The triglyceride content in skeletal muscle is associated with hepatic but not peripheral insulin resistance in elderly twins

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 12, 2012, Pages 4571-4577

  Grunnet, Louise Groth ^a   Laurila, Esa ^b   Hansson, Ola ^b   Almgren, Peter ^b   Groop, Leif ^b   Brøns, Charlotte ^a   Poulsen, Pernille ^c   Vaag, Allan ^a  

^a Rigshospitalet   (Denmark)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ADULT; AEROBIC CAPACITY; ARTICLE; BODY COMPOSITION; BODY FAT; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HEPATIC INSULIN RESISTANCE; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; MUSCLE BIOPSY; PERIPHERAL INSULIN RESISTANCE; PRIORITY JOURNAL; SKELETAL MUSCLE; TWINS; VASTUS LATERALIS MUSCLE;

AGED; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE INTOLERANCE; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MIDDLE AGED; MUSCLE, SKELETAL; QUANTITATIVE TRAIT, HERITABLE; REGISTRIES; TRIGLYCERIDES; TWINS;

EID: 84870737014     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2061     Document Type: Article

References (40)

1. Phillips DI, Caddy S, Ilic V, Fielding BA, Frayn KN, Borthwick AC, Taylor R 1996 Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45:947-950 (Pubitemid 26282544)
2. Perseghin G, Scifo P, DeCobelli F, Pagliato E, Battezzati A, Arcelloni C, Vanzulli A, Testolin G, Pozza G, Del Maschio A, Luzi L 1999 Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600-1606 (Pubitemid 29356869)
3. Morino K, Petersen KF, Shulman GI 2006 Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 55:S9-S15 (Pubitemid 44927027)
4. Pan DA, Lillioja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH 1997 Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983-988 (Pubitemid 27220998)
5. Gaster M, Ottosen PD, Vach W, Christiansen H, Staehr P, Beck-Nielsen H, Schrøder HD 2003 GLUT4 expression in human muscle fibres is not correlated with intracellular triglyceride (TG) content. Is TG a maker or a marker of insulin resistance? APMIS 111:338-348 (Pubitemid 36560552)
6. Gaster M, Beck-Nielsen H 2006 Triacylglycerol accumulation is not primarily affected in myotubes established from type 2 diabetic subjects. Biochim Biophys Acta 1761:100-110
7. van Loon LJ, Goodpaster BH 2006 Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state. Pflugers Arch 451:606-616 (Pubitemid 43042172)
8. Dubé J, Goodpaster BH 2006 Assessment of intramuscular triglycerides: contribution to metabolic abnormalities. Curr Opin Clin Nutr Metab Care 9:553-559 (Pubitemid 44258029)
9. Kiens B 2006 Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol Rev 86:205-243
10. Virtue S, Vidal-Puig A 2010 Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective. Biochim Biophys Acta 1801:338-349
11. Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE 2012 Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death Differ 19:1003-1012
12. Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P 2012 Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483:350-354
13. Hauge M 1981 The Danish twin register. In: Mednick SA, Baert AE, Bachman BP, eds. An empirical basis for the primary prevention of psychosocial disorders. Oxford, UK: Oxford University Press; 217-221
14. Poulsen P, Levin K, Beck-Nielsen H, Vaag A 2002 Age-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twins. Diabetologia 45:1649-1657 (Pubitemid 35478134)
15. Poulsen P, Levin K, Petersen I, Christensen K, Beck-Nielsen H, Vaag A 2005 Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins. Diabetes 54:275-283 (Pubitemid 40105123)
16. Poulsen P, Vaag A 2006 The intrauterine environment as reflected by birth size and twin and zygosity status influences insulin action and intracellular glucose metabolism in an age- or time-dependent manner. Diabetes 55:1819-1825 (Pubitemid 44324138)
17. Clausen JP, Oxhøj H, Hansen JF, Pedersen-Bjergaard O, Henningsen P, Uhrenholdt A 1980 Exercise test and exercise ECG in the diagnosis and treatment of ischemic heart disease. Ugeskr Laeger 142:1743-1749 (Pubitemid 10042865)
18. Frayn KN 1983 Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634 (Pubitemid 13044099)
19. Vaag A, Alford F, Henriksen FL, Christopher M, Beck-Nielsen H 1995 Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM. Diabetologia 38:326-336
