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Volumn 12, Issue 6, 2012, Pages 697-704

Design of non-standard insulin analogs for the treatment of diabetes mellitus

Author keywords

Basal; Diabetes mellitus; Glycemic control; Insulin analog; Polyethylene glycol; Prandial; Protein engineering

Indexed keywords

INSULIN ASPART; INSULIN DEGLUDEC; INSULIN DERIVATIVE; INSULIN DETEMIR; INSULIN GLARGINE; INSULIN GLULISINE; INSULIN LISPRO; INSULIN PEGLISPRO; SHORT ACTING INSULIN;

EID: 84870713727     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-012-0318-z     Document Type: Article
Times cited : (41)

References (83)
  • 6
    • 0030805003 scopus 로고    scopus 로고
    • The new era of biotech insulin analogues
    • Brange J. The new era of biotech insulin analogues. Diabetologia. 1997;40:S48-53.
    • (1997) Diabetologia , vol.40
    • Brange, J.1
  • 7
    • 59949100151 scopus 로고    scopus 로고
    • Insulin analog therapy: Improving the match with physiologic insulin secretion
    • Freeman JS. Insulin analog therapy: improving the match with physiologic insulin secretion. J Am Osteopath Assoc. 2009;109:26-36.
    • (2009) J Am Osteopath Assoc , vol.109 , pp. 26-36
    • Freeman, J.S.1
  • 10
    • 0035032976 scopus 로고    scopus 로고
    • Insulin self-Association and the relationship to pharmacokinetics and pharmacodynamics
    • DeFelippis MR, Chance RE, Frank BH. Insulin self-Association and the relationship to pharmacokinetics and pharmacodynamics. Crit Rev Ther Drug Carrier Syst. 2001;18:201-64.
    • (2001) Crit Rev Ther Drug Carrier Syst , vol.18 , pp. 201-264
    • DeFelippis, M.R.1    Chance, R.E.2    Frank, B.H.3
  • 11
    • 0028336707 scopus 로고
    • Preparation of an insulin with improved pharmacokinetics relative to human insulin through consideration of structural homology with insulin-like growth factor i
    • DiMarchi RD, Chance RE, Long HB, Shields JE, Slieker LJ. Preparation of an insulin with improved pharmacokinetics relative to human insulin through consideration of structural homology with insulin-like growth factor I. Horm Res. 1994;41 SUPPL. 2:93-6.
    • (1994) Horm Res , vol.41 , Issue.SUPPL. 2 , pp. 93-96
    • DiMarchi, R.D.1    Chance, R.E.2    Long, H.B.3    Shields, J.E.4    Slieker, L.J.5
  • 12
    • 0027231640 scopus 로고
    • Action profile of the rapid acting insulin analogue: Human insulin b28asp
    • Heinemann L, Heise T, Jorgensen LN, Starke AA. Action profile of the rapid acting insulin analogue: human insulin B28Asp. Diabet Med. 1993;10:535-9.
    • (1993) Diabet Med , vol.10 , pp. 535-539
    • Heinemann, L.1    Heise, T.2    Jorgensen, L.N.3    Starke, A.A.4
  • 14
    • 0242490139 scopus 로고    scopus 로고
    • Insulin glulisine. Aventis pharma
    • Barlocco D. Insulin glulisine. Aventis Pharma. Curr Opin Investig Drugs. 2003;4:1240-4.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 1240-1244
    • Barlocco, D.1
  • 15
    • 65749106538 scopus 로고    scopus 로고
    • Insulin glulisine: An evaluation of its pharmacodynamic properties and clinical application
    • Helms KL, Kelley KW. Insulin glulisine: an evaluation of its pharmacodynamic properties and clinical application. Ann Pharmacother. 2009;43:658-68.
    • (2009) Ann Pharmacother , vol.43 , pp. 658-668
    • Helms, K.L.1    Kelley, K.W.2
  • 16
    • 77956637560 scopus 로고    scopus 로고
    • Rapid-Acting insulin analogues in basal-bolus regimens in type 1 diabetes mellitus
    • Garg S, Ampudia-Blasco FJ, Pfohl M. Rapid-Acting insulin analogues in Basal-bolus regimens in type 1 diabetes mellitus. Endocr Pract. 2010;16:486-5.
