal J 2009 Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3′-triiodo-L-thyronine. Endocrinology 150:2491-2496
12. Mayerl S, Visser TJ, Darras VM, Horn S, Heuer H 2012 Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain. Endocrinology 153:1528-1537
13. Visser WE, Vrijmoeth P, Visser FE, Arts WF, van Toor H, Visser TJ 28 August 2012 Identification, functional analysis, prevalence and treatment of monocarboxylate transporter 8 (MCT8) mutations in a cohort of adult patients with mental retardation. Clin Endocrinol (Oxf) 10.1111/cen.12023
14. Wémeau JL, Pigeyre M, Proust-Lemoine E, d'Herbomez M, Gottrand F, Jansen J, Visser TJ, Ladsous M 2008 Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8. J Clin Endocrinol Metab 93:2084-2088 (Pubitemid 351831519)
15. Trajkovic-Arsic M, Visser TJ, Darras VM, Friesema EC, Schlott B, Mittag J, Bauer K, Heuer H 2010 Consequences of MCT8 deficiency for renal transport and metabolism of thyroid hormones in mice. Endocrinology 151:802-809
16. Liao XH, Di Cosmo C, Dumitrescu AM, Hernandez A, Van Sande J, St Germain DL, Weiss RE, Galton VA, Refetoff S 2011 Distinct roles of deiodinases on the phenotype of Mct8 defect: a comparison of eight different mouse genotypes. Endocrinology 152:1180-1191
17. Trajkovic-Arsic M, Müller J, Darras VM, Groba C, Lee S, Weih D, Bauer K, Visser TJ, Heuer H 2010 Impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice. Endocrinology 151:5053-5062
18. Di Cosmo C, Liao XH, Dumitrescu AM, Philp NJ, Weiss RE, Refetoff S 2010 Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion. J Clin Invest 120:3377-3388
19. Di Cosmo C, Liao XH, Dumitrescu AM, Weiss RE, Refetoff S 2009 A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport. Endocrinology 150:4450-4458
20. Verge CF, Konrad D, Cohen M, Di Cosmo C, Dumitrescu AM, Marcinkowski T, Hameed S, Hamilton J, Weiss RE, Refetoff S 2012 Diiodothyropropionic acid (DITPA) in the treatment of MCT8 deficiency. J Clin Endocrinol Metab 97:4515-4523
21. Ladenson PW, McCarren M, Morkin E, Edson RG, Shih MC, Warren SR, Barnhill JG, Churby L, Thai H, O'Brien T, Anand I, Warner A, Hattler B, Dunlap M, Erikson J, Goldman S 2010 Effects of the thyromimetic agent diiodothyropropionic acid on body weight, body mass index, and serum lipoproteins: a pilot prospective, randomized, controlled study. J Clin Endocrinol Metab 95:1349-1354
22. Mayerl S, Visser TJ, Bauer R, Darras V, Heuer H 2012 Consequences of brain-specific thyroid hormone deprivation in Mct8/Oatp1c1 double knockout mice. Thyroid 22(Suppl 1):A-6
23. Visser WE, Jansen J, Friesema EC, Kester MH, Mancilla E, Lundgren J, van der Knaap MS, Lunsing RJ, Brouwer OF, Visser TJ 2009 Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations. Hum Mutat 30:29-38