20. Kiens B, Richter EA 1996 Types of carbohydrate in an ordinary diet affect insulin action and muscle substrates in humans. Am J Clin Nutr 63:47-53 (Pubitemid 26005726)
21. Steele R 1959 Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82:420-430
22. Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA 2005 Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty acyl-CoAs and insulin action in type 2 diabetic patients. Diabetes 54:3148-3153 (Pubitemid 43334368)
23. Elia M, Livesey G 1992 Energy expenditure and fuel Selection in biological systems: the theory and practise of calculations based on indirect calorimetry and tracer methods. World Rev Nutr Diet 70:68-131
24. Neale MC, Cardon LR 1992 Methodology for genetic studies of twins and families. Nato Science Series. Dordrecht, The Netherlands: Kluwer Academic Publishers; 35-53
25. Chang CJ, Wu CH, Lu FH, Wu JS, Chiu NT, Yao WJ 1999 Discriminating glucose tolerance status by regions of interest of dualenergy x-ray absorptiometry. Clinical implications of body fat distribution. Diabetes Care 22:1938-1943 (Pubitemid 30433968)
26. Eriksson KF, Lindgärde F 1991 Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. The 6-year Malmo feasibility study. Diabetologia 34:891-898
27. Tripathy D, Eriksson KF, Orho-Melander M, Fredriksson J, Ahlqvist G, Groop L 2004 Parallel manifestation of insulin resistance and β cell decompensation is compatible with a common defect in type 2 diabetes. Diabetologia 47:782-793 (Pubitemid 38756990)
28. Steffensen CH, Roepstorff C, Madsen M, Kiens B 2002 Myocellular triacylglycerol breakdown in females but not in males during exercise. Am J Physiol Endocrinol Metab 282:E634-E642 (Pubitemid 34654780)
29. Haugaard SB, Mu H, Vaag A, Madsbad S 2009 Intramyocellular triglyceride content in man, influence of sex, obesity and glycaemic control. Eur J Endocrinol 161:57-64
30. Salgin B, Sleigh AJ, Williams RM, Jackson SJ, Bluck LJ, Murgatroyd PR, Humphreys SM, Harding S, Carpenter TA, Dunger DB 2009 Intramyocellular lipid levels are associated with peripheral but not hepatic insulin sensitivity in normal healthy subjects. Clin Sci (Lond) 117:111-118
31. Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI 2005 Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 54:603-608 (Pubitemid 40322060)
32. Misra A, Sinha S, Kumar M, Jagannathan NR, Pandey RM 2003 Proton magnetic resonance spectroscopy study of soleus muscle in non-obese healthy and type 2 diabetic Asian Northern Indian males: high intramyocellular lipid content correlates with excess body fat and abdominal obesity. Diabet Med 20:361-367 (Pubitemid 36605620)
33. Hwang JH, Stein DT, Barzilai N, Cui MH, Tonelli J, Kishore P, Hawkins M 2007 Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am J Physiol Endocrinol Metab 293:E1663-E1669 (Pubitemid 350255117)
34. Anderwald C, Bernroider E, Krssak M, Stingl H, Brehm A, Bischof MG, Nowotny P, Roden M, Waldhäusl W 2002 Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscle. Diabetes 51:3025-3032
35. Kotronen A, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H 2008 Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome. Diabetologia 51:130-138 (Pubitemid 50003448)
36. van Herpen NA, Schrauwen-Hinderling VB, Schaart G, Mensink RP, Schrauwen P 2011 Three weeks on a high-fat diet increases intrahepatic lipid accumulation and decreases metabolic flexibility in healthy overweight men. J Clin Endocrinol Metab 96:E691-E695
37. Moro C, Bajpeyi S, Smith SR 2008 Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity. Am J Physiol Endocrinol Metab 294:E203-E213 (Pubitemid 351231448)
38. Watt MJ 2009 Storing up trouble: does accumulation of intramyo-cellular triglycerides protect skeletal muscle from insulin resistance? Clin Exp Pharmacol Physiol 36:5-11
39. Bergman RN, Kim SP, Catalano KJ, Hsu IR, Chiu JD, Kabir M, Hucking K, Ader M 2006 Whyvisceral fat is bad: mechanisms of the metabolic syndrome. Obesity (Silver Spring) 14(Suppl 1):16S-19S
40. Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, Savoye M, Rothman DL, Shulman GI, Caprio S 2002 Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51:1022-1027 (Pubitemid 34438345)