    • (2010) Endocr Pract , vol.16 , pp. 486-485
    • Garg, S.1    Ampudia-Blasco, F.J.2    Pfohl, M.3
  • 17
    • 0642373574 scopus 로고    scopus 로고
    • Are analogue insulins better than soluble in continuous subcutaneous insulin infusion? Results of a meta-Analysis
    • Colquitt J, Royle P, Waugh N. Are analogue insulins better than soluble in continuous subcutaneous insulin infusion? Results of a meta-Analysis. Diab Med. 2003;20:863-6.
    • (2003) Diab Med , vol.20 , pp. 863-866
    • Colquitt, J.1    Royle, P.2    Waugh, N.3
  • 18
    • 80655141686 scopus 로고    scopus 로고
    • Closed-loop insulin delivery for treatment of type 1 diabetes
    • Elleri D, Dunger DB, Hovorka R. Closed-loop insulin delivery for treatment of type 1 diabetes. BMC Med. 2011;9:120.
    • (2011) BMC Med , vol.9 , pp. 120
    • Elleri, D.1    Dunger, D.B.2    Hovorka, R.3
  • 19
    • 84855182418 scopus 로고    scopus 로고
    • Advances in pump technology: Insulin patch pumps, combined pumps and glucose sensors, and implanted pumps
    • Schaepelynck P, Darmon P, Molines L, Jannot-Lamotte MF, Treglia C, Raccah D. Advances in pump technology: insulin patch pumps, combined pumps and glucose sensors, and implanted pumps. Diabetes Metabol. 2011;37 SUPPL. 4:S85-93.
    • (2011) Diabetes Metabol , vol.37 , Issue.SUPPL. 4
    • Schaepelynck, P.1    Darmon, P.2    Molines, L.3    Jannot-Lamotte, M.F.4    Treglia, C.5    Raccah, D.6
  • 20
    • 77952985211 scopus 로고    scopus 로고
    • Optimal control of blood glucose: The diabetic patient or the machine?
    • Brown L, Edelman ER. Optimal control of blood glucose: the diabetic patient or the machine? Sci Transl Med. 2010;2:1-5.
    • (2010) Sci Transl Med , vol.2 , pp. 1-5
    • Brown, L.1    Edelman, E.R.2
  • 24
    • 84865117076 scopus 로고    scopus 로고
    • Insulin fibrillation and protein design: Topological resistance of single-chainanalogs to thermal degradation with application to a pump reservoir
    • Phillips NB, Whittaker J, Ismail-Beigi F, Weiss MA. Insulin fibrillation and protein design: topological resistance of single-chainanalogs to thermal degradation with application to a pump reservoir. J Diabetes Sci Technol. 2012;6:277-88.
    • (2012) J Diabetes Sci Technol , vol.6 , pp. 277-288
    • Phillips, N.B.1    Whittaker, J.2    Ismail-Beigi, F.3    Weiss, M.A.4
  • 25
    • 66949118931 scopus 로고    scopus 로고
    • Effect of a local heating device on insulin and glucose pharmacokinetic profiles in an open-label, randomized, two-period, one-way crossover study in patients with type 1 diabetes using continuous subcutaneous insulin infusion
    • Raz I, Weiss R, Yegorchikov Y, Bitton G, Nagar R, Pesach B. Effect of a local heating device on insulin and glucose pharmacokinetic profiles in an open-label, randomized, two-period, one-way crossover study in patients with type 1 diabetes using continuous subcutaneous insulin infusion. Clin Ther. 2009;31:980-7.
    • (2009) Clin Ther , vol.31 , pp. 980-987
    • Raz, I.1    Weiss, R.2    Yegorchikov, Y.3    Bitton, G.4    Nagar, R.5    Pesach, B.6
  • 27
    • 84855831064 scopus 로고    scopus 로고
    • Use of recombinant human hyaluronidase to accelerate rapid insulin analogue absorption: Experience with subcutaneous injection and continuous infusion
    • Vaughn DE, Muchmore DB. Use of recombinant human hyaluronidase to accelerate rapid insulin analogue absorption: experience with subcutaneous injection and continuous infusion. Endocr Pract. 2011;17:914-21.
