Impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice

Endocrinology

Volumn 151, Issue 10, 2010, Pages 5053-5062

  Trajkovic Arsic, Marija ^a   Müller, Julia ^a   Darras, Veerle M ^c   Groba, Claudia ^a   Lee, Sooyeon ^a   Weih, Debra ^a   Bauer, Karl ^a,d   Visser, Theo J ^b   Heuer, Heike ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE HORMONE; PROTEIN D1; THYROID HORMONE; THYROTROPIN; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG; CARRIER PROTEIN; IODIDE PEROXIDASE; IODOTHYRONINE DEIODINASE TYPE I; PAIRED BOX TRANSCRIPTION FACTOR; PAX8 PROTEIN, MOUSE; PROTIRELIN RECEPTOR; SLC16A2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HORMONE BLOOD LEVEL; HORMONE METABOLISM; HORMONE RELEASE; HORMONE SUBSTITUTION; HORMONE SYNTHESIS; HYPOPHYSIS; HYPOTHALAMUS; MONOCARBOXYLATE TRANSPORTER 8 DEFICIENCY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; THYROID GLAND; ANIMAL; BIOLOGICAL MODEL; BLOOD; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; GENETICS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; KIDNEY; KNOCKOUT MOUSE; LIVER; METABOLISM; PHYSIOLOGY;

ANIMALS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IODIDE PEROXIDASE; KIDNEY; LIVER; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PAIRED BOX TRANSCRIPTION FACTORS; RECEPTORS, THYROTROPIN-RELEASING HORMONE; THYROID GLAND; THYROID HORMONES; THYROTROPIN;

EID: 77957284457     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0593     Document Type: Article

References (31)

1. Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barret TG, Mancilla EE, Svensson J, Kester MHA, Kuiper GG, Balkassmi S, Uitterlinden AG, Koehrle J, Rodien P, Halestrap AP, Visser TJ 2004 Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 364:1435-1437
2. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S 2004 A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74:168-175
3. Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE 2005 Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. Am J Hum Genet 77:41-53
4. 3 levels caused by mutations in monocarboxylate transporter 8. Nat Clin Pract Endocrinol Metab 2:512-523
5. Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S 2006 Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology 147:4036-4043
6. Trajkovic M, Visser TJ, Mittag J, Horn S, Lukas J, Darras VM, Raivich G, Bauer K, Heuer H 2007 Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8. J Clin Invest 117:627-635
7. Ceballos A, Belinchon MM, Sanchez-Mendoza E, Grijota-Martinez C, Dumitrescu AM, Refetoff S, Morte B, Bernal J 2009 Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3′-triiodo-L-thyronine. Endocrinology 150:2491-2496
8. 3 transporter mutated in Allan-Herndon-Dudley syndrome. J Neurosci 29:9439-9449
9. Trajkovic-Arsic M, Visser TJ, Darras VM, Friesema EC, Schlott B, Mittag J, Bauer K, Heuer H 2010 Consequences of monocarboxylate transporter 8 deficiency for renal transport and metabolism of thyroid hormones in mice. Endocrinology 151:802-809
10. Price NT, Jackson VN, Halestrap AP 1998 Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J 329:321-328
11. Heuer H, Maier MK, Iden S, Mittag J, Friesema EC, Visser TJ, Bauer K 2005 The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology 146:1701-1706
12. Nishimura M, Naito S 2008 Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies. Drug Metab Pharmacokinet 23:22-44
13. Heuer H, Visser TJ 2009 Minireview: Pathophysiological importance of thyroid hormone transporters. Endocrinology 150:1078-1083
14. Biebermann H, Ambrugger P, Tarnow P, von Moers A, Schweizer U, Grueters A 2005 Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8. Eur J Endocrinol 153:359-366
15. Mansouri A, Chowdhury K, Gruss P 1998 Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet 19:87-90
16. Flamant F, Poguet AL, Plateroti M, Chassande O, Gauthier K, Streichenberger N, Mansouri A, Samarut J 2002 Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRα gene. Mol Endocrinol 16:24-32
17. Rabeler R, Mittag J, Geffers L, Rüther U, Leitges M, Parlow AF, Visser TJ, Bauer K 2004 Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Mol Endocrinol 18:1450-1460
18. Friedrichsen S, Christ S, Heuer H, Schäfer MK, Mansouri A, Bauer K, Visser TJ 2003 Regulation of iodothyronine deiodinases in the pax8-/- mouse model of congenital hypothyroidism. Endocrinology 144:777-784
19. Darras VM, Huybrechts LM, Berghman L, Kühn ER, Decuypere E 1990 Ontogeny of the effect of purified chicken growth hormone on the liver 5′ monodeiodination activity in the chicken: reversal of the activity after hatching. Gen Comp Endocrinol 77:212-220
20. Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH 2006 Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol Endocrinol 20:2761-2772
21. Schäfer MK, Day R 1995 In situ hybridization techniques to study processing enzyme expression at the cellular level. Methods Neurosci 23:16-44
22. Heuer H, Schafer MK, O'Donnell D, Walker P, Bauer K 2000 Expression of thyrotropin-releasing hormone receptor 2 (TRH-R2) in the central nervous system of rats. J Comp Neurol 428:319-336
23. Mittag J, Friedrichsen S, Heuer H, Polsfuss S, Visser TJ, Bauer K 2005 Athyroid Pax8-/- mice cannot be rescued by the inactivation of thyroid hormone receptor alpha1. Endocrinology 146:3179-3184
24. 3 replacement does not prevent excitotoxic cell death but reduces developmental neuronal apoptosis in newborn mice. Eur J Paediatr Neurol 11:129-135
25. Alkemade A, Friesema EC, Kuiper GG, Wiersinga WM, Swaab DF, Visser TJ, Fliers E 2006 Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary. Eur J Endocrinol 154:491-500
26. Taylor T, Weintraub BD 1985 Differential regulation of thyrotropin subunit apoprotein and carbohydrate biosynthesis by thyroid hormone. Endocrinology 116:1535-1542
27. Weintraub BD, Gesundheit N, Taylor T, Gyves PW 1989 Effect of TRH on TSH glycosylation and biological action. Ann NY Acad Sci 553:205-213
28. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ 2003 Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 278:40128-40135
29. Friedrichsen S, Christ S, Heuer H, Schäfer MK, Parlow AF, Visser TJ, Bauer K 2004 Expression of pituitary hormones in the Pax8-/- mouse model of congenital hypothyroidism. Endocrinology 145:1276-1283
30. Mittag J, Friedrichsen S, Strube A, Heuer H, Bauer K 2009 Analysis of hypertrophic thyrotrophs in pituitaries of athyroid Pax8-/- mice. Endocrinology 150:4443-4449
31. Wémeau JL, Pigeyre M, Proust-Lemoine E, d'Herbomez M, Gottrand F, Jansen J, Visser TJ, Ladsous M 2008 Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8. J Clin Endocrinol Metab 93:2084-2088