Crystallographic and solution studies of N-lithocholyl insulin: A new generation of prolonged-acting human insulins

Biochemistry

Volumn 43, Issue 20, 2004, Pages 5987-5995

  Whittingham, Jean L ^a   Jonassen, Ib ^b   Havelund, Svend ^b   Roberts, Shirley M ^a   Dodson, Eleanor J ^a   Verma, Chandra S ^a,c   Wilkinson, Anthony J ^a   Dodson, G Guy ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b NOVO NORDISK A S   (Denmark)

^c BIOINFORMATICS INSTITUTE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CRYSTALLIZATION; ENZYMES; INSULIN; MOLECULAR STRUCTURE; X RAY CRYSTALLOGRAPHY;

BLOOD STREAMS; MACROMOLECULAR COMPLEXES;

BIOCHEMISTRY;

INSULIN DERIVATIVE; LITHOCHOLIC ACID; N LITHOCHOLYLINSULIN; UNCLASSIFIED DRUG;

ACYLATION; ADDITION REACTION; ALBUMIN BLOOD LEVEL; ARTICLE; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG ABSORPTION; DRUG CONFORMATION; DRUG MECHANISM; HUMAN; HYDROPHOBICITY; INJECTION SITE; INSULIN BINDING; INSULIN TREATMENT; MACROMOLECULE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; OPTICAL RESOLUTION; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DELAYED-ACTION PREPARATIONS; HUMANS; INSULIN; LITHOCHOLIC ACID; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, QUATERNARY; RECEPTOR, INSULIN;

EID: 2442662934     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036163s     Document Type: Article

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