    • (2011) Endocr Pract , vol.17 , pp. 914-921
    • Vaughn, D.E.1    Muchmore, D.B.2
  • 28
    • 34249872741 scopus 로고    scopus 로고
    • Novel microneedle patches for active insulin delivery are efficient in maintaining glycaemic control: An initial comparison with subcutaneous administration
    • Nordquist L, Roxhed N, Griss P, Stemme G. Novel microneedle patches for active insulin delivery are efficient in maintaining glycaemic control: an initial comparison with subcutaneous administration. Pharm Res. 2007;24:1381-8.
    • (2007) Pharm Res , vol.24 , pp. 1381-1388
    • Nordquist, L.1    Roxhed, N.2    Griss, P.3    Stemme, G.4
  • 29
    • 79953171920 scopus 로고    scopus 로고
    • Intradermal microneedle delivery of insulin lispro achieves faster insulin absorption and insulin action than subcutaneous injection
    • Pettis RJ, Ginsberg B, Hirsch L, Sutter D, Keith S, McVey E, et al. Intradermal microneedle delivery of insulin lispro achieves faster insulin absorption and insulin action than subcutaneous injection. Diabetes Technol Ther. 2011;13:435-42.
    • (2011) Diabetes Technol Ther , vol.13 , pp. 435-442
    • Pettis, R.J.1    Ginsberg, B.2    Hirsch, L.3    Sutter, D.4    Keith, S.5    McVey, E.6
  • 30
    • 84856019647 scopus 로고    scopus 로고
    • Improved pharmacokinetic and pharmacodynamic profile of rapid-Acting insulin using needle-free jet injection technology
    • Engwerda EE, Abbink EJ, Tack CJ, de Galan BE. Improved pharmacokinetic and pharmacodynamic profile of rapid-Acting insulin using needle-free jet injection technology. Diabetes Care. 2011;34:1804-8.
    • (2011) Diabetes Care , vol.34 , pp. 8
    • Engwerda, E.E.1    Abbink, E.J.2    Tack, C.J.3    De Galan, B.E.4
  • 31
    • 77956134435 scopus 로고    scopus 로고
    • Intra-individual variability of the metabolic effect of a novel rapid-Acting insulin (viaject) in comparison to regular human insulin
    • Hompesch M, McManus L, Pohl R, Simms P, Pfutzner A, Bulow E, et al. Intra-individual variability of the metabolic effect of a novel rapid-Acting insulin (VIAject) in comparison to regular human insulin. J Diabetes Sci Technol. 2008;2:568-71.
    • (2008) J Diabetes Sci Technol , vol.2 , pp. 568-571
    • Hompesch, M.1    McManus, L.2    Pohl, R.3    Simms, P.4    Pfutzner, A.5    Bulow, E.6
  • 32
    • 84857032198 scopus 로고    scopus 로고
    • U-100, ph-neutral formulation of viaject (r): Faster onset of action than insulin lispro in patients with type 1 diabetes
    • Heinemann L, Nosek L, Flacke F, Albus K, Krasner A, Pichotta P, et al. U-100, pH-Neutral formulation of VIAject (R): faster onset of action than insulin lispro in patients with type 1 diabetes. Diabetes Obes Metab. 2011;14:222-227.
    • (2011) Diabetes Obes Metab , vol.14 , pp. 222-227
    • Heinemann, L.1    Nosek, L.2    Flacke, F.3    Albus, K.4    Krasner, A.5    Pichotta, P.6
  • 33
    • 77951236321 scopus 로고    scopus 로고
    • Beyond the canonical 20 amino acids: Expanding the genetic lexicon
    • Young TS, Schultz PG. Beyond the canonical 20 amino acids: expanding the genetic lexicon. J Biol Chem. 2010;285:11039-44.
    • (2010) J Biol Chem , vol.285 , pp. 11039-11044
    • Young, T.S.1    Schultz, P.G.2
  • 35
    • 59849119877 scopus 로고    scopus 로고
    • Basal bolus dosing: A clinical experience
    • King AB, Armstrong DU. Basal bolus dosing: a clinical experience. Curr Diabetes Rev. 2005;1:215-20.
    • (2005) Curr Diabetes Rev , vol.1 , pp. 215-220
    • King, A.B.1    Armstrong, D.U.2
  • 36
    • 55949103730 scopus 로고    scopus 로고
    • The role of new basal insulin analogues in the initiation and optimization of insulin therapy in type 2 diabetes
    • Baxter MA. The role of new basal insulin analogues in the initiation and optimization of insulin therapy in type 2 diabetes. Acta Diabetol. 2008;45:253-68.
    • (2008) Acta Diabetol , vol.45 , pp. 253-268
    • Baxter, M.A.1
  • 37
    • 80053400535 scopus 로고    scopus 로고
    • Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: Systematic review and meta-Analysis
    • Pontiroli AE, Miele L, Morabito A. Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: systematic review and meta-Analysis. Diabetes Obes Metabol. 2011;13:1008-19.
    • (2011) Diabetes Obes Metabol , vol.13 , pp. 1008-1019
    • Pontiroli, A.E.1    Miele, L.2    Morabito, A.3
  • 38
    • 0023918646 scopus 로고
    • Soluble, prolonged-Acting insulin derivatives. Iii. Degree of protraction, crystallizability and chemical stability of insulins substituted in positions a21, b13, b23, b27, and b30
    • Markussen J, Diers I, Hougaard P, Langkjaer L, Norris K, Snel L, et al. Soluble, prolonged-Acting insulin derivatives. III. Degree of protraction, crystallizability and chemical stability of insulins substituted in positions A21, B13, B23, B27, and B30. Protein Eng. 1988;2:157-66.
    • (1988) Protein Eng , vol.2 , pp. 157-166
    • Markussen, J.1    Diers, I.2    Hougaard, P.3    Langkjaer, L.4    Norris, K.5    Snel, L.6
  • 39
    • 0036332546 scopus 로고    scopus 로고
    • Insulin glargine (lantus
    • Owens DR, Griffiths S. Insulin glargine (Lantus). Int J Pract. 2002;56:460-6.
    • (2002) Int J Pract , vol.56 , pp. 460-466
    • Owens, D.R.1    Griffiths, S.2
  • 41
    • 0034117810 scopus 로고    scopus 로고
    • Time-Action profile of the long-Acting insulin analog insulin glargine (hoe901) in comparison with those of nph insulin and placebo
    • Heinemann L, Linkeschova R, Rave K, Hompesch B, Sedlak M, Heise T. Time-Action profile of the long-Acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo. Diabetes Care. 2000;23:644-9.
    • (2000) Diabetes Care , vol.23 , pp. 644-649
    • Heinemann, L.1    Linkeschova, R.2    Rave, K.3    Hompesch, B.4    Sedlak, M.5    Heise, T.6
  • 43
    • 33847364416 scopus 로고    scopus 로고
    • Pi-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity
    • Kohn WD, Micanovic R, Myers SL, Vick AM, Kahl SD, Zhang L, et al. pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity. Peptides. 2007;28:935-48.
    • (2007) Peptides , vol.28 , pp. 935-948
    • Kohn, W.D.1    Micanovic, R.2    Myers, S.L.3    Vick, A.M.4    Kahl, S.D.5    Zhang, L.6
  • 44
    • 4344701890 scopus 로고    scopus 로고
    • The mechanism of protraction of insulin detemir, a longacting, acylated analog of human insulin
    • Havelund S, Plum A, Ribel U, Jonassen I, Volund A, Markussen J, et al. The mechanism of protraction of insulin detemir, a longacting, acylated analog of human insulin. Pharm Res. 2004;21:1498-504.
    • (2004) Pharm Res , vol.21 , pp. 1498-1504
    • Havelund, S.1    Plum, A.2    Ribel, U.3    Jonassen, I.4    Volund, A.5    Markussen, J.6
  • 45
    • 2442662934 scopus 로고    scopus 로고
    • Crystallographic and solution studies of nlithocholyl insulin: A new generation of prolonged-Acting human insulins
    • Whittingham JL, Jonassen I, Havelund S, Roberts SM, Dodson EJ, Verma CS, et al. Crystallographic and solution studies of Nlithocholyl insulin: a new generation of prolonged-Acting human insulins. Biochemistry. 2004;43:5987-95.
    • (2004) Biochemistry , vol.43 , pp. 5987-5995
    • Whittingham, J.L.1    Jonassen, I.2    Havelund, S.3    Roberts, S.M.4    Dodson, E.J.5    Verma, C.S.6
  • 47
    • 79952488537 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-long-Acting basal insulin, once a day or 3 times a week vs insulin glargine once a day in patients with type 2 diabetes: A 16-week, randomized, open-label, phase 2 trial
    • Zinman B, Fulcher G, Rao PV, Thomas N, Endahl LA, Johansen T, et al. Insulin degludec, an ultra-long-Acting basal insulin, once a day or 3 times a week vs insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomized, open-label, phase 2 trial. Lancet. 2011;377:924-31.
    • (2011) Lancet , vol.377 , pp. 924-931
    • Zinman, B.1    Fulcher, G.2    Rao, P.V.3    Thomas, N.4    Endahl, L.A.5    Johansen, T.6
  • 48
    • 79956110739 scopus 로고    scopus 로고
    • Insulin degludec in type 1 diabetes: A randomized controlled trial of a new-generation ultra-long-Acting insulin compared with insulin glargine
    • Birkeland KI, Home PD, Wendisch U, Ratner RE, Johansen T, Endahl LA, et al. Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-Acting insulin compared with insulin glargine. Diabetes Care. 2011;34:661-5.
    • (2011) Diabetes Care , vol.34 , pp. 661-665
    • Birkeland, K.I.1    Home, P.D.2    Wendisch, U.3    Ratner, R.E.4    Johansen, T.5    Endahl, L.A.6
  • 49
    • 79956136690 scopus 로고    scopus 로고
    • A new-generation ultra-long-Acting basal insulin with a bolus boost compared with insulin glargine in insulin-naive people with type 2 diabetes: A randomized, controlled trial
    • Heise T, Tack CJ, Cuddihy R, Davidson J, Gouet D, Liebl A, et al. A new-generation ultra-long-Acting basal insulin with a bolus boost compared with insulin glargine in insulin-naive people with type 2 diabetes: a randomized, controlled trial. Diabetes Care. 2011;34:669-74.
    • (2011) Diabetes Care , vol.34 , pp. 669-674
    • Heise, T.1    Tack, C.J.2    Cuddihy, R.3    Davidson, J.4    Gouet, D.5    Liebl, A.6
  • 50
    • 84859896417 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-longacting basal insulin, vs insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (begin basal-bolus type 1): A phase 3, randomized, open-label, treat-to-target non-inferiority trial
    • Phase 3 open label treat-to-target clinical trial data for insulin degludec done in patients with type 1 diabetes
    • Heller S, Buse J, Fisher M, Garg S, Marre M, Merker L, et al. Insulin degludec, an ultra-longacting basal insulin, vs insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus type 1): a phase 3, randomized, open-label, treat-to-target non-inferiority trial. Lancet. 2012;379:1489-97. Phase 3 open label treat-to-target clinical trial data for insulin degludec done in patients with type 1 diabetes.
    • (2012) Lancet , vol.379 , pp. 1489-1497
    • Heller, S.1    Buse, J.2    Fisher, M.3    Garg, S.4    Marre, M.5    Merker, L.6
  • 51
    • 84859921058 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-longacting basal insulin, vs insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (begin basal-bolus type 2): A phase 3, randomized, open-label, treat-to-target non-inferiority trial
    • Phase 3 open label treat-to-target clinical trial data for insulin degludec done in patients with type 2 diabetes
    • Garber AJ, King AB, Del Prato S, Sreenan S, Balci MK, Munoz- Torres M, et al. Insulin degludec, an ultra-longacting basal insulin, vs insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomized, open-label, treat-to-target non-inferiority trial. Lancet. 2012;379:1498-507. Phase 3 open label treat-to-target clinical trial data for insulin degludec done in patients with type 2 diabetes.
    • (2012) Lancet , vol.379 , pp. 1498-1507
    • Garber, A.J.1    King, A.B.2    Del Prato, S.3    Sreenan, S.4    Balci, M.K.5    Munoz- Torres, M.6
  • 53
    • 0025827116 scopus 로고
    • Insulin hexamers: New conformations and applications
    • Brader ML, Dunn MF. Insulin hexamers: new conformations and applications. Trends Biochem Sci. 1991;16:341-5.
    • (1991) Trends Biochem Sci , vol.16 , pp. 341-345
    • Brader, M.L.1    Dunn, M.F.2
  • 59
    • 84864460325 scopus 로고    scopus 로고
    • Design of the novel protraction mechanism of insulin degludec, an ultra-long-Acting basal insulin
    • The mechanism of the long-Acting insulin degludec analog isclearly laid out here along with much of the relevant biophysical data
    • Jonassen I, Havelund S,Hoeg-Jensen T, Steensgaard DB,Wahlund PO, Ribel U. Design of the novel protraction mechanism of insulin degludec, an ultra-long-Acting basal insulin. Pharm Res. 2012;2104- 2114. The mechanism of the long-Acting insulin degludec analog isclearly laid out here along with much of the relevant biophysical data.
    • (2012) Pharm Res , pp. 2104-2114
    • Jonassen, I.1    Havelund, S.2    Hoeg-Jensen, T.3    Steensgaard, D.B.4    Wahlund, P.O.5    Ribel, U.6
  • 60
    • 77951245183 scopus 로고    scopus 로고
    • Supramolecular protein engineering: Design of zinc-stapled insulin hexamers as a long acting depot
    • Phillips NB, Wan ZL, Whittaker L, Hu SQ, Huang K, Hua QX, et al. Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J Biol Chem. 2010;285:11755-9.
    • (2010) J Biol Chem , vol.285 , pp. 11755-11759
    • Phillips, N.B.1    Wan, Z.L.2    Whittaker, L.3    Hu, S.Q.4    Huang, K.5    Hua, Q.X.6
  • 61
    • 84874420438 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics (pk) and glucodynamics (gd) of the novel long-Acting basal insulin ly2605541 in healthy subjects
    • PA: Eli Lilly and Co; Data that illustrates the extended effect of pegylated insulin lispro obtained in healthy human adults using a single dose
    • Sinha VP, Howey DC, Kwang D, Soon W, Choi SL, Mace KF, et al. Single-dose pharmacokinetics (PK) and glucodynamics (GD) of the novel, long-Acting basal insulin LY2605541 in healthy subjects. In: Poster presented at the American Diabetes Association's 72nd Scientific Sessions. Philadelphia, PA: Eli Lilly and Co; 2012. Data that illustrates the extended effect of pegylated insulin lispro obtained in healthy human adults using a single dose.
    • (2012) Poster Presented at the American Diabetes Association's 72nd Scientific Sessions. Philadelphia
    • Sinha, V.P.1    Howey, D.C.2    Kwang, D.3    Soon, W.4    Choi, S.L.5    Mace, K.F.6
  • 63
    • 84870680668 scopus 로고    scopus 로고
    • Ly2605541: Leveraging hydrodynamic size to develop a novel basal insulin 896-p
    • Philadelphia, PA: Lilly Laboratories; Explains the rationale behind the design of pegylated insulin lispro and provides the supporting data done in rats
    • Hansen RJ, Cutler JGB, Vick A, Koester A, Li S, Siesky AM, et al. LY2605541: Leveraging hydrodynamic size to develop a novel basal insulin 896-P. In: Poster presented at the American Diabetes Association's 72nd Scientific Sessions. Philadelphia, PA: Lilly Laboratories; 2012. Explains the rationale behind the design of pegylated insulin lispro and provides the supporting data done in rats.
    • (2012) Poster Presented at the American Diabetes Association's 72nd Scientific Sessions
    • Hansen, R.J.1    Cutler, J.G.B.2    Vick, A.3    Koester, A.4    Li, S.5    Siesky, A.M.6
  • 64
    • 84874406104 scopus 로고    scopus 로고
    • Novel pegylated basal insulin ly2605541 has a preferential hepatic effect on glucose metabolism
    • Philadelphia, PA: Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine
    • Moore MC, Smith MS, Mace KF, Sinha VP, Dodson M, Jacober SJ, et al. Novel PEGylated basal Insulin LY2605541 has a preferential hepatic effect on glucose metabolism. In: Poster presented at the American Diabetes Association's 72nd Scientific Sessions. Philadelphia, PA: Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine; 2012.
    • (2012) Poster Presented at the American Diabetes Association's 72nd Scientific Sessions
    • Moore, M.C.1    Smith, M.S.2    Mace, K.F.3    Sinha, V.P.4    Dodson, M.5    Jacober, S.J.6
  • 65
    • 33845938292 scopus 로고    scopus 로고
    • Pegylated proteins: Evaluation of their safety in the absence of definitive metabolism studies
    • Webster R, Didier E, Harris P, Siegel N, Stadler J, Tilbury L, et al. PEGylated proteins: evaluation of their safety in the absence of definitive metabolism studies. Drug Metabol Dispos. 2007;35:9-16.
    • (2007) Drug Metabol Dispos , vol.35 , pp. 9-16
    • Webster, R.1    Didier, E.2    Harris, P.3    Siegel, N.4    Stadler, J.5    Tilbury, L.6
  • 66
    • 0037124546 scopus 로고    scopus 로고
    • The origin of pegnology
    • Davis FF. The origin of pegnology. Adv Drug Deliv Rev. 2002;54:457-8.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 457-458
    • Davis, F.F.1
  • 67
    • 26944452043 scopus 로고    scopus 로고
    • Pegylation, successful approach to drug delivery
    • Veronese FM, Pasut G. PEGylation, successful approach to drug delivery. Drug Discov Today. 2005;10:1451-8.
    • (2005) Drug Discov Today , vol.10 , pp. 1451-1458
    • Veronese, F.M.1    Pasut, G.2
  • 69
    • 84863884698 scopus 로고    scopus 로고
    • α-Helical element at the hormonebinding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase
    • Whittaker J, Whittaker LJ, Roberts Jr. CT, Phillips NB, Ismail- Beigi F, Lawrence MC, et al. α-Helical element at the hormonebinding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase. Proc Natl Acad Sci U S A. 2012;109:11166-71.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 11166-11171
    • Whittaker, J.1    Whittaker, L.J.2    Roberts Jr., C.T.3    Phillips, N.B.4    Ismail-Beigi, F.5    Lawrence, M.C.6
  • 70
    • 33749485995 scopus 로고    scopus 로고
    • Novel insulin analogues and its mitogenic potential
    • Zib I, Raskin P. Novel insulin analogues and its mitogenic potential. Diabetes Obes Metabol. 2006;8:611-20.
    • (2006) Diabetes Obes Metabol , vol.8 , pp. 611-620
    • Zib, I.1    Raskin, P.2
  • 71
    • 78650190900 scopus 로고    scopus 로고
    • Insulin glargine and nph insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice
    • Nagel JM, Staffa J, Renner-Muller I, Horst D, Vogeser M, Langkamp M, et al. Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice. Horm Canc. 2010;1:320-30.
    • (2010) Horm Canc , vol.1 , pp. 320-330
    • Nagel, J.M.1    Staffa, J.2    Renner-Muller, I.3    Horst, D.4    Vogeser, M.5    Langkamp, M.6
  • 72
    • 79960700555 scopus 로고    scopus 로고
    • Glargine promotes proliferation of breast adenocarcinoma cell line mcf-7 via akt activation
    • Teng JA, Hou RL, Li DL, Yang RP, Qin J. Glargine promotes proliferation of breast adenocarcinoma cell line MCF-7 via AKT activation. Horm Metab Res. 2011;43:519-23.
    • (2011) Horm Metab Res , vol.43 , pp. 519-523
    • Teng, J.A.1    Hou, R.L.2    Li, D.L.3    Yang, R.P.4    Qin, J.5
  • 73
    • 84858070444 scopus 로고    scopus 로고
    • The relationship between the exposure time of insulin glargine andrisk of breast andprostate cancer: An observational study of the time-dependent effects of antidiabetic treatments in patients with diabetes
    • LindM, FahlenM, Eliasson B,Oden A. The relationship between the exposure time of insulin glargine andrisk of breast andprostate cancer: an observational study of the time-dependent effects of antidiabetic treatments in patients with diabetes. Prim Care Diabetes. 2011;6:53- 59.
    • (2011) Prim Care Diabetes , vol.6 , pp. 53-59
    • Lind, M.1    Fahlen, M.2    Eliasson, B.3    Oden, A.4
  • 74
    • 84856696946 scopus 로고    scopus 로고
    • Insulin glargine and risk of cancer: A cohort study in the french national healthcare insurance database
    • Blin P, Lassalle R, Dureau-Pournin C, Ambrosino B, Bernard MA, Abouelfath A, et al. Insulin glargine and risk of cancer: a cohort study in the French National Healthcare Insurance Database. Diabetologia. 2012;55:644-653.
    • (2012) Diabetologia , vol.55 , pp. 644-653
    • Blin, P.1    Lassalle, R.2    Dureau-Pournin, C.3    Ambrosino, B.4    Bernard, M.A.5    Abouelfath, A.6
  • 75
    • 84856715759 scopus 로고    scopus 로고
    • Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: Results from a large population-based follow-up study
    • Ruiter R, Visser LE, van Herk-Sukel MP, Coebergh JW, Haak HR, Geelhoed-Duijvestijn PH, et al. Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study. Diabetologia. 2012;55:51-62.
    • (2012) Diabetologia , vol.55 , pp. 51-62
    • Ruiter, R.1    Visser, L.E.2    Van Herk-Sukel, M.P.3    Coebergh, J.W.4    Haak, H.R.5    Geelhoed-Duijvestijn, P.H.6
  • 76
    • 1842515683 scopus 로고    scopus 로고
    • Continuous subcutaneous insulin infusion with short-Acting insulin analogues or human regular insulin: Efficacy, safety, quality of life, and cost-effectiveness
    • Radermecker RP, Scheen AJ. Continuous subcutaneous insulin infusion with short-Acting insulin analogues or human regular insulin: efficacy, safety, quality of life, and cost-effectiveness. Diabetes Metabol Res Rev. 2004;20:178-88.
    • (2004) Diabetes Metabol Res Rev , vol.20 , pp. 178-188
    • Radermecker, R.P.1    Scheen, A.J.2
  • 77
    • 11844250564 scopus 로고    scopus 로고
    • Insulin analogues
    • Hirsch IB. Insulin analogues. N Engl J Med. 2005;352:174-83.
    • (2005) N Engl J Med , vol.352 , pp. 174-183
    • Hirsch, I.B.1
  • 78
    • 58149346043 scopus 로고    scopus 로고
    • Is the use of insulin analogues cost-effective?
    • Leichter S. Is the use of insulin analogues cost-effective? Adv Ther. 2008;25:285-99.
    • (2008) Adv Ther , vol.25 , pp. 285-299
    • Leichter, S.1
  • 79
    • 61449180331 scopus 로고    scopus 로고
    • Cost-effectiveness of insulin analogues for diabetes mellitus
    • Cameron CG, Bennett HA. Cost-effectiveness of insulin analogues for diabetes mellitus. CMAJ. 2009;180:400-7.
    • (2009) CMAJ , vol.180 , pp. 400-407
    • Cameron, C.G.1    Bennett, H.A.2
  • 80
    • 0042528355 scopus 로고    scopus 로고
    • Global epidemic of type 2 diabetes: Implications for developing countries
    • Osei K. Global epidemic of type 2 diabetes: implications for developing countries. Ethn Dis. 2003;13:S102-6.
    • (2003) Ethn Dis , vol.13
    • Osei, K.1
  • 81
    • 0037398399 scopus 로고    scopus 로고
    • Pathogenesis of type 1 and type 2 diabetes mellitus in sub-saharan africa: Implication for transitional populations
    • Osei K, Schuster DP, Amoah AG, Owusu SK. Pathogenesis of type 1 and type 2 diabetes mellitus in sub-Saharan Africa: implication for transitional populations. J Cardiovasc Risk. 2003;10:85-96.
    • (2003) J Cardiovasc Risk , vol.10 , pp. 85-96
    • Osei, K.1    Schuster, D.P.2    Amoah, A.G.3    Owusu, S.K.4
  • 82
    • 16544369929 scopus 로고    scopus 로고
    • The global challenge of diabetes
    • Lefebvre P, Pierson A. The global challenge of diabetes. World Hosp Health Serv. 2004;40:37-40, 42.
    • (2004) World Hosp Health Serv , vol.40 , Issue.42 , pp. 37-40
    • Lefebvre, P.1    Pierson, A.